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T-Wave Alternans in Patients With Suspected Acute Coronary Syndrome (TWA)

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT01137513
Recruitment Status : Completed
First Posted : June 4, 2010
Last Update Posted : May 26, 2014
Information provided by (Responsible Party):
Loma Linda University

Brief Summary:
The purpose of this study is to measure T-Wave Alternans (TWA) in patients with acute coronary syndrome. Researchers are blinded to clinical TWA measurements. The investigators will then try to determine if T-Wave alternans correlates with clinical outcome of patients with Acute Coronary Syndrome. During routine care of the patient, the T Wave Alternans is measured.

Condition or disease Intervention/treatment
Chest Pain Acute Coronary Syndrome Acute Myocardial Infarction Device: Observational Measurement of T-wave Alternans Device: T-wave Alternans

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Study Type : Observational
Actual Enrollment : 252 participants
Observational Model: Cohort
Time Perspective: Prospective
Official Title: T-Wave Alternans in Patients Acute Coronary Syndrome
Study Start Date : July 2010
Actual Primary Completion Date : December 2013
Actual Study Completion Date : December 2013

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Chest Pain

Group/Cohort Intervention/treatment
Chest Pain
Acute Myocardial ischemia
Device: Observational Measurement of T-wave Alternans
Measurement is similar to typical EKG

Device: T-wave Alternans
T-Wave Alternans will be measured in an observational fashion

Primary Outcome Measures :
  1. correlation of T-Wave Alternans with Acute myocardial Ischemia [ Time Frame: 6 month ]
    We hope to correlate the Twave Alternans with Acute Myocardial Ischemia. Most importantly we are trying to create a sensitive measure of acute myocardial Ischemia or a rule out study.

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years and older   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Probability Sample
Study Population
18-100 Pt presenting with Chest Pain

Inclusion Criteria:

  • Adults with Acute Chest Pain

Exclusion Criteria:

  • Patients with underlying myoclonic tremors making measurement artifact unreliable
  • Less than 18 years of age
  • Skin disorders that do not allow the Cardiac Monitor Leads to adhere to the skin

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT01137513

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United States, California
Loma Linda University
Loma Linda, California, United States, 92562
Sponsors and Collaborators
Loma Linda University

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Responsible Party: Loma Linda University Identifier: NCT01137513     History of Changes
Other Study ID Numbers: RS-49780
First Posted: June 4, 2010    Key Record Dates
Last Update Posted: May 26, 2014
Last Verified: May 2014
Keywords provided by Loma Linda University:
Chest Pain
Acute coronary syndrome
Additional relevant MeSH terms:
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Myocardial Infarction
Acute Coronary Syndrome
Chest Pain
Pathologic Processes
Myocardial Ischemia
Heart Diseases
Cardiovascular Diseases
Vascular Diseases
Neurologic Manifestations
Signs and Symptoms