Analgesia Effects of Intravenous Ketamine After Spinal Anesthesia for Non-elective Cesarean Section
|The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.|
|ClinicalTrials.gov Identifier: NCT03450499|
Recruitment Status : Completed
First Posted : March 1, 2018
Last Update Posted : August 20, 2019
|Condition or disease||Intervention/treatment||Phase|
|Non Elective Cesarean Section and Ketamine Analgesia||Drug: Ketamine Drug: Placebo||Phase 4|
|Study Type :||Interventional (Clinical Trial)|
|Actual Enrollment :||80 participants|
|Intervention Model:||Parallel Assignment|
|Masking:||Double (Participant, Investigator)|
|Official Title:||Analgesia Effects of Intravenous Ketamine After Spinal Anesthesia for Non-elective Cesarean Section|
|Actual Study Start Date :||April 1, 2018|
|Actual Primary Completion Date :||March 7, 2019|
|Actual Study Completion Date :||March 7, 2019|
Experimental: analgesic effects of ketamine
the experimental group will receive ketamine intravenously at 0.25 mg per kg before skin incision.
the analgesic affects of ketamine will be compared between the experimental and placebo group.
Other Name: ketamine hydrochloride
Placebo Comparator: placebo
they will receive same volume of 0.9% normal saline as calculated for experimental group before skin incision.
the analgesic requirement will be calculated in placebo group.
- Total opioid requirement postoperatively [ Time Frame: 24 hrs ]Total opioid required up to 24 postoperatively in ketamine and placebo group.
- Postoperative numerator rating scores(NRS)up to 24 hrs . postoperative ) [ Time Frame: 24 hrs ]• Postoperative NRS Scores (on arrival to Post operative care unit), 2, 4, 6, 8, 12 and 24 h ).The NRS ranges from 0- 10 and 0 refers to no pain and 10 means extreme possible pain perceived.
- Time to first perception of pain [ Time Frame: 24 hrs ]Time to first perception of pain
- Incidence of side effects [ Time Frame: 24 hrs ]Incidence of post operative nausea and vomiting, shivering, sedation scores, side effects related to ketamine during the first 24h
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT03450499
|BP Koirala Institute of Health Sciences (BPKIHS)|
|Dharān Bāzār, Koshi, Nepal, 56700|