Measurements of Myocardial Relaxation Time by MRI During Respiration (ARTEMIS)
|ClinicalTrials.gov Identifier: NCT03234205|
Recruitment Status : Completed
First Posted : July 31, 2017
Last Update Posted : August 3, 2017
Measurement of T2 transversal relaxation time by magnetic resonance has a major interest in cardiac imagery. It has been initially used for quantitative evaluation of heart viability and more recently for edema characterization. It allows to prematurely detect a cardiac transplant rejection. This technique needs successively around ten FSE sequences during apnea. Weak reproducibility of successive apneas and discomfort of patient limit the precision of this measurement and consequently its use in standard care. The ARTEMIS study method allows the examination during free respiration without prolonging the duration of examination compared to the examination during apnea. Moreover, image processing is simplified and correction of respiratory movements renders results more reliable.
This is a pilot study of evaluation of ARTEMIS technique of image reconstruction. ARTEMIS is a method of MRI image reconstruction for measurements of T2 transversal relaxation. It allows to obtain diagnostic images without movement artifacts.
The primary objective si to show the feasibility of ARTEMIS method for measurement of myocardial T2 relaxation time during free respiration in cardiac transplant patients.
The secondary objective is to collect quantitative data to compare ARTEMIS method of measurement of T2 during free respiration and standard clinical practice during apnea.
|Condition or disease||Intervention/treatment||Phase|
|Heart Transplantation||Device: MRI scan||Not Applicable|
|Study Type :||Interventional (Clinical Trial)|
|Actual Enrollment :||9 participants|
|Intervention Model:||Single Group Assignment|
|Masking:||None (Open Label)|
|Primary Purpose:||Device Feasibility|
|Official Title:||Measurements of Myocardial Relaxation Time by MRI During Respiration|
|Actual Study Start Date :||August 31, 2011|
|Actual Primary Completion Date :||December 19, 2012|
|Actual Study Completion Date :||December 19, 2012|
|Experimental: MRI scan during free respiration||
Device: MRI scan
MRI standard protocol with addition of:
- Image quality assessed y senior radiologists [ Time Frame: baseline ]
- Movement correction in images assessed by senior radiologists [ Time Frame: baseline ]
- Quantitative measurement of myocardial transversal relaxation time in 6 segments of short median axe cross-section of left ventricle in standard and ARTEMIS images [ Time Frame: baseline ]
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT03234205
|CHRU de Nancy Brabois|
|Vandoeuvre les nancy, France|