Studying Genes in Samples From Younger Patients With Desmoplastic Small Round Cell Tumor Registered on COG-D9902 or COG-ABTR01B1
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|ClinicalTrials.gov Identifier: NCT01430637|
Recruitment Status : Completed
First Posted : September 8, 2011
Last Update Posted : May 18, 2016
RATIONALE: Studying samples of blood and tumor tissue from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer.
PURPOSE: This research study is studying genes in samples from younger patients with desmoplastic small round cell tumor registered on COG-D9902 or COG-ABTR01B1.
|Condition or disease||Intervention/treatment|
|Sarcoma||Genetic: DNA analysis Genetic: RNA analysis Genetic: gene expression analysis Genetic: mutation analysis Genetic: nucleic acid sequencing Genetic: polymerase chain reaction Other: laboratory biomarker analysis Other: pharmacogenomic studies|
- To perform whole-exome sequencing on desmoplastic small round cell tumor (DSRCT) samples and their available matched normal samples to identify novel mutations, single nucleotide polymorphisms, or copy number changes associated with these tumors.
- To identify regions of interest that may be involved in the pathogenesis (including the region of EWSR1-WT1 translocation) from the whole-exome sequencing and perform detailed resequencing and transcriptone sequencing to further define the molecular aberrations at the RNA level.
OUTLINE: This is a multicenter study.
Archived tumor tissue samples are analyzed for DNA sequencing, effects of RNA on gene expression levels, novel RNA isoforms, splice variants, and translocations.
|Study Type :||Observational|
|Estimated Enrollment :||20 participants|
|Observational Model:||Case Control|
|Official Title:||Comprehensive Genome Sequencing of Desmoplastic Small Round Cell Tumors|
|Study Start Date :||September 2011|
|Actual Primary Completion Date :||May 2016|
- Identification of novel mutations, single nucleotide polymorphisms, and copy number changes associated with DSRCT
- Identification of genomic regions involved in pathogenesis of DSRCT
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01430637
|Principal Investigator:||Pooja Hingorani, MD||Phoenix Children's Hospital|