Does Pulmonary Rehabilitation Improve Frailty?
Frailty is a state of health with predisposition to adverse events, morbidity and mortality. Frailty consists of weakness, slowness, low physical activity, exhaustion, and wasting. Frailty is associated with increased hospitalizations and death in lung disease. It is unknown if pulmonary rehabilitation will improve frailty markers.
Other: Pulmonary Rehabilitation
Other: Gait Speed Test
Device: Activity Monitor
|Study Design:||Intervention Model: Single Group Assignment
Masking: Open Label
|Official Title:||Does Pulmonary Rehabilitation Improve Frailty in Chronic Lung Disease?|
- Change in Frailty Phenotype [ Time Frame: Six months ] [ Designated as safety issue: No ]Frailty phenotype is 3 or more of: slow gait speed, exhaustion, decreased hand grip strength, decreased activity level, or wasting. Grip strength parameters, gait speed, exhaustion per Fried et al. 2001. Wasting is defined as further decrease in fat free mass by body composition measurement using DEXA. Low physical activity would be activity monitor in lower quartile.
- Wasting [ Time Frame: Six months ] [ Designated as safety issue: No ]Defined as a further decrease in fat free mass by body composition measured by DEXA. Loss of >10 pounds unintentionally.
- Change in Strength [ Time Frame: Six Months ] [ Designated as safety issue: No ]Grip Strength - Dynamometer. Frailty characterized as lowest 20% by gender and body mass index.
- Change in gait speed [ Time Frame: Six Months ] [ Designated as safety issue: No ]Fast gait speed test (15 feet). Frailty characterized as slowest 20% by walking time by gender and height.
- Change in Exhaustion [ Time Frame: Six Months ] [ Designated as safety issue: No ]Self-reported exhaustion - measured by the CES-D scale.
- Change in Activity [ Time Frame: Six Months ] [ Designated as safety issue: No ]Energy expenditure- Armband Activity Monitor. Low activity is defined as activity in the lowest 20% -0 <383Kcals/week for men or <270Kcals/week for women.
|Study Start Date:||July 2015|
|Estimated Primary Completion Date:||July 2016 (Final data collection date for primary outcome measure)|
One arm study - all participants will go to pulmonary rehabilitation, received questionnaires, DEXA scans, Dynamometer and gait speed tests and activity measured through an activity monitor.
Other: Pulmonary Rehabilitation
Measures of frailty taken before and after pulmonary rehabilitation.Device: Dynamometer
Grip TestRadiation: DEXA
Body Composition TestingOther: Gait Speed Test
15 foot walk testDevice: Activity Monitor
Measures energy expenditure and activityOther: Questionnaires
Health-related questionnaires measuring self-reported exhaustion, emotions and disease symptoms.
Individuals referred to pulmonary rehabilitation will be examined for frailty markers. After completing pulmonary rehabilitation, the same tests will be performed. The effects of pulmonary rehabilitation will be examined.
Please refer to this study by its ClinicalTrials.gov identifier: NCT02512874
|United States, Minnesota|
|Mayo Clinic in Rochester|
|Rochester, Minnesota, United States, 55905|
|Principal Investigator:||Cassie Kennedy, MD||Mayo Clinic|