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Trial record 14 of 228 for:    Recruiting, Not yet recruiting, Available Studies | Aortic stenosis

Interest of Pulse Wave Velocity Measurement as a Predictor of Severity of Aortic Stenosis (VOPRABIO)

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ClinicalTrials.gov Identifier: NCT03140735
Recruitment Status : Recruiting
First Posted : May 4, 2017
Last Update Posted : August 8, 2018
Sponsor:
Information provided by (Responsible Party):
Centre Hospitalier Universitaire, Amiens

Brief Summary:
Aortic valve pathology is the third most common cardiovascular disease after coronary artery disease and hypertension, which is responsible for severe morbidity and mortality in elderly patients and requires surgical treatment in its most severe form of progression. The purpose of this study is to find a link between arterial stiffness and degenerative aortic stenosis. If this link is established, arterial stiffness may become a medical therapeutic target in order to delay the evolution of the disease.

Condition or disease Intervention/treatment Phase
Pulse Wave Aortic Stenosis Other: Study the relationship between the arterial rigidity of large vessels and the presence and severity of degenerative aortic constriction Other: Control group without heart disease Not Applicable

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Study Type : Interventional  (Clinical Trial)
Estimated Enrollment : 900 participants
Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)
Primary Purpose: Other
Official Title: Interest of Pulse Wave Velocity Measurement as a Predictor of Severity of Aortic Stenosis
Actual Study Start Date : July 3, 2017
Estimated Primary Completion Date : June 20, 2027
Estimated Study Completion Date : June 20, 2027

Resource links provided by the National Library of Medicine


Arm Intervention/treatment
Control group of 150 heart disease-free individuals Other: Control group without heart disease
Control group without heart disease

Patients with aortic sclerosis Other: Study the relationship between the arterial rigidity of large vessels and the presence and severity of degenerative aortic constriction
Study the relationship between the arterial rigidity of large vessels and the presence and severity of degenerative aortic constriction

Patients with moderate aortic stenting (RA) Other: Study the relationship between the arterial rigidity of large vessels and the presence and severity of degenerative aortic constriction
Study the relationship between the arterial rigidity of large vessels and the presence and severity of degenerative aortic constriction

Patients with Serious Aortic Retention Other: Study the relationship between the arterial rigidity of large vessels and the presence and severity of degenerative aortic constriction
Study the relationship between the arterial rigidity of large vessels and the presence and severity of degenerative aortic constriction




Primary Outcome Measures :
  1. Analysis of echocardiographic measurements of possible differences between average VOP and Sao i in terms of RA severities [ Time Frame: 10 years ]
    Analysis of echocardiographic measurements of possible differences between average VOP and Sao i in terms of RA severities



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Ages Eligible for Study:   18 Years and older   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • Patients over 18 years of age, without legal protection (guardianship or curatorship),
  • Stable hemodynamic status.
  • Affiliation to a social security scheme

Exclusion Criteria:

  • Hemodynamically unstable patients: Systolic PA <10 cmHg, rapid peripheral pulse and spinning, mottling, obnubilation, oliguria, sweating, coma
  • History of significant valvulopathy other than an aortic stenosis,
  • Pregnancy.
  • Patient under tutelage or curatelle or deprived of public right.

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT03140735


Contacts
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Contact: Christophe TRIBOUILLOY, PhD +33322455885 tribouilloy.christophe@chu-amiens.fr

Locations
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France
CHU Amiens Picardie Recruiting
Amiens, Picardie, France, 80054
Contact: Christophe TRIBOUILLOY, PhD    +33322455885    tribouilloy.christophe@chu-amiens.fr   
Sponsors and Collaborators
Centre Hospitalier Universitaire, Amiens

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Responsible Party: Centre Hospitalier Universitaire, Amiens
ClinicalTrials.gov Identifier: NCT03140735     History of Changes
Other Study ID Numbers: PI2016_843_0035
First Posted: May 4, 2017    Key Record Dates
Last Update Posted: August 8, 2018
Last Verified: August 2018

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Studies a U.S. FDA-regulated Drug Product: No
Studies a U.S. FDA-regulated Device Product: No

Additional relevant MeSH terms:
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Aortic Valve Stenosis
Constriction, Pathologic
Pathological Conditions, Anatomical
Heart Valve Diseases
Heart Diseases
Cardiovascular Diseases
Ventricular Outflow Obstruction