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Trial record 4 of 118 for:    "spinocerebellar ataxia type 3" OR "Spinocerebellar Ataxias"

Machado-Joseph Disease in Israel

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ClinicalTrials.gov Identifier: NCT02175290
Recruitment Status : Recruiting
First Posted : June 26, 2014
Last Update Posted : March 16, 2017
Sponsor:
Information provided by (Responsible Party):

Study Description
Brief Summary:
Machado-Joseph disease (MJD) or spinocerebellar ataxia type 3 (SCA-3) is the most common dominant ataxia. The genetic cause of this late-onset degenerative disorder is the expansion of a (CAG)n tract located in the exonic region of the ATXN3 gene. In 1994 the first case of MJD among the Yemenite Jewish subpopulation living in Israel was published. The puropse of this study is to describe the clinical phenotype and genotype of the Yemenite Jewish subpopulation with MJD living in Israel

Condition or disease
Spinocerebellar Ataxia 3

Study Design

Study Type : Observational [Patient Registry]
Estimated Enrollment : 250 participants
Observational Model: Cohort
Time Perspective: Prospective
Target Follow-Up Duration: 3 Years
Official Title: Machado-Joseph Disease in Israel: Clinical Phenotype and Genotype of a Jew Yemenite Subpopulation
Study Start Date : June 2014
Estimated Primary Completion Date : June 2017
Estimated Study Completion Date : June 2018


Groups and Cohorts

Group/Cohort
Spinocerebellar Ataxia 3 Yemenite Jews patients


Outcome Measures

Primary Outcome Measures :
  1. clinical phenotype of SCA3 Yemenite Jews patients [ Time Frame: 3 years ]

Eligibility Criteria

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
Spinocerebellar Ataxia 3 Yemenite Jews patients
Criteria

Inclusion Criteria:

  • Spinocerebellar Ataxia 3 Yemenite Jews patients

Exclusion Criteria:

  • All others
Contacts and Locations

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02175290


Contacts
Contact: Carlos R Gordon, MD;DSc 972-9-7471581 cgordon@post.tau.ac.il
Contact: Roy Zaltzman, MD;PhD 972-9-7471581 royzaltzman@gmail.com

Locations
Israel
Department of Neurology, Meir Medical Center Recruiting
Kfar-saba, Israel, 44281
Contact: Carlos R Gordon, MD;DSc    972-9-7471581    cgordon@post.tau.ac.il   
Sponsors and Collaborators
Meir Medical Center
More Information

Responsible Party: Meir Medical Center
ClinicalTrials.gov Identifier: NCT02175290     History of Changes
Other Study ID Numbers: MMC140006CTIL
First Posted: June 26, 2014    Key Record Dates
Last Update Posted: March 16, 2017
Last Verified: April 2016
Individual Participant Data (IPD) Sharing Statement:
Plan to Share IPD: Undecided

Additional relevant MeSH terms:
Spinocerebellar Ataxias
Spinocerebellar Degenerations
Machado-Joseph Disease
Cerebellar Ataxia
Cerebellar Diseases
Brain Diseases
Central Nervous System Diseases
Nervous System Diseases
Spinal Cord Diseases
Heredodegenerative Disorders, Nervous System
Neurodegenerative Diseases
Ataxia
Dyskinesias
Neurologic Manifestations
Genetic Diseases, Inborn