A Comparison of the Effect of Carvedilol and Metoprolol on Airways Tone in Patients With Heart Failure
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|ClinicalTrials.gov Identifier: NCT00384566|
Recruitment Status : Withdrawn (In order to join forces with another study already running which aims to answer the same question.)
First Posted : October 6, 2006
Last Update Posted : June 24, 2015
This study looks at the effect of two drugs (carvedilol and metoprolol) which are used for patients with CHF (chronic heart failure).
These agents are beta-blockers and, although effective in heart failure, may cause increases in airways tone and thus limit air getting into the lower parts of the lungs. Carvedilol is more active at blocking the receptor that opens up the airways and therefore theoretically may be more likely to reduce airways tone than metoprolol, although this has never been studied in patients with heart failure, and that is the purpose of the present study.
We are looking to enrol 45 patients with heart failure and mild obstruction to the flow of air in their lungs. Patients will be randomised to either carvedilol or metoprolol (standard doses). Following a minimum of 2 weeks of therapy of study medication the patient will undergo a study day involving an assessment of their lung function, an assessment of their heart failure, a "living with heart failure" questionnaire, blood tests and blood pressure and heart rate readings.
Patients will then be crossed over to the alternate medication. Following 2 weeks on the target dose the patient will undergo their second study day which will be the same as the first.
The results obtained from each study day will be compared.
|Condition or disease||Intervention/treatment||Phase|
|Heart Failure Chronic Obstructive Airway Disease||Drug: Carvedilol Drug: Metoprolol||Phase 4|
|Study Type :||Interventional (Clinical Trial)|
|Actual Enrollment :||0 participants|
|Intervention Model:||Crossover Assignment|
|Masking:||None (Open Label)|
|Official Title:||The CAMERA Study: CArvedilol MEtoprolol Respiratory Assessment Investigator Trial|
|Study Start Date :||June 2005|
|Actual Primary Completion Date :||April 2008|
|Actual Study Completion Date :||April 2008|
anit hypertensive medication
|Active Comparator: 2||
Anti hypertensive medication
- Respiratory function [ Time Frame: Each study visit ]
- NYHA class with the use of the 7 point scale (Packer). [ Time Frame: Baseline, cross over, end of study ]
- Minnesota "living with Heart Failure" questionnaire. [ Time Frame: Baseline, cross over, end of study ]
- U+E [ Time Frame: Screening, cross over, end of study ]
- BP and HR [ Time Frame: every visit ]
- plasma N-terminal pro-BNP [ Time Frame: Screening, cross over, end of study ]
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00384566
|Melbourne, Victoria, Australia, 3004|
|Principal Investigator:||Henry Krum, Professor||Monash University / Alfred Hospital|