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This proposal will evaluate the glucocorticoid mediated changes in body fat distribution and metabolism that occur in patients with Cushing's disease. Our objective is to identify the mechanisms that influence both the accumulation of lipodystrophic fat and also the changes in energy expenditure and metabolism that accompany them. These findings may have important implications not only for those with Cushing's disease, but for the millions of Americans who are treated with chronic glucocorticoids for an array of clinical conditions.
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Layout table for eligibility information
Ages Eligible for Study:
18 Years to 70 Years (Adult, Older Adult)
Sexes Eligible for Study:
Accepts Healthy Volunteers:
Patients with ACTH-dependent Cushing's syndrome
Aged 18-70 yrs
Body mass index (BMI) <35 kg/m2
Urine free cortisol (UFC) ≥150ug/d
Pituitary tumor >6mm on MRI or an inferior petrosal sinus sampling with central to peripheral plasma adrenocorticotropic hormone (ACTH) gradient
Normal renal and thyroid function
Alcohol >2 drinks/day
HIV given potential for lipodystrophic confounding
Pregnancy and nursing
Use of beta-blockers, β-adrenergic or diabetes medications other than insulin
History of claustrophobia or difficulty lying flat