New Quantitive MRI Parameters in Assessing Kidneys of Autosomal Dominant Polycystic Kidney Disease (MRI Pilot)
|ClinicalTrials.gov Identifier: NCT02250287|
Recruitment Status : Completed
First Posted : September 26, 2014
Last Update Posted : June 17, 2016
The purpose of this study is to establish normal Magnetic Resonance quantitative values (tissues stiffness, Apparent Diffusion Coefficient values and Blood Oxygen Level Determination values for both renal cortex and medullary tissues and total renal blood flow) for young Autosomal Dominant Polycystic Kidney Disease patients with normal renal function, and normal young adult controls without Autosomal Dominant Polycystic Kidney Disease and normal renal function.
Hypothesis: Newer Magnetic Resonance quantitative imaging parameters (tissue stiffness, Apparent Diffusion Coefficient, Blood Oxygen Level Determination levels, Magnetization Transfer and renal blood flow) will have different values in young adult ADPKD patients as compared to normal volunteers.
|Condition or disease|
|Autosomal Dominant Polycystic Kidney Disease Kidney Disease|
|Study Type :||Observational|
|Actual Enrollment :||20 participants|
|Observational Model:||Case Control|
|Official Title:||Pilot and Feasibility Study: Evaluation of New Quantitative Magnetic Resonance Imaging Parameters in Assessing the Kidneys of Autosomal Dominant Polycystic Kidney Disease|
|Study Start Date :||December 2014|
|Actual Primary Completion Date :||March 2016|
|Actual Study Completion Date :||March 2016|
- Evaluate renal tissue stiffness [ Time Frame: baseline ]The renal parenchymal tissue stiffness is measured in kilopascals with magnetic resonance elastography sequence.
- Magnetization transfer ratio [ Time Frame: baseline ]The magnetization transfer ratio of renal tissue is measured with magnetization transfer sequence and expressed as a ratio.
- Diffusion [ Time Frame: baseline ]Diffusion is quantified as apparent diffusion coefficient (x10-3/mm2) in renal tissue is measured with intravoxel incoherent motion imaging (IVIM) sequence and diffusion tensor imaging (DTI).
- Perfusion quantified as blood flow in mL/s. [ Time Frame: baseline ]Perfusion in the renal tissue is measured with arterial spin labeling sequence and phase contrast magnetic resonance angiography.
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02250287
|United States, Minnesota|
|Rochester, Minnesota, United States, 55905|
|Principal Investigator:||Sudhakar Venkatesh, MD||Mayo Clinic|