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Shift Work Health Effects

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ClinicalTrials.gov Identifier: NCT04813536
Recruitment Status : Not yet recruiting
First Posted : March 24, 2021
Last Update Posted : March 24, 2021
Sponsor:
Information provided by (Responsible Party):
Mariam Roshdy Elkhayat, Assiut University

Study Description
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Brief Summary:

To identify the health effects of shift work on nurses in Assuit university hospitals .

To estimate effect of shift work on co-morbidities among nurses . To determine the shift work associated risk factors predisposing nurses to poor health outcomes and injuries.


Condition or disease Intervention/treatment
Shift-work Disorder Other: the Standard Shiftwork Index questionnaire Other: complete blood picture Other: lipid profile

Detailed Description:

The word 'shiftwork' is commonly used to describe irregular, odd, untraditional working hours, or working hours that are away from day work period. Shiftwork dates back to the late 1800s, as applied to guardians of old kingdoms and in the military services. After the innovation of the light, shift work expanded for nonstop production as in steel factories, iron foundries, and material plants. Approximately one-fourth of the workforce in hospitals works unusual hours (away from the traditional diurnal work period) . Shiftwork has a number of advantages and disadvantages to employers, employees, and their families. The advantages for employers include optimal use of energy, facilities, and other resources through extended capital operating time. The advantages for employees include increased income, more free time for daily activities, and saving time by avoiding traffic rush hours. Shiftwork is associated with both short-term and long-term disadvantages on physical and psychophysiological health. Short-term effects include fatigue and difficulties with sleep. Difficulties with sleep are found to be the most common complaint among shift workers. Sleep disturbances were the main reasons that led shift workers to leave night shiftwork owing to disturbed health habits compared with day workers .Gastrointestinal disorders were reported 2-5 times more commonly among shift workers than daytime workers. These disorders range from minor complaints (e.g., constipation, heart burn, distension, and disturbed appetite) to serious gastrointestinal disorders, which may develop into chronic diseases such as chronic gastritis or peptic ulcers. Shiftwork has been also linked to type 2 diabetes and obesity as sleep deprivation activates the immune system and influences glucose metabolism .

An association between shiftwork and cardiovascular diseases (CVDs) has been reported. There is a higher risk for CVD such as hypertension, subclinical atherosclerosis, and ischemic heart disease compared with daytime workers . Different types of cancer have been reported in shift workers including cancers of the breast, colon, and endometrium. Shiftwork system causes circadian rhythm disruption, which is probably carcinogenic to humans.

Also, shiftwork causes disruption in both social and domestic lifestyle, which is a major consequence of shiftwork, especially with maternal employment that may have some adverse influences on their young children's cognitive and behavioral outcomes.

Study Design
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Study Type : Observational
Estimated Enrollment : 108 participants
Observational Model: Case-Control
Time Perspective: Retrospective
Official Title: Effect of Work Shift on the Nurses' Health in the Main Assiut University Hospital
Estimated Study Start Date : June 2021
Estimated Primary Completion Date : June 2022
Estimated Study Completion Date : December 2022
Groups and Cohorts
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Group/Cohort Intervention/treatment
nurses in Assiut university hospitals
currently working nurses exposed to shift work
 Other: the Standard Shiftwork Index questionnaire
  1. Biographical information: This includes personal data (e.g., age, sex, marital status, and domestic situations), shift details (e.g., shift start and end times), organization of shiftwork, and general job satisfaction
  2. Sleep and fatigue: Measures the effect of shiftwork on perceived sleep quality and quantity and fatigue

Other: complete blood picture
5ml blood to estimate changes of total leucocytic count, Hemoglobin, eosinophilic, monocyte

Other: lipid profile
5ml blood to estimate changes of plasma triglycerides, total cholesterol, low-density lipoprotein cholesterol (LDL-C), and HDL-C
control group
currently working nurses not exposed to shift work
 Other: the Standard Shiftwork Index questionnaire
  1. Biographical information: This includes personal data (e.g., age, sex, marital status, and domestic situations), shift details (e.g., shift start and end times), organization of shiftwork, and general job satisfaction
  2. Sleep and fatigue: Measures the effect of shiftwork on perceived sleep quality and quantity and fatigue

Other: complete blood picture
5ml blood to estimate changes of total leucocytic count, Hemoglobin, eosinophilic, monocyte

Other: lipid profile
5ml blood to estimate changes of plasma triglycerides, total cholesterol, low-density lipoprotein cholesterol (LDL-C), and HDL-C


Outcome Measures
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Primary Outcome Measures :
  1. complete blood picture [ Time Frame: once baseline at time of the data collection of study ]
    total leucocytic count

  2. complete blood picture [ Time Frame: once baseline at time of the data collection of study ]
    Hemoglobin

  3. complete blood picture [ Time Frame: once baseline at time of the data collection of study ]
    eosinophilic count

  4. complete blood picture [ Time Frame: once baseline at time of the data collection of study ]
    monocyte count

  5. lipid profile [ Time Frame: once baseline at time of data collection ]
    plasma triglycerides

  6. lipid profile [ Time Frame: once baseline at time of data collection ]
    total cholesterol

  7. lipid profile [ Time Frame: once baseline at time of data collection ]
    low-density lipoprotein cholesterol (LDL-C)

  8. lipid profile [ Time Frame: once baseline at time of data collection ]
    HDL-C

  9. Sleep Questionnaire [ Time Frame: once baseline at time of data collection ]
    part of standard shift work index,consists of 11 items and aims to identify sleep habits, as well as the extent to which sleep is depending on which shift has been or is about to be worked. A higher score is associated being associated with higher sleep disturbance


Eligibility Criteria
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Ages Eligible for Study:   18 Years to 60 Years   (Adult)
Sexes Eligible for Study:   Female
Sampling Method:   Non-Probability Sample
Study Population
Active working nurses working in Assiut University Hospitals with minimum exposure to work shift for 1 year
Criteria

Inclusion Criteria:

  • Active working nurses working in Assiut University Hospitals with minimum exposure to work shift for 1 year .
  • Had free pre-employment records

Exclusion Criteria:

  • Nurses don't record shift work exposure.
  • Nurses with less than 1 year exposure to shift work, or don't recorded shift work exposure.
  • Nurses known to had autoimmune disorder or endocrinal disorder before joining job.
Contacts and Locations
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Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT04813536


Contacts
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Contact: Mariam R Elkhayat, lecturer +20 00201003708261 mariam.elkhayat@aun.edu.eg
Contact: Samar Mohsen, demonstrator samarmohsen2030@gmail.com

Sponsors and Collaborators
Assiut University
More Information
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Publications:

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Responsible Party: Mariam Roshdy Elkhayat, lecturer, Assiut University
ClinicalTrials.gov Identifier: NCT04813536    
Other Study ID Numbers: shift work
First Posted: March 24, 2021    Key Record Dates
Last Update Posted: March 24, 2021
Last Verified: March 2021

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Studies a U.S. FDA-regulated Drug Product: No
Studies a U.S. FDA-regulated Device Product: No