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Acute Kidney Injury as a Risk Factor for Myocardial Injury and Ventricular Dysfunction

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
 
ClinicalTrials.gov Identifier: NCT04768751
Recruitment Status : Completed
First Posted : February 24, 2021
Last Update Posted : February 24, 2021
Sponsor:
Information provided by (Responsible Party):
Alaa Ali M. Elzohry, South Egypt Cancer Institute

Study Description
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Brief Summary:

Acute kidney injury (AKI) is classically described as an abrupt or rapidly reversible reduction in the excretion of nitrogenous waste products, including urea, nitrogen and creatinine. Acute kidney injury definition emphasizes on the filtration function of the kidney, a measure that is unique and easily and routinely measured .

Acute kidney injury is associated with significantly increased resource utilization and health care costs.

Major adverse cardiac events (MACE) after non cardiac surgery are a leading cause of morbidity and mortality. The reported incidence of postoperative myocardial infarction (POMI) among patients undergoing non cardiac surgery is between 3% and 6%.


Condition or disease Intervention/treatment
Acute Kidney Injury Ventricular Dysfunction Myocardium; Injury Diagnostic Test: kidney assessment

Study Design
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Study Type : Observational
Actual Enrollment : 520 participants
Observational Model: Cohort
Time Perspective: Prospective
Official Title: Assessment of Acute Kidney Injury as a Risk Factor for Myocardial Injury and Ventricular Systolic Dysfunction After Non-Cardiac Surgery in Critical Patients
Actual Study Start Date : March 5, 2019
Actual Primary Completion Date : August 20, 2020
Actual Study Completion Date : August 30, 2020
Groups and Cohorts
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Intervention Details:
  • Diagnostic Test: kidney assessment
    Urea, BUN, and Creatinine BLOOD LEVELS

Outcome Measures
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Primary Outcome Measures :
  1. development myocardial injury [ Time Frame: through study completion, an average of 15 days ]
    New echocardiographic findings suggestive of ischemia (new regional wall motion abnormalities) or cardiac troponin T >.0.32 ng/ml


Eligibility Criteria
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Ages Eligible for Study:   18 Years to 70 Years   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Probability Sample
Study Population
Patients with normal kidney functions and free normal heart functions
Criteria

Inclusion Criteria:

  • Patients with normal kidney functions and free normal heart functions, were enrolled to this study

Exclusion Criteria:

  • patients with chronic kidney disease, cardiac disease, who with minor operations, or emergency, were excluded from the study.
Contacts and Locations
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Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT04768751


Locations
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Egypt
Alaa Ali Elzohry
Assuit, Egypt, +2071516
Sponsors and Collaborators
South Egypt Cancer Institute
More Information
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Responsible Party: Alaa Ali M. Elzohry, 4- Lecturer of Anesthesia, ICU and Pain Relief, South Egypt Cancer Institute, Assiut University, Egypt, South Egypt Cancer Institute
ClinicalTrials.gov Identifier: NCT04768751    
Other Study ID Numbers: Acute Kidney injury
First Posted: February 24, 2021    Key Record Dates
Last Update Posted: February 24, 2021
Last Verified: February 2021
Individual Participant Data (IPD) Sharing Statement:
Plan to Share IPD: Undecided

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Studies a U.S. FDA-regulated Drug Product: No
Studies a U.S. FDA-regulated Device Product: No
Additional relevant MeSH terms:
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Acute Kidney Injury
Ventricular Dysfunction
Wounds and Injuries
Renal Insufficiency
 Kidney Diseases
Urologic Diseases
Heart Diseases
Cardiovascular Diseases