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Effects of Single Plasma Exchange and Double Filtration Plasmapheresis (DFPP) on Peripheral Lymphocyte Phenotypes in Patients With Chronic Inflammatory Demyelinating Polyradiculoneuropathy (LYMPHOARESIS)

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ClinicalTrials.gov Identifier: NCT04742374
Recruitment Status : Recruiting
First Posted : February 8, 2021
Last Update Posted : July 7, 2021
Sponsor:
Information provided by (Responsible Party):
Centre Hospitalier Universitaire de Nīmes

Study Description
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Brief Summary:
CIDP, a rare disorder affecting young adults, causes gradual weakness of the limbs, areflexia and impaired sensory function. New CIDP phenotypes without antibodies but with modified cell profiles have been described. Treatments include corticotherapy, IVIg and plasmapheresis but the latter's action mechanisms remain unclear. Plasmapheresis supposedly removes toxic agents like antibodies from plasma but it is uncertain whether it has an immune-modulating effect. Also, the refining mechanisms of the two main plasmapheresis techniques - single plasma exchange and double filtration plasmapheresis (DFPP) - are different and unclear. This study aims to compare the evolution of peripheral lymphocyte profiles in patients with CIDP according to their treatment (single centrifugation plasmapheresis or DFPP) to better grasp the action mechanisms of both techniques.

Condition or disease Intervention/treatment Phase
Polyradiculoneuropathy, Chronic Inflammatory Demyelinating Biological: Blood sampling Early Phase 1

Study Design
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Layout table for study information
Study Type : Interventional  (Clinical Trial)
Estimated Enrollment : 5 participants
Allocation: Randomized
Intervention Model: Crossover Assignment
Intervention Model Description: Proof-of-concept, monocentric, prospective, Single-Case Experimental Design
Masking: Single (Participant)
Masking Description: Randomisation to one of two treatments before alternation.
Primary Purpose: Treatment
Official Title: Comparison of the Effects of 2 Therapeutic Plasmapheresis Techniques: Single Plasma Exchange and Double Filtration Plasmapheresis (DFPP) on Peripheral Lymphocyte Phenotypes in Patients With Chronic Inflammatory Demyelinating Polyradiculoneuropathy (CIDP). A Monocentric Prospective Study With a Single-Case Experimental Design
Actual Study Start Date : February 1, 2021
Actual Primary Completion Date : April 30, 2021
Estimated Study Completion Date : May 1, 2022

Resource links provided by the National Library of Medicine


Arms and Interventions
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Arm Intervention/treatment
Experimental: Group A
Patients alternating single plasma exchange followed by double filtration plasmapheresis etc.
 Biological: Blood sampling
Blood sampling before and after each type of cycle, Single Plasma Exchange or Double Filtration Plasmapheresis
Experimental: Group B
Patients alternating double filtration plasmapheresis followed by single plasma exchange etc.
 Biological: Blood sampling
Blood sampling before and after each type of cycle, Single Plasma Exchange or Double Filtration Plasmapheresis


Outcome Measures
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Primary Outcome Measures :
  1. Cycle 1, Group A : TH1 cells BEFORE single plasma exchange [ Time Frame: Day 0, Time 0 ]
    5 mL of blood will be collected in an EDTA tube BEFORE single plasma exchange and the number of TH1 peripheral lymphocyte cells will be measured in %.

  2. Cycle 1, Group A : TH1 cells AFTER single plasma exchange [ Time Frame: Day 0, Hour 3 ]
    5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and the number of TH1 peripheral lymphocyte cells will be measured in %.

  3. Cycle 1, Group A : TH1 cells 7-10 days AFTER single plasma exchange [ Time Frame: Day 7 -10 ]
    5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and the number of TH1 peripheral lymphocyte cells will be measured in %.

  4. Cycle 1, Group A : TH17 cells BEFORE first single plasma exchange [ Time Frame: Day 0, Time 0 ]
    5 mL of blood will be collected in an EDTA tube BEFORE single plasma exchange and the number of TH17 peripheral lymphocyte cells will be measured in %.

  5. Cycle 1, Group A : TH17 cells AFTER single plasma exchange [ Time Frame: Day 0, Hour 3 ]
    5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and the number of TH17 peripheral lymphocyte cells will be measured in %.

  6. Cycle 1, Group A : TH17 cells 7 - 10 days AFTER single plasma exchange [ Time Frame: Day 7 - 10 ]
    5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and the number of TH17 peripheral lymphocyte cells will be measured in %.

  7. Cycle 1, Group A : T-reg cells BEFORE first single plasma exchange [ Time Frame: Day 0, Hour 0 ]
    5 mL of blood will be collected in an EDTA tube BEFORE single plasma exchange and the number of T-reg cells will be measured in %.

  8. Cycle 1, Group A : T-reg cells AFTER single plasma exchange [ Time Frame: Day 0, Hour 3 ]
    5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and the number of T-reg cells will be measured in %.

  9. Cycle 1, Group A : T-reg cells 7 - 10 days AFTER single plasma exchange [ Time Frame: Day 7 - 10 ]
    5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and the number of T-reg cells will be measured in %.

  10. Cycle 1, Group B : TH1 cells BEFORE first double filtration plasmapheresis [ Time Frame: Day 0, Hour 0 ]
    5 mL of blood will be collected in an EDTA tube BEFORE double filtration plasmapheresis and the number of TH1 peripheral lymphocyte cells will be measured in %.

  11. Cycle 1, Group B : TH1 cells AFTER the first double filtration plasmapheresis [ Time Frame: Day 0, Hour 3 ]
    5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and the number of TH1 peripheral lymphocyte cells will be measured in %.

  12. Cycle 1, Group B : TH1 cells 7-10 days AFTER the first double filtration plasmapheresis [ Time Frame: Day 7 - 10 ]
    5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and the number of TH1 peripheral lymphocyte cells will be measured in %.

  13. Cycle 1, Group B : TH17 cells BEFORE the first double filtration plasmapheresis [ Time Frame: Day0, Hour 0 ]
    5 mL of blood will be collected in an EDTA tube BEFORE double filtration plasmapheresis and the number of TH17 cells will be measured in %.

  14. Cycle 1, Group B : TH17 cells AFTER the first double filtration plasmapheresis [ Time Frame: Day 0, Hour 3 ]
    5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and the number of TH17 cells will be measured in %.

  15. Cycle 1, Group B : T17 cells 7-10 days AFTER double filtration plasmapheresis [ Time Frame: Day 7-10 ]
    5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and the number of TH17 cells will be measured in %.

  16. Cycle 1, Group B : T-reg cells BEFORE double filtration plasmapheresis [ Time Frame: Day 0, Hour 0 ]
    5 mL of blood will be collected in an EDTA tube BEFORE double filtration plasmapheresis and the number of T-reg cells will be measured in %.

  17. Cycle 1, Group B : T-reg cells AFTER double filtration plasmapheresis [ Time Frame: Day 0, Hour 3 ]
    5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and the number of T-reg cells will be measured in %.

  18. Cycle 1, Group B : T-reg cells 7-10 days AFTER double filtration plasmapheresis [ Time Frame: Day 7 - 10 ]
    5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and the number of T-reg cells will be measured in %.

  19. Cycle 2, Group A: TH1 cells BEFORE double filtration plasmapheresis [ Time Frame: Day 0, Hour 0 ]
    5 mL of blood will be collected in an EDTA tube BEFORE double filtration plasmapheresis and the number of TH1 cells will be measured in %.

  20. Cycle 2, Group A: TH1 cells AFTER double filtration plasmapheresis [ Time Frame: Day 0, Hour 3 ]
    5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and the number of TH1 cells will be measured in %.

  21. Cycle 2, Group A: TH1 cells 7-10 days AFTER double filtration plasmapheresis [ Time Frame: Day 7 - 10 ]
    5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and the number of TH1 cells will be measured in %.

  22. Cycle 2, Group A: TH17 cells BEFORE double filtration plasmapheresis [ Time Frame: Day 0, Hour 0 ]
    5 mL of blood will be collected in an EDTA tube BEFORE double filtration plasmapheresis and the number of TH17 cells will be measured in %.

  23. Cycle 2, Group A: TH17 cells AFTER double filtration plasmapheresis [ Time Frame: Day 0, Hour 3 ]
    5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and the number of TH17 cells will be measured in %.

  24. Cycle 2, Group A: TH17 cells 7-10 days AFTER double filtration plasmapheresis [ Time Frame: Day 7-10 ]
    5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and the number of TH17 cells will be measured in %.

  25. Cycle 2, Group A: T-reg cells BEFORE double filtration plasmapheresis [ Time Frame: Day 0, Hour 0 ]
    5 mL of blood will be collected in an EDTA tube BEFORE double filtration plasmapheresis and the number of T-reg cells will be measured in %.

  26. Cycle 2, Group A: T-reg cells AFTER double filtration plasmapheresis [ Time Frame: Day 0, Hour 3 ]
    5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and the number of T-reg cells will be measured in %.

  27. Cycle 2, Group A: T-reg cells 7-10 days AFTER double filtration plasmapheresis [ Time Frame: Day 7-10 ]
    5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and the number of T-reg cells will be measured in %.

  28. Cycle 2, Group B: TH1 cells BEFORE single plasma exchange [ Time Frame: Day 0, Hour 0 ]
    5 mL of blood will be collected in an EDTA tube BEFORE single plasma exchange and the number of TH1 cells will be measured in %.

  29. Cycle 2, Group B: TH1 cells AFTER single plasma exchange [ Time Frame: Day 0, Hour 3 ]
    5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and the number of TH1 cells will be measured in %.

  30. Cycle 2, Group B: TH1 cells 7-10 days AFTER single plasma exchange [ Time Frame: Day 7-10 ]
    5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and the number of TH1 cells will be measured in %.

  31. Cycle 2, Group B: T17 cells BEFORE single plasma exchange [ Time Frame: Day 0, Hour 0 ]
    5 mL of blood will be collected in an EDTA tube BEFORE single plasma exchange and the number of T17 cells will be measured in %.

  32. Cycle 2, Group B: TH17 cells AFTER single plasma exchange [ Time Frame: Day 0, Hour 3 ]
    5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and the number of T17 cells will be measured in %.

  33. Cycle 2, Group B: TH17 cells 7-10 days AFTER single plasma exchange [ Time Frame: Day 7-10 ]
    5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and the number of TH17 cells will be measured in %.

  34. Cycle 2, Group B: T-reg cells BEFORE single plasma exchange [ Time Frame: Day 0, Hour 0 ]
    5 mL of blood will be collected in an EDTA tube BEFORE single plasma exchange and the number of T-reg cells will be measured in %.

  35. Cycle 2, Group B: T-reg cells AFTER single plasma exchange [ Time Frame: Day 0, Hour 3 ]
    5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and the number of T-reg cells will be measured in %.

  36. Cycle 2, Group B: T-reg cells 7-10 days AFTER single plasma exchange [ Time Frame: Day 7-10 ]
    5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and the number of T-reg cells will be measured in %.

  37. Cycle 3, Group A: TH1 cells BEFORE single plasma exchange [ Time Frame: Day 1, Hour 1 ]
    5 mL of blood will be collected in an EDTA tube BEFORE single plasma exchange and the number of TH1 peripheral lymphocyte cells will be measured in %.

  38. Cycle 3, Group A: TH1 cells AFTER single plasma exchange [ Time Frame: Day 1, Hour 3 ]
    5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and the number of TH1 peripheral lymphocyte cells will be measured in %.

  39. Cycle 3, Group A: T1 cells 7-10 days AFTER single plasma exchange [ Time Frame: Day 7 - 10 ]
    5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and the number of TH1 peripheral lymphocyte cells will be measured in %.

  40. Cycle 3, Group A: TH17 cells BEFORE single plasma exchange [ Time Frame: Day 1, Hour 1 ]
    5 mL of blood will be collected in an EDTA tube BEFORE single plasma exchange and the number of TH17 cells will be measured in %.

  41. Cycle 3, Group A: TH17 cells AFTER single plasma exchange [ Time Frame: Day 1, Hour 3 ]
    5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and the number of TH17 cells will be measured in %.

  42. Cycle 3, Group A: TH17 cells 7-10 days AFTER single plasma exchange [ Time Frame: Day 7 - 10 ]
    5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and the number of TH17 cells will be measured in %.

  43. Cycle 3, Group A: T-reg cells BEFORE single plasma exchange [ Time Frame: Day 0, Hour 0 ]
    5 mL of blood will be collected in an EDTA tube BEFORE single plasma exchange and the number of T-reg cells will be measured in %.

  44. Cycle 3, Group A: T-reg cells AFTER single plasma exchange [ Time Frame: Day 0, Hour 3 ]
    5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and the number of T-reg cells will be measured in %.

  45. Cycle 3, Group A: T-reg cells 7-10 days AFTER single plasma exchange [ Time Frame: Day 7-10 ]
    5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and the number of T-reg cells will be measured in %.

  46. Cycle 3, Group B: TH1 cells BEFORE double filtration plasmapheresis [ Time Frame: Day 0, Hour 0 ]
    5 mL of blood will be collected in an EDTA tube BEFORE double filtration plasmapheresis and the number of TH1 peripheral lymphocyte cells will be measured in %.

  47. Cycle 3, Group B: TH1 cells AFTER double filtration plasmapheresis [ Time Frame: Day 0, Hour 3 ]
    5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and the number of TH1 peripheral lymphocyte cells will be measured in %.

  48. Cycle 3, Group B: TH1 cells 7-10 days AFTER double filtration plasmapheresis [ Time Frame: Day 7-10 ]
    5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and the number of TH1 peripheral lymphocyte cells will be measured in %.

  49. Cycle 3, Group B: TH17 cells BEFORE double filtration plasmapheresis [ Time Frame: Day 0, Hour 0 ]
    5 mL of blood will be collected in an EDTA tube BEFORE double filtration plasmapheresis and the number of TH17 cells will be measured in %.

  50. Cycle 3, Group B: TH17 cells AFTER double filtration plasmapheresis [ Time Frame: Day 0, Hour 3 ]
    5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and the number of TH17 cells will be measured in %.

  51. Cycle 3, Group B: TH17 cells 7-10 days AFTER double filtration plasmapheresis [ Time Frame: Day 7-10 ]
    5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and the number of TH17 cells will be measured in %.

  52. Cycle 3, Group B: T-reg cells BEFORE double filtration plasmapheresis [ Time Frame: Day 0, Hour 0 ]
    5 mL of blood will be collected in an EDTA tube BEFORE double filtration plasmapheresis and the number of T-reg cells will be measured in %.

  53. Cycle 3, Group B: T-reg cells AFTER double filtration plasmapheresis [ Time Frame: Day 0, Hour 3 ]
    5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and the number of T-reg cells will be measured in %.

  54. Cycle 3, Group B: T-reg cells 7-10 days AFTER double filtration plasmapheresis [ Time Frame: Day 7-10 ]
    5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and the number of T-reg cells will be measured in %.

  55. Cycle 4, Group A: T1 cells BEFORE double filtration plasmapheresis [ Time Frame: Day 0, Hour 0 ]
    5 mL of blood will be collected in an EDTA tube BEFORE double filtration plasmapheresis and the number of T1 peripheral lymphocyte cells will be measured in %.

  56. Cycle 4, Group A: T1 cells AFTER double filtration plasmapheresis [ Time Frame: Day 0, Hour 3 ]
    5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and the number of T1 peripheral lymphocyte cells will be measured in %.

  57. Cycle 4, Group A: TH1 cells 7-10 days AFTER double filtration plasmapheresis [ Time Frame: Day 7 - 10 ]
    5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and the number of TH1 peripheral lymphocyte cells will be measured in %.

  58. Cycle 4, Group A: TH17 cells BEFORE double filtration plasmapheresis [ Time Frame: Day 0, Hour 0 ]
    5 mL of blood will be collected in an EDTA tube BEFORE double filtration plasmapheresis and the number of TH17 cells will be measured in %.

  59. Cycle 4, Group A: TH17 cells AFTER double filtration plasmapheresis [ Time Frame: Day 0, Hour 3 ]
    5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and the number of TH17 cells will be measured in %.

  60. Cycle 4, Group A: TH17 cells 7-10 days AFTER double filtration plasmapheresis [ Time Frame: Day 7 - 10 ]
    5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and the number of TH17 peripheral lymphocyte cells will be measured in %.

  61. Cycle 4, Group A: T-reg cells BEFORE double filtration plasmapheresis [ Time Frame: Day 0, Hour 0 ]
    5 mL of blood will be collected in an EDTA tube BEFORE double filtration plasmapheresis and the number of T-reg cells will be measured in %.

  62. Cycle 4, Group A: T-reg cells AFTER double filtration plasmapheresis [ Time Frame: Day 0, Hour 3 ]
    5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and the number of T-reg cells will be measured in %.

  63. Cycle 4, Group A: T-reg cells 7-10 days AFTER double filtration plasmapheresis [ Time Frame: Day 7 - 10 ]
    5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and the number of T-reg peripheral lymphocyte cells will be measured in %.

  64. Cycle 4, Group B : TH1 cells BEFORE single plasma exchange [ Time Frame: Day 0, Hour 0 ]
    5 mL of blood will be collected in an EDTA tube BEFORE single plasma exchange and the number of TH1 peripheral lymphocyte cells will be measured in %.

  65. Cycle 4, Group B : TH1 cells AFTER single plasma exchange [ Time Frame: Day 0, Hour 3 ]
    5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and the number of TH1 peripheral lymphocyte cells will be measured in %.

  66. Cycle 4, Group B : TH1 cells 7-10 days AFTER single plasma exchange [ Time Frame: Day 7 -10 ]
    5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and the number of TH1 peripheral lymphocyte cells will be measured in %.

  67. Cycle 4, Group B : TH17 cells BEFORE single plasma exchange [ Time Frame: Day 0, Hour 0 ]
    5 mL of blood will be collected in an EDTA tube BEFORE single plasma exchange and the number of TH17 cells will be measured in %.

  68. Cycle 4, Group B : TH17 cells AFTER single plasma exchange [ Time Frame: Day 0, Hour 3 ]
    5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and the number of TH17 cells will be measured in %.

  69. Cycle 4, Group B : T17 cells 7-10 days AFTER single plasma exchange [ Time Frame: Day 7 -10 ]
    5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and the number of T1 peripheral lymphocyte cells will be measured in %.

  70. Cycle 4, Group B : T-reg cells BEFORE single plasma exchange [ Time Frame: Day 0, Hour 0 ]
    5 mL of blood will be collected in an EDTA tube BEFORE single plasma exchange and the number of T-reg cells will be measured in %.

  71. Cycle 4, Group B : T-reg cells AFTER single plasma exchange [ Time Frame: Day 0, Hour 3 ]
    5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and the number of T-reg cells will be measured in %.

  72. Cycle 4, Group B : T-reg cells 7-10 days AFTER single plasma exchange [ Time Frame: Day 7 - 10 ]
    5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and the number of T-reg cells will be measured in %.

  73. Cycle 5, Group A : TH1 cells BEFORE single plasma exchange [ Time Frame: Day 0, Hour 0 ]
    5 mL of blood will be collected in an EDTA tube BEFORE single plasma exchange and the number of TH1 peripheral lymphocyte cells will be measured in %.

  74. Cycle 5, Group A : TH1 cells AFTER single plasma exchange [ Time Frame: Day 0, Hour 3 ]
    5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and the number of TH1 peripheral lymphocyte cells will be measured in %.

  75. Cycle 5, Group A : TH1 cells 7-10 days AFTER single plasma exchange [ Time Frame: Day 7 - 10 ]
    5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and the number of TH1 cells will be measured in %.

  76. Cycle 5, Group A : TH17 cells BEFORE single plasma exchange [ Time Frame: Day 0, Hour 0 ]
    5 mL of blood will be collected in an EDTA tube BEFORE single plasma exchange and the number of TH17 cells will be measured in %.

  77. Cycle 5, Group A : TH17 cells AFTER single plasma exchange [ Time Frame: Day 0, Hour 3 ]
    5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and the number of TH17 cells will be measured in %.

  78. Cycle 5, Group A : TH17 cells 7-10 days AFTER single plasma exchange [ Time Frame: Day 7 - 10 ]
    5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and the number of TH17 cells will be measured in %.

  79. Cycle 5, Group A : T-reg cells BEFORE single plasma exchange [ Time Frame: Day 0, Hour 0 ]
    5 mL of blood will be collected in an EDTA tube BEFORE single plasma exchange and the number of T-reg cells will be measured in %.

  80. Cycle 5, Group A : T-reg cells AFTER single plasma exchange [ Time Frame: Day 0, Hour 3 ]
    5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and the number of T-reg cells will be measured in %.

  81. Cycle 5, Group A : T-reg cells 7-10 days AFTER single plasma exchange [ Time Frame: Day 7 - 10 ]
    5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and the number of T-reg cells will be measured in %.

  82. Cycle 5, Group B : TH1 cells BEFORE double filtration plasmapheresis [ Time Frame: Day 0, Hour 0 ]
    5 mL of blood will be collected in an EDTA tube BEFORE double filtration plasmapheresis and the number of TH1 peripheral lymphocyte cells will be measured in %.

  83. Cycle 5, Group B : TH1 cells AFTER double filtration plasmapheresis [ Time Frame: Day 0, Hour 3 ]
    5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and the number of TH1 peripheral lymphocyte cells will be measured in %.

  84. Cycle 5, Group B : TH1 cells 7-10 days AFTER double filtration plasmapheresis [ Time Frame: Day 7-10 ]
    5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and the number of TH1 peripheral lymphocyte cells will be measured in %.

  85. Cycle 5, Group B : TH17 cells BEFORE double filtration plasmapheresis [ Time Frame: Day 0, Hour 0 ]
    5 mL of blood will be collected in an EDTA tube BEFORE double filtration plasmapheresis and the number of TH17 cells will be measured in %.

  86. Cycle 5, Group B : TH17 cells AFTER double filtration plasmapheresis [ Time Frame: Day 0, Hour 3 ]
    5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and the number of TH17 cells will be measured in %.

  87. Cycle 5, Group B : TH17 cells 7-10 days AFTER double filtration plasmapheresis [ Time Frame: Day 7-10 ]
    5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and the number of TH17 cells will be measured in %.

  88. Cycle 5, Group B : T-reg cells BEFORE double filtration plasmapheresis [ Time Frame: Day 0, Hour 0 ]
    5 mL of blood will be collected in an EDTA tube BEFORE double filtration plasmapheresis and the number of T-reg cells will be measured in %.

  89. Cycle 5, Group B : T-reg cells AFTER double filtration plasmapheresis [ Time Frame: Day 0, Hour 3 ]
    5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and the number of T-reg cells will be measured in %.

  90. Cycle 5, Group B : T-reg cells 7-10 days AFTER double filtration plasmapheresis [ Time Frame: Day 7-10 ]
    5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and the number of T-reg cells will be measured in %.

  91. Cycle 6, Group A : TH1 cells BEFORE double filtration plasmapheresis [ Time Frame: Day 0 Hour 0 ]
    5 mL of blood will be collected in an EDTA tube BEFORE double filtration plasmapheresis and the number of TH1 peripheral lymphocyte cells will be measured in %.

  92. Cycle 6, Group A : TH1 cells AFTER double filtration plasmapheresis [ Time Frame: Day 0 Hour 3 ]
    5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and the number of TH1 peripheral lymphocyte cells will be measured in %.

  93. Cycle 6, Group A : TH1 cells 7-10 days AFTER double filtration plasmapheresis [ Time Frame: Day 7-10 ]
    5 mL of blood will be collected in an EDTA tube 7-10 days AFTER double filtration plasmapheresis and the number of TH1 peripheral lymphocyte cells will be measured in %.

  94. Cycle 6, Group A : TH17 cells BEFORE double filtration plasmapheresis [ Time Frame: Day 0 Hour 0 ]
    5 mL of blood will be collected in an EDTA tube BEFORE double filtration plasmapheresis and the number of TH17 cells will be measured in %.

  95. Cycle 6, Group A : TH17 cells AFTER double filtration plasmapheresis [ Time Frame: Day 0 Hour 3 ]
    5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and the number of TH17 cells will be measured in %.

  96. Cycle 6, Group A : TH17 cells 7-10 days AFTER double filtration plasmapheresis [ Time Frame: Day 7-10 ]
    5 mL of blood will be collected in an EDTA tube 7-10 days AFTER double filtration plasmapheresis and the number of TH17 cells will be measured in %.

  97. Cycle 6, Group A : T-reg cells BEFORE double filtration plasmapheresis [ Time Frame: Day 0 Hour 0 ]
    5 mL of blood will be collected in an EDTA tube BEFORE double filtration plasmapheresis and the number of T-reg cells will be measured in %.

  98. Cycle 6, Group A : T-reg cells AFTER double filtration plasmapheresis [ Time Frame: Day 0 Hour 3 ]
    5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and the number of T-reg cells will be measured in %.

  99. Cycle 6, Group A : T-reg cells 7-10 days AFTER double filtration plasmapheresis [ Time Frame: Day 7-10 ]
    5 mL of blood will be collected in an EDTA tube 7-10 days AFTER double filtration plasmapheresis and the number of T-reg cells will be measured in %.

  100. Cycle 6, Group B : TH1 cells BEFORE single plasma exchange [ Time Frame: Day 0 Hour 0 ]
    5 mL of blood will be collected in an EDTA tube BEFORE single plasma exchange and the number of TH1 peripheral lymphocyte cells will be measured in %.

  101. Cycle 6, Group B : TH1 cells AFTER single plasma exchange [ Time Frame: Day 0 Hour 3 ]
    5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and the number of TH1 peripheral lymphocyte cells will be measured in %.

  102. Cycle 6, Group B : TH1 cells 7-10 days AFTER single plasma exchange [ Time Frame: Day 7-10 ]
    5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and the number of TH1 peripheral lymphocyte cells will be measured in %.

  103. Cycle 6, Group B : TH17 cells BEFORE single plasma exchange [ Time Frame: Day 0 Hour 0 ]
    5 mL of blood will be collected in an EDTA tube BEFORE single plasma exchange and the number of TH17 cells will be measured in %.

  104. Cycle 6, Group B : TH17 cells AFTER single plasma exchange [ Time Frame: Day 0 Hour 3 ]
    5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and the number of TH17 cells will be measured in %.

  105. Cycle 6, Group B : TH17 cells 7-10 days AFTER single plasma exchange [ Time Frame: Day 7-10 ]
    5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and the number of TH17 cells will be measured in %.

  106. Cycle 6, Group B : T-reg cells BEFORE single plasma exchange [ Time Frame: Day 0 Hour 0 ]
    5 mL of blood will be collected in an EDTA tube BEFORE single plasma exchange and the number of T-reg cells will be measured in %.

  107. Cycle 6, Group B : T-reg cells AFTER single plasma exchange [ Time Frame: Day 0 Hour 3 ]
    5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and the number of T-reg cells will be measured in %.

  108. Cycle 6, Group B : T-reg cells 7-10 days AFTER single plasma exchange [ Time Frame: Day 7-10 ]
    5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and the number of T-reg cells will be measured in %.


Secondary Outcome Measures :
  1. Cycle 1, Group A : T4 lymphocytes BEFORE single plasma exchange [ Time Frame: Day 0 Hour 0 ]
    5 mL of blood will be collected in an EDTA tube BEFORE single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  2. Cycle 1, Group A : T4-DR+ lymphocytes BEFORE single plasma exchange [ Time Frame: Day 0 Hour 0 ]
    5 mL of blood will be collected in an EDTA tube BEFORE single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  3. Cycle 1, Group A : T8 lymphocytes BEFORE single plasma exchange [ Time Frame: Day 0 Hour 0 ]
    5 mL of blood will be collected in an EDTA tube BEFORE single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  4. Cycle 1, Group A : T8 DR+ lymphocytes BEFORE single plasma exchange [ Time Frame: Day 0 Hour 0 ]
    5 mL of blood will be collected in an EDTA tube BEFORE single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  5. Cycle 1, Group A : B lymphocytes BEFORE single plasma exchange [ Time Frame: Day 0 Hour 0 ]
    5 mL of blood will be collected in an EDTA tube BEFORE single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  6. Cycle 1, Group A : CD45RA+CCR7+ cells BEFORE single plasma exchange [ Time Frame: Day 0 Hour 0 ]
    5 mL of blood will be collected in an EDTA tube BEFORE single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  7. Cycle 1, Group A : CD45RA-CCR7+ cells BEFORE single plasma exchange [ Time Frame: Day 0 Hour 0 ]
    5 mL of blood will be collected in an EDTA tube BEFORE single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  8. Cycle 1, Group A : CD45RA-CCR7- cells BEFORE single plasma exchange [ Time Frame: Day 0 Hour 0 ]
    5 mL of blood will be collected in an EDTA tube BEFORE single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  9. Cycle 1, Group A : CCR6-CXCR3- cells BEFORE single plasma exchange [ Time Frame: Day 0 Hour 0 ]
    5 mL of blood will be collected in an EDTA tube BEFORE single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  10. Cycle 1, Group A : T4 lymphocytes AFTER single plasma exchange [ Time Frame: Day 0 Hour 3 ]
    5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  11. Cycle 1, Group A : T4-DR+ lymphocytes AFTER single plasma exchange [ Time Frame: Day 0 Hour 3 ]
    5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  12. Cycle 1, Group A : T8 lymphocytes AFTER single plasma exchange [ Time Frame: Day 0 Hour 3 ]
    5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  13. Cycle 1, Group A : T8 DR+ lymphocytes AFTER single plasma exchange [ Time Frame: Day 0 Hour 3 ]
    5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  14. Cycle 1, Group A : B lymphocytes AFTER single plasma exchange [ Time Frame: Day 0 Hour 3 ]
    5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  15. Cycle 1, Group A : CD45RA+CCR7+ cells AFTER single plasma exchange [ Time Frame: Day 0 Hour 3 ]
    5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  16. Cycle 1, Group A : CD45RA-CCR7+ cells AFTER single plasma exchange [ Time Frame: Day 0 Hour 3 ]
    5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  17. Cycle 1, Group A : CD45RA-CCR7- cells AFTER single plasma exchange [ Time Frame: Day 0 Hour 3 ]
    5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  18. Cycle 1, Group A : CR6-CXCR3- cells AFTER single plasma exchange [ Time Frame: Day 0 Hour 3 ]
    5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  19. Cycle 1, Group A : T4 lymphocytes 7-10 days AFTER single plasma exchange [ Time Frame: Day 7-10 ]
    5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  20. Cycle 1, Group A : T4-DR+ lymphocytes 7-10 days AFTER single plasma exchange [ Time Frame: Day 7-10 ]
    5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  21. Cycle 1, Group A : T8 lymphocytes 7-10 days AFTER single plasma exchange [ Time Frame: Day 7-10 ]
    5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  22. Cycle 1, Group A : T8 DR+ lymphocytes 7-10 days AFTER single plasma exchange [ Time Frame: Day 7-10 ]
    5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  23. Cycle 1, Group A : B lymphocytes 7-10 days AFTER single plasma exchange [ Time Frame: Day 7-10 ]
    5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  24. Cycle 1, Group A : CD45RA+CCR7+ cells 7-10 days AFTER single plasma exchange [ Time Frame: Day 7-10 ]
    5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  25. Cycle 1, Group A : CD45RA-CCR7+ cells 7-10 days AFTER single plasma exchange [ Time Frame: Day 7-10 ]
    5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  26. Cycle 1, Group A : CD45RA-CCR7- cells 7-10 days AFTER single plasma exchange [ Time Frame: Day 7-10 ]
    5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  27. Cycle 1, Group A : CCR6-CXCR3- cells 7-10 days AFTER single plasma exchange [ Time Frame: Day 7-10 ]
    5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  28. Cycle 1, Group B: T4 lymphocytes BEFORE double filtration plasmapheresis [ Time Frame: Day 0 Hour 0 ]
    5 mL of blood will be collected in an EDTA tube BEFORE double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  29. Cycle 1, Group B: T4 DR+ lymphocytes BEFORE double filtration plasmapheresis [ Time Frame: Day 0 Hour 0 ]
    5 mL of blood will be collected in an EDTA tube BEFORE double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  30. Cycle 1, Group B: T8 lymphocytes BEFORE double filtration plasmapheresis [ Time Frame: Day 0 Hour 0 ]
    5 mL of blood will be collected in an EDTA tube BEFORE double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  31. Cycle 1, Group B: T8 DR+ lymphocytes BEFORE double filtration plasmapheresis [ Time Frame: Day 0 Hour 0 ]
    5 mL of blood will be collected in an EDTA tube BEFORE double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  32. Cycle 1, Group B: B lymphocytes BEFORE double filtration plasmapheresis [ Time Frame: Day 0 Hour 0 ]
    5 mL of blood will be collected in an EDTA tube BEFORE double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  33. Cycle 1, Group B: CD45RA+CCR7+ cells BEFORE double filtration plasmapheresis [ Time Frame: Day 0 Hour 0 ]
    5 mL of blood will be collected in an EDTA tube BEFORE double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  34. Cycle 1, Group B: CD45RA-CCR7+ cells BEFORE double filtration plasmapheresis [ Time Frame: Day 0 Hour 0 ]
    5 mL of blood will be collected in an EDTA tube BEFORE double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  35. Cycle 1, Group B: CD45RA-CCR7- cells BEFORE double filtration plasmapheresis [ Time Frame: Day 0 Hour 0 ]
    5 mL of blood will be collected in an EDTA tube BEFORE double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  36. Cycle 1, Group B: CCR6-CXCR3- cells BEFORE double filtration plasmapheresis [ Time Frame: Day 0 Hour 0 ]
    5 mL of blood will be collected in an EDTA tube BEFORE double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  37. Cycle 1, Group B:T4 lymphocytes AFTER double filtration plasmapheresis [ Time Frame: Day 0 Hour 3 ]
    5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  38. Cycle 1, Group B:T4 DR+ lymphocytes AFTER double filtration plasmapheresis [ Time Frame: Day 0 Hour 3 ]
    5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  39. Cycle 1, Group B:T8 lymphocytes AFTER double filtration plasmapheresis [ Time Frame: Day 0 Hour 3 ]
    5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  40. Cycle 1, Group B:T8 DR+ lymphocytes AFTER double filtration plasmapheresis [ Time Frame: Day 0 Hour 3 ]
    5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  41. Cycle 1, Group B: B lymphocytes AFTER double filtration plasmapheresis [ Time Frame: Day 0 Hour 3 ]
    5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  42. Cycle 1, Group B: CD45RA+CCR7+ cells AFTER double filtration plasmapheresis [ Time Frame: Day 0 Hour 3 ]
    5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  43. Cycle 1, Group B: CD45RA-CCR7+ cells AFTER double filtration plasmapheresis [ Time Frame: Day 0 Hour 3 ]
    5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  44. Cycle 1, Group B: CD45RA-CCR7- cells AFTER double filtration plasmapheresis [ Time Frame: Day 0 Hour 3 ]
    5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  45. Cycle 1, Group B: CCR6-CXCR3- cells AFTER double filtration plasmapheresis [ Time Frame: Day 0 Hour 3 ]
    5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  46. Cycle 1, Group B: T4 lymphocytes 7-10 days AFTER double filtration plasmapheresis [ Time Frame: Day 7-10 ]
    5 mL of blood will be collected in an EDTA tube 7-10 days AFTER double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  47. Cycle 1, Group B: T4 DR+ lymphocytes 7-10 days AFTER double filtration plasmapheresis [ Time Frame: Day 7-10 ]
    5 mL of blood will be collected in an EDTA tube 7-10 days AFTER double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  48. Cycle 1, Group B: T8 lymphocytes 7-10 days AFTER double filtration plasmapheresis [ Time Frame: Day 7-10 ]
    5 mL of blood will be collected in an EDTA tube 7-10 days AFTER double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  49. Cycle 1, Group B: T8 DR+ lymphocytes 7-10 days AFTER double filtration plasmapheresis [ Time Frame: Day 7-10 ]
    5 mL of blood will be collected in an EDTA tube 7-10 days AFTER double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  50. Cycle 1, Group B: B lymphocytes 7-10 days AFTER double filtration plasmapheresis [ Time Frame: Day 7-10 ]
    5 mL of blood will be collected in an EDTA tube 7-10 days AFTER double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  51. Cycle 1, Group B: CD45RA+CCR7+ cells 7-10 days AFTER double filtration plasmapheresis [ Time Frame: Day 7-10 ]
    5 mL of blood will be collected in an EDTA tube 7-10 days AFTER double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  52. Cycle 1, Group B: CD45RA-CCR7+ cells 7-10 days AFTER double filtration plasmapheresis [ Time Frame: Day 7-10 ]
    5 mL of blood will be collected in an EDTA tube 7-10 days AFTER double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  53. Cycle 1, Group B: CD45RA-CCR7- cells 7-10 days AFTER double filtration plasmapheresis [ Time Frame: Day 7-10 ]
    5 mL of blood will be collected in an EDTA tube 7-10 days AFTER double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  54. Cycle 1, Group B: CCR6-CXCR3- cells 7-10 days AFTER double filtration plasmapheresis [ Time Frame: Day 7-10 ]
    5 mL of blood will be collected in an EDTA tube 7-10 days AFTER double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  55. Cycle 2, Group A : T4 lymphocytes BEFORE double filtration plasmapheresis [ Time Frame: Day 0 Hour 0 ]
    5 mL of blood will be collected in an EDTA tube BEFORE double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  56. Cycle 2, Group A : T4 DR+ lymphocytes BEFORE double filtration plasmapheresis [ Time Frame: Day 0 Hour 0 ]
    5 mL of blood will be collected in an EDTA tube BEFORE double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  57. Cycle 2, Group A : T8 lymphocytes BEFORE double filtration plasmapheresis [ Time Frame: Day 0 Hour 0 ]
    5 mL of blood will be collected in an EDTA tube BEFORE double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  58. Cycle 2, Group A : T8 DR+ lymphocytes BEFORE double filtration plasmapheresis [ Time Frame: Day 0 Hour 0 ]
    5 mL of blood will be collected in an EDTA tube BEFORE double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  59. Cycle 2, Group A : B lymphocytes BEFORE double filtration plasmapheresis [ Time Frame: Day 0 Hour 0 ]
    5 mL of blood will be collected in an EDTA tube BEFORE double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) a,d measured as a percentage.

  60. Cycle 2, Group A : CD45RA+CCR7+ cells BEFORE double filtration plasmapheresis [ Time Frame: Day 0 Hour 0 ]
    5 mL of blood will be collected in an EDTA tube BEFORE double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) a,d measured as a percentage.

  61. Cycle 2, Group A : CD45RA-CCR7+ cells BEFORE double filtration plasmapheresis [ Time Frame: Day 0 Hour 0 ]
    5 mL of blood will be collected in an EDTA tube BEFORE double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) a,d measured as a percentage.

  62. Cycle 2, Group A : CD45RA-CCR7- cells BEFORE double filtration plasmapheresis [ Time Frame: Day 0 Hour 0 ]
    5 mL of blood will be collected in an EDTA tube BEFORE double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) a,d measured as a percentage.

  63. Cycle 2, Group A : CCR6-CXCR3- cells BEFORE double filtration plasmapheresis [ Time Frame: Day 0 Hour 0 ]
    5 mL of blood will be collected in an EDTA tube BEFORE double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) a,d measured as a percentage.

  64. Cycle 2, Group A : T4 lymphocytes AFTER double filtration plasmapheresis [ Time Frame: Day 0 Hour 3 ]
    5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) a,d measured as a percentage.

  65. Cycle 2, Group A : T4 DR+ lymphocytes AFTER double filtration plasmapheresis [ Time Frame: Day 0 Hour 3 ]
    5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  66. Cycle 2, Group A : T8 lymphocytes AFTER double filtration plasmapheresis [ Time Frame: Day 0 Hour 3 ]
    5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  67. Cycle 2, Group A : T8 DR+ lymphocytes AFTER double filtration plasmapheresis [ Time Frame: Day 0 Hour 3 ]
    5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  68. Cycle 2, Group A : B lymphocytes AFTER double filtration plasmapheresis [ Time Frame: Day 0 Hour 3 ]
    5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  69. Cycle 2, Group A : CD45RA+CCR7+ cells AFTER double filtration plasmapheresis [ Time Frame: Day 0 Hour 3 ]
    5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  70. Cycle 2, Group A : CD45RA-CCR7+ cells AFTER double filtration plasmapheresis [ Time Frame: Day 0 Hour 3 ]
    5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  71. Cycle 2, Group A : CD45RA-CCR7- cells AFTER double filtration plasmapheresis [ Time Frame: Day 0 Hour 3 ]
    5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  72. Cycle 2, Group A : CCR6-CXCR3- cells AFTER double filtration plasmapheresis [ Time Frame: Day 0 Hour 3 ]
    5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  73. Cycle 2, Group A : T4 lymphocytes 7-10 days AFTER double filtration plasmapheresis [ Time Frame: Day 7 - 10 ]
    5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  74. Cycle 2, Group A : T4 DR+ lymphocytes 7-10 days AFTER double filtration plasmapheresis [ Time Frame: Day 7 - 10 ]
    5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  75. Cycle 2, Group A : T8 lymphocytes 7-10 days AFTER double filtration plasmapheresis [ Time Frame: Day 7 - 10 ]
    5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  76. Cycle 2, Group A : T8 DR+ lymphocytes 7-10 days AFTER double filtration plasmapheresis [ Time Frame: Day 7 - 10 ]
    5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  77. Cycle 2, Group A : B lymphocytes 7-10 days AFTER double filtration plasmapheresis [ Time Frame: Day 7 - 10 ]
    5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  78. Cycle 2, Group A : CD45RA+CCR7+ cells 7-10 days AFTER double filtration plasmapheresis [ Time Frame: Day 7 - 10 ]
    5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  79. Cycle 2, Group A : CD45RA-CCR7+ cells 7-10 days AFTER double filtration plasmapheresis [ Time Frame: Day 7 - 10 ]
    5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  80. Cycle 2, Group A : CD45RA-CCR7- cells 7-10 days AFTER double filtration plasmapheresis [ Time Frame: Day 7 - 10 ]
    5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  81. Cycle 2, Group A : CCR6-CXCR3- cells 7-10 days AFTER double filtration plasmapheresis [ Time Frame: Day 7 - 10 ]
    5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  82. Cycle 2, Group B : T4 lymphocytes BEFORE single plasma exchange [ Time Frame: Day 0 Hour 0 ]
    5 mL of blood will be collected in an EDTA tube BEFORE single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  83. Cycle 2, Group B : T4 DR+ lymphocytes BEFORE single plasma exchange [ Time Frame: Day 0 Hour 0 ]
    5 mL of blood will be collected in an EDTA tube BEFORE single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  84. Cycle 2, Group B : T8 lymphocytes BEFORE single plasma exchange [ Time Frame: Day 0 Hour 0 ]
    5 mL of blood will be collected in an EDTA tube BEFORE single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  85. Cycle 2, Group B : T8 DR+ lymphocytes BEFORE single plasma exchange [ Time Frame: Day 0 Hour 0 ]
    5 mL of blood will be collected in an EDTA tube BEFORE single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  86. Cycle 2, Group B : B lymphocytes BEFORE single plasma exchange [ Time Frame: Day 0 Hour 0 ]
    5 mL of blood will be collected in an EDTA tube BEFORE single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  87. Cycle 2, Group B : CD45RA+CCR7+ cells BEFORE single plasma exchange [ Time Frame: Day 0 Hour 0 ]
    5 mL of blood will be collected in an EDTA tube BEFORE single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  88. Cycle 2, Group B : CD45RA-CCR7+ cells BEFORE single plasma exchange [ Time Frame: Day 0 Hour 0 ]
    5 mL of blood will be collected in an EDTA tube BEFORE single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  89. Cycle 2, Group B : CD45RA-CCR7- cells BEFORE single plasma exchange [ Time Frame: Day 0 Hour 0 ]
    5 mL of blood will be collected in an EDTA tube BEFORE single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  90. Cycle 2, Group B : CCR6-CXCR3- cells BEFORE single plasma exchange [ Time Frame: Day 0 Hour 0 ]
    5 mL of blood will be collected in an EDTA tube BEFORE single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  91. Cycle 2, Group B : T4 lymphocytes AFTER single plasma exchange [ Time Frame: Day 0 Hour 3 ]
    5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  92. Cycle 2, Group B : T4 DR+ lymphocytes AFTER single plasma exchange [ Time Frame: Day 0 Hour 3 ]
    5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  93. Cycle 2, Group B : T8 lymphocytes AFTER single plasma exchange [ Time Frame: Day 0 Hour 3 ]
    5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  94. Cycle 2, Group B : T8 DR+ lymphocytes AFTER single plasma exchange [ Time Frame: Day 0 Hour 3 ]
    5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  95. Cycle 2, Group B : B lymphocytes AFTER single plasma exchange [ Time Frame: Day 0 Hour 3 ]
    5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  96. Cycle 2, Group B : CD45RA+CCR7+ cells AFTER single plasma exchange [ Time Frame: Day 0 Hour 3 ]
    5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  97. Cycle 2, Group B : CD45RA-CCR7+ cells AFTER single plasma exchange [ Time Frame: Day 0 Hour 3 ]
    5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  98. Cycle 2, Group B : CD45RA-CCR7- cells AFTER single plasma exchange [ Time Frame: Day 0 Hour 3 ]
    5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  99. Cycle 2, Group B : CCR6-CXCR3- cells AFTER single plasma exchange [ Time Frame: Day 0 Hour 3 ]
    5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  100. Cycle 2, Group B : T4 lymphocytes 7-10 days AFTER single plasma exchange [ Time Frame: Day 7-10 ]
    5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  101. Cycle 2, Group B : T4 DR+ lymphocytes 7-10 days AFTER single plasma exchange [ Time Frame: Day 7-10 ]
    5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  102. Cycle 2, Group B : T8 lymphocytes 7-10 days AFTER single plasma exchange [ Time Frame: Day 7-10 ]
    5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  103. Cycle 2, Group B : T8 DR+ lymphocytes 7-10 days AFTER single plasma exchange [ Time Frame: Day 7-10 ]
    5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  104. Cycle 2, Group B : B lymphocytes 7-10 days AFTER single plasma exchange [ Time Frame: Day 7-10 ]
    5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  105. Cycle 2, Group B : CD45RA+CCR7+ cells 7-10 days AFTER single plasma exchange [ Time Frame: Day 7-10 ]
    5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  106. Cycle 2, Group B : CD45RA-CCR7+ cells 7-10 days AFTER single plasma exchange [ Time Frame: Day 7-10 ]
    5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  107. Cycle 2, Group B : CD45RA-CCR7- cells 7-10 days AFTER single plasma exchange [ Time Frame: Day 7-10 ]
    5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured a percentage.

  108. Cycle 2, Group B : CCR6-CXCR3- cells 7-10 days AFTER single plasma exchange [ Time Frame: Day 7-10 ]
    5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  109. Cycle 3, Group A : T4 lymphocytes BEFORE single plasma exchange [ Time Frame: Day 0 Hour 0 ]
    5 mL of blood will be collected in an EDTA tube BEFORE single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  110. Cycle 3, Group A : T4 DR+ lymphocytes BEFORE single plasma exchange [ Time Frame: Day 0 Hour 0 ]
    5 mL of blood will be collected in an EDTA tube BEFORE single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  111. Cycle 3, Group A : T8 lymphocytes BEFORE single plasma exchange [ Time Frame: Day 0 Hour 0 ]
    5 mL of blood will be collected in an EDTA tube BEFORE single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  112. Cycle 3, Group A : T8 DR+ lymphocytes BEFORE single plasma exchange [ Time Frame: Day 0 Hour 0 ]
    5 mL of blood will be collected in an EDTA tube BEFORE single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  113. Cycle 3, Group A : B lymphocytes BEFORE single plasma exchange [ Time Frame: Day 0 Hour 0 ]
    5 mL of blood will be collected in an EDTA tube BEFORE single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  114. Cycle 3, Group A : CC45RA+CCR7+ cells BEFORE single plasma exchange [ Time Frame: Day 0 Hour 0 ]
    5 mL of blood will be collected in an EDTA tube BEFORE single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  115. Cycle 3, Group A : CC45RA-CCR7+ cells BEFORE single plasma exchange [ Time Frame: Day 0 Hour 0 ]
    5 mL of blood will be collected in an EDTA tube BEFORE single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  116. Cycle 3, Group A : CC45RA-CCR7- cells BEFORE single plasma exchange [ Time Frame: Day 0 Hour 0 ]
    5 mL of blood will be collected in an EDTA tube BEFORE single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  117. Cycle 3, Group A : CCR6-CXCR3- cells BEFORE single plasma exchange [ Time Frame: Day 0 Hour 0 ]
    5 mL of blood will be collected in an EDTA tube BEFORE single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  118. Cycle 3, Group A : T4 lymphocytes AFTER single plasma exchange [ Time Frame: Day 0 Hour 3 ]
    5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  119. Cycle 3, Group A : T4 DR+ lymphocytes AFTER single plasma exchange [ Time Frame: Day 0 Hour 3 ]
    5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  120. Cycle 3, Group A : T8 lymphocytes AFTER single plasma exchange [ Time Frame: Day 0 Hour 3 ]
    5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  121. Cycle 3, Group A : T8 DR+ lymphocytes AFTER single plasma exchange [ Time Frame: Day 0 Hour 3 ]
    5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  122. Cycle 3, Group A : B lymphocytes AFTER single plasma exchange [ Time Frame: Day 0 Hour 3 ]
    5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  123. Cycle 3, Group A : CD45RA+CCR7+ cells AFTER single plasma exchange [ Time Frame: Day 0 Hour 3 ]
    5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  124. Cycle 3, Group A : CD45RA-CCR7+ cells AFTER single plasma exchange [ Time Frame: Day 0 Hour 3 ]
    5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  125. Cycle 3, Group A : CD45RA-CCR7- cells AFTER single plasma exchange [ Time Frame: Day 0 Hour 3 ]
    5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  126. Cycle 3, Group A : CCR6-CXCR3- cells AFTER single plasma exchange [ Time Frame: Day 0 Hour 3 ]
    5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  127. Cycle 3, Group A : T4 DR+ lymphocytes 7-10 days AFTER single plasma exchange [ Time Frame: Day 7-10 ]
    5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  128. Cycle 3, Group A : T4 lymphocytes 7 -10 days AFTER single plasma exchange [ Time Frame: Day 7-10 ]
    5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  129. Cycle 3, Group A : T8 lymphocytes 7-10 days AFTER single plasma exchange [ Time Frame: Day 7-10 ]
    5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  130. Cycle 3, Group A : T8 DR+ lymphocytes 7-10 days AFTER single plasma exchange [ Time Frame: Day 7-10 ]
    5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  131. Cycle 3, Group A : B lymphocytes 7-10 days AFTER single plasma exchange [ Time Frame: Day 7-10 ]
    5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  132. Cycle 3, Group A : CD45RA+CCR7+ cells 7-10 days AFTER single plasma exchange [ Time Frame: Day 7-10 ]
    5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  133. Cycle 3, Group A : CD45RA-CCR7+ cells 7-10 days AFTER single plasma exchange [ Time Frame: Day 7-10 ]
    5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  134. Cycle 3, Group A : CD45RA-CCR7- cells 7-10 days AFTER single plasma exchange [ Time Frame: Day 7-10 ]
    5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  135. Cycle 3, Group A : CCR6-CXCR3- cells 7-10 days AFTER single plasma exchange [ Time Frame: Day 7-10 ]
    5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  136. Cycle 3, Group B : T4 lymphocytes BEFORE double filtration plasmapheresis [ Time Frame: Day 0 Hour 0 ]
    5 mL of blood will be collected in an EDTA tube BEFORE double filtration and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  137. Cycle 3, Group B : T4 DR+ lymphocytes BEFORE double filtration plasmapheresis [ Time Frame: Day 0 Hour 0 ]
    5 mL of blood will be collected in an EDTA tube BEFORE double filtration and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  138. Cycle 3, Group B : T8 lymphocytes BEFORE double filtration plasmapheresis [ Time Frame: Day 0 Hour 0 ]
    5 mL of blood will be collected in an EDTA tube BEFORE double filtration and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  139. Cycle 3, Group B : T8 DR+ lymphocytes BEFORE double filtration plasmapheresis [ Time Frame: Day 0 Hour 0 ]
    5 mL of blood will be collected in an EDTA tube BEFORE double filtration and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  140. Cycle 3, Group B : B lymphocytes BEFORE double filtration plasmapheresis [ Time Frame: Day 0 Hour 0 ]
    5 mL of blood will be collected in an EDTA tube BEFORE double filtration and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  141. Cycle 3, Group B : CD45RA+CCR7+ cells BEFORE double filtration plasmapheresis [ Time Frame: Day 0 Hour 0 ]
    5 mL of blood will be collected in an EDTA tube BEFORE double filtration and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  142. Cycle 3, Group B : CD45RA-CCR7+ cells BEFORE double filtration plasmapheresis [ Time Frame: Day 0 Hour 0 ]
    5 mL of blood will be collected in an EDTA tube BEFORE double filtration and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  143. Cycle 3, Group B : CD45RA-CCR7- cells BEFORE double filtration plasmapheresis [ Time Frame: Day 0 Hour 0 ]
    5 mL of blood will be collected in an EDTA tube BEFORE double filtration and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  144. Cycle 3, Group B : CCR6-CXCR3- cells BEFORE double filtration plasmapheresis [ Time Frame: Day 0 Hour 0 ]
    5 mL of blood will be collected in an EDTA tube BEFORE double filtration and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  145. Cycle 3, Group B : T4 lymphocytes AFTER double filtration plasmapheresis [ Time Frame: Day 0 Hour 3 ]
    5 mL of blood will be collected in an EDTA tube AFTER double filtration and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  146. Cycle 3, Group B : T4 DR+ lymphocytes AFTER double filtration plasmapheresis [ Time Frame: Day 0 Hour 3 ]
    5 mL of blood will be collected in an EDTA tube AFTER double filtration and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  147. Cycle 3, Group B : T8 lymphocytes AFTER double filtration plasmapheresis [ Time Frame: Day 0 Hour 3 ]
    5 mL of blood will be collected in an EDTA tube AFTER double filtration and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  148. Cycle 3, Group B : T8 DR+ lymphocytes AFTER double filtration plasmapheresis [ Time Frame: Day 0 Hour 3 ]
    5 mL of blood will be collected in an EDTA tube AFTER double filtration and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  149. Cycle 3, Group B : B lymphocytes AFTER double filtration plasmapheresis [ Time Frame: Day 0 Hour 3 ]
    5 mL of blood will be collected in an EDTA tube AFTER double filtration and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  150. Cycle 3, Group B : CD45RA+CCR7+ cells AFTER double filtration plasmapheresis [ Time Frame: Day 0 Hour 3 ]
    5 mL of blood will be collected in an EDTA tube AFTER double filtration and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  151. Cycle 3, Group B : CD45RA-CCR7+ cells AFTER double filtration plasmapheresis [ Time Frame: Day 0 Hour 3 ]
    5 mL of blood will be collected in an EDTA tube AFTER double filtration and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  152. Cycle 3, Group B : CD45RA-CCR7- cells AFTER double filtration plasmapheresis [ Time Frame: Day 0 Hour 3 ]
    5 mL of blood will be collected in an EDTA tube AFTER double filtration and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  153. Cycle 3, Group B : CCR6-CXCR3- cells AFTER double filtration plasmapheresis [ Time Frame: Day 0 Hour 3 ]
    5 mL of blood will be collected in an EDTA tube AFTER double filtration and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  154. Cycle 3, Group B : T4 lymphocytes 7-10 days AFTER double filtration plasmapheresis [ Time Frame: Day 7-10 ]
    5 mL of blood will be collected in an EDTA tube AFTER double filtration and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  155. Cycle 3, Group B : T4 DR+ lymphocytes 7-10 days AFTER double filtration plasmapheresis [ Time Frame: Day 7-10 ]
    5 mL of blood will be collected in an EDTA tube AFTER double filtration and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  156. Cycle 3, Group B : T8 lymphocytes 7-10 days AFTER double filtration plasmapheresis [ Time Frame: Day 7-10 ]
    5 mL of blood will be collected in an EDTA tube AFTER double filtration and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  157. Cycle 3, Group B : T8 DR+ lymphocytes 7-10 days AFTER double filtration plasmapheresis [ Time Frame: Day 7-10 ]
    5 mL of blood will be collected in an EDTA tube AFTER double filtration and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  158. Cycle 3, Group B : B lymphocytes 7-10 days AFTER double filtration plasmapheresis [ Time Frame: Day 7-10 ]
    5 mL of blood will be collected in an EDTA tube AFTER double filtration and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  159. Cycle 3, Group B : CD45RA+CCR7+ cells 7-10 days AFTER double filtration plasmapheresis [ Time Frame: Day 7-10 ]
    5 mL of blood will be collected in an EDTA tube AFTER double filtration and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  160. Cycle 3, Group B : CD45RA-CCR7+ cells 7-10 days AFTER double filtration plasmapheresis [ Time Frame: Day 7-10 ]
    5 mL of blood will be collected in an EDTA tube AFTER double filtration and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  161. Cycle 3, Group B : CD45RA-CCR7- cells 7-10 days AFTER double filtration plasmapheresis [ Time Frame: Day 7-10 ]
    5 mL of blood will be collected in an EDTA tube AFTER double filtration and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  162. Cycle 3, Group B : CCR6-CXCR3- cells 7-10 days AFTER double filtration plasmapheresis [ Time Frame: Day 7-10 ]
    5 mL of blood will be collected in an EDTA tube AFTER double filtration and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  163. Cycle 4, Group A : T4 lymphocytes BEFORE double filtration plasmapheresis [ Time Frame: Day 0 Hour 0 ]
    5 mL of blood will be collected in an EDTA tube BEFORE double filtration and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  164. Cycle 4, Group A : T4 DR+ lymphocytes BEFORE double filtration plasmapheresis [ Time Frame: Day 0 Hour 0 ]
    5 mL of blood will be collected in an EDTA tube BEFORE double filtration and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  165. Cycle 4, Group A : T8 lymphocytes BEFORE double filtration plasmapheresis [ Time Frame: Day 0 Hour 0 ]
    5 mL of blood will be collected in an EDTA tube BEFORE double filtration and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  166. Cycle 4, Group A : T8 DR+ lymphocytes BEFORE double filtration plasmapheresis [ Time Frame: Day 0 Hour 0 ]
    5 mL of blood will be collected in an EDTA tube BEFORE double filtration and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  167. Cycle 4, Group A : B lymphocytes BEFORE double filtration plasmapheresis [ Time Frame: Day 0 Hour 0 ]
    5 mL of blood will be collected in an EDTA tube BEFORE double filtration and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  168. Cycle 4, Group A : CD45RA+CCR7+ cells BEFORE double filtration plasmapheresis [ Time Frame: Day 0 Hour 0 ]
    5 mL of blood will be collected in an EDTA tube BEFORE double filtration and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  169. Cycle 4, Group A : CD45RA-CCR7+ cells BEFORE double filtration plasmapheresis [ Time Frame: Day 0 Hour 0 ]
    5 mL of blood will be collected in an EDTA tube BEFORE double filtration and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  170. Cycle 4, Group A : CD45RA-CCR7- cells BEFORE double filtration plasmapheresis [ Time Frame: Day 0 Hour 0 ]
    5 mL of blood will be collected in an EDTA tube BEFORE double filtration and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  171. Cycle 4, Group A : CCR6-CXCR3- cells BEFORE double filtration plasmapheresis [ Time Frame: Day 0 Hour 0 ]
    5 mL of blood will be collected in an EDTA tube BEFORE double filtration and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  172. Cycle 4, Group A : T4 lymphocytes AFTER double filtration plasmapheresis [ Time Frame: Day 0 Hour 3 ]
    5 mL of blood will be collected in an EDTA tube AFTER double filtration and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  173. Cycle 4, Group A : T4 DR+ lymphocytes AFTER double filtration plasmapheresis [ Time Frame: Day 0 Hour 3 ]
    5 mL of blood will be collected in an EDTA tube AFTER double filtration and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  174. Cycle 4, Group A : T8 lymphocytes AFTER double filtration plasmapheresis [ Time Frame: Day 0 Hour 3 ]
    5 mL of blood will be collected in an EDTA tube AFTER double filtration and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  175. Cycle 4, Group A : T8 DR+ lymphocytes AFTER double filtration plasmapheresis [ Time Frame: Day 0 Hour 3 ]
    5 mL of blood will be collected in an EDTA tube AFTER double filtration and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  176. Cycle 4, Group A : B lymphocytes AFTER double filtration plasmapheresis [ Time Frame: Day 0 Hour 3 ]
    5 mL of blood will be collected in an EDTA tube AFTER double filtration and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  177. Cycle 4, Group A : CD45RA+CCR7+ cells AFTER double filtration plasmapheresis [ Time Frame: Day 0 Hour 3 ]
    5 mL of blood will be collected in an EDTA tube AFTER double filtration and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  178. Cycle 4, Group A : CD45RA-CCR7+ cells AFTER double filtration plasmapheresis [ Time Frame: Day 0 Hour 3 ]
    5 mL of blood will be collected in an EDTA tube AFTER double filtration and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  179. Cycle 4, Group A : CD45RA-CCR7- cells AFTER double filtration plasmapheresis [ Time Frame: Day 0 Hour 3 ]
    5 mL of blood will be collected in an EDTA tube AFTER double filtration and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  180. Cycle 4, Group A : CCR6-CXCR3- cells AFTER double filtration plasmapheresis [ Time Frame: Day 0 Hour 3 ]
    5 mL of blood will be collected in an EDTA tube AFTER double filtration and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  181. Cycle 4, Group A : T4 lymphocytes 7-10 days AFTER double filtration plasmapheresis [ Time Frame: Day 7-10 ]
    5 mL of blood will be collected in an EDTA tube AFTER double filtration and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  182. Cycle 4, Group A : T4 DR+ lymphocytes 7-10 days AFTER double filtration plasmapheresis [ Time Frame: Day 7-10 ]
    5 mL of blood will be collected in an EDTA tube AFTER double filtration and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  183. Cycle 4, Group A : T8 lymphocytes 7-10 days AFTER double filtration plasmapheresis [ Time Frame: Day 7-10 ]
    5 mL of blood will be collected in an EDTA tube AFTER double filtration and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  184. Cycle 4, Group A : T8 DR+ lymphocytes 7-10 days AFTER double filtration plasmapheresis [ Time Frame: Day 7-10 ]
    5 mL of blood will be collected in an EDTA tube AFTER double filtration and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  185. Cycle 4, Group A : B lymphocytes 7-10 days AFTER double filtration plasmapheresis [ Time Frame: Day 7-10 ]
    5 mL of blood will be collected in an EDTA tube AFTER double filtration and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  186. Cycle 4, Group A : CD45RA+CCR7+ cells 7-10 days AFTER double filtration plasmapheresis [ Time Frame: Day 7-10 ]
    5 mL of blood will be collected in an EDTA tube AFTER double filtration and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  187. Cycle 4, Group A : CD45RA-CCR7+ cells 7-10 days AFTER double filtration plasmapheresis [ Time Frame: Day 7-10 ]
    5 mL of blood will be collected in an EDTA tube AFTER double filtration and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  188. Cycle 4, Group A : CD45RA-CCR7- cells 7-10 days AFTER double filtration plasmapheresis [ Time Frame: Day 7-10 ]
    5 mL of blood will be collected in an EDTA tube AFTER double filtration and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  189. Cycle 4, Group A : CCR6-CXCR3- cells 7-10 days AFTER double filtration plasmapheresis [ Time Frame: Day 7-10 ]
    5 mL of blood will be collected in an EDTA tube AFTER double filtration and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  190. Cycle 4, Group B : T4 lymphocytes BEFORE plasma exchange [ Time Frame: Day 0 Hour 0 ]
    5 mL of blood will be collected in an EDTA tube BEFORE single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  191. Cycle 4, Group B : T4 DR+ lymphocytes BEFORE plasma exchange [ Time Frame: Day 0 Hour 0 ]
    5 mL of blood will be collected in an EDTA tube BEFORE single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  192. Cycle 4, Group B : T8 lymphocytes BEFORE plasma exchange [ Time Frame: Day 0 Hour 0 ]
    5 mL of blood will be collected in an EDTA tube BEFORE single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  193. Cycle 4, Group B : T8 DR+ lymphocytes BEFORE single plasma exchange [ Time Frame: Day 0 Hour 0 ]
    5 mL of blood will be collected in an EDTA tube BEFORE single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  194. Cycle 4, Group B : B lymphocytes BEFORE single plasma exchange [ Time Frame: Day 0 Hour 0 ]
    5 mL of blood will be collected in an EDTA tube BEFORE single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  195. Cycle 4, Group B : CD45RA+CCR7+ cells BEFORE single plasma exchange [ Time Frame: Day 0 Hour 0 ]
    5 mL of blood will be collected in an EDTA tube BEFORE single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  196. Cycle 4, Group B : CD45RA-CCR7+ cells BEFORE single plasma exchange [ Time Frame: Day 0 Hour 0 ]
    5 mL of blood will be collected in an EDTA tube BEFORE single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  197. Cycle 4, Group B : CD45RA-CCR7- cells BEFORE single plasma exchange [ Time Frame: Day 0 Hour 0 ]
    5 mL of blood will be collected in an EDTA tube BEFORE single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  198. Cycle 4, Group B : CCR6-CXCR3- cells BEFORE single plasma exchange [ Time Frame: Day 0 Hour 0 ]
    5 mL of blood will be collected in an EDTA tube BEFORE single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  199. Cycle 4, Group B : T4 lymphocytes AFTER single plasma exchange [ Time Frame: Day 0 Hour 3 ]
    5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  200. Cycle 4, Group B : T4 DR+ lymphocytes AFTER single plasma exchange [ Time Frame: Day 0 Hour 3 ]
    5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  201. Cycle 4, Group B : T8 lymphocytes AFTER single plasma exchange [ Time Frame: Day 0 Hour 3 ]
    5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  202. Cycle 4, Group B : T8 DR+ lymphocytes AFTER single plasma exchange [ Time Frame: Day 0 Hour 3 ]
    5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  203. Cycle 4, Group B : B lymphocytes AFTER single plasma exchange [ Time Frame: Day 0 Hour 3 ]
    5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  204. Cycle 4, Group B : CD45RA+CCR7+ cells AFTER single plasma exchange [ Time Frame: Day 0 Hour 3 ]
    5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  205. Cycle 4, Group B : CD45RA-CCR7+ cells AFTER single plasma exchange [ Time Frame: Day 0 Hour 3 ]
    5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  206. Cycle 4, Group B : CD45RA-CCR7- cells AFTER single plasma exchange [ Time Frame: Day 0 Hour 3 ]
    5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  207. Cycle 4, Group B : CCR6-CXCR3- cells AFTER single plasma exchange [ Time Frame: Day 0 Hour 3 ]
    5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  208. Cycle 4, Group B : T4 lymphocytes 7-10 days AFTER single plasma exchange [ Time Frame: Day 7-10 ]
    5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  209. Cycle 4, Group B : T4 DR+ lymphocytes 7-10 days AFTER single plasma exchange [ Time Frame: Day 7-10 ]
    5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  210. Cycle 4, Group B : T8 lymphocytes 7-10 days AFTER single plasma exchange [ Time Frame: Day 7-10 ]
    5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  211. Cycle 4, Group B : T8 DR+ lymphocytes 7-10 days AFTER single plasma exchange [ Time Frame: Day 7-10 ]
    5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  212. Cycle 4, Group B : B lymphocytes 7-10 days AFTER single plasma exchange [ Time Frame: Day 7-10 ]
    5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  213. Cycle 4, Group B : CD45RA+CCR7+ cells 7-10 days AFTER single plasma exchange [ Time Frame: Day 7-10 ]
    5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  214. Cycle 4, Group B : CD45RA-CCR7+ cells 7-10 days AFTER single plasma exchange [ Time Frame: Day 7-10 ]
    5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  215. Cycle 4, Group B : CD45RA-CCR7- cells 7-10 days AFTER single plasma exchange [ Time Frame: Day 7-10 ]
    5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  216. Cycle 4, Group B : CCR6-CXCR3- cells 7-10 days AFTER single plasma exchange [ Time Frame: Day 7-10 ]
    5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  217. Cycle 5, Group A : T4 lymphocytes BEFORE single plasma exchange [ Time Frame: Day 0, Hour 0 ]
    5 mL of blood will be collected in an EDTA tube BEFORE single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  218. Cycle 5, Group A : T4 DR+ lymphocytes BEFORE single plasma exchange [ Time Frame: Day 0, Hour 0 ]
    5 mL of blood will be collected in an EDTA tube BEFORE single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  219. Cycle 5, Group A : T8 lymphocytes BEFORE single plasma exchange [ Time Frame: Day 0, Hour 0 ]
    5 mL of blood will be collected in an EDTA tube BEFORE single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  220. Cycle 5, Group A : T8 DR+ lymphocytes BEFORE single plasma exchange [ Time Frame: Day 0, Hour 0 ]
    5 mL of blood will be collected in an EDTA tube BEFORE single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  221. Cycle 5, Group A : B lymphocytes BEFORE single plasma exchange [ Time Frame: Day 0, Hour 0 ]
    5 mL of blood will be collected in an EDTA tube BEFORE single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  222. Cycle 5, Group A : CD45RA+CCR7+ cells BEFORE single plasma exchange [ Time Frame: Day 0, Hour 0 ]
    5 mL of blood will be collected in an EDTA tube BEFORE single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  223. Cycle 5, Group A : CD45RA-CCR7+ cells BEFORE single plasma exchange [ Time Frame: Day 0, Hour 0 ]
    5 mL of blood will be collected in an EDTA tube BEFORE single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  224. Cycle 5, Group A : CD45RA-CCR7- cells BEFORE single plasma exchange [ Time Frame: Day 0, Hour 0 ]
    5 mL of blood will be collected in an EDTA tube BEFORE single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  225. Cycle 5, Group A : CCR6-CXCR3- cells BEFORE single plasma exchange [ Time Frame: Day 0, Hour 0 ]
    5 mL of blood will be collected in an EDTA tube BEFORE single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  226. Cycle 5, Group A : T4 lymphocytes AFTER single plasma exchange [ Time Frame: Day 0, Hour 3 ]
    5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  227. Cycle 5, Group A : T4 DR+ lymphocytes AFTER single plasma exchange [ Time Frame: Day 0, Hour 3 ]
    5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  228. Cycle 5, Group A : T8 lymphocytes AFTER single plasma exchange [ Time Frame: Day 0, Hour 3 ]
    5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  229. Cycle 5, Group A : T8 DR+ lymphocytes AFTER single plasma exchange [ Time Frame: Day 0, Hour 3 ]
    5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  230. Cycle 5, Group A : B lymphocytes AFTER single plasma exchange [ Time Frame: Day 0, Hour 3 ]
    5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  231. Cycle 5, Group A : CD45RA+CCR7+ cells AFTER single plasma exchange [ Time Frame: Day 0, Hour 3 ]
    5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  232. Cycle 5, Group A : CD45RA-CCR7+ cells AFTER single plasma exchange [ Time Frame: Day 0, Hour 3 ]
    5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  233. Cycle 5, Group A : CD45RA-CCR7- cells AFTER single plasma exchange [ Time Frame: Day 0, Hour 3 ]
    5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  234. Cycle 5, Group A : CCR6-CXCR3- cells AFTER single plasma exchange [ Time Frame: Day 0, Hour 3 ]
    5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  235. Cycle 5, Group A : T4 lymphocytes 7-10 days AFTER single plasma exchange [ Time Frame: Day 7-10 ]
    5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  236. Cycle 5, Group A : T4 DR+ lymphocytes 7-10 days AFTER single plasma exchange [ Time Frame: Day 7-10 ]
    5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  237. Cycle 5, Group A : T8 lymphocytes 7-10 days AFTER single plasma exchange [ Time Frame: Day 7-10 ]
    5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  238. Cycle 5, Group A : T8 DR+ lymphocytes 7-10 days AFTER single plasma exchange [ Time Frame: Day 7-10 ]
    5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  239. Cycle 5, Group A : B lymphocytes 7-10 days AFTER single plasma exchange [ Time Frame: Day 7-10 ]
    5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  240. Cycle 5, Group A : CD45RA+CCR7+ cells 7-10 days AFTER single plasma exchange [ Time Frame: Day 7-10 ]
    5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  241. Cycle 5, Group A : CD45RA-CCR7+ cells 7-10 days AFTER single plasma exchange [ Time Frame: Day 7-10 ]
    5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  242. Cycle 5, Group A : CD45RA-CCR7- cells 7-10 days AFTER single plasma exchange [ Time Frame: Day 7-10 ]
    5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  243. Cycle 5, Group A : CCR6-CXCR3- cells 7-10 days AFTER single plasma exchange [ Time Frame: Day 7-10 ]
    5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  244. Cycle 5, Group B : T4 lymphocytes BEFORE double filtration plasmapheresis [ Time Frame: Day 0, Hour 0 ]
    5 mL of blood will be collected in an EDTA tube BEFORE double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  245. Cycle 5, Group B : T4 DR+ lymphocytes BEFORE double filtration plasmapheresis [ Time Frame: Day 0, Hour 0 ]
    5 mL of blood will be collected in an EDTA tube BEFORE double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  246. Cycle 5, Group B : T8 lymphocytes BEFORE double filtration plasmapheresis [ Time Frame: Day 0, Hour 0 ]
    5 mL of blood will be collected in an EDTA tube BEFORE double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  247. Cycle 5, Group B : T8 DR+ lymphocytes BEFORE double filtration plasmapheresis [ Time Frame: Day 0, Hour 0 ]
    5 mL of blood will be collected in an EDTA tube BEFORE double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  248. Cycle 5, Group B : B lymphocytes BEFORE double filtration plasmapheresis [ Time Frame: Day 0, Hour 0 ]
    5 mL of blood will be collected in an EDTA tube BEFORE double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  249. Cycle 5, Group B : CD45RA+CCR7+ cells BEFORE double filtration plasmapheresis [ Time Frame: Day 0, Hour 0 ]
    5 mL of blood will be collected in an EDTA tube BEFORE double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  250. Cycle 5, Group B : CD45RA-CCR7+ cells BEFORE double filtration plasmapheresis [ Time Frame: Day 0, Hour 0 ]
    5 mL of blood will be collected in an EDTA tube BEFORE double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  251. Cycle 5, Group B : CD45RA-CCR7- cells BEFORE double filtration plasmapheresis [ Time Frame: Day 0, Hour 0 ]
    5 mL of blood will be collected in an EDTA tube BEFORE double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  252. Cycle 5, Group B : CCR6-CXCR3- cells BEFORE double filtration plasmapheresis [ Time Frame: Day 0, Hour 0 ]
    5 mL of blood will be collected in an EDTA tube BEFORE double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  253. Cycle 5, Group B : T4 lymphocytes AFTER double filtration plasmapheresis [ Time Frame: Day 0, Hour 3 ]
    5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  254. Cycle 5, Group B : T4 DR+ lymphocytes AFTER double filtration plasmapheresis [ Time Frame: Day 0, Hour 3 ]
    5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  255. Cycle 5, Group B : T8 lymphocytes AFTER double filtration plasmapheresis [ Time Frame: Day 0, Hour 3 ]
    5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  256. Cycle 5, Group B : T8 DR+ lymphocytes AFTER double filtration plasmapheresis [ Time Frame: Day 0, Hour 3 ]
    5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  257. Cycle 5, Group B : B lymphocytes AFTER double filtration plasmapheresis [ Time Frame: Day 0, Hour 3 ]
    5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  258. Cycle 5, Group B : CD45RA+CCR7+ cells AFTER double filtration plasmapheresis [ Time Frame: Day 0, Hour 3 ]
    5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  259. Cycle 5, Group B : CD45RA-CCR7+ cells AFTER double filtration plasmapheresis [ Time Frame: Day 0, Hour 3 ]
    5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  260. Cycle 5, Group B : CD45RA-CCR7- cells AFTER double filtration plasmapheresis [ Time Frame: Day 0, Hour 3 ]
    5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  261. Cycle 5, Group B : CCR6-CXCR3- cells AFTER double filtration plasmapheresis [ Time Frame: Day 0, Hour 3 ]
    5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  262. Cycle 5, Group B : T4 lymphocytes 7-10 days AFTER double filtration plasmapheresis [ Time Frame: Day 7-10 ]
    5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  263. Cycle 5, Group B : T4 DR+ lymphocytes 7-10 days AFTER double filtration plasmapheresis [ Time Frame: Day 7-10 ]
    5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  264. Cycle 5, Group B : T8 lymphocytes 7-10 days AFTER double filtration plasmapheresis [ Time Frame: Day 7-10 ]
    5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  265. Cycle 5, Group B : T8 DR+ lymphocytes 7-10 days AFTER double filtration plasmapheresis [ Time Frame: Day 7-10 ]
    5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  266. Cycle 5, Group B : B lymphocytes 7-10 days AFTER double filtration plasmapheresis [ Time Frame: Day 7-10 ]
    5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  267. Cycle 5, Group B : CD45RA+CCR7+ cells 7-10 days AFTER double filtration plasmapheresis [ Time Frame: Day 7-10 ]
    5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  268. Cycle 5, Group B : CD45RA-CCR7+ cells 7-10 days AFTER double filtration plasmapheresis [ Time Frame: Day 7-10 ]
    5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  269. Cycle 5, Group B : CD45RA-CCR7- cells 7-10 days AFTER double filtration plasmapheresis [ Time Frame: Day 7-10 ]
    5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  270. Cycle 5, Group B : CCR6-CXCR3- cells 7-10 days AFTER double filtration plasmapheresis [ Time Frame: Day 7-10 ]
    5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  271. Cycle 6, Group A : T4 lymphocytes BEFORE double filtration plasmapheresis [ Time Frame: Day 0, Hour 0 ]
    5 mL of blood will be collected in an EDTA tube BEFORE double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  272. Cycle 6, Group A : T4 DR+ lymphocytes BEFORE double filtration plasmapheresis [ Time Frame: Day 0, Hour 0 ]
    5 mL of blood will be collected in an EDTA tube BEFORE double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  273. Cycle 6, Group A : T8 lymphocytes BEFORE double filtration plasmapheresis [ Time Frame: Day 0, Hour 0 ]
    5 mL of blood will be collected in an EDTA tube BEFORE double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  274. Cycle 6, Group A : T8 DR+ lymphocytes BEFORE double filtration plasmapheresis [ Time Frame: Day 0, Hour 0 ]
    5 mL of blood will be collected in an EDTA tube BEFORE double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  275. Cycle 6, Group A : B lymphocytes BEFORE double filtration plasmapheresis [ Time Frame: Day 0, Hour 0 ]
    5 mL of blood will be collected in an EDTA tube BEFORE double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  276. Cycle 6, Group A : CD45RA+CCR7+ cells BEFORE double filtration plasmapheresis [ Time Frame: Day 0, Hour 0 ]
    5 mL of blood will be collected in an EDTA tube BEFORE double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  277. Cycle 6, Group A : CD45RA-CCR7+ cells BEFORE double filtration plasmapheresis [ Time Frame: Day 0, Hour 0 ]
    5 mL of blood will be collected in an EDTA tube BEFORE double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  278. Cycle 6, Group A : CD45RA-CCR7- cells BEFORE double filtration plasmapheresis [ Time Frame: Day 0, Hour 0 ]
    5 mL of blood will be collected in an EDTA tube BEFORE double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  279. Cycle 6, Group A : CCR6-CXCR3- cells BEFORE double filtration plasmapheresis [ Time Frame: Day 0, Hour 0 ]
    5 mL of blood will be collected in an EDTA tube BEFORE double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  280. Cycle 6, Group A : T4 lymphocytes AFTER double filtration plasmapheresis [ Time Frame: Day 0, Hour 3 ]
    5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  281. Cycle 6, Group A : T4 DR+ lymphocytes AFTER double filtration plasmapheresis [ Time Frame: Day 0, Hour 3 ]
    5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  282. Cycle 6, Group A : T8 lymphocytes AFTER double filtration plasmapheresis [ Time Frame: Day 0, Hour 3 ]
    5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  283. Cycle 6, Group A : T8 DR+ lymphocytes AFTER double filtration plasmapheresis [ Time Frame: Day 0, Hour 3 ]
    5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  284. Cycle 6, Group A : B lymphocytes AFTER double filtration plasmapheresis [ Time Frame: Day 0, Hour 3 ]
    5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  285. Cycle 6, Group A : CD45RA+CCR7+ cells AFTER double filtration plasmapheresis [ Time Frame: Day 0, Hour 3 ]
    5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  286. Cycle 6, Group A : CD45RA-CCR7+ cells AFTER double filtration plasmapheresis [ Time Frame: Day 0, Hour 3 ]
    5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  287. Cycle 6, Group A : CD45RA-CCR7- cells AFTER double filtration plasmapheresis [ Time Frame: Day 0, Hour 3 ]
    5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  288. Cycle 6, Group A : CCR6-CXCR3- cells AFTER double filtration plasmapheresis [ Time Frame: Day 0, Hour 3 ]
    5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  289. Cycle 6, Group A : T4 lymphocytes 7-10 days AFTER double filtration plasmapheresis [ Time Frame: Day 7-10 ]
    5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  290. Cycle 6, Group A : T4 DR+ lymphocytes 7-10 days AFTER double filtration plasmapheresis [ Time Frame: Day 7-10 ]
    5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  291. Cycle 6, Group A : T8 lymphocytes 7-10 days AFTER double filtration plasmapheresis [ Time Frame: Day 7-10 ]
    5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  292. Cycle 6, Group A : T8 DR+ lymphocytes 7-10 days AFTER double filtration plasmapheresis [ Time Frame: Day 7-10 ]
    5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  293. Cycle 6, Group A : B lymphocytes 7-10 days AFTER double filtration plasmapheresis [ Time Frame: Day 7-10 ]
    5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  294. Cycle 6, Group A : CD45RA+CCR7+ cells 7-10 days AFTER double filtration plasmapheresis [ Time Frame: Day 7-10 ]
    5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  295. Cycle 6, Group A : CD45RA-CCR7+ cells 7-10 days AFTER double filtration plasmapheresis [ Time Frame: Day 7-10 ]
    5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  296. Cycle 6, Group A : CD45RA-CCR7- cells 7-10 days AFTER double filtration plasmapheresis [ Time Frame: Day 7-10 ]
    5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  297. Cycle 6, Group A : CCR6-CXCR3- cells 7-10 days AFTER double filtration plasmapheresis [ Time Frame: Day 7-10 ]
    5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  298. Cycle 6, Group B : T4 lymphocytes BEFORE single plasma exchange [ Time Frame: Day 0, H0 ]
    5 mL of blood will be collected in an EDTA tube BEFORE single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  299. Cycle 6, Group B : T4 DR+ lymphocytes BEFORE single plasma exchange [ Time Frame: Day 0, H0 ]
    5 mL of blood will be collected in an EDTA tube BEFORE single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  300. Cycle 6, Group B : T8 lymphocytes BEFORE single plasma exchange [ Time Frame: Day 0, H0 ]
    5 mL of blood will be collected in an EDTA tube BEFORE single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  301. Cycle 6, Group B : T8 DR+ lymphocytes BEFORE single plasma exchange [ Time Frame: Day 0, H0 ]
    5 mL of blood will be collected in an EDTA tube BEFORE single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  302. Cycle 6, Group B : B lymphocytes BEFORE single plasma exchange [ Time Frame: Day 0, H0 ]
    5 mL of blood will be collected in an EDTA tube BEFORE single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  303. Cycle 6, Group B : CD45RA+CCR7+ cells BEFORE single plasma exchange [ Time Frame: Day 0, H0 ]
    5 mL of blood will be collected in an EDTA tube BEFORE single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  304. Cycle 6, Group B : CD45RA-CCR7+ cells BEFORE single plasma exchange [ Time Frame: Day 0, H0 ]
    5 mL of blood will be collected in an EDTA tube BEFORE single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  305. Cycle 6, Group B : CD45RA-CCR7- cells BEFORE single plasma exchange [ Time Frame: Day 0, H0 ]
    5 mL of blood will be collected in an EDTA tube BEFORE single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  306. Cycle 6, Group B : CCR6-CXCR3- cells BEFORE single plasma exchange [ Time Frame: Day 0, H0 ]
    5 mL of blood will be collected in an EDTA tube BEFORE single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  307. Cycle 6, Group B : T4 lymphocytes AFTER single plasma exchange [ Time Frame: Day 0, H3 ]
    5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  308. Cycle 6, Group B : T4 DR+ lymphocytes AFTER single plasma exchange [ Time Frame: Day 0, H3 ]
    5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  309. Cycle 6, Group B : T8 lymphocytes AFTER single plasma exchange [ Time Frame: Day 0, H3 ]
    5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  310. Cycle 6, Group B : T8 DR+ lymphocytes AFTER single plasma exchange [ Time Frame: Day 0, H3 ]
    5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  311. Cycle 6, Group B : B lymphocytes AFTER single plasma exchange [ Time Frame: Day 0, H3 ]
    5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  312. Cycle 6, Group B : CD45RA+CCR7+ cells AFTER single plasma exchange [ Time Frame: Day 0, H3 ]
    5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  313. Cycle 6, Group B : CD45RA-CCR7+ cells AFTER single plasma exchange [ Time Frame: Day 0, H3 ]
    5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  314. Cycle 6, Group B : CD45RA-CCR7- cells AFTER single plasma exchange [ Time Frame: Day 0, H3 ]
    5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  315. Cycle 6, Group B : CCR6-CXCR3- cells AFTER single plasma exchange [ Time Frame: Day 0, H3 ]
    5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  316. Cycle 6, Group B : T4 lymphocytes 7-10 days AFTER single plasma exchange [ Time Frame: Day 7-10 ]
    5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  317. Cycle 6, Group B : T4 DR+ lymphocytes 7-10 days AFTER single plasma exchange [ Time Frame: Day 7-10 ]
    5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  318. Cycle 6, Group B : T8 lymphocytes 7-10 days AFTER single plasma exchange [ Time Frame: Day 7-10 ]
    5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  319. Cycle 6, Group B : T8 DR+ lymphocytes 7-10 days AFTER single plasma exchange [ Time Frame: Day 7-10 ]
    5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  320. Cycle 6, Group B : B lymphocytes 7-10 days AFTER single plasma exchange [ Time Frame: Day 7-10 ]
    5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  321. Cycle 6, Group B : CD45RA+CCR7+ cells 7-10 days AFTER single plasma exchange [ Time Frame: Day 7-10 ]
    5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  322. Cycle 6, Group B : CD45RA-CCR7+ cells 7-10 days AFTER single plasma exchange [ Time Frame: Day 7-10 ]
    5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  323. Cycle 6, Group B : CD45RA-CCR7- cells 7-10 days AFTER single plasma exchange [ Time Frame: Day 7-10 ]
    5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.

  324. Cycle 6, Group B : CCR6-CXCR3- cells 7-10 days AFTER single plasma exchange [ Time Frame: Day 7-10 ]
    5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.


Other Outcome Measures:
  1. Group A, Cycle 1 : Link between variations in lymphocyte sub-populations and the clinical evolution . [ Time Frame: Day 7-10 after the end of Cycle 1 (each cycle lasts 3 hours) ]
    All the above primary and secondary outcome measures will be compared with clinical information in the patient file in order to determine a link between these variations at the end of each treatment cycle.

  2. Group B, Cycle 1 : Link between variations in lymphocyte sub-populations and the clinical evolution . [ Time Frame: Day 7-10 after the end of Cycle 1 (each cycle lasts 3 hours) ]
    All the above primary and secondary outcome measures will be compared with clinical information in the patient file in order to determine a link between these variations at the end of each treatment cycle.

  3. Group A, Cycle 2 : Link between variations in lymphocyte sub-populations and the clinical evolution . [ Time Frame: Day 7-10 after the end of Cycle 2 (each cycle lasts 3 hours) ]
    All the above primary and secondary outcome measures will be compared with clinical information in the patient file in order to determine a link between these variations at the end of each treatment cycle.

  4. Group B, Cycle 2 : Link between variations in lymphocyte sub-populations and the clinical evolution . [ Time Frame: Day 7-10 after the end of Cycle 2 (each cycle lasts 3 hours) ]
    All the above primary and secondary outcome measures will be compared with clinical information in the patient file in order to determine a link between these variations at the end of each treatment cycle.

  5. Group A, Cycle 3 : Link between variations in lymphocyte sub-populations and the clinical evolution . [ Time Frame: Day 7-10 after the end of Cycle 3 (each cycle lasts 3 hours) ]
    All the above primary and secondary outcome measures will be compared with clinical information in the patient file in order to determine a link between these variations at the end of each treatment cycle.

  6. Group B, Cycle 3 : Link between variations in lymphocyte sub-populations and the clinical evolution . [ Time Frame: Day 7-10 after the end of Cycle 3 (each cycle lasts 3 hours) ]
    All the above primary and secondary outcome measures will be compared with clinical information in the patient file in order to determine a link between these variations at the end of each treatment cycle.

  7. Group A, Cycle 4 : Link between variations in lymphocyte sub-populations and the clinical evolution . [ Time Frame: Day 7-10 after the end of Cycle 4 (each cycle lasts 3 hours) ]
    All the above primary and secondary outcome measures will be compared with clinical information in the patient file in order to determine a link between these variations at the end of each treatment cycle.

  8. Group B, Cycle 4 : Link between variations in lymphocyte sub-populations and the clinical evolution . [ Time Frame: Day 7-10 after the end of Cycle 4 (each cycle lasts 3 hours) ]
    All the above primary and secondary outcome measures will be compared with clinical information in the patient file in order to determine a link between these variations at the end of each treatment cycle.

  9. Group A, Cycle 5 : Link between variations in lymphocyte sub-populations and the clinical evolution . [ Time Frame: Day 7-10 after the end of Cycle 5 (each cycle lasts 3 hours) ]
    All the above primary and secondary outcome measures will be compared with clinical information in the patient file in order to determine a link between these variations at the end of each treatment cycle.

  10. Group B, Cycle 5 : Link between variations in lymphocyte sub-populations and the clinical evolution . [ Time Frame: Day 7-10 after the end of Cycle 5 (each cycle lasts 3 hours) ]
    All the above primary and secondary outcome measures will be compared with clinical information in the patient file in order to determine a link between these variations at the end of each treatment cycle.

  11. Group A, Cycle 6 : Link between variations in lymphocyte sub-populations and the clinical evolution . [ Time Frame: Day 7-10 after the end of Cycle 6 (each cycle lasts 3 hours) ]
    All the above primary and secondary outcome measures will be compared with clinical information in the patient file in order to determine a link between these variations at the end of each treatment cycle.

  12. Group B, Cycle 6 : Link between variations in lymphocyte sub-populations and the clinical evolution . [ Time Frame: Day 7-10 after the end of Cycle 6 (each cycle lasts 3 hours) ]
    All the above primary and secondary outcome measures will be compared with clinical information in the patient file in order to determine a link between these variations at the end of each treatment cycle.

  13. Group A, Cycle 1 : Cost of single plasma exchange to the health institution. [ Time Frame: Day 7-10 after the end of Cycle 1 (each cycle lasts 3 hours) ]
    The cost of each cycle will be recorded in Euros in the electronic clinical research file and the average amount will be calculated from this information at the end of 6 cycles.

  14. Group B, Cycle 1 : Cost of double filtration plasmapheresis to the health institution. [ Time Frame: Day 7-10 after the end of Cycle 1 (each cycle lasts 3 hours) ]
    The cost of each cycle will be recorded in Euros in the electronic clinical research file and the average amount will be calculated from this information at the end of 6 cycles.

  15. Group A, Cycle 2 : Cost of double filtration plasmapheresis to the health institution. [ Time Frame: Day 7-10 after the end of Cycle 2 (each cycle lasts 3 hours) ]
    The cost of each cycle will be recorded in Euros in the electronic clinical research file and the average amount will be calculated from this information at the end of 6 cycles.

  16. Group B, Cycle 2 : Cost of single plasma exchange to the health institution. [ Time Frame: Day 7-10 after the end of Cycle 2 (each cycle lasts 3 hours) ]
    The cost of each cycle will be recorded in Euros in the electronic clinical research file and the average amount will be calculated from this information at the end of 6 cycles.

  17. Group A, Cycle 3 : Cost of single plasma exchange to the health institution. [ Time Frame: Day 7-10 after the end of Cycle 3 (each cycle lasts 3 hours) ]
    The cost of each cycle will be recorded in Euros in the electronic clinical research file and the average amount will be calculated from this information at the end of 6 cycles.

  18. Group B, Cycle 3 : Cost of double filtration plasmapheresis to the health institution. [ Time Frame: Day 7-10 after the end of Cycle 3 (each cycle lasts 3 hours) ]
    The cost of each cycle will be recorded in Euros in the electronic clinical research file and the average amount will be calculated from this information at the end of 6 cycles.

  19. Group A, Cycle 4 : Cost of double filtration plasmapheresis to the health institution. [ Time Frame: Day 7-10 after the end of Cycle 4 (each cycle lasts 3 hours) ]
    The cost of each cycle will be recorded in Euros in the electronic clinical research file and the average amount will be calculated from this information at the end of 6 cycles.

  20. Group B, Cycle 4 : Cost of single plasma exchange to the health institution. [ Time Frame: Day 7-10 after the end of Cycle 4 (each cycle lasts 3 hours) ]
    The cost of each cycle will be recorded in Euros in the electronic clinical research file and the average amount will be calculated from this information at the end of 6 cycles.

  21. Group A, Cycle 5 : Cost of single plasma exchange to the health institution. [ Time Frame: Day 7-10 after the end of Cycle 5 (each cycle lasts 3 hours) ]
    The cost of each cycle will be recorded in Euros in the electronic clinical research file and the average amount will be calculated from this information at the end of 6 cycles.

  22. Group B, Cycle 5 : Cost of double filtration to the health institution. [ Time Frame: Day 7-10 after the end of Cycle 5 (each cycle lasts 3 hours) ]
    The cost of each cycle will be recorded in Euros in the electronic clinical research file and the average amount will be calculated from this information at the end of 6 cycles.

  23. Group A, Cycle 6 : Cost of double filtration to the health institution. [ Time Frame: Day 7-10 after the end of Cycle 6 (each cycle lasts 3 hours) ]
    The cost of each cycle will be recorded in Euros in the electronic clinical research file and the average amount will be calculated from this information at the end of 6 cycles.

  24. Group B, Cycle 6 : Cost of double filtration to the health institution. [ Time Frame: Day 7-10 after the end of Cycle 6 (each cycle lasts 3 hours) ]
    The cost of each cycle will be recorded in Euros in the electronic clinical research file and the average amount will be calculated from this information at the end of 6 cycles.

  25. Constitution of a biological resource centre using the blood samples taken in view of future research, especially immunological phenotyping. [ Time Frame: Day 0, Hour 0 ]
    After all the above analyses, the unused aliquots from the samples taken (bottom of tubes) will be conserved and indexed.

  26. Constitution of a biological resource centre using the blood samples taken in view of future research, especially immunological phenotyping. [ Time Frame: Day 0, Hour 3 ]
    After all the above analyses, the unused aliquots from the samples taken (bottom of tubes) will be conserved and indexed.

  27. Constitution of a biological resource centre using the blood samples taken in view of future research, especially immunological phenotyping. [ Time Frame: Day 7-10 ]
    After all the above analyses, the unused aliquots from the samples taken (bottom of tubes) will be conserved and indexed.


Eligibility Criteria
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Information from the National Library of Medicine

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.


Layout table for eligibility information
Ages Eligible for Study:   18 Years and older   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • Patients with confirmed Chronic Inflammatory Demyelinating Polyneuropathy (CIDP) without pathogenic antibodies and stable under therapeutic plasmapheresis with one session every 2-3 weeks for at least two months.
  • Patients who have given free written informed consent.
  • Patients who have signed the consent form.
  • Patients affiliated to or beneficiaries of a health insurance scheme.
  • Adult patients (≥18 ans).

Exclusion Criteria:

  • Patients Under the age of 18.
  • Patients under immunosuppressive treatment for less than 3 months.
  • Patients participating in Category 1 research involving human subjects.
  • Patients in an exclusion period determined by another study.
  • Patients under legal protection, guardianship or curatorship.
  • Patients unable to express consent.
  • Patients for whom it is impossible to give informed information.
  • Pregnant, parturient or breastfeeding patients.
Contacts and Locations
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Top of Page Study Description Study Design Arms and Interventions Outcome Measures Eligibility Criteria Contacts and Locations More Information

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT04742374


Contacts
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Contact: Olivier Moranne, Professor +334 66 68 32 56 Olivier.MORANNE@chu-nimes.fr
Contact: Annissa MEGZARI +334 66 68 30 52 anissa.megzari@chu-nimes.fr

Locations
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France
Olivier MORANNE Recruiting
Nîmes, France
Contact: Olivier Moranne, MD-PhD    04.66.68.31.49    olivier.moranne@chu-nimes.fr   
Sponsors and Collaborators
Centre Hospitalier Universitaire de Nīmes
More Information
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Top of Page Study Description Study Design Arms and Interventions Outcome Measures Eligibility Criteria Contacts and Locations More Information
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Responsible Party: Centre Hospitalier Universitaire de Nīmes
ClinicalTrials.gov Identifier: NCT04742374    
Other Study ID Numbers: NIMAO/2020-01/OM001
First Posted: February 8, 2021    Key Record Dates
Last Update Posted: July 7, 2021
Last Verified: July 2021

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Studies a U.S. FDA-regulated Drug Product: No
Studies a U.S. FDA-regulated Device Product: No
Keywords provided by Centre Hospitalier Universitaire de Nīmes:
Plasma exchange
Double filtration plasmapheresis
Additional relevant MeSH terms:
Layout table for MeSH terms
Polyradiculoneuropathy
Polyradiculoneuropathy, Chronic Inflammatory Demyelinating
Autoimmune Diseases of the Nervous System
Nervous System Diseases
Demyelinating Diseases
 Polyneuropathies
Peripheral Nervous System Diseases
Neuromuscular Diseases
Autoimmune Diseases
Immune System Diseases