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Comparing EVCO and EVOO

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ClinicalTrials.gov Identifier: NCT04738929
Recruitment Status : Completed
First Posted : February 4, 2021
Last Update Posted : February 4, 2021
Sponsor:
Collaborator:
Hacettepe University
Information provided by (Responsible Party):
Ziyaerokaymetin, Ankara City Hospital Bilkent

Study Description
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Brief Summary:
The aim of this study is to compare acute effects of consuming extra virgin coconut oil (EVCO) as a source of medium chain fatty acids and extra virgin olive oil (EVOO) as a source of long chain fatty acids in normal weight and obese subjects.

Condition or disease Intervention/treatment Phase
Obesity Appetitive Behavior Other: Extra virgin coconut oil or extra virgin olive oil Not Applicable

Detailed Description:
Twenty male subjects (10 normal weight; 10 obese) consumed breakfast meals containing skimmed milk, fat-free white cheese, bread and EVCO (25 g) or EVOO (25 g). Visual analog scale evaluations, resting metabolic rate measurements and selected blood parameters analysis (glucose, triglyceride, insulin and plasma peptide YY) were performed before and after the test breakfast meals. In addition, energy intakes were evaluated by ad libitum lunch meal at 180 min.
Study Design
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Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 20 participants
Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: None (Open Label)
Primary Purpose: Treatment
Official Title: Comparing Acute Effects of Extra Virgin Coconut Oil and Extra Virgin Olive Oil Consumption on Appetite and Food Intake in Normal Weight and Obese Male Subjects
Actual Study Start Date : January 3, 2019
Actual Primary Completion Date : June 3, 2019
Actual Study Completion Date : June 3, 2019

Resource links provided by the National Library of Medicine

Drug Information available for: Olive oil

Arms and Interventions
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Arm Intervention/treatment
Experimental: Normal weight
Normal weight subjects (BMI=18.5-25)
 Other: Extra virgin coconut oil or extra virgin olive oil
Subjects consumed standard breakfast meals containing "extra virgin coconut oil" or "extra virgin olive oil"
Experimental: Obese
Obese subjects (BMI=30-34.99)
 Other: Extra virgin coconut oil or extra virgin olive oil
Subjects consumed standard breakfast meals containing "extra virgin coconut oil" or "extra virgin olive oil"


Outcome Measures
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Primary Outcome Measures :
  1. Energy expenditure change [ Time Frame: 0, 60, 120, 180 minutes ]
    kcal

  2. Subjective appetite feelings change [ Time Frame: 0, 30, 60, 120, 180 minutes ]
    visual analogue scales rating (0-10 cm)

  3. glucose change [ Time Frame: 0, 30, 60, 120, 180 minutes ]
    mg/dl

  4. insulin change [ Time Frame: 0, 30, 60, 120, 180 minutes ]
    mU/L

  5. peptide YY change [ Time Frame: 0, 30, 60, 120, 180 minutes ]
    pg/dl

  6. triglycerides change [ Time Frame: 0, 30, 60, 120, 180 minutes ]
    mg/dl

  7. Ad libitum energy intake [ Time Frame: 180 minute ]
    kcal


Eligibility Criteria
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Ages Eligible for Study:   19 Years to 40 Years   (Adult)
Sexes Eligible for Study:   Male
Gender Based Eligibility:   Yes
Gender Eligibility Description:   Only male subjects were included to eliminate potential variations due to hormonal changes during menstrual cycles of female subjects.
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • Metabolically healthy
  • Aged 19-40 years
  • Normal weight (BMI=18.5-24.9 kg/m²) and obese men (BMI=30-34.99 kg/m²)

Exclusion Criteria:

  • smoking,
  • alcohol consumption,
  • weight gain/loss recently (> %5, in three months),
  • any genetic and metabolic diseases,
  • any food allergy/intolerance,
  • any medication,
  • restrained eating habits.
Contacts and Locations
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Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT04738929


Locations
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Turkey
Presidency of Republic of Turkey Health Center
Ankara, Turkey
Sponsors and Collaborators
Ankara City Hospital Bilkent
Hacettepe University
Investigators
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Principal Investigator: Ziya Erokay Metin, Dr. Ankara City Hospital Bilkent
Study Chair: Pelin Bilgiç, Assoc. Prof. Hacettepe University
Study Chair: Mercan Merve Tengilimoğlu Metin, Assis. Prof. Hacettepe University
Study Chair: Muzaffer Akkoca, Assoc. Prof. Saglik Bilimleri Universitesi
More Information
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Responsible Party: Ziyaerokaymetin, Principal Investigator, Ankara City Hospital Bilkent
ClinicalTrials.gov Identifier: NCT04738929    
Other Study ID Numbers: EVCO
First Posted: February 4, 2021    Key Record Dates
Last Update Posted: February 4, 2021
Last Verified: February 2021
Individual Participant Data (IPD) Sharing Statement:
Plan to Share IPD: No

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Studies a U.S. FDA-regulated Drug Product: No
Studies a U.S. FDA-regulated Device Product: No
Keywords provided by Ziyaerokaymetin, Ankara City Hospital Bilkent:
Extra virgin coconut oil; medium chain fatty acids; extra virgin olive oil; obesity; peptide YY; resting metabolic rate.
Additional relevant MeSH terms:
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Obesity
Overnutrition
Nutrition Disorders
Overweight
Body Weight