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Study of the Evolution Profile of the Renal Doppler in the Perioperative Hepathic Transplantation (DOP-RENAL)

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ClinicalTrials.gov Identifier: NCT04682236
Recruitment Status : Recruiting
First Posted : December 23, 2020
Last Update Posted : December 28, 2020
Sponsor:
Information provided by (Responsible Party):
University Hospital, Strasbourg, France

Study Description
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Brief Summary:
Liver transplantation is associated with a modification of the perfusion pressures of the abdominal organs (preoperative portal hypertension in connection with liver pathology, and normalization of the perfusion pressures during surgery). This abrupt change in the infusion regime is probably responsible for an alteration in renal function in some patients, and the identification of renal vascular profiles using Doppler could point to pathological profiles, which should be diagnosed early.

Condition or disease
Acute Renal Failure

Study Design
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Study Type : Observational
Estimated Enrollment : 30 participants
Observational Model: Case-Control
Time Perspective: Retrospective
Official Title: Study of the Evolution Profile of the Renal Doppler in the Perioperative Hepathic Transplantation - Interest in Predicting the Occurence of Acute Postoperative Renal Faillure
Actual Study Start Date : November 25, 2020
Estimated Primary Completion Date : May 25, 2022
Estimated Study Completion Date : May 25, 2022
Groups and Cohorts
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Outcome Measures
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Primary Outcome Measures :
  1. Retrospective analysis of the development profiles of renal dopplers in perioperative liver transplantation [ Time Frame: Files analysed retrospectily from July 1st, 2019 to June 30, 2020 will be examined ]

Eligibility Criteria
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Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years and older   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
Adult patient operated on at the HUS for a liver transplant, between July 1, 2019 and June 30, 2020
Criteria

Inclusion Criteria:

  • Patient of full age (≥18 years)
  • Patient operated on at the HUS for a liver transplant, between July 1, 2019 and June 30, 2020.
  • Patients having undergone an evaluation of hepatic and renal vascular profiles perioperatively.
  • Patients hospitalized in the surgical intensive care unit after hepatic transplant surgery.
  • Patient not having expressed, after information, the reuse of his data for the purposes of this research

Exclusion Criteria:

  • Patient who expressed his opposition to participating in the study
  • Patient with suspected obstructive acute renal failure
  • Stenosis of renal arteries known at the time
  • End-stage renal disease on dialysis
  • Impossibility of giving the subject informed information (difficulties in understanding the subject, etc.)
  • Subject under safeguard of justice
Contacts and Locations
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Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT04682236


Contacts
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Contact: Julien POTTECHER, MD, PhD 33 3 88 12 70 95 julien.pottecher@chru-strasbourg.fr
Contact: Saïd CHAYER, PhD, HDR 33 3 88 11 66 90 said.chayer@chru-strasbourg.fr

Locations
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France
Strasbourg University Hospitals - Anesthesia-intensive care unit Recruiting
Strasbourg, France, 67091
Contact: Julien POTTECHER, MD, PhD    33 3 88 12 70 95    julien.pottecher@chru-strasbourg.fr   
Contact: Saïd CHAYER, PhD, HDR    33 3 88 11 66 90    said.chayer@chru-strasbourg.fr   
Principal Investigator: Julien POTTECHER, MD, PhD         
Sub-Investigator: Kevin COGNE, MD         
Sub-Investigator: Cédric MUNSCH, MD         
Sub-Investigator: Benjamin LEBAS, MD         
Sponsors and Collaborators
University Hospital, Strasbourg, France
Investigators
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Study Director: Julien POTTECHER, MD, PhD Strasbourg University Hospitals - Anesthesia-intensive care unit
More Information
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Responsible Party: University Hospital, Strasbourg, France
ClinicalTrials.gov Identifier: NCT04682236    
Other Study ID Numbers: 8059
First Posted: December 23, 2020    Key Record Dates
Last Update Posted: December 28, 2020
Last Verified: December 2020

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Studies a U.S. FDA-regulated Drug Product: No
Studies a U.S. FDA-regulated Device Product: No
Keywords provided by University Hospital, Strasbourg, France:
Acute Renal Failure
Chronic renal failure
Liver transplant
Renal vascular profiles
 Intraoperative hemodynamic instability
Acute tubular necrosis
Renal doppler
Additional relevant MeSH terms:
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Renal Insufficiency
Acute Kidney Injury
Kidney Diseases
Urologic Diseases