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Prevalence of Musculoskeletal Symptoms in the Cambridge NIHR BioResource

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ClinicalTrials.gov Identifier: NCT04632563
Recruitment Status : Not yet recruiting
First Posted : November 17, 2020
Last Update Posted : November 17, 2020
Sponsor:
Collaborator:
University of Cambridge
Information provided by (Responsible Party):
Professor Andrew McCaskie, Cambridge University Hospitals NHS Foundation Trust

Study Description
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Brief Summary:

Musculoskeletal diseases, such as osteoarthritis, represent a large proportion of the global burden of disease with hip and knee osteoarthritis alone being the 11th greatest cause of disease burden.

The purpose of this study is to determine the level of musculoskeletal symptoms in members of the Cambridge National Institute for Health Research (NIHR) BioResource and see if this is associated with their possession of genetic markers that have been identified as being associated with osteoarthritis.

This will allow us to determine the real level of musculoskeletal symptoms in this large cohort of volunteers and provide basic information that could be used to facilitate further musculoskeletal research in the NIHR BioResource population.


Condition or disease Intervention/treatment
Musculoskeletal Diseases Musculoskeletal Injury Other: Questionnaire including MSK-HQ (Musculoskeletal Health Questionnaire)

Detailed Description:

All active members of the Cambridge NIHR BioResource will be approached.

They will be sent an email outlining the purpose of the study and asking that if they would like to take part to please complete the online questionnaire which will be linked to in the email.

For those individuals who agree to participate and complete the questionnaire, the Cambridge NIHR BioResource will provide the genetic marker information it already holds for specific markers that are known to be associated with osteoarthritis.

Study Design
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Study Type : Observational
Estimated Enrollment : 5000 participants
Observational Model: Other
Time Perspective: Cross-Sectional
Official Title: Prevalence of Musculoskeletal Symptoms in the Cambridge NIHR BioResource
Estimated Study Start Date : November 2020
Estimated Primary Completion Date : April 2021
Estimated Study Completion Date : August 2021
Groups and Cohorts
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Group/Cohort Intervention/treatment
Member of BioResource
Any BioResource member who consents to take part in the study and completes the study questionnaire.
 Other: Questionnaire including MSK-HQ (Musculoskeletal Health Questionnaire)
A questionnaire regarding musculoskeletal past medical history and current symptoms.


Outcome Measures
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Primary Outcome Measures :
  1. MSK Symptom Levels [ Time Frame: 3 months ]
    Musculoskeletal Symptoms in respondents

  2. Osteoarthritis genetic marker [ Time Frame: 6 months ]
    Possession (or not) of specific genetic markers for osteoarthritis (obtained from information already held by the NIHR BioResource)


Secondary Outcome Measures :
  1. MSK Cohort [ Time Frame: 6 months ]
    Identification of those with particular musculoskeletal injuries and conditions for future studies


Eligibility Criteria
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Ages Eligible for Study:   18 Years and older   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
All members of the Cambridge NIHR BioResource
Criteria

Inclusion Criteria:

  • Member of the NIHR BioResource
  • Willing to consent to participate

Exclusion Criteria:

  • Previous self-report of osteoarthritis on joining BioResource
Contacts and Locations
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Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT04632563


Contacts
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Contact: Benjamin Davies +44 1223 217551 bmd35@cam.ac.uk

Sponsors and Collaborators
Cambridge University Hospitals NHS Foundation Trust
University of Cambridge
Investigators
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Principal Investigator: Andrew McCaskie University of Cambridge
More Information
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Responsible Party: Professor Andrew McCaskie, Professor of Orthopaedic Surgery / Head of Department, Cambridge University Hospitals NHS Foundation Trust
ClinicalTrials.gov Identifier: NCT04632563    
Other Study ID Numbers: A095310
First Posted: November 17, 2020    Key Record Dates
Last Update Posted: November 17, 2020
Last Verified: November 2020
Individual Participant Data (IPD) Sharing Statement:
Plan to Share IPD: No
Plan Description: Sharing of participant level data does not fall within the consent or ethical approval of the study.

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Studies a U.S. FDA-regulated Drug Product: No
Studies a U.S. FDA-regulated Device Product: No
Additional relevant MeSH terms:
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Musculoskeletal Diseases