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Physical Activity and the Risk of COVID-19 Infection and Mortality

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
 
ClinicalTrials.gov Identifier: NCT04631861
Recruitment Status : Completed
First Posted : November 17, 2020
Last Update Posted : November 17, 2020
Sponsor:
Information provided by (Responsible Party):
Dong-Hyuk Cho, Wonju Severance Christian Hospital

Study Description
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Brief Summary:
Coronavirus disease 2019 (COVID-19) is an infectious disease caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Currently, there is no cure for COVID-19, except for supportive treatments. Quarantine for a defined period is the best option to reduce the spread of COVID-19. Physical activity has been shown to reduce the risk of serious community-acquired infections. However, it remains unanswered is whether physical activity has protective effects against SARS-CoV-2 infection and COVID-19 related mortality. This study aimed to examine the association of PA with the morbidity and mortality of COVID-19 infection in the entire South Korean population.

Condition or disease
Covid19

Study Design
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Study Type : Observational
Actual Enrollment : 132069 participants
Observational Model: Case-Control
Time Perspective: Retrospective
Official Title: Physical Activity and the Risk of COVID-19 Infection and Mortality
Actual Study Start Date : January 1, 2014
Actual Primary Completion Date : July 31, 2020
Actual Study Completion Date : July 31, 2020

Resource links provided by the National Library of Medicine


Groups and Cohorts
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Outcome Measures
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Primary Outcome Measures :
  1. SARS-CoV-2 positivity rate (%) [ Time Frame: 7 years ]
    The SARS-CoV-2 infection was confirmed using the real-time reverse transcriptase polymerase chain reaction of pharyngeal and nasal swab samples, in accordance with the WHO recommendations

  2. COVID-19 related mortality rate (%) [ Time Frame: 7 years ]
    The COVID-19 related mortality was defined as the termination of isolation due to death.


Eligibility Criteria
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Ages Eligible for Study:   18 Years and older   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Probability Sample
Study Population
The Korean nationwide COVID-19 study was a retrospective, nationwide study including all Koreans who tested positive for SARS-CoV-2, aimed at evaluating the characteristics and outcomes of patients with COVID-19. Case patients were defined as individuals over 18 years old with positive results for the SARS-CoV-2 test. For every case patient, we selected up to 20 random controls from the target population who underwent the national health screening.
Criteria

Inclusion Criteria:

  • all Koreans who tested positive for SARS-CoV-2
  • more than 18 years old
  • who underwent public health screening between 2014 and 2017

Exclusion Criteria:

  • missing values about physical activity
Contacts and Locations
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Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT04631861


Sponsors and Collaborators
Wonju Severance Christian Hospital
Investigators
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Principal Investigator: Dong-Hyuk Cho Yonsei Wonju Christian Hospital
More Information
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Publications of Results:

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Responsible Party: Dong-Hyuk Cho, Clinical assistant professor, Wonju Severance Christian Hospital
ClinicalTrials.gov Identifier: NCT04631861    
Other Study ID Numbers: 2020AN0292
First Posted: November 17, 2020    Key Record Dates
Last Update Posted: November 17, 2020
Last Verified: November 2020
Individual Participant Data (IPD) Sharing Statement:
Plan to Share IPD: No
Plan Description: The present study are not publicly accessible due to Korean personal information projection act.

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Studies a U.S. FDA-regulated Drug Product: No
Studies a U.S. FDA-regulated Device Product: No
Keywords provided by Dong-Hyuk Cho, Wonju Severance Christian Hospital:
Physical activity
Additional relevant MeSH terms:
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COVID-19
Infections
Respiratory Tract Infections
Pneumonia, Viral
Pneumonia
Virus Diseases
 Coronavirus Infections
Coronaviridae Infections
Nidovirales Infections
RNA Virus Infections
Lung Diseases
Respiratory Tract Diseases