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Volumetric Analysis of Resorption Types on CBCT

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ClinicalTrials.gov Identifier: NCT04617301
Recruitment Status : Completed
First Posted : November 5, 2020
Last Update Posted : November 5, 2020
Sponsor:
Information provided by (Responsible Party):
DİLARA NİL GÜNAÇAR, Recep Tayyip Erdogan University Training and Research Hospital

Study Description
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Brief Summary:
More accurate management of resorption can be achieved thanks to the three-dimensions volumetric and linear analysis, and the axial classification presented in this study.

Condition or disease
Endodontic Disease Tooth Resorption

Detailed Description:

The aim of this study was to investigate the volumetric and linear analysis, and to present the axial classification of root resorptions using cone beam computed tomography (CBCT).

A total of 43 teeth of external cervical resorption (ECR) (n=27), external replacement resorption (ERR) (n=4) and internal root resorption (IRR) (n=12) were identified from 34 patients. The volume of resorption and total tooth, the widest lengths of these resorptions, and the amount of thinnest dentin thickness around them were measured and compared according to age and sex. Additionally, the eight regional axial classification was performed and the percentages in these regions were evaluated. Significance was set at p=0.05 for statistical analysis.

More accurate management of resorption can be achieved thanks to the three-dimensions volumetric and linear analysis, and the axial classification presented in this study.

Study Design
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Study Type : Observational
Actual Enrollment : 43 participants
Observational Model: Case-Crossover
Time Perspective: Retrospective
Official Title: Three-dimensional Volumetric/ Linear Analysis and Axial Classification of Root Resorptions Using Cone Beam Computed Tomography: A Retrospective Study
Actual Study Start Date : June 22, 2020
Actual Primary Completion Date : August 10, 2020
Actual Study Completion Date : October 21, 2020
Groups and Cohorts
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Group/Cohort
Group 1. Internal root resorption (IRR)
Internal root resorption is the progressive destruction of intraradicular dentin and dentinal tubules along the middle and apical thirds of the canal walls as a result of clastic activities. It is seen as a radiolucent area around the pulpal cavity, usually of incisors and mandibular molars. The various etiological factors suggested for internal root resorption include traumatic injury; infection and orthodontic treatment.
Group 2. external cervical resorption (ECR)

Cementum is considered to protect the underlying root dentin from being resorbed. It is broadly accepted that damage to or deficiency of this protective cementum layer below the epithelial attachment exposes the root surface to osteoclasts, which then resorb the dentin.

Clinical sign; Located in cervical region of tooth Pink spot might be noted by patient/dentist Tooth usually responds positively to vitality tests unless there is pulpal involvement (in very advanced cases) Spontaneous and profuse bleeding on probing Sharp, thinned out edges around the resorptive cavity
Grup 3. external replacement resorption (ERR)
external replacement resorption also known as trauma-induced resorption - and this resorption may occur in teeth that also have external inflammatory resorption. This review will not discuss external replacement resorption in detail but it will be mentioned where relevant as both types of resorption may occur in some cases. This is because replacement resorption is a consequence of the same injuries that typically cause external inflammatory resorption - such as intrusion and avulsion where there is significant damage to the external root surface during the injury, as well as sometimes during the repositioning/ replantation of the tooth.


Outcome Measures
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Primary Outcome Measures :
  1. Volume of total tooth and resorbed area [ Time Frame: for three months from the beginning of the study ]
    The total volume and the resorption volume were measured with used 3D semi-automatic segmentation program (ITK-SNAP 2.4)

  2. Measurement widest mesio-distal length, bucco-lingual length and corono-apical length of the resorbed lesion [ Time Frame: for three months from the beginning of the study ]
    Linear measurement were measured with used Planmeca ProMax 3D Classic (Planmeca Promax 3D; Planmeca Oy; Helsinki, Finland)

  3. Linear measurements for thinnest dentin (buccal, distal, mesial and lingual/ palatinal) and resorbed area (mesio-distal length and bucco-lingual length) were made on axial sections [ Time Frame: for three months from the beginning of the study ]
    Linear measurement were measured with used Planmeca ProMax 3D Classic (Planmeca Promax 3D; Planmeca Oy; Helsinki, Finland)

  4. The corono-apical length was measured on sagittal sections where the tooth axis was perpendicular to the ground plane. [ Time Frame: for three months from the beginning of the study ]
    Linear measurement were measured with used Planmeca ProMax 3D Classic (Planmeca Promax 3D; Planmeca Oy; Helsinki, Finland)

  5. the axial section of the tooth was divided into eight parts and regional settlement classification was performed [ Time Frame: for three months from the beginning of the study ]
    Segmentation were made with used Planmeca ProMax 3D Classic (Planmeca Promax 3D; Planmeca Oy; Helsinki, Finland)


Eligibility Criteria
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Information from the National Library of Medicine

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Ages Eligible for Study:   12 Years to 71 Years   (Child, Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Probability Sample
Study Population
Cases of resorption that had CBCT images were included in the study. Radiographic features of resorption were defined in the images of 34 patients in accordance with these criteria. A total of 43 teeth with ECR (n=27), ERR (n=4), and IRR (n=12) were identified from 34 patients.
Criteria

Inclusion Criteria:

  • Cases of resorption that had CBCT images

Exclusion Criteria:

  • those presenting pathologic lesions, congenital/developmental anomalies or teeth with root canal filling
  • those whose CBCT scans failed to present satisfactory quality.
  • Additionally, SR, TAP, and EIR cases were excluded because their true dimensions could not be completely determined before resorption.
Contacts and Locations
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Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT04617301


Locations
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Turkey
Recep Tayyip Erdogan University Training and Research Hospital
Rize, Turkey, 53100
Sponsors and Collaborators
Recep Tayyip Erdogan University Training and Research Hospital
Investigators
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Study Chair: Dilara Nil Günaçar Recep Tayyip Erdogan University Training and Research Hospital
More Information
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Publications:

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Responsible Party: DİLARA NİL GÜNAÇAR, assistant professor, Recep Tayyip Erdogan University Training and Research Hospital
ClinicalTrials.gov Identifier: NCT04617301    
Other Study ID Numbers: 2020/98
First Posted: November 5, 2020    Key Record Dates
Last Update Posted: November 5, 2020
Last Verified: October 2020

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Studies a U.S. FDA-regulated Drug Product: No
Studies a U.S. FDA-regulated Device Product: No
Keywords provided by DİLARA NİL GÜNAÇAR, Recep Tayyip Erdogan University Training and Research Hospital:
cone beam computed tomography
endodontics
tooth Resorption
Additional relevant MeSH terms:
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Dental Pulp Diseases
Tooth Resorption
Tooth Diseases
Stomatognathic Diseases