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Determination of Risk Factors for the Development of Obesity and Hypertension in Children According to Perinatal Programming of Metabolism

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ClinicalTrials.gov Identifier: NCT04611412
Recruitment Status : Recruiting
First Posted : November 2, 2020
Last Update Posted : November 2, 2020
Sponsor:
Information provided by (Responsible Party):
Samarkand State Medical Institute

Study Description
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Brief Summary:
to determine the risk factors for developing obesity in children with exogenous-constitutional obesity and arterial hypertension, according to the theories of early programming of metabolism

Condition or disease Intervention/treatment
Metabolic Syndrome Other: Risk Factors

Detailed Description:
A retrospective cohort study of 55 children aged 12 to 18 years (average 14.60±0.24 years) with exogenous-constitutional obesity was conducted, with 24 girls (43.6%) and 31 (56.4%) boys. Children were identified during dispensary examinations in family clinics in Samarkand in the period 2018-2019. All the examined children belonged to the Uzbek population.
Study Design
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Study Type : Observational
Estimated Enrollment : 55 participants
Observational Model: Cohort
Time Perspective: Retrospective
Official Title: Determination of Risk Factors for the Development of Obesity and Hypertension in Children According to Perinatal Programming of Metabolism
Estimated Study Start Date : December 15, 2020
Estimated Primary Completion Date : December 30, 2023
Estimated Study Completion Date : January 2, 2024

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Groups and Cohorts
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Group/Cohort Intervention/treatment
1 group
Group I consisted of 17 people (16.83%) with a uniform type of obesity
 Other: Risk Factors
BMI in children and adolescents was compared with percentile charts developed by who for children from 5 to 19 years of age (WHO Growth Reference, 2007). Body mass index was defined as the ratio of body weight (in kg) to body length in the supine position or height in the standing position (m2).
2 group
Group II included 38 children with AO, and 20 of them had normal BLOOD pressure
 Other: Risk Factors
BMI in children and adolescents was compared with percentile charts developed by who for children from 5 to 19 years of age (WHO Growth Reference, 2007). Body mass index was defined as the ratio of body weight (in kg) to body length in the supine position or height in the standing position (m2).


Outcome Measures
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Primary Outcome Measures :
  1. Risk factors of metabolic syndrome [ Time Frame: up to 36 months ]

    A retrospective, cohort study of 55 children aged 12 to 18 years with exogenous constitutional obesity will be conducted Children with exogenous-constitutional obesity were divided by the presence of abdominal (visceral) obesity and the presence of hypertension.

    Parents will be interviewed and medical records (forms 003/y and 112) of children with exogenous constitutional obesity will be analyzed. Also, on the basis of a specially developed questionnaire, children with exogenous constitutional obesity were surveyed. When conducting a survey of children and their parents, the following factors will be of particular importance: heredity, pregnancy, weight and body length at birth, the nature of nutrition in the first two years of life, eating habits, and physical activity.



Eligibility Criteria
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Ages Eligible for Study:   12 Years to 18 Years   (Child, Adult)
Sexes Eligible for Study:   All
Sampling Method:   Probability Sample
Study Population
the cohort study will include 55 children aged 12 to 18 with exogenous constitutional obesity
Criteria

Inclusion Criteria:

  • SDS (standart deviation score) of body mass index (BMI) ranging from +2.0 to +3.0

Exclusion Criteria:

  • secondary obesity and overweight genetic syndromes,
  • refusal of the child and/or parents to be examined
Contacts and Locations
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Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT04611412


Locations
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Uzbekistan
Samarkand State Medical Institute Recruiting
Samarkand, Uzbekistan, 140100
Contact: Lilya M Garifulina, PhD    +998915497971    ms.garifulina77@mail.ru   
Sponsors and Collaborators
Samarkand State Medical Institute
More Information
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Responsible Party: Samarkand State Medical Institute
ClinicalTrials.gov Identifier: NCT04611412    
Other Study ID Numbers: Project #4
First Posted: November 2, 2020    Key Record Dates
Last Update Posted: November 2, 2020
Last Verified: October 2020
Individual Participant Data (IPD) Sharing Statement:
Plan to Share IPD: No
Plan Description: Study participants will perform all types of medical and diagnostic activities

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Studies a U.S. FDA-regulated Drug Product: No
Studies a U.S. FDA-regulated Device Product: No
Keywords provided by Samarkand State Medical Institute:
Metabolic Syndrome
children
obesity
Additional relevant MeSH terms:
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Hypertension
Obesity
Metabolic Syndrome
Vascular Diseases
Cardiovascular Diseases
Overnutrition
Nutrition Disorders
 Overweight
Body Weight
Insulin Resistance
Hyperinsulinism
Glucose Metabolism Disorders
Metabolic Diseases