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Relationship Between Tooth Decay and Trabecular Bone

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
 
ClinicalTrials.gov Identifier: NCT04608526
Recruitment Status : Completed
First Posted : October 29, 2020
Last Update Posted : October 29, 2020
Sponsor:
Information provided by (Responsible Party):
Sema Aydınoglu, Recep Tayyip Erdogan University Training and Research Hospital

Study Description
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Brief Summary:
Chewing, a movement that matures with experiences, has effects on the growth and development of the stomatognathic system. Tooth decay, which is known to have effects on chewing, can affect the jaw bone due to its indirect effect on the mechanical forces transmitted to the jaw bone. This study was aimed to evaluate the relationship between dental caries and jaw bone trabeculation during the growth and development processes in children by fractal dimension analysis method. 40 patients with deep-dentin caries / apical rarefying osteitis on the right or left side, 40 patients with deep-dentin caries / apical rarefying osteitis on either the right and left sides and 40 patients without deep-dentin caries / apical rarefying osteitis between 8-13 ages were randomly selected. Digital panoramic images of the selected patients were analyzed with fractal dimension analysis.

Condition or disease Intervention/treatment
Dental Caries in Children Pediatric Patients Radiology Diagnostic Test: Fractal analysis

Study Design
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Study Type : Observational
Actual Enrollment : 120 participants
Observational Model: Case-Crossover
Time Perspective: Retrospective
Official Title: Evaluation of the Relationship Between Tooth Decay and Trabecular Bone Structure in Pediatric Patients by Fractal Analysis Method: A Retrospective Study
Actual Study Start Date : June 1, 2020
Actual Primary Completion Date : September 1, 2020
Actual Study Completion Date : October 19, 2020

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Tooth Decay

Groups and Cohorts
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Group/Cohort Intervention/treatment
Group 1
Patients without deep dentin caries / apical rarefying osteitis
 Diagnostic Test: Fractal analysis
Fractal dimension (FD) analysis, which can be measured in panoramic radiographs, is a technique that can be used to measure mandibular trabecular architecture and to determine early periodontal changes in alveolar bone. Fractal analysis method, which has become more and more popular in recent years; has features such as being easily accessible, not being affected by variables such as projection geometry and radiological density and providing objective data about trabecular structures. It can be measured in the patients' existing panoramic images and does not require extra imaging and material.
Group 2
Patients with deep dentin caries / apical rarefying osteitis on the right or left sides
 Diagnostic Test: Fractal analysis
Fractal dimension (FD) analysis, which can be measured in panoramic radiographs, is a technique that can be used to measure mandibular trabecular architecture and to determine early periodontal changes in alveolar bone. Fractal analysis method, which has become more and more popular in recent years; has features such as being easily accessible, not being affected by variables such as projection geometry and radiological density and providing objective data about trabecular structures. It can be measured in the patients' existing panoramic images and does not require extra imaging and material.
Group 3
Patients with deep dentin caries / apical rarefying osteitis on either the right and left side
 Diagnostic Test: Fractal analysis
Fractal dimension (FD) analysis, which can be measured in panoramic radiographs, is a technique that can be used to measure mandibular trabecular architecture and to determine early periodontal changes in alveolar bone. Fractal analysis method, which has become more and more popular in recent years; has features such as being easily accessible, not being affected by variables such as projection geometry and radiological density and providing objective data about trabecular structures. It can be measured in the patients' existing panoramic images and does not require extra imaging and material.


Outcome Measures
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Primary Outcome Measures :
  1. The effects of dental caries on the jawbone in children aged between 8-13 years [ Time Frame: for two months from the beginning of the study ]

    Digital panoramic radiographs of the patients included in the study were recorded in high resolution TIF (tagged image file) format to ensure standardization of the images and adjusted to 2836 x 1500 pixels. ImageJ version 1.53a, and bundled with 64-bit Java for Windows (National Institutes of Health, Bethesda) were used for fractal analysis of the images.

    Fractal analysis on digital panoramic radiographs transferred to ImageJ (National Institutes of Health, Bethesda) program, 3 ROI (region of interest) areas of 15x15 pixels were determined for each patient with condyle, antegonial notch in the right and left hemimandible and in the center of the ramus.The number of frames containing the trabecular structure and the total number of frames were calculated for different dimensions. The values were transferred to the logarithmic scale and the slope of the curve fitting the points on the graph gave the result of the fractal measurement.



Eligibility Criteria
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Ages Eligible for Study:   8 Years to 13 Years   (Child)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Probability Sample
Study Population
  • systemically healthy,
  • 8-13 years-old,
  • applied to the Clinic between January 2018 and April 2020 patients
Criteria

Inclusion Criteria:

  • Panoramic radiographs of systemically healthy 8-13 years-old patients,
  • Who applied to the Clinic between January 2018 and April 2020 were retrospectively scanned.
  • Patients with 1st molars whose root development was completed and the 2nd molars not erupted yet were included.

Exclusion Criteria:

  • Patients with temporomandibular joint disorders, any systemic disease, exposed to trauma in the area to be measured, received orthodontic treatment for the last 2 years or had an ongoing orthodontic treatment, unilateral / bilateral cross-bite and had parafunctional habits in their anamnesis were excluded.
Contacts and Locations
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Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT04608526


Locations
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Turkey
Sema Aydinoğlu
Rize, Turkey
Sponsors and Collaborators
Recep Tayyip Erdogan University Training and Research Hospital
Investigators
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Study Director: SEMA AYDINOĞLU Recep Tayyip Erdogan University Training and Research Hospital
More Information
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Responsible Party: Sema Aydınoglu, assistant professor, Recep Tayyip Erdogan University Training and Research Hospital
ClinicalTrials.gov Identifier: NCT04608526    
Other Study ID Numbers: 2020/127
First Posted: October 29, 2020    Key Record Dates
Last Update Posted: October 29, 2020
Last Verified: October 2020
Individual Participant Data (IPD) Sharing Statement:
Plan to Share IPD: No

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Studies a U.S. FDA-regulated Drug Product: No
Studies a U.S. FDA-regulated Device Product: No
Keywords provided by Sema Aydınoglu, Recep Tayyip Erdogan University Training and Research Hospital:
Disturbances in dental development
fractal analysis
pediatric patients
radiology
Additional relevant MeSH terms:
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Dental Caries
Tooth Demineralization
Tooth Diseases
Stomatognathic Diseases