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Stress Cardiac MRI in Ischemic Patients

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ClinicalTrials.gov Identifier: NCT04588675
Recruitment Status : Not yet recruiting
First Posted : October 19, 2020
Last Update Posted : October 19, 2020
Sponsor:
Information provided by (Responsible Party):
Abdulrahman Emam Eldeen, Assiut University

Study Description
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Brief Summary:
The aim of this study is to assess the diagnostic accuracy of CMR feature-tracking (FT) at rest & during stress with low dose dobutamine (LDD) in the evaluation of viability in ischemic cardiomyopathy (ICM) patients and compare it with delayed gadolinium enhancement (DGE).

Condition or disease Intervention/treatment
Ischemic Cardiomyopathy Diagnostic Test: MRI

Study Design
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Study Type : Observational
Estimated Enrollment : 50 participants
Observational Model: Case-Control
Time Perspective: Cross-Sectional
Official Title: Assessment of Myocardial Viability by Cardiac Magnetic Resonance Feature Tracking at Rest and During Stress by Low Dose Dobutamine
Estimated Study Start Date : November 2021
Estimated Primary Completion Date : December 2021
Estimated Study Completion Date : June 2022

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Cardiomyopathy

Groups and Cohorts
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Intervention Details:
  • Diagnostic Test: MRI
    the patients will underwent dobutamine stress cardiac MRI

Outcome Measures
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Primary Outcome Measures :
  1. comparison of myocardial strain with late gadolinium enhancement [ Time Frame: Baseline ]
    analysis of the myocardial strain by low dose dobutamine and test if it can assess myocardial viability


Eligibility Criteria
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Ages Eligible for Study:   20 Years to 75 Years   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
50 patients with chronic LV systolic dysfunction due to coronary artery disease (CAD)
Criteria

Inclusion Criteria:

  • All patients recruited into the study have chronic LV systolic dysfunction due to coronary artery disease (CAD)

Exclusion Criteria:

  • All patients with a contraindication to MR study:

    • Patients with implanted non-MRI compatible electronic devices (e.g. Cardiac pacemakers, intracranial metallic clips, implanted hearing aids, etc.)
    • Patients with foreign bodies in the eye.
    • Claustrophobic patients.
  • Patients diagnosed with recent acute coronary syndrome within 4 weeks.
  • Patients who had contraindications for MRI or contrast agents, and those with poor image quality due to either inadequate breath holding or arrhythmias
Contacts and Locations
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Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT04588675


Contacts
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Contact: Abdulrahman Hamdan 1005363950 ext 0020 abdulrahman.emam@med.au.edu.eg

Sponsors and Collaborators
Assiut University
More Information
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Publications:

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Responsible Party: Abdulrahman Emam Eldeen, Principal Investigator, Assiut University
ClinicalTrials.gov Identifier: NCT04588675    
Other Study ID Numbers: Stress cardiac MRI
First Posted: October 19, 2020    Key Record Dates
Last Update Posted: October 19, 2020
Last Verified: October 2020

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Studies a U.S. FDA-regulated Drug Product: No
Studies a U.S. FDA-regulated Device Product: No
Additional relevant MeSH terms:
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Cardiomyopathies
Ischemia
Pathologic Processes
Heart Diseases
Cardiovascular Diseases