Low-load Blood Flow Restriction Training in COPD (LL-BFRT COPD)
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|ClinicalTrials.gov Identifier: NCT04151771|
Recruitment Status : Recruiting
First Posted : November 5, 2019
Last Update Posted : February 23, 2021
Peripheral muscle weakness is a predominant problem in patients with COPD and treated using exercise training in pulmonary rehabilitation. Despite pulmonary rehabilitation being an effective intervention, muscle strength impairment is a persisting problem in COPD patients. Patients have problems to tolerate the high training loads, which are necessary to develop strength. Low-load blood flow restriction training (LL-BFRT) might therefore be an option to enhance muscular response of patients with COPD to strength training. Up to now, no studies investigating LL-BFRT in respiratory diseases are available.
The primary outcome of this randomized pilot study is knee extensor muscle strength. Secondary, the study will evaluate if LL-BFRT is well tolerated and feasible in COPD patients attending outpatient pulmonary rehabilitation.
|Condition or disease||Intervention/treatment||Phase|
|COPD Muscle Weakness||Other: Low-load blood flow restriction training Other: Usual outpatient pulmonary rehabilitation||Not Applicable|
|Study Type :||Interventional (Clinical Trial)|
|Estimated Enrollment :||30 participants|
|Intervention Model:||Parallel Assignment|
|Masking:||Single (Outcomes Assessor)|
|Official Title:||Low-load Blood Flow Restriction Training in COPD|
|Actual Study Start Date :||December 27, 2019|
|Estimated Primary Completion Date :||December 2021|
|Estimated Study Completion Date :||December 2021|
Experimental: LL-BFRT group
Participants randomised into intervention group are attending pulmonary rehabilitation in which strengthening exercises of the lower limb are performed using LL-BFRT.
Other: Low-load blood flow restriction training
The intervention group will perform the exercises of the lower limbs using LL-BFRT with an occlusion pressure of 70% of arterial occlusion pressure with low training loads (30% of the 1 repetition maximum).
Other Name: LL-BFRT
Active Comparator: Usual pulmonary rehabilitation group
Participants randomised into control group are attending usual pulmonary rehabilitation as established.
Other: Usual outpatient pulmonary rehabilitation
The control group will perform outpatient pulmonary rehabilitation as established.
- Knee extensor strength [ Time Frame: during 12 weeks (24 exercise sessions) ]Between-group difference in total change in isometric muscle strength of the knee extensor muscles, measured by handheld dynamometry in newtonmeter
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT04151771
|Contact: Christian F Clarenbach, MD||+41 44 255 17 firstname.lastname@example.org|