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Normal Range of Superior Mesenteric Artery in Young Chinese Population and Its Correlation With Retroperitoneal Adipose Tissue

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ClinicalTrials.gov Identifier: NCT03937193
Recruitment Status : Recruiting
First Posted : May 3, 2019
Last Update Posted : July 16, 2020
Sponsor:
Collaborator:
North District Hospital
Information provided by (Responsible Party):
Professor Winnie W.C. Chu, Chinese University of Hong Kong

Study Description
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Brief Summary:
In literature, superior mesenteric artery (SMA) angle, also named as aortomesenteric angle (AMA), varies greatly in both adult and children; while the aortomesenteric distance also ranges widely. Both AMA and AMD are influenced by retroperitoneal fat. Decrease of AMA and AMD may lead to the superior mesenteric artery syndrome(SMAS), which is a rare medical condition mainly presenting with duodenum obstruction. To our knowledge, normal range of AMA and AMD in local young Chinese population remain unclear; on the other hand, there have only a few studies exploring the relationship between them. This project proposes to establish the normal range of AMA and AMD in local young Chinese population, and to further investigate how the retroperitoneal adipose tissue correlates with AMA and AMD. The normal range obtained in this proposed study will provide more specific reference value to distinguish abnormal AMA and AMD, and to improve the diagnosis accuracy of SMAS in local population. Moreover, this study will provide deeper insight concerning the impact of retroperitoneal fat on AMA and AMD.

Condition or disease Intervention/treatment
Aortomesenteric Angle Aortomesenteric Distance Retroperitoneal Adipose Tissue Diagnostic Test: computerized tomography

Study Design
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Study Type : Observational
Estimated Enrollment : 510 participants
Observational Model: Ecologic or Community
Time Perspective: Retrospective
Official Title: Normal Range of Superior Mesenteric Artery on Computerized Tomography in Young Chinese Population and Its Correlation With Retroperitoneal Adipose Tissue
Actual Study Start Date : July 25, 2019
Estimated Primary Completion Date : June 30, 2021
Estimated Study Completion Date : June 30, 2022

Resource links provided by the National Library of Medicine

MedlinePlus related topics: CT Scans

Groups and Cohorts
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Group/Cohort Intervention/treatment
Non-SMAS group
subjects in this group are not clinically diagnosed as superior mesenteric artery syndrome(SMAS).
 Diagnostic Test: computerized tomography
abdomen contrast computerized tomography performed for both emergency and elective purposes in HK public hospitals.
SMAS group
subjects in this group are clinically diagnosed as superior mesenteric artery syndrome(SMAS).
 Diagnostic Test: computerized tomography
abdomen contrast computerized tomography performed for both emergency and elective purposes in HK public hospitals.


Outcome Measures
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Primary Outcome Measures :
  1. aortomesenteric angle (AMA) [ Time Frame: 2 years ]
    aortomesenteric angle in degree measured on sagittal CT image

  2. aortomesenteric distance (AMD) [ Time Frame: 2 years ]
    aortomesenteric distance in millimeter(mm) on axial CT image

  3. visceral fat area [ Time Frame: 2 years ]
    visceral fat area in square centimeter(cm2) evaluated by image post-processing software

  4. subcutaneous fat area [ Time Frame: 2 years ]
    subcutaneous fat area in square centimeter(cm2) evaluated by image post-processing software

  5. area ratio of visceral fat to subcutaneous fat [ Time Frame: 2 years ]
    area ratio in percentage(%)


Eligibility Criteria
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Ages Eligible for Study:   10 Years to 35 Years   (Child, Adult)
Sexes Eligible for Study:   All
Sampling Method:   Probability Sample
Study Population
The investigators will retrospectively recruit individuals from the local population who had undergone abdomen contrast CT scans within hospitals in the New Territories East Cluster (NTEC) of Hong Kong for both emergency and elective purposes in the year 2013-2019. Total sample will comprise two groups: (1) Non-SMAS Group (N=500); and (2) SMAS group (N=10).
Criteria

Inclusion Criteria:

  • With age range of 10-35 years old.
  • Chinese ethnicity.
  • With abdomen contrast CT.

Exclusion Criteria:

  • Any patients with diagnosis of SMAS will be excluded from the Non-SMAS group.
  • Patients who had undergone more than one CT scan during the research period.
  • Previous retroperitoneal, abdominal surgery.
  • Conditions causing significant weight loss, e.g. anorexia nervosa, malabsorption.
  • Presence of abdominal masses or pathology that will affect the anatomy of aorta- superior mesenteric artery and the retroperitoneal structures.
  • Presence of severe scoliosis and/or history of spinal fixation that may increase incidence of SMA syndrome.
  • Presence of free intraperitoneal or retroperitoneal fluid that may affect fat measurement, e.g. following trauma, or ascites.
Contacts and Locations
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Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT03937193


Contacts
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Contact: Chiu Wing CHU, MBChB, MD 3505-2299 winniechu@cuhk.edu.hk
Contact: Kai Ho Yam, MBChB ykh778@ha.org.hk

Locations
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China
Department of Radiology， North District Hospital Recruiting
Hong Kong, China
Contact: Kai Ho Yam         
Sponsors and Collaborators
Chinese University of Hong Kong
North District Hospital
Investigators
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Principal Investigator: Kai Ho Yam, MBChB Department of Radiology, North District Hospital, Hong Kong
More Information
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Top of Page Study Description Study Design Groups and Cohorts Outcome Measures Eligibility Criteria Contacts and Locations More Information
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Responsible Party: Professor Winnie W.C. Chu, Professor, Chinese University of Hong Kong
ClinicalTrials.gov Identifier: NCT03937193    
Other Study ID Numbers: NTEC-2019-0296
First Posted: May 3, 2019    Key Record Dates
Last Update Posted: July 16, 2020
Last Verified: July 2020
Individual Participant Data (IPD) Sharing Statement:
Plan to Share IPD: No

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Studies a U.S. FDA-regulated Drug Product: No
Studies a U.S. FDA-regulated Device Product: No
Keywords provided by Professor Winnie W.C. Chu, Chinese University of Hong Kong:
aortomesenteric angle
aortomesenteric distance
retroperitoneal adipose tissue
computerized tomography
young Chinese population