Antibiotic-resistant Bacterial Infection of Hepatic Patients
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|ClinicalTrials.gov Identifier: NCT03855709|
Recruitment Status : Not yet recruiting
First Posted : February 27, 2019
Last Update Posted : February 27, 2019
|Condition or disease||Intervention/treatment|
|Antibiotic Resistant Infection Liver Cirrhoses||Diagnostic Test: microbiological culture and sensetivity|
Bacterial infection signifies major clinical challenge in cirrhotic patients where about 35% of these patients acquire hospital-acquired infections compared with 5% of other hospital in-patients without cirrhosis.It is associated with a mortality rate of 38% with a four-fold increase compared to individuals without cirrhosis.
Cirrhotic patients have a high risk for antimicrobial resistance because of chronic use of prescribed antibiotics like quinolones in secondary prophylaxis for spontaneous bacterial peritonitis. In addition, undergoing invasive procedures and recurrent hospital admissions encourage both increased occurrence of antimicrobial resistance and the spread of resistant pathogens in these patients.
Epidemiology, risk factors and clinical outcomes of MDR infections have raised a special attention in cirrhosis. Some studies reported bacterial resistance in about 50% of examined patients and it is associated with treatment failure, septic shock and hospital mortality especially in nosocomial and healthcare related infections
|Study Type :||Observational|
|Estimated Enrollment :||200 participants|
|Official Title:||Patterns of Antibiotic Resistant Bacterial Infections in Liver Intensive Care Unit|
|Estimated Study Start Date :||May 2019|
|Estimated Primary Completion Date :||May 2020|
|Estimated Study Completion Date :||July 2020|
- Diagnostic Test: microbiological culture and sensetivity
microbioloical culture will be used to detect microbiological profile in hepatic patients with infections, drug sensitivity to detect resistent bacteria which will be confirmed using PCR detection of resistent gene
- Detection of different bacterial causing infections in hepatic patients [ Time Frame: baseline ]Bacteriological cultures will be performed with VITEK 2 COMPACT-15 automated system (bioMerieux Inc, Mercy L'etoil, Fransa).
- To detect antibiotic resistant bacteria among these patients. [ Time Frame: baseline ]molecular detection of genes responsible for antibiotic resistance using PCR for isolates bacteria
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Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT03855709
|Contact: Karema Azoz Mostafafirstname.lastname@example.org|