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Molecular Assessment of Oral Mutans Streptococcus Isolated From Different Patients

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ClinicalTrials.gov Identifier: NCT03802669
Recruitment Status : Completed
First Posted : January 14, 2019
Last Update Posted : September 17, 2019
Sponsor:
Information provided by (Responsible Party):
Naglaa Ibrahim Ezz, October University for Modern Sciences and Arts

Study Description
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Brief Summary:
90 saliva samples will be isolated from patient who possess different ages and caries activity, attending outpatient clinic of October University of Modern Sciences and Arts. Then the determination of the best selective media for mutans streptococcus isolated from saliva and authenticate the MS via PCR technique.

Condition or disease Intervention/treatment
Dental Caries Other: oral mutans streptococcus

Study Design
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Study Type : Observational
Actual Enrollment : 90 participants
Observational Model: Case-Control
Time Perspective: Cross-Sectional
Official Title: Molecular Assessment of Oral Mutans Streptococcus Isolated From Patients With Different Age and Caries Activity Via Selective Media and Protein Pattern.
Actual Study Start Date : January 12, 2019
Actual Primary Completion Date : February 15, 2019
Actual Study Completion Date : May 20, 2019
Groups and Cohorts
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Group/Cohort Intervention/treatment
caries free children aged between 3-6 Other: oral mutans streptococcus
quantitative assessment of mutans streptococcus of each group by using PCR and protein pattern
caries active children aged between 3-6 Other: oral mutans streptococcus
quantitative assessment of mutans streptococcus of each group by using PCR and protein pattern
caries free children aged between 6-12 Other: oral mutans streptococcus
quantitative assessment of mutans streptococcus of each group by using PCR and protein pattern
caries active children aged between 6-12 Other: oral mutans streptococcus
quantitative assessment of mutans streptococcus of each group by using PCR and protein pattern
caries free adult aged between 18-25 Other: oral mutans streptococcus
quantitative assessment of mutans streptococcus of each group by using PCR and protein pattern
caries active adult aged between 18-25 Other: oral mutans streptococcus
quantitative assessment of mutans streptococcus of each group by using PCR and protein pattern


Outcome Measures
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Primary Outcome Measures :
  1. oral mutans streptococcus screening [ Time Frame: immediately ]
    screening of oral mutans streptococcus of each group to determine the differences


Eligibility Criteria
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Ages Eligible for Study:   3 Years to 25 Years   (Child, Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Probability Sample
Study Population
patients attending out patient clinic of October University for Modern Sciences and Arts.
Criteria

Inclusion Criteria:

  • healthy participant

Exclusion Criteria:

  • participant received antimicrobial therapy in previous month.
  • participant who taking xylitol chewing gum or undergo fluoride therapy.
Contacts and Locations
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Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT03802669


Locations
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Egypt
October University of Modern Sciences and Arts
Cairo, Egypt
Sponsors and Collaborators
October University for Modern Sciences and Arts
Investigators
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Principal Investigator: Naglaa Ezzeldin, lecturer October University for Modern Sciences and Arts
More Information
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Top of Page Study Description Study Design Groups and Cohorts Outcome Measures Eligibility Criteria Contacts and Locations More Information
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Responsible Party: Naglaa Ibrahim Ezz, Lecturer of pediatric dentistry department, faculty of dentistry, October University for Modern Sciences and Arts
ClinicalTrials.gov Identifier: NCT03802669    
Other Study ID Numbers: ETH10
First Posted: January 14, 2019    Key Record Dates
Last Update Posted: September 17, 2019
Last Verified: September 2019
Individual Participant Data (IPD) Sharing Statement:
Plan to Share IPD: No

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Studies a U.S. FDA-regulated Drug Product: No
Studies a U.S. FDA-regulated Device Product: No
Keywords provided by Naglaa Ibrahim Ezz, October University for Modern Sciences and Arts:
human saliva
mutans streptococcus
PCR
caries activity
Additional relevant MeSH terms:
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Dental Caries
Tooth Demineralization
Tooth Diseases
Stomatognathic Diseases