Trial record 1 of 1 for:
NCT03748641
A Study of Niraparib in Combination With Abiraterone Acetate and Prednisone Versus Abiraterone Acetate and Prednisone for Treatment of Participants With Metastatic Prostate Cancer (MAGNITUDE)
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The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Know the risks and potential benefits of clinical studies and talk to your health care provider before participating. Read our disclaimer for details. |
| ClinicalTrials.gov Identifier: NCT03748641 |
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Recruitment Status :
Recruiting
First Posted : November 21, 2018
Last Update Posted : October 31, 2019
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Sponsor:
Janssen Research & Development, LLC
Information provided by (Responsible Party):
Janssen Research & Development, LLC
- Study Details
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Brief Summary:
The purpose of this study is to evaluate the effectiveness of niraparib in combination with abiraterone acetate and prednisone (AA-P) compared to AA-P plus placebo.
| Condition or disease | Intervention/treatment | Phase |
|---|---|---|
| Metastatic Prostate Cancer | Drug: Niraparib Drug: Abiraterone Acetate Drug: Prednisone Drug: Placebo | Phase 3 |
This study will assess efficacy and safety of niraparib in combination with AA-P for the treatment of participants with metastatic prostate cancer. Niraparib is an orally available, highly selective poly (adenosine diphosphate [ADP]-ribose) polymerase (PARP) inhibitor, with potent activity against PARP-1 and PARP-2 deoxyribonucleic acid (DNA)-repair polymerases. AA is a pro-drug of abiraterone and selectively inhibits the enzyme 17α-hydroxylase/C17,20-lyase (CYP17), which is found in the testes and adrenals, as well as in prostate tissues and tumors. In participants with metastatic prostate cancer, DNA-repair gene defects (DRD) are identified in approximately 15 percent (%) to 20% of tumors. The study will consist of 4 phases: a prescreening phase for biomarker evaluation only, a screening phase, a double-blind treatment phase, and a follow up phase. During the prescreening phase participants will be evaluated for DRD and then will be assigned to one of the 2 cohorts based on their biomarker status. Treatment will be administered daily and is planned to be continuous until disease progression, unacceptable toxicity, death, or the sponsor terminates the study. Efficacy, pharmacokinetics, biomarkers, participants reported outcomes and safety will be assessed. The total duration of study will be approximately up to 73 months.
| Study Type : | Interventional (Clinical Trial) |
| Estimated Enrollment : | 1000 participants |
| Allocation: | Randomized |
| Intervention Model: | Parallel Assignment |
| Masking: | Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor) |
| Primary Purpose: | Treatment |
| Official Title: | A Phase 3 Randomized, Placebo-controlled, Double-blind Study of Niraparib in Combination With Abiraterone Acetate and Prednisone Versus Abiraterone Acetate and Prednisone in Subjects With Metastatic Prostate Cancer |
| Actual Study Start Date : | January 25, 2019 |
| Estimated Primary Completion Date : | July 21, 2022 |
| Estimated Study Completion Date : | February 25, 2025 |
Resource links provided by the National Library of Medicine
Genetics Home Reference related topics:
Prostate cancer
| Arm | Intervention/treatment |
|---|---|
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Experimental: Niraparib + Abiraterone Acetate-Prednisone (AA-P)
Participants will receive oral administration of niraparib 200 milligram (mg) (2 capsules of 100 mg each) in combination with abiraterone acetate (AA) 1000 mg (4 tablets of 250 mg each) tablets and prednisone 10 mg (2 tablets of 5 mg each) tablets daily in each cycle (each cycle of 28 days).
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Drug: Niraparib
Participants will receive niraparib 200 mg (2 capsules of 100 mg each) capsules once daily.
Other Name: JNJ-64091742 Drug: Abiraterone Acetate Participants will receive abiraterone acetate 1000 mg (4 tablets of 250 mg each) tablets once daily. Drug: Prednisone Participants will receive prednisone 10 mg (2 tablets of 5 mg each) tablets daily. |
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Active Comparator: Placebo + AA-P
Participants will receive oral administration of matching placebo capsules in combination with AA 1000 mg (4 tablets of 250 mg each) tablets and prednisone 10 mg (2 tablets of 5 mg each) tablets daily in each cycle (each cycle of 28 days).
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Drug: Abiraterone Acetate
Participants will receive abiraterone acetate 1000 mg (4 tablets of 250 mg each) tablets once daily. Drug: Prednisone Participants will receive prednisone 10 mg (2 tablets of 5 mg each) tablets daily. Drug: Placebo Participants will receive matching placebo capsules once daily. |
Primary Outcome Measures :
- Radiographic Progression Free Survival (rPFS) [ Time Frame: Approximately 40 months ]As per blinded independent central review, rPFS is defined as time from randomization date to date of radiographic progression or death, whichever occurs first. Radiographic progression will be evaluated by Prostate Cancer Working Group 3 (PCWG3) as follows: progression of soft tissue lesions measured by computed tomography/magnetic resonance imaging as per response evaluation criteria in solid tumors (RECIST) 1.1; progression by bone lesions observed by bone scan and based on PCWG3. As per criteria, any bone progression must be confirmed by a subsequent scan greater than or equal to (>=) 6 weeks later. Week 8 scan will be baseline to which all subsequent scans will be compared to determine progression. Bone progression is defined as one of the following: participants whose confirmatory scan shows >=2 new lesions will be considered to have bone scan progression and who did not show >= 2 new lesions will not be considered to have bone scan progression when compared to Week 8 scan.
Secondary Outcome Measures :
- Overall survival (OS) [ Time Frame: Approximately up to 73 months ]OS is defined as the time from date of randomization to date of death from any cause.
- Time to Symptomatic Progression [ Time Frame: Up to 40 months ]Time to symptomatic progression is defined as the need to initiate/record any of the following; a. the use of external beam radiation therapy (EBRT) for skeletal symptoms; b. the need for tumor-related orthopedic surgical intervention; c. other cancer-related procedures (for example: nephrostomy insertion, bladder catheter insertion, EBRT, or surgery for tumor symptoms other than skeletal); d. cancer-related morbid events (for example: fracture [symptomatic and/or pathologic, cord compression, urinary obstructive events); e. initiation of new systemic anti-cancer therapy because of cancer pain.
- Time to Initiation of Cytotoxic Chemotherapy [ Time Frame: Up to 40 months ]Time to initiation of cytotoxic chemotherapy is defined as the time from date of randomization to the date of initiation of cytotoxic chemotherapy for prostate cancer.
- Observed Plasma Concentrations of Niraparib [ Time Frame: Cycle 2 to 7; Each Cycle is of 28 days (Up to 7 months) ]Observed plasma concentrations of niraparib with descriptive statistics will be reported.
- Observed Trough Plasma Concentrations of Abiraterone [ Time Frame: Cycles 2 and 3; Each Cycle is of 28 days (Up to 3 months) ]Observed trough plasma concentrations of abiraterone with descriptive statistics will be reported.
- Number of Participants with Treatment-Emergent Adverse events (TEAEs) [ Time Frame: Approximately up to 73 months ]An adverse event (AE) is any untoward medical occurrence in a clinical study participant administered a medicinal (investigational or non investigational) product. AE does not necessarily have a causal relationship with intervention. AE can therefore be any unfavorable and unintended sign (including an abnormal finding), symptom, or disease temporally associated with use of a medicinal (investigational or non-investigational) product, whether or not related to that medicinal product. TEAEs are those events that occur or worsen on or after first dose of study drug through 30 days after last dose of study drug.
- Number of Participants with Treatment-Emergent Adverse events by Severity [ Time Frame: Approximately up to 73 months ]An adverse event is any untoward medical occurrence in a clinical study participant administered a medicinal (investigational or non-investigational) product. AE does not necessarily have a causal relationship with intervention. AE can therefore be any unfavorable and unintended sign (including an abnormal finding), symptom, or disease temporally associated with use of a medicinal (investigational or non-investigational) product, whether or not related to that medicinal product. TEAEs are those events that occur or worsen on or after first dose of study drug through 30 days after last dose of study drug. Severity criteria includes grades:1) Mild: easily tolerated, causing minimal discomfort and no interference with everyday activities 2) Moderate: sufficient discomfort to cause interference with normal activity 3) Severe: extreme distress, significant impairment of functioning/incapacitation. Prevents everyday activities 4) Life-threatening: urgent intervention indicated 5) Death
- Number of Participants with Laboratory Abnormalities as Measure of Safety [ Time Frame: Approximately up to 73 months ]Number of participants with laboratory abnormalities (hematology, serum chemistry and liver function test) will be determined.
Information from the National Library of Medicine
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.
| Ages Eligible for Study: | 18 Years and older (Adult, Older Adult) |
| Sexes Eligible for Study: | Male |
| Accepts Healthy Volunteers: | No |
Criteria
Inclusion Criteria:
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Deoxyribonucleic acid (DNA)-repair gene defects (DRD) status (as identified by the sponsor's required assays) as follows:
- Cohort 1: positive for DRD
- Cohort 2: not positive for DRD (i.e. No DRD)
- Metastatic disease documented by positive bone scan or metastatic lesions on computed tomography (CT) or magnetic resonance imaging (MRI)
- Metastatic prostate cancer in the setting of castrate levels of testosterone less than or equal to (<=) 50 nanogram per deciliter (ng/dL) on a gonadotropin releasing hormone analog (GnRHa) or bilateral orchiectomy
- Able to continue GnRHa during the study if not surgically castrate
- Score of <= 3 on the brief pain inventory-short form (BPI-SF) question number 3 (worst pain in last 24 hours)
Exclusion Criteria:
- Prior treatment with a poly (adenosine diphosphate [ADP]-ribose) polymerase (PARP) inhibitor
- Systemic therapy (that is, novel second-generation AR-targeted therapy such as enzalutamide, apalutamide, or darolutamide; taxane-based chemotherapy, or more than 4 months of abiraterone acetate plus prednisone [AA-P] prior to randomization) in the metastatic castration-sensitive prostate cancer (mCRPC) setting; or AA-P outside of the mCRPC setting
- Symptomatic brain metastases
- History or current diagnosis of myelodysplastic syndrome (MDS)/acute myeloid leukemia (AML)
- Other prior malignancy (exceptions: adequately treated basal cell or squamous cell skin cancer, superficial bladder cancer, or any other cancer in situ currently in complete remission) <= 2 years prior to randomization, or malignancy that currently requires active systemic therapy
Information from the National Library of Medicine
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT03748641
Contacts
| Contact: Study Contact | 844-434-4210 | JNJ.CT@sylogent.com |
Hide Study Locations
Locations
| United States, Arizona | |
| Mayo Clinic Arizona | Not yet recruiting |
| Phoenix, Arizona, United States, 85054 | |
| Urological Associates of Southern Arizona, P.C. | Recruiting |
| Tucson, Arizona, United States, 85741 | |
| United States, California | |
| Kaiser Permanente | Not yet recruiting |
| Riverside, California, United States, 92505 | |
| San Bernardino Urological Associates | Recruiting |
| San Bernardino, California, United States, 92404 | |
| University of California San Francisco | Not yet recruiting |
| San Francisco, California, United States, 94158 | |
| Kaiser Permanente Medical Center | Withdrawn |
| Vallejo, California, United States, 95119 | |
| United States, Colorado | |
| The Urology Center of Colorado | Not yet recruiting |
| Denver, Colorado, United States, 80211 | |
| Urology Associates of Denver | Withdrawn |
| Englewood, Colorado, United States, 80113 | |
| Foothills Urology - Golden Off | Recruiting |
| Golden, Colorado, United States, 80401-5027 | |
| United States, Connecticut | |
| VA Connecticut Healthcare | Recruiting |
| West Haven, Connecticut, United States, 06516 | |
| United States, Florida | |
| Bay Pines VA Healthcare System | Recruiting |
| Bay Pines, Florida, United States, 33744 | |
| Advanced Urology Institute | Recruiting |
| Daytona Beach, Florida, United States, 32114 | |
| University of Florida | Not yet recruiting |
| Jacksonville, Florida, United States, 32209 | |
| United States, Illinois | |
| Veterans Affairs Medical Ctr | Not yet recruiting |
| Hines, Illinois, United States, 60141 | |
| United States, Kansas | |
| University of Kansas Medical Center | Withdrawn |
| Kansas City, Kansas, United States, 66160 | |
| United States, Kentucky | |
| Norton Healthcare | Recruiting |
| Louisville, Kentucky, United States, 40202 | |
| United States, Maryland | |
| Rcca Md, Llc | Recruiting |
| Bethesda, Maryland, United States, 20817 | |
| Chesapeake Urology Research Associates | Recruiting |
| Towson, Maryland, United States, 21204 | |
| United States, Massachusetts | |
| Massachusetts General | Recruiting |
| Boston, Massachusetts, United States, 02114 | |
| United States, Missouri | |
| Kansas City Veterans Affairs Medical Center | Not yet recruiting |
| Kansas City, Missouri, United States, 64128 | |
| United States, Nebraska | |
| Adult Pediatric Urology & Urogynecology, P.C | Recruiting |
| Omaha, Nebraska, United States, 68114 | |
| United States, Nevada | |
| Comprehensive Cancer Centers of Nevada | Recruiting |
| Las Vegas, Nevada, United States, 89169 | |
| United States, New Jersey | |
| Delaware Valley Urology, LLC | Recruiting |
| Mount Laurel, New Jersey, United States, 08054 | |
| United States, New York | |
| Icahn School of Medicine at Mount Sinai - The Derald H. Ruttenberg | Not yet recruiting |
| New York, New York, United States, 10029 | |
| Memorial Sloan Kettering Cancer Center | Not yet recruiting |
| New York, New York, United States, 10065 | |
| Upstate Cancer Center | Not yet recruiting |
| Syracuse, New York, United States, 13210 | |
| United States, Pennsylvania | |
| Lancaster Urology | Recruiting |
| Lancaster, Pennsylvania, United States, 17604 | |
| VA Pittsburgh | Recruiting |
| Pittsburgh, Pennsylvania, United States, 15240 | |
| United States, South Carolina | |
| Carolina Urologic Research Center | Recruiting |
| Myrtle Beach, South Carolina, United States, 29572 | |
| United States, Texas | |
| University of Texas MD Anderson Cancer Center | Recruiting |
| Houston, Texas, United States, 77030 | |
| United States, Utah | |
| Utah Cancer Specialists | Not yet recruiting |
| Salt Lake City, Utah, United States, 84106 | |
| United States, Virginia | |
| Salem VA Medical Center | Recruiting |
| Salem, Virginia, United States, 80113 | |
| Urology of Virginia, PLCC | Recruiting |
| Virginia Beach, Virginia, United States, 23462 | |
| United States, Washington | |
| NorthWest Medical Specialties, PLLC | Recruiting |
| Tacoma, Washington, United States, 98405 | |
| Argentina | |
| Hospital Aleman | Recruiting |
| Buenos Aires, Argentina, C1118AAT | |
| Hospital Italiano de Buenos Aires | Withdrawn |
| C.a.b.a., Argentina, C1181ACF | |
| Fundación CENIT para la Investigación en Neurociencias | Recruiting |
| Capital Federal, Argentina, CP 1125 | |
| Centro de Urologia (CDU) | Recruiting |
| Ciudad Automoma Buenos Aires, Argentina, C1120AAT | |
| CEMIC Saavedra | Recruiting |
| Ciudad Autonoma Buenos Aires, Argentina, C1431FWN | |
| Cemaic - Centro Privado de Especialidades Medicas Ambulatorias e Investigacion Clinica | Recruiting |
| Cordoba, Argentina, 5000 | |
| Hospital Privado - Centro Medico de Cordoba | Recruiting |
| Cordoba, Argentina, X5016KEH | |
| Instituto de Investigaciones Clinicas Mar del Plata | Recruiting |
| Mar del Plata, Argentina, B7600FZN | |
| Hospital Privado de Comunidad | Recruiting |
| Mar del Plata, Argentina, B7602CBM | |
| Centro de Investigacion Pergamino SA | Recruiting |
| Pergamino, Argentina, B2700CPM | |
| Sanatorio Britanico de Rosario | Recruiting |
| Rosario, Argentina, 2000 | |
| Sanatorio Parque | Recruiting |
| Rosario, Argentina, S2000SDV | |
| ARS Médica | Recruiting |
| San Salvador de Jujuy, Argentina, Y4600AFW | |
| Australia | |
| Royal Adelaide Hospital | Recruiting |
| Adelaide, Australia, 5116 | |
| Pindara Private Hospital | Recruiting |
| Benowa, Australia, 4217 | |
| Sunshine Coast University Hospital | Recruiting |
| Birtinya, Australia, 4575 | |
| Princess Alexandra Hospital | Not yet recruiting |
| Brisbane, Australia, 4102 | |
| Chris O'Brien Lifehouse | Withdrawn |
| Camperdown, Australia, 2050 | |
| St. Vincent's Hospital Sydney | Recruiting |
| Darlinghurst, Australia, 2010 | |
| Royal Hobart Hospital | Recruiting |
| Hobart, Australia, 7000 | |
| Macquarie University | Recruiting |
| Macquarie University, Australia, 2109 | |
| Cabrini Health | Recruiting |
| Malvern, Australia, 3144 | |
| Peter MacCallum Cancer Centre | Recruiting |
| Melbourne, Australia, 3000 | |
| Fiona Stanley Hospital | Recruiting |
| Murdoch, Australia, 6150 | |
| Hollywood Private Hospital | Recruiting |
| Nedlands, Australia, 6009 | |
| Prince Of Wales Hospital | Recruiting |
| Randwick, Australia, 2031 | |
| Sydney Adventist Hospital | Recruiting |
| Wahroonga, Australia, 2076 | |
| Wollongong Private Hospital | Recruiting |
| Wollongong, Australia, 2500 | |
| Belgium | |
| OLV Ziekenhuis Aalst | Recruiting |
| Aalst, Belgium, 9300 | |
| ZNA Middelheim | Recruiting |
| Antwerpen, Belgium, 2020 | |
| Grand Hôpital de Charleroi, site Notre Dame | Recruiting |
| Charleroi, Belgium, 6000 | |
| AZ Maria Middelares | Recruiting |
| Gent, Belgium, 9000 | |
| Centre Hospitalier Universitaire de Liege Domaine Universitaire du Sart Tilman | Recruiting |
| Liege, Belgium, B-4000 | |
| Brazil | |
| Hospital Do Cancer De Barretos - Fundacao Pio Xii | Not yet recruiting |
| Barretos, Brazil, 14784-400 | |
| PERSONAL - Oncologia de Precisão e Personalizada | Not yet recruiting |
| Belo Horizonte, Brazil, 30130-090 | |
| Hospital Sírio Libanes Unidade Brasilia | Not yet recruiting |
| Brasilia, Brazil, 70200-730 | |
| CIONC - Centro Integrado de Oncologia de Curitiba | Not yet recruiting |
| Curitiba, Brazil, 80810-050 | |
| Hospital Araújo Jorge da Associação de Combate ao Câncer em Goiás | Not yet recruiting |
| Goiânia, Brazil, 74605-070 | |
| Hospital de Caridade de Ijui - CACON | Not yet recruiting |
| Ijui, Brazil, 98700-000 | |
| Clínica de Neoplasias Litoral Ltda. | Not yet recruiting |
| Itajai, Brazil, 88301-220 | |
| Instituto Joinvilense De Hematologia e Oncologia | Not yet recruiting |
| Joinville, Brazil, 89201260 | |
| Centro de Tratamento de câncer Medradius | Not yet recruiting |
| Maceió, Brazil, 57052-765 | |
| Liga Norte Riograndense Contra O Cancer | Not yet recruiting |
| Natal, Brazil, 59075-740 | |
| Irmandade Santa Casa de Misericordia de Porto Alegre | Not yet recruiting |
| Porto Alegre, Brazil, 90020-090 | |
| Instituto Nacional do Cancer - INCA | Not yet recruiting |
| Rio de Janeiro, Brazil, 20230-130 | |
| Hospital Universitário Pedro Ernesto | Not yet recruiting |
| Rio de Janeiro, Brazil, 20551-030 | |
| Instituto COI de Pesquisa, Educacao e Gestao | Not yet recruiting |
| Rio de Janeiro, Brazil, 22793-080 | |
| Hospital Santa Isabel | Not yet recruiting |
| Salvador, Brazil, 40050-410 | |
| CEPHO - Faculdade de Medicina do ABC | Not yet recruiting |
| Santo André, Brazil, 09060-870 | |
| Santa Casa de Misericordia de São Paulo | Not yet recruiting |
| Sao Paulo, Brazil, 01221-020 | |
| Instituto de Ensino E Pesquisa Sao Lucas | Not yet recruiting |
| Sao Paulo, Brazil, 01236-030 | |
| ICESP - INSTITUTO DO CANCER DO ESTADO DE SAO PAULO OCTAVIO FRIAS de OLIVEIRA | Not yet recruiting |
| Sao Paulo, Brazil, 01246-000 | |
| Fundacao Antonio Prudente | Not yet recruiting |
| Sao Paulo, Brazil, 01509900 | |
| IBCC Instituto Brasileiro de Controle do Cancer | Not yet recruiting |
| Sao Paulo, Brazil, 03102-002 | |
| IOS - Instituto de Oncologia de Sorocaba Dr. Gilson Delgado | Not yet recruiting |
| Sorocaba, Brazil, 18030-005 | |
| Instituto de Assistência Médica ao Servidor Público Estadual - HSPE-FMO | Not yet recruiting |
| São Paulo, Brazil, 04039-004 | |
| Instituto do Cancer De Tres Lagoas | Not yet recruiting |
| Três Lagoas, Brazil, 79601-001 | |
| Instituto do Cancer De Tres Lagoas | Withdrawn |
| Três Lagoas, Brazil, 79603110 | |
| Bulgaria | |
| MHAT Deva Maria | Not yet recruiting |
| Burgas, Bulgaria, 8001 | |
| UMHAT 'Dr. Georgi Stranski', EAD | Not yet recruiting |
| Pleven, Bulgaria, 5800 | |
| Complex Oncology Center - Plovdiv EOOD | Not yet recruiting |
| Plovdiv, Bulgaria, 4004 | |
| Specialized Hospital for Active Treatment in Oncology EAD | Not yet recruiting |
| Sofia, Bulgaria, 1756 | |
| SHATOD 'Dr. Marko Antonov Markov' | Not yet recruiting |
| Varna, Bulgaria, 9010 | |
| Comprehensive Cancer Center | Not yet recruiting |
| Vratsa, Bulgaria, 3001 | |
| Canada, Alberta | |
| Southern Alberta Institute of Urology / Prostate Cancer Centre | Recruiting |
| Calgary, Alberta, Canada, T2V 1P9 | |
| Canada, British Columbia | |
| British Columbia Cancer Agency (BCCA) - Vancouver Centre | Recruiting |
| Vancouver, British Columbia, Canada, V5Z 4E6 | |
| British Columbia Cancer Agency - Vancouver Island Centre | Recruiting |
| Victoria, British Columbia, Canada, V8R 6V5 | |
| Canada, Ontario | |
| McMaster Institute of Urology | Recruiting |
| Hamilton, Ontario, Canada, L8N 4A6 | |
| Cancer Centre of Southeastern Ontario (Kingston Regional Cancer Centre) | Recruiting |
| Kingston, Ontario, Canada, K7L 3N6 | |
| Sunnybrook Health Sciences Center | Recruiting |
| Toronto, Ontario, Canada, M4N 3M5 | |
| University Health Network (UHN) Princess Margaret Cancer Centre | Recruiting |
| Toronto, Ontario, Canada, M5G 2M9 | |
| Canada, Quebec | |
| Centre de Recherche du CHUM | Recruiting |
| Montreal, Quebec, Canada, H2X 0A9 | |
| Canada, Saskatchewan | |
| Saskatoon Cancer Centre | Not yet recruiting |
| Saskatoon, Saskatchewan, Canada, S7N 4H4 | |
| China | |
| Cancer Hospital Chinese Academy of Medical Sciences | Not yet recruiting |
| Beijing, China, 100021 | |
| Peking University First Hospital | Not yet recruiting |
| Beijing, China, 100034 | |
| Beijing Friendship Hospital | Not yet recruiting |
| Beijing, China, 100050 | |
| Beijing Cancer Hospital of Peking University | Not yet recruiting |
| Beijing, China, 100142 | |
| Peking University Third Hospital | Not yet recruiting |
| Beijing, China, 100191 | |
| Beijing Hospital | Not yet recruiting |
| BeiJing, China, 100730 | |
| Sichuan Provincial People's Hospital | Not yet recruiting |
| Chengdu, China, 610072 | |
| Southwest Hospital, The Third Military Medical University | Not yet recruiting |
| Chongqing, China, 400025 | |
| Chongqing Cancer hospital | Not yet recruiting |
| Chongqing, China, 400030 | |
| Fujian Medical University Union Hospital | Not yet recruiting |
| Fuzhou, China, 350001 | |
| Sun Yat-Sen Memorial Hospital Sun Yat-sen University | Not yet recruiting |
| Guangzhou, China, 510120 | |
| Guangzhou First Municipal People's Hospital | Not yet recruiting |
| GuangZhou, China, 510180 | |
| The First Affiliated hospital of Anliui Medical University | Not yet recruiting |
| Hefei, China | |
| Nanjing Drum Tower Hospital | Not yet recruiting |
| Nanjing, China, 210008 | |
| Jiangsu Cancer Hospital | Not yet recruiting |
| Nanjing, China, 210009 | |
| Drug clinical trial ethics committee of Ningbo First Hospital | Not yet recruiting |
| Ningbo, China, 315010 | |
| Fudan University Shanghai Cancer Center | Not yet recruiting |
| Shanghai, China, 200032 | |
| Shanghai Zhongshan Hospital | Not yet recruiting |
| ShangHai, China, 200032 | |
| Huashan Hospital Fudan University | Not yet recruiting |
| Shanghai, China, 200040 | |
| ShangHai Huadong Hospital | Not yet recruiting |
| ShangHai, China, 200040 | |
| Renji Hospital, Shanghai Jiaotong University School of Medicine | Not yet recruiting |
| ShangHai, China, 200127 | |
| The Fifth People's Hospital of Shanghai, Fudan University | Not yet recruiting |
| ShangHai, China, 200240 | |
| The First Affiliated Hospital of Soochow University | Not yet recruiting |
| Suzhou, China, 215006 | |
| Tianjin Medical University Cancer Hospital | Not yet recruiting |
| Tianjin, China, 300060 | |
| The Central Hospital of Wuhan | Not yet recruiting |
| Wuhan, China, 430014 | |
| Tongji Hospital, Tongji Medical College of Huazhong University of Science and Technology | Not yet recruiting |
| Wuhan, China, 430030 | |
| Wuxi People's Hospital | Not yet recruiting |
| Wuxi, China, 214023 | |
| First Affiliated Hospital, Xi'an Jiaotong University | Not yet recruiting |
| Xi'an, China, 710061 | |
| Czechia | |
| Fakultni nemocnice Hradec Kralove | Recruiting |
| Hradec Králove, Czechia, 500 05 | |
| Krajská nemocnice Liberec | Recruiting |
| Liberec, Czechia, 460 63 | |
| Uromedical Center s.r.o. | Recruiting |
| Olomouc, Czechia, 77900 | |
| Multiscan s.r.o. | Recruiting |
| Pardubice, Czechia, 53203 | |
| Fakultni nemocnice Plzen, Urologicka klinika | Recruiting |
| Plzen, Czechia, 305 99 | |
| Urologicka klinika 1.LF UK a VFN | Recruiting |
| Praha 2, Czechia, 120 00 | |
| Thomayerova nemocnice, Onkologicka klinika | Recruiting |
| Praha 4, Czechia, 140 59 | |
| France | |
| CHRU De Besancon | Recruiting |
| Besancon, France, 25030 | |
| Institut Bergonié | Recruiting |
| Bordeaux, France, 33000 | |
| Centre Jean Perrin | Recruiting |
| Clermont Ferrand, France, 63011 | |
| Centre Leon Bérard | Recruiting |
| Lyon, France, 69008 | |
| Institut Regional du Cancer de Montpellier Val d'Aurelle | Not yet recruiting |
| Montpellier, France, 34298 | |
| Polyclinique de Gentilly | Recruiting |
| Nancy, France, 54100 | |
| Centre Antoine Lacassagne | Recruiting |
| Nice Cedex 2, France, 06189 | |
| Hopital Europeen Georges-Pompidou | Not yet recruiting |
| Paris Cedex 15, France, 75908 | |
| Institut de Cancérologie de l'Ouest (ICO) | Recruiting |
| Saint Herblain, France, 44805 | |
| HIA Begin | Recruiting |
| Saint Mande, France, 94163 | |
| Hôpitaux Universitaire de Strasbourg -CHU | Recruiting |
| Strasbourg, France, 67091 | |
| Germany | |
| Charite - Universitatsmedizin Berlin (CCM) | Not yet recruiting |
| Berlin, Germany, 12200 | |
| Städtisches Klinikum Braunschweig gGmbH - Standort Salzdahlumer | Recruiting |
| Braunschweig, Germany, 38126 | |
| Urologicum Duisburg | Recruiting |
| Duisburg, Germany, 47179 | |
| Universitätsklinikum des Saarlandes | Not yet recruiting |
| Homburg, Germany, 66424 | |
| Klinik und Poliklinik für Urologie | Not yet recruiting |
| Köln, Germany, 50937 | |
| Universitätsklinikum Otto-von-Guericke-Universität Magdeburg | Not yet recruiting |
| Magdeburg, Germany, 39120 | |
| Universitaetsklinikum Muenster | Not yet recruiting |
| Muenster, Germany, 48149 | |
| Studienpraxis Urologie Drs. Feyerabend | Recruiting |
| Nuertingen, Germany, 72622 | |
| Hungary | |
| Semmelweis Egyetem, Urológia Klinika | Recruiting |
| Budapest, Hungary, 1082 | |
| Országos Onkológiai Intézet, C Belgyógyászati-Onkológiai és Klinikai Farmakológiai Osztály | Recruiting |
| Budapest, Hungary, 1122 | |
| Szent János Kórház és Észak-budai Egyesített Kórházak | Withdrawn |
| Budapest, Hungary, 1125 | |
| Debreceni Egyetem Klinikai Kozpont | Recruiting |
| Debrecen, Hungary, 4032 | |
| Bekes Megyei Kozponti Korhaz Pandy Kalman Tagkorhaz | Recruiting |
| Gyula, Hungary, 5700 | |
| Szabolcs-Szatmar-Bereg Megyei Korhazak es Egyetemi Oktatokorhaz, Josa Andras Oktatokorhaz | Not yet recruiting |
| Nyiregyhaza, Hungary, 4400 | |
| Uro-Clin Kft. | Completed |
| Pécs, Hungary, 7621 | |
| Szegedi Tudomanyegyetem | Recruiting |
| Szeged, Hungary, 6725 | |
| Markusovszky Egyetemi Oktatokorhaz | Not yet recruiting |
| Szombathely, Hungary, 9700 | |
| Israel | |
| Asaf Harofe Medical Center | Recruiting |
| Beer Yaakov, Israel, 60930 | |
| Rambam Health Care Campus | Recruiting |
| Haifa, Israel, 31096 | |
| Rabin Medical Center | Recruiting |
| Petah Tikva, Israel, 49100 | |
| Sheba Medical Center Tel Hashomer | Recruiting |
| Ramat Gan, Israel, 52621 | |
| Italy | |
| AUSL Romagna - Ospedale di Faenza | Recruiting |
| Faenza, Italy, 48018 | |
| Ospedale San Raffaele | Recruiting |
| Milano, Italy, 20132 | |
| ASST Grande Ospedale Metropolitano Niguarda | Recruiting |
| Milano, Italy, 20162 | |
| Oncologia Medica A - Ist Naz Tumori G Pascale | Recruiting |
| Napoli, Italy, 80131 | |
| Istituto Oncologico Veneto Iov Irccs Padova | Recruiting |
| Padova, Italy, 35128 | |
| Oncologia Medica - Azienda Ospedaliero Universitaria Di Parma | Not yet recruiting |
| Parma, Italy, 43126 | |
| Ospedale S. Maria Della Misericordia Centro Operativo Studi Clinici SC Oncologia Medica | Recruiting |
| Perugia, Italy, 06132 | |
| Azienda Ospedaliero Universitaria Pisana | Recruiting |
| Pisa, Italy, 56126 | |
| Fondazione Policlinico Universitario A. Gemelli IRCCS | Recruiting |
| Roma, Italy, 00168 | |
| Campus Bio-Medico di Roma | Not yet recruiting |
| Roma, Italy, 128 | |
| Azienda Ospedaliera S. Maria Terni | Recruiting |
| Terni, Italy, 5100 | |
| A.O.U. Città della Salute e della Scienza | Recruiting |
| Torino, Italy, 10126 | |
| Ospedale Santa Chiara Trento | Recruiting |
| Trento, Italy, 38122 | |
| Korea, Republic of | |
| Pusan National University Hospital. | Recruiting |
| Busan, Korea, Republic of, 49241 | |
| Kyungpook National University Chilgok Hospital | Recruiting |
| Daegu, Korea, Republic of, 41404 | |
| Keimyung University Dongsan Hospital | Recruiting |
| Daegu, Korea, Republic of, 42601 | |
| Chungnam National University Hospital | Recruiting |
| Daejeon, Korea, Republic of, 35015 | |
| National Cancer Center | Recruiting |
| Goyang-Si, Korea, Republic of, 10408 | |
| Chonnam National University Hospital | Recruiting |
| Gwangju, Korea, Republic of, 61469 | |
| Seoul National University Bundang Hospital | Recruiting |
| Seongnam-si, Korea, Republic of, 13620 | |
| Seoul National University Hospital | Recruiting |
| Seoul, Korea, Republic of, 03080 | |
| Severance Hospital | Recruiting |
| Seoul, Korea, Republic of, 03722 | |
| Asan Medical Center | Recruiting |
| Seoul, Korea, Republic of, 05505 | |
| Gangnam Severance Hospital | Recruiting |
| Seoul, Korea, Republic of, 06273 | |
| Samsung Medical Center | Recruiting |
| Seoul, Korea, Republic of, 06351 | |
| Seoul St. Mary's Hospital | Recruiting |
| Seoul, Korea, Republic of, 06591 | |
| Ajou University Hospital | Recruiting |
| Suwon, Korea, Republic of, 443-721 | |
| Malaysia | |
| Hospital Pulau Pinang | Recruiting |
| George Town, Malaysia, 10990 | |
| Hospital Sultan Ismail | Recruiting |
| Johor Bahru, Malaysia, 81100 | |
| Hospital Likas | Recruiting |
| Kota Kinabalu, Malaysia, 88996 | |
| Hospital Kuala Lumpur | Recruiting |
| Kuala Lumpur, Malaysia, 53000 | |
| University Malaya Medical Centre | Recruiting |
| Kuala Lumpur, Malaysia, 59100 | |
| Sarawak General Hospital | Recruiting |
| Kuching, Malaysia, 93586 | |
| Mexico | |
| iBiomed Research Unit | Recruiting |
| Aguascalientes, Mexico, 20010 | |
| Mexico Centre for Clinical Research, S.A. de C.V. | Not yet recruiting |
| Ciudad de Mexico, Mexico, 03100 | |
| Consultorio de Especialidad en Urologia Privado | Recruiting |
| Durango, Mexico, 34000 | |
| Centro Medico Nacional Siglo XXI IMSS | Not yet recruiting |
| Mexico, Mexico, 06720 | |
| Avix Investigacion Clinica, S.C. | Not yet recruiting |
| Monterrey, Mexico, 64710 | |
| Consultorio Privado | Not yet recruiting |
| Zapopan, Mexico, 45040 | |
| Netherlands | |
| NKI-AVL, Amsterdam | Recruiting |
| Amsterdam, Netherlands, 1066 CX | |
| Universitair Medisch Centrum Groningen | Not yet recruiting |
| Groningen, Netherlands, 9713 GZ | |
| MC Haaglanden Lok Antoniushove - Afd.Interne - INT | Recruiting |
| Leidschendam, Netherlands, 2262 BA | |
| St. Antonius Ziekenhuis (St. Antonius Hospital) | Recruiting |
| Nieuwegein, Netherlands, 3430EM | |
| Canisius-Wilhelminaziekenhuis | Recruiting |
| Nijmegen, Netherlands, 6532 SZ | |
| Erasmus MC | Recruiting |
| Rotterdam, Netherlands, 3075 EA | |
| Zuyderland Medical Center | Recruiting |
| Sittard-Geleen, Netherlands, 6162 BG | |
| Poland | |
| Szpital Uniwersytecki NR 1 IM. Dr. Antoniego Jurasza | Recruiting |
| Bydgoszcz, Poland, 85-094 | |
| Centrum Onkologii im. Prof. F. Lukaszczyka | Recruiting |
| Bydgoszcz, Poland, 85-796 | |
| Uniwersyteckie Centrum Kliniczne | Recruiting |
| Gdańsk, Poland, 80-214 | |
| Szpitale Pomorskie Sp. z o.o. | Recruiting |
| Gdynia, Poland, 81-519 | |
| Wojewodzki Szpital Specjalistyczny im. M. Kopernika w Lodzi | Recruiting |
| Lodz, Poland, 93-509 | |
| Wielkopolskie Centrum Onkologii | Withdrawn |
| Poznan, Poland, 61-866 | |
| Urologica Praktyka Lekarska Adam Marcheluk | Recruiting |
| Siedlce, Poland, 08-110 | |
| Pomorski Uniwersytet Medyczny w Szczecinie | Not yet recruiting |
| Szczecin, Poland, 70-111 | |
| Szpital Św. Elżbiety Mokotowskie Centrum Medyczne | Withdrawn |
| Warszawa, Poland, 02-616 | |
| Centrum Onkologii - Instytut im. M. Sklodowskiej-Curie | Recruiting |
| Warszawa, Poland, 02‐781 | |
| Dolnoslaskie Centrum Onkologii | Recruiting |
| Wrocław, Poland, 53-413 | |
| Portugal | |
| Hospitais da universidade de Coimbra | Not yet recruiting |
| Coimbra, Portugal, 3000-075 | |
| Instituto Português de Oncologia de Coimbra Francisco Gentil, EPE | Not yet recruiting |
| Coimbra, Portugal, 3000-075 | |
| Centro Hospitalar Lisboa Norte, EPE/Hosp. Santa Maria | Not yet recruiting |
| Lisboa, Portugal, 1649-035 | |
| Champalimaud Foundation Champalimaud Centre | Not yet recruiting |
| Lisbon, Portugal, 1400-038 | |
| H. Santo António - Centro Hospitalar do Porto | Not yet recruiting |
| Porto, Portugal, 4099-001 | |
| Puerto Rico | |
| VA Caribbean Healthcare System | Not yet recruiting |
| San Juan, Puerto Rico, 00921 | |
| Russian Federation | |
| Altai Regional Oncology Dispensary | Recruiting |
| Barnaul, Russian Federation, 656045 | |
| Ivanovo Regional Oncology Dispensary | Recruiting |
| Ivanovo, Russian Federation, 153040 | |
| Naval Clinical Hospital | Not yet recruiting |
| Kaliningrad, Russian Federation, 236029 | |
| State Health Establishment Kursk Regional Oncology Dispensary | Not yet recruiting |
| Kursk, Russian Federation, 305035 | |
| Russian Scientific Center of Roentgenoradiology | Recruiting |
| Moscow, Russian Federation, 117997 | |
| Moscow City Clinical Hospital # 62 | Recruiting |
| Moscow, Russian Federation, 125130 | |
| Clinical Diagnostic Centre of Nizhny Novgorod Region | Recruiting |
| Nizhny Novgorod, Russian Federation, 603000 | |
| Clinical Oncology Dispensary | Recruiting |
| Omsk, Russian Federation, 644013 | |
| LLC Novaya Clinica | Recruiting |
| Pyatigorsk, Russian Federation, 357500 | |
| Pyatigorsk Regional Oncology Dispensary | Recruiting |
| Pyatigorsk, Russian Federation, 357502 | |
| Private Medical Institution Euromedservice | Recruiting |
| Saint Petersburg, Russian Federation, 196603 | |
| Leningrad Regional Oncology Dispensary | Not yet recruiting |
| Saint-Petersburg, Russian Federation, 191104 | |
| Russian Scientific Center of Radiology and Surgical Technologies | Not yet recruiting |
| Saint-Petersburg, Russian Federation, 197758 | |
| Republican Oncology Dispensary | Not yet recruiting |
| Saransk, Russian Federation, 430032 | |
| Oncologic Dispensary No.2 | Recruiting |
| Sochi, Russian Federation, 354057 | |
| Tambov Regional Oncology Clinical Dispansary | Recruiting |
| Tambov, Russian Federation, 392013 | |
| Tomsk Cancer Research Institute | Recruiting |
| Tomsk, Russian Federation, 634050 | |
| Medical-sanitary unit 'Neftyanik' | Recruiting |
| Tyumen, Russian Federation, 625000 | |
| Vologda Regional Oncological Dispensary | Recruiting |
| Vologda, Russian Federation, 160012 | |
| South Africa | |
| Clinresco Centres Pty Ltd | Recruiting |
| Johannesburg, South Africa, 1619 | |
| Clinical Research Unit | Recruiting |
| Pretoria, South Africa, 0001 | |
| East Rand Urology Research Unit | Withdrawn |
| Vosloorus, South Africa, 1475 | |
| Spain | |
| Hosp. Del Mar | Recruiting |
| Barcelona, Spain, 08003 | |
| Hosp. de La Santa Creu I Sant Pau | Recruiting |
| Barcelona, Spain, 08025 | |
| Hosp. Clinic I Provincial de Barcelona | Not yet recruiting |
| Barcelona, Spain, 08036 | |
| Hospital Juan Canalejo | Recruiting |
| Coruña, Spain, 15006 | |
| Hosp. de Jerez de La Frontera | Recruiting |
| Jerez de la Frontera, Spain, 11407 | |
| Hosp. Gral. Univ. Gregorio Maranon | Not yet recruiting |
| Madrid, Spain, 28007 | |
| Hosp. Univ. Ramon Y Cajal | Recruiting |
| Madrid, Spain, 28034 | |
| Hosp. Clinico San Carlos | Not yet recruiting |
| Madrid, Spain, 28040 | |
| Hosp. Virgen de La Victoria | Not yet recruiting |
| Málaga, Spain, 29010 | |
| Hosp. Quiron Madrid Pozuelo | Recruiting |
| Pozuelo de Alarcon, Spain, 28223 | |
| Corporacio Sanitari Parc Tauli | Recruiting |
| Sabadell, Spain, 08208 | |
| Hosp. Univ. Marques de Valdecilla | Recruiting |
| Santander, Spain, 39008 | |
| Hosp. Univ. I Politecni La Fe | Recruiting |
| Valencia, Spain, 46026 | |
| Sweden | |
| Södersjukhuset | Not yet recruiting |
| Stockholm, Sweden, 11861 | |
| Karolinska Universitetssjukhuset Solna | Recruiting |
| Stockholm, Sweden, 17176 | |
| Akademiska Sjukhuset | Recruiting |
| Uppsala, Sweden, 751 85 | |
| Taiwan | |
| Kaohsiung Medical University Chung-Ho Memorial Hospital | Recruiting |
| Kaohsiung, Taiwan, 807 | |
| China Medical University Hospital | Recruiting |
| Taichung, Taiwan, 403 | |
| Taichung Veterans General Hospital | Recruiting |
| Taichung, Taiwan, 40705 | |
| Tungs' Taichung MetroHarbor Hospital | Recruiting |
| Taichung, Taiwan, 435 | |
| Chi Mei Medical Center - Yong Kang | Recruiting |
| Tainan, Taiwan, 710 | |
| National Taiwan University Hospital | Recruiting |
| Taipei, Taiwan, 100 | |
| Taipei Veterans General Hospital | Recruiting |
| Taipei, Taiwan, 11217 | |
| Chang Gung Memorial Hospital | Recruiting |
| Taoyuan, Taiwan, 33305 | |
| Turkey | |
| Cukurova University, Faculty of Medicine | Recruiting |
| Adana, Turkey, 01330 | |
| Dr.Abdurrahman Yurtaslan Oncology Training and Research Hospital | Recruiting |
| Ankara, Turkey, 06200 | |
| Ankara Sehir Hastanesi | Recruiting |
| Ankara, Turkey, 6560 | |
| Akdeniz University Medical Faculty | Recruiting |
| Antalya, Turkey, 07070 | |
| Trakya University Medical Faculty | Recruiting |
| Edirne, Turkey, 22030 | |
| Istanbul University Cerrahpasa Medical Faculty | Recruiting |
| Istanbul, Turkey, 34096 | |
| Bakirkoy Training and Research Hospital | Recruiting |
| Istanbul, Turkey, 34147 | |
| Istanbul Medeniyet University Goztepe Training and Research Hospital | Recruiting |
| Istanbul, Turkey, 34722 | |
| Izmır Medical Park Hospital | Recruiting |
| Izmir, Turkey, 35575 | |
| Kocaeli University Medical Faculty | Recruiting |
| Kocaeli, Turkey, 41380 | |
| Ukraine | |
| Communal Nonprofit Enterprise 'Cherkasy Regional Oncology Dispensary Of Cherkasy Regional Council' | Recruiting |
| Cherkasy, Ukraine, 18009 | |
| Dnipropetrovsk State Medical Academy, Dnipropetrovk State Clinical Hospital NA Mechnikov I.I. | Recruiting |
| Dnipo, Ukraine, 49005 | |
| Municipal Institution 'Clinical Oncology Dispensary' Under Dnipropetrovsk Regional Council | Recruiting |
| Dnipro, Ukraine, 49100 | |
| Dnipropetrovsk State Medical Academy, Dnipropetrovsk City Multifield Clinical Hospital # 4 | Recruiting |
| Dnipro, Ukraine, 49102 | |
| Ivano-Frankivsk Regional Clinical Hospital | Recruiting |
| Ivano-Frankivsk, Ukraine, 76008 | |
| Municipal non-profit enterprise 'Regional Center of Oncology' | Recruiting |
| Khakhiv, Ukraine, 61070 | |
| Regional Clinical Center of Urology and Nephrology n.a. V.I. Shapoval | Recruiting |
| Kharkiv, Ukraine, 61037 | |
| State Institution National Cancer Institute | Recruiting |
| Kyiv, Ukraine, 03022 | |
| State Institution Institute of Urology NAMS of Ukraine based on Kyiv City Clinical Oncology Center | Recruiting |
| Kyiv, Ukraine, 03115 | |
| Communal Noncommercial Enterprise of Lviv Regional Council 'Lviv Regional Clinical Hospital' | Recruiting |
| Lviv, Ukraine, 79031 | |
| ME 'Poltava Regional Clinical Hospital n.a. M.V. Sklifosovsky of the Poltava Regional Council' | Recruiting |
| Poltava, Ukraine, 36024 | |
| Municipal Oncology Centre of Uzhgorod Central Municipal Clinical Hospitlal | Recruiting |
| Uzhgorod, Ukraine, 88000 | |
| Zaporizhzhia medical Academy of postgraduate education, Zaporizhzhia Regoinal Clinical Hospital | Not yet recruiting |
| Zaporizhzhya, Ukraine, 69600 | |
| United Kingdom | |
| Royal Blackburn Hospital | Recruiting |
| Blackburn, United Kingdom, BB2 3HH | |
| Royal Lancaster Infirmary | Recruiting |
| Lancaster, United Kingdom, LA1 4RP | |
| UCL Cancer Institute | Recruiting |
| London, United Kingdom, WC1E 6DD | |
| Torbay Hospital-Devon | Recruiting |
| Torquay, United Kingdom, TQ2 7AA | |
| Royal Cornwall Hospitals NHS Trust - Royal Cornwall Hospital | Recruiting |
| Truro, United Kingdom, TR1 3LJ | |
| New Cross Hospital | Recruiting |
| Wolverhampton, United Kingdom, WV10 0QP | |
Sponsors and Collaborators
Janssen Research & Development, LLC
Investigators
| Study Director: | Janssen Research & Development, LLC Clinical Trial | Janssen Research & Development, LLC |
Additional Information:
| Responsible Party: | Janssen Research & Development, LLC |
| ClinicalTrials.gov Identifier: | NCT03748641 History of Changes |
| Other Study ID Numbers: |
CR108534 2017-003364-12 ( EudraCT Number ) 64091742PCR3001 ( Other Identifier: Janssen Research & Development, LLC ) |
| First Posted: | November 21, 2018 Key Record Dates |
| Last Update Posted: | October 31, 2019 |
| Last Verified: | October 2019 |
| Studies a U.S. FDA-regulated Drug Product: | Yes |
| Studies a U.S. FDA-regulated Device Product: | No |
Additional relevant MeSH terms:
|
Prostatic Neoplasms Genital Neoplasms, Male Urogenital Neoplasms Neoplasms by Site Neoplasms Genital Diseases, Male Prostatic Diseases Prednisone Abiraterone Acetate Niraparib Anti-Inflammatory Agents Glucocorticoids |
Hormones Hormones, Hormone Substitutes, and Hormone Antagonists Physiological Effects of Drugs Antineoplastic Agents, Hormonal Antineoplastic Agents Steroid Synthesis Inhibitors Enzyme Inhibitors Molecular Mechanisms of Pharmacological Action Hormone Antagonists Cytochrome P-450 Enzyme Inhibitors Poly(ADP-ribose) Polymerase Inhibitors |