Sprint Interval Training in Patients With Chronic Obstructive Lung Disease

• ClinicalTrials.gov Identifier: NCT03735615
• Recruitment Status: Completed
• First Posted: November 8, 2018
• Last Update Posted: January 13, 2020
• Sponsor: Norwegian University of Science and Technology
• Information provided by (Responsible Party): Norwegian University of Science and Technology

Study Description

Brief Summary:

Exercise therapy is a cornerstone in the management of patients with Chronic Obstructive Pulmonary disease (COPD), and supervised walking exercise three times a week over 12 weeks improves walking ability and quality of life. Despite this, very few patients exercise on a regular basis. The underuse of exercise in COPD patients can partly be explained by discomfort during exercise because it evokes dyspnea, and thereby explain lack of participation in exercise. If the goal is to offer the best medical therapy to these patients, new and effective exercise training methods must be explored and defined since exercise training is an important part of pulmonary rehabilitation.

Intention is to study a new training method called sprint interval training (SIT), which consists of high intensity bouts with very short duration. The idea behind SIT is to avoid the dyspnea associated with traditional endurance training, thus maximizing exercise power without excessive discomfort. The investigators will study training adaptations in patients with COPD and compare the results with age-matched controls.

It is expected that both COPD-patients and healthy elderly will improve exercise cycle time until exhaustion after SIT training, and also that the improvement will be larger in the healthy group due to higher absolute training intensity.

Condition or disease	Intervention/treatment	Phase
Pulmonary Disease, Chronic Obstructive	Behavioral: sprint interval training	Not Applicable

Study Design

• Study Type: Interventional (Clinical Trial)
• Actual Enrollment: 20 participants
• Allocation: Non-Randomized
• Intervention Model: Parallel Assignment
• Intervention Model Description: 10 patients with stable chronic obstructive lung disease (COPD) stage 3 and 4 according to GOLD guidelines (www.goldcopd.org), recruited from outpatient ward of the Lung Department at St Olav University Hospital. Control group of 10 age-matched but otherwise healthy subjects
• Masking: None (Open Label)
• Primary Purpose: Treatment
• Official Title: Sprint Interval Training in Patients With Chronic Obstructive Lung Disease
• Actual Study Start Date: November 15, 2018
• Actual Primary Completion Date: March 10, 2019
• Actual Study Completion Date: March 10, 2019

Arms and Interventions

Arm	Intervention/treatment
Experimental: chronic obstructive lung disease	Behavioral: sprint interval training; Each training session will be performed 3 times per week for 3 weeks. Each session consists of 3-5x20 sec all-out cycling efforts against a load corresponding to 0.05-0.07 kg/kg body mass, separated by 3-5 min of low intensity cycling (20-50 W), on a lode bicycle ergometer (Excalibur Sport V2.0, Groningen, the Netherlands). All training sessions includes a 5 min warm-up and 3 min cool-down.
Experimental: healthy control	Behavioral: sprint interval training; Each training session will be performed 3 times per week for 3 weeks. Each session consists of 3-5x20 sec all-out cycling efforts against a load corresponding to 0.05-0.07 kg/kg body mass, separated by 3-5 min of low intensity cycling (20-50 W), on a lode bicycle ergometer (Excalibur Sport V2.0, Groningen, the Netherlands). All training sessions includes a 5 min warm-up and 3 min cool-down.

Outcome Measures

Primary Outcome Measures :

1. exercise cycle time to exhaustion [ Time Frame: 3 weeks ]

Eligibility Criteria

• Ages Eligible for Study: 50 Years and older (Adult, Older Adult)
• Sexes Eligible for Study: All
• Accepts Healthy Volunteers: No

Criteria

Inclusion Criteria (patients):

• stable CPOD stage 3 and 4 according to GOLD guidelines (www.goldcopd.org)
• post bronchodilator FEV < 50%

Exclusion Criteria:

• having participated in a pulmonary rehabilitation program during the last 3 months.

Contacts and Locations

Locations

Norway

St Olavs University Hospital

Trondheim, Norway

Sponsors and Collaborators

Norwegian University of Science and Technology

Investigators

• Study Director: Øystein Risa, phd; Norwegian University of Science and Technology

More Information

• Responsible Party: Norwegian University of Science and Technology
• ClinicalTrials.gov Identifier: NCT03735615
• Other Study ID Numbers: 2018/723
• First Posted: November 8, 2018
• Last Update Posted: January 13, 2020
• Last Verified: January 2020

Individual Participant Data (IPD) Sharing Statement:

• Plan to Share IPD: No

• Studies a U.S. FDA-regulated Drug Product: No
• Studies a U.S. FDA-regulated Device Product: No

Keywords provided by Norwegian University of Science and Technology:

Exercise therapy; High-Intensity Interval Training

Additional relevant MeSH terms:

Lung Diseases; Pulmonary Disease, Chronic Obstructive; Lung Diseases, Obstructive; Respiratory Tract Diseases