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Power Production in Older Adults With Knee Osteoarthritis

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ClinicalTrials.gov Identifier: NCT03680807
Recruitment Status : Completed
First Posted : September 21, 2018
Last Update Posted : February 8, 2019
Sponsor:
Information provided by (Responsible Party):
Evelien Van Roie, KU Leuven

Study Description
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Brief Summary:
Knee osteoarthritis is an important cause of functional disabilities at old age. Previous research has demonstrated that individuals with knee osteoarthritis have reduced knee-extensor strength in comparison to healthy individuals. However, rapid power production declines more than strength as a consequence of ageing and is more predictive of functional capacity. However, limited research has investigated whether individuals with knee osteoarthritis have reduced ability to develop strength and power rapidly on top of reduced maximal strength capacities, which is the primary aim of the current study.

Condition or disease Intervention/treatment
Osteo Arthritis Knee Diagnostic Test: Muscle function test

Study Design
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Study Type : Observational
Actual Enrollment : 48 participants
Observational Model: Case-Control
Time Perspective: Cross-Sectional
Official Title: Power Production in Older Adults With Knee Osteoarthritis Compared to Healthy Counterparts
Actual Study Start Date : September 1, 2018
Actual Primary Completion Date : December 20, 2018
Actual Study Completion Date : December 20, 2018

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Osteoarthritis

Groups and Cohorts
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Group/Cohort Intervention/treatment
Older adults with knee osteoarthritis (>50 years) Diagnostic Test: Muscle function test
Power and strength tests of the knee-extensor muscles, handgrip strength, functional capacity tests
Healthy older adults (> 50 years) Diagnostic Test: Muscle function test
Power and strength tests of the knee-extensor muscles, handgrip strength, functional capacity tests


Outcome Measures
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Primary Outcome Measures :
  1. Rate of power development [ Time Frame: up to 3 months ]
    Subjects perform a test protocol on a Biodex dynamometer, consisting of isotonic contractions of the leg-extensor muscles. Subjects are instructed to kick as fast as possible against different (relative) loads. The rate of power development (watt/s) is defined as the linear slope of the power-time curve and is measured from the onset of movement till peak power.


Secondary Outcome Measures :
  1. Maximal isometric strength [ Time Frame: up to 3 months ]
    Maximal strength (Nm) is measured by means of unilateral isometric knee-extensor tests on a Biodex dynamometer.

  2. Maximal isokinetic strength [ Time Frame: up to 3 months ]
    Maximal strength (Nm) is measured by means of unilateral isokinetic knee-extensor tests on a Biodex dynamometer.

  3. Stair Climbing performance [ Time Frame: up to 3 months ]
    Stair ascent duration (in s), the time needed to ascent a flight of stairs.

  4. Gait speed [ Time Frame: up to 3 months ]
    The average speed to walk 10m as fast as possible (in m/s).

  5. 5 repetition sit-to-stand test [ Time Frame: up to 3 months ]
    The time needed to perform 5 sit-to-stand transitions (in s).

  6. Timed-up-and-go [ Time Frame: up to 3 months ]
    The time needed to stand up from a chair, walk 3m, turn, walk back and sit down.

  7. Handgrip strength [ Time Frame: up to 3 months ]
    Handgrip strength (kg) evaluated with Jamar dynamometer.


Eligibility Criteria
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Ages Eligible for Study:   50 Years to 80 Years   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
Adults between 50 and 80 years with or without knee osteoarthritis. Subjects are sedentary or recreationally active.
Criteria

Inclusion Criteria:

Group with knee osteoarthritis:

- Diagnosed with knee osteoarthritis based on RX.

Exclusion Criteria:

Healthy group:

  • Systematic engagement in (resistance) exercise in the 12-months prior to participation
  • Cardiovascular disease
  • Neurological disorders
  • Cognitive malfunctioning
  • Severe knee or hip problems

Group with knee osteoarthritis:

  • Systematic engagement in (resistance) exercise in the 12-months prior to participation
  • Cardiovascular disease
  • Neurological disorders
  • Cognitive malfunctioning
  • Severe hip problems
Contacts and Locations
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Top of Page Study Description Study Design Groups and Cohorts Outcome Measures Eligibility Criteria Contacts and Locations More Information

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT03680807


Locations
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Belgium
Department of Movement Sciences
Leuven, Belgium, 3001
Sponsors and Collaborators
KU Leuven
More Information
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Top of Page Study Description Study Design Groups and Cohorts Outcome Measures Eligibility Criteria Contacts and Locations More Information
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Responsible Party: Evelien Van Roie, Dr., KU Leuven
ClinicalTrials.gov Identifier: NCT03680807    
Other Study ID Numbers: S60595
First Posted: September 21, 2018    Key Record Dates
Last Update Posted: February 8, 2019
Last Verified: February 2019
Individual Participant Data (IPD) Sharing Statement:
Plan to Share IPD: No

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Studies a U.S. FDA-regulated Drug Product: No
Studies a U.S. FDA-regulated Device Product: No
Keywords provided by Evelien Van Roie, KU Leuven:
Knee osteoarthritis
power production
functional capacity
Additional relevant MeSH terms:
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Osteoarthritis
Osteoarthritis, Knee
Arthritis
 Joint Diseases
Musculoskeletal Diseases
Rheumatic Diseases