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Hearing Study: Sensitivity to Features of Speech Sounds

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ClinicalTrials.gov Identifier: NCT03666676
Recruitment Status : Recruiting
First Posted : September 12, 2018
Last Update Posted : November 17, 2021
Sponsor:
Collaborator:
National Institute on Deafness and Other Communication Disorders (NIDCD)
Information provided by (Responsible Party):
Laurel Carney, University of Rochester

Study Description
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Brief Summary:
The purpose of this study is to better understand the sensitivity of listeners to the fast changes in frequency or amplitude of sounds that occur in speech. The investigators are studying ways to manipulate these aspects of sounds in an effort to make speech sounds more clear.

Condition or disease Intervention/treatment Phase
Hearing Loss, Sensorineural Other: Signal processing to improve intelligibility Not Applicable

Detailed Description:
The investigators will test listeners with normal hearing or with mild or moderate hearing loss. Tests will first focus on sensitivity to changes in fast changes in amplitude (loudness) or frequency (pitch) in sounds. Then the investigators will test the intelligibility of synthetic vowels and syllables in which these "chirps" are manipulated. Finally, the investigators will test intelligibility of words in noise while manipulating sounds in an effort to improve clarity.
Study Design
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Study Type : Interventional  (Clinical Trial)
Estimated Enrollment : 200 participants
Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)
Primary Purpose: Basic Science
Official Title: Auditory Processing of Complex Sounds - Sensitivity to Chirps
Actual Study Start Date : June 9, 2020
Estimated Primary Completion Date : November 30, 2023
Estimated Study Completion Date : November 30, 2023

Resource links provided by the National Library of Medicine


Arms and Interventions
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Arm Intervention/treatment
Active Comparator: Normal Hearing
Signal processing to improve intelligibility
 Other: Signal processing to improve intelligibility
Signal processing will be used to manipulate frequency and amplitude fluctuations in complex sounds.
Active Comparator: Mild hearing loss
Signal processing to improve intelligibility
 Other: Signal processing to improve intelligibility
Signal processing will be used to manipulate frequency and amplitude fluctuations in complex sounds.
Active Comparator: Moderate hearing loss
Signal processing to improve intelligibility
 Other: Signal processing to improve intelligibility
Signal processing will be used to manipulate frequency and amplitude fluctuations in complex sounds.


Outcome Measures
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Primary Outcome Measures :
  1. Discrimination thresholds for formant-freq difference limens [ Time Frame: 5 years ]
    Measures of discrimination thresholds (in units of "% of Formant Frequency" at the discrimination threshold) for different formant bandwidths and for different alignments of formants and harmonics.


Secondary Outcome Measures :
  1. % of correct synthetic vowels [ Time Frame: 5 years ]
    % correct answers

  2. % of correct synthetic syllables [ Time Frame: 5 years ]
    % correct answers

  3. % of correct words [ Time Frame: 5 years ]
    % correct answers using SPiN test


Eligibility Criteria
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Ages Eligible for Study:   18 Years to 80 Years   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • Normal hearing, mild or moderate symmetric sensorineural hearing loss.

Exclusion Criteria:

  • Asymmetric hearing thresholds (more than 15 decibels (dB) threshold difference between the two ears at any frequency up to 4 kHz).
  • Severe hearing loss (greater than 60 dB hearing thresholds at any frequency up to 4 kHz).
Contacts and Locations
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Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT03666676


Contacts
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Contact: Laurel H Carney 5852763948 laurel.carney@rochester.edu

Locations
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United States, New York
University of Rochester Recruiting
Rochester, New York, United States, 14642
Contact: Laurel Carney    585-276-3948    laurel.carney@rochester.edu   
Sponsors and Collaborators
University of Rochester
National Institute on Deafness and Other Communication Disorders (NIDCD)
More Information
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Top of Page Study Description Study Design Arms and Interventions Outcome Measures Eligibility Criteria Contacts and Locations More Information
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Responsible Party: Laurel Carney, Professor, University of Rochester
ClinicalTrials.gov Identifier: NCT03666676    
Other Study ID Numbers: 73346
R01DC001641 ( U.S. NIH Grant/Contract )
First Posted: September 12, 2018    Key Record Dates
Last Update Posted: November 17, 2021
Last Verified: November 2021
Individual Participant Data (IPD) Sharing Statement:
Plan to Share IPD: No

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Studies a U.S. FDA-regulated Drug Product: No
Studies a U.S. FDA-regulated Device Product: No
Additional relevant MeSH terms:
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Hearing Loss
Hearing Loss, Sensorineural
Hearing Disorders
Ear Diseases
 Otorhinolaryngologic Diseases
Sensation Disorders
Neurologic Manifestations
Nervous System Diseases