Initiation of Adapted Physical Activity for Patients With Advanced Pediatric Malignancies
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| ClinicalTrials.gov Identifier: NCT03659968 |
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Recruitment Status : Unknown
Verified September 2018 by Assistance Publique Hopitaux De Marseille.
Recruitment status was: Not yet recruiting
First Posted : September 6, 2018
Last Update Posted : September 6, 2018
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Adapted physical activity (APA) in the context of cancer is a field of growing interest and has been explored in numerous publications. In adults, the effects of APA on survival, symptoms and quality of life are established and its physiological consequences on immunity, angiogenesis and hormone secretion are under investigation.
In children and adolescents, evidence is scarce: pilot studies show clinical benefit of physical activity practiced in a wide variety of situations and protocols with low level of scientific evidence. It is therefore not possible to recommend this practice in pediatrics despite the large number of initiatives and the conviction of many clinicians that there is a benefit for patients. In particular, there are few trials in children with advanced cancer pathologies or in palliative care. However, these patients have a high prevalence of severe symptoms (pain, digestive disorders, asthenia, and anxiety) for which physical activity may represent a therapeutic option.
The purpose of our study is to describe a protocol of adapted physical activity and to evaluate its feasibility and toxicity according to a well-known and validated methodology in oncology used in drug development.
Methodology is based on a simple and reproducible intervention combining brisk walking on treadmill and exercises of muscular strengthening with varying durations and intensities depending on physical capabilities of patients.
The primary objective is to define the volume of physical activity that can be proposed to a patient starting APA based on the assessment of his physical condition evaluated by a 6-minutes walking distance test.
Inclusion criteria are broad to allow study population to represent the diversity of patients in pediatric palliative oncology. Stratification of patients in three groups based on a 6-minutes walking distance test aims to adapt intervention to physical capability of patients and improve tolerance.
Dose escalation will be set with a "3 + 3" regimen used in drug early phases trials.
Primary outcome measure is perceived tolerance evaluated by the patient with a subjective scoring on CREST scale. Any score greater than 8/10 defines intolerance.
| Condition or disease | Intervention/treatment | Phase |
|---|---|---|
| Pediatric Cancer | Other: Physical activity training | Not Applicable |
Adapted physical activity (APA) in the context of cancer is a field of growing interest and has been explored in numerous publications. In adults, the effects of APA on survival, symptoms and quality of life are established and its physiological consequences on immunity, angiogenesis and hormone secretion are under investigation.
In children and adolescents, evidence is scarce: pilot studies show clinical benefit of physical activity practiced in a wide variety of situations and protocols with low level of scientific evidence. It is therefore not possible to recommend this practice in pediatrics despite the large number of initiatives and the conviction of many clinicians that there is a benefit for patients. In particular, there are few trials in children with advanced cancer pathologies or in palliative care. However, these patients have a high prevalence of severe symptoms (pain, digestive disorders, asthenia, and anxiety) for which physical activity may represent a therapeutic option.
The purpose of our study is to describe a protocol of adapted physical activity and to evaluate its feasibility and toxicity according to a well-known and validated methodology in oncology used in drug development.
Methodology is based on a simple and reproducible intervention combining brisk walking on treadmill and exercises of muscular strengthening with varying durations and intensities depending on physical capabilities of patients.
The primary objective is to define the volume of physical activity that can be proposed to a patient starting APA based on the assessment of his physical condition evaluated by a 6-minutes walking distance test.
Inclusion criteria are broad to allow study population to represent the diversity of patients in pediatric palliative oncology. Stratification of patients in three groups based on a 6-minutes walking distance test aims to adapt intervention to physical capability of patients and improve tolerance.
Dose escalation will be set with a "3 + 3" regimen used in drug early phases trials.
Primary outcome measure is perceived tolerance evaluated by the patient with a subjective scoring on CREST scale. Any score greater than 8/10 defines intolerance.
Secondary objectives include the description of tolerance during sessions with shortness of breath and pain scores, the comparison of objective (HR) and perceived measures, and the study of patient's characteristics and medical history as confusion factors.
The evolution of the patient's physical capability will be evaluated at the end of the study. The continuation of physical activity beyond the duration of participation will be documented. The impact on pathology-related symptoms and quality of life will be reported.
| Study Type : | Interventional (Clinical Trial) |
| Estimated Enrollment : | 23 participants |
| Allocation: | N/A |
| Intervention Model: | Single Group Assignment |
| Masking: | None (Open Label) |
| Primary Purpose: | Other |
| Official Title: | Phase I Dose-escalation Study of Adapted Physical Activity in Children and Adolescent Suffering From Advanced Malignancies. |
| Estimated Study Start Date : | December 2018 |
| Estimated Primary Completion Date : | May 2020 |
| Estimated Study Completion Date : | January 2021 |
| Arm | Intervention/treatment |
|---|---|
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Experimental: EXPERIMENTAL GROUP
patients in advanced phase of pediatric cancer Physical activity training will be performed in drug development
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Other: Physical activity training
brisk walking on treadmill and exercises of muscular strengthening with varying durations and intensities depending on physical capabilities of patients |
- Perceived tolerance [ Time Frame: 6 weeks ]Evaluated by the patient with a subjective scoring on scale (from 0 to 10). Any score greater than 8/10 define intolerance. Any score under 8/10 definite "acceptable tolerance"
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| Ages Eligible for Study: | 5 Years to 17 Years (Child) |
| Sexes Eligible for Study: | All |
| Accepts Healthy Volunteers: | No |
Inclusion Criteria:
- Patients aged from 5 to 17 years old.
- Cancer with no curative therapeutic options.
- Stable disease (with or without treatment).
- Ability to complete 100 meters walking without help and muscular strengthening exercises.
- Written informed consent, including agreement of parents or legal guardian for minors.
Exclusion Criteria:
- Participation to another Phase I trial
- Dyspnoea exertional
- Cardio-vascular pathology
- Life expectancy of less than 3 months
- Progressive disease
- Expected inability to comply to medical follow up
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT03659968
| Contact: GABRIEL REVON RIVIERE, MD | +33 491385541 | Gabriel.REVON-RIVIERE@ap-hm.fr |
| France | |
| Assiatnce Publique Des Hopitaux de Marseille | |
| Marseille, Paca, France, 13354 | |
| Contact: GABRIEL REVOBN RIVIERE, MD +33 491385541 Gabriel.REVON-RIVIERE@ap-hm.fr | |
| Study Director: | EMILIE GARRIDO PRADALIE | APHM |
| Responsible Party: | Assistance Publique Hopitaux De Marseille |
| ClinicalTrials.gov Identifier: | NCT03659968 |
| Other Study ID Numbers: |
2017-70 |
| First Posted: | September 6, 2018 Key Record Dates |
| Last Update Posted: | September 6, 2018 |
| Last Verified: | September 2018 |
| Studies a U.S. FDA-regulated Drug Product: | No |
| Studies a U.S. FDA-regulated Device Product: | No |
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Neoplasms |