Functional Exercise Response on osteoArthritis Relaxation Imaging (FERARI)

• ClinicalTrials.gov Identifier: NCT03657303
• Recruitment Status: Active, not recruiting
• First Posted: September 5, 2018
• Last Update Posted: February 28, 2022
• Sponsor: Cambridge University Hospitals NHS Foundation Trust
• Information provided by (Responsible Party): Professor Fiona J Gilbert, Cambridge University Hospitals NHS Foundation Trust

Study Description

Brief Summary:

Osteoarthritis (OA) is the most prevalent cause of mobility impairment and disability in the elderly. Indications at early stages of OA include decreased organisation of the collagen matrix, loss of proteoglycans and increased hydration. Late-stage joint disease can be diagnosed with X-ray, CT, and conventional MRI, but there are no validated methods to image early changes in cartilage microstructure, which are direly needed in early phase clinical development. Newly developed therapies and evaluation techniques are required at earlier stages of disease to offset the growing numbers and costs of end-stage disease.

MRI can probe soft-tissue with physical measurements that are not available through other methods. Quantitative MRI signal relaxation properties are particularly promising for assessing early changes in the cartilage composition. These relaxation properties are sensitive to water content and cartilage macromolecular structure.

Mechanical joint-loading and exercise affects quantitative MRI through cartilage compression and nonuniform deformation. A study measuring MRI relaxation times and using static joint-loading weights has shown differences between OA and healthy subjects. Cartilage volume, which is expected to be related to these relaxation times, recovers within an hour after exercise in healthy runners, with the menisci lagging in their volume recovery rate. Previous exercise studies have not measured post-exercise cartilage recovery using compositional techniques, such as physiologically-sensitive T1ρ and T2, nor probed compositional responses with OA subjects.

The investigators will examine a single knee of an initial 18 participants with MR. Participants will be drawn from two groups: (1) 12 participants aged 40-60 years old with clinical and x-ray features of OA and (2) 6 control subjects (matched to cases for age, sex and body mass index in a 1:2 ratio) who do not have clinical features of OA.

Participants will undergo an initial (baseline) MR examination, followed by repeat MR examinations at approximately 1 month and 1 year following the baseline examination.

This will allow the investigators to explore the possibility of mechanical joint-loading and exercise to differentiate early stage OA from healthy subjects and assess both the reliability of the MR measurements and the expected progression in the MR measurements in OA subjects in the absence of any disease-modifying intervention.

Condition or disease	Intervention/treatment
Osteoarthritis	Device: Magnetic resonance imaging (MRI)

Study Design

• Study Type: Observational
• Actual Enrollment: 18 participants
• Observational Model: Case-Control
• Time Perspective: Prospective
• Official Title: Functional Exercise Response on osteoArthritis Relaxation Imaging
• Actual Study Start Date: November 21, 2019
• Estimated Primary Completion Date: June 2022
• Estimated Study Completion Date: June 2022

Groups and Cohorts

Group/Cohort	Intervention/treatment
Healthy volunteers	Device: Magnetic resonance imaging (MRI); Participants will undergo an initial (baseline) MR examination, followed by repeat MR examinations at approximately 1 month and 1 year following the baseline examination.
Osteoarthritis patients	Device: Magnetic resonance imaging (MRI); Participants will undergo an initial (baseline) MR examination, followed by repeat MR examinations at approximately 1 month and 1 year following the baseline examination.

Outcome Measures

Primary Outcome Measures :

1. Establish effect sizes for MR parameters in OA patients compared to healthy volunteers. [ Time Frame: 1 year ]

Secondary Outcome Measures :

1. Establish effect sizes for MR parameters in subjects with OA at 1 year compared to baseline. [ Time Frame: 1 year ]
2. Establish reliability of the MR protocol and analysis techniques. [ Time Frame: 1 month - 1 year ]
   Test-Retest Reliability

Eligibility Criteria

• Ages Eligible for Study: 40 Years to 60 Years (Adult)
• Sexes Eligible for Study: All
• Accepts Healthy Volunteers: Yes
• Sampling Method: Non-Probability Sample

Study Population

Group 1 will consist of 12 patients aged 40-60 who have presented to the Orthopaedic clinic with a painful knee, and have mild/moderate OA on plain radiographs (Kellgren- Lawrence grade 2-3). Group 2 will consist of 5 healthy volunteer controls, matched (1:2 ratio) to cases for age, sex and body mass index who do not have knee pain.

Criteria

Group 1 Inclusion Criteria:

• Meets ACR criteria for OA Kellgren-Lawrence grade 2-3 on knee radiograph
• Neutral alignment
• Single symptomatic joint
• Aged 40-60 years old
• Ambulatory and in good general health
• Knee able to fit inside in-vivo knee coil (approx. 18 cm diameter)

Group 2 Inclusion Criteria:

• No current symptoms of knee pain or stiffness or other clinical features of OA
• Aged 40-60 years old
• Written consent to participate in the study
• Ambulatory and in good general health
• Knee able to fit inside in-vivo knee coil (approx. 18 cm diameter)

Exclusion Criteria for both groups:

• History of ipsilateral lower limb fracture
• History of ipsilateral lower limb surgery (including arthroscopy)
• Metabolic bone disease
• Inflammatory arthritis
• Haematological malignancy
• Paget's disease
• Bone metastases
• Contraindication to MR imaging (e.g. pacemaker, severe claustrophobia)
• No pregnant patients will be included
• Unable to consent

Contacts and Locations

Locations

United Kingdom

Addenbrooke's Hospital

Cambridge, Cambridgeshire, United Kingdom, CB2 0QQ

Sponsors and Collaborators

Cambridge University Hospitals NHS Foundation Trust

More Information

• Responsible Party: Professor Fiona J Gilbert, Head of Department - Radiology, Cambridge University Hospitals NHS Foundation Trust
• ClinicalTrials.gov Identifier: NCT03657303
• Other Study ID Numbers: A094874
• First Posted: September 5, 2018
• Last Update Posted: February 28, 2022
• Last Verified: February 2022

• Studies a U.S. FDA-regulated Drug Product: No
• Studies a U.S. FDA-regulated Device Product: No

Keywords provided by Professor Fiona J Gilbert, Cambridge University Hospitals NHS Foundation Trust:

Joint Diseases; Musculoskeletal Diseases; Arthritis

Additional relevant MeSH terms:

Osteoarthritis; Arthritis; Joint Diseases; Musculoskeletal Diseases; Rheumatic Diseases