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Prognostic Indicators of Survival Following Cardiopulmonary Resuscitation in Patients With Cardiac Arrest

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
 
ClinicalTrials.gov Identifier: NCT03597425
Recruitment Status : Unknown
Verified July 2018 by GengLong Liu, First Affiliated Hospital, Sun Yat-Sen University.
Recruitment status was:  Recruiting
First Posted : July 24, 2018
Last Update Posted : July 24, 2018
Sponsor:
Information provided by (Responsible Party):
GengLong Liu, First Affiliated Hospital, Sun Yat-Sen University

Study Description
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Brief Summary:
Cardiopulmonary resuscitation (CPR) occurs approximately 200,000 times/yr in hospitals in the UnitedStates, with 18% of patients surviving to discharge. Just over half of these survivors are neurologically intact or with mild defiits at the time of discharge. Do-not-resuscitate (DNR) orders are used to withhold CPR from patients who are unlikely to benefi or for whom it is inconsistent with their treatment goals or personal preferences. It would be helpful to identify patients with a very low likelihood of survival to discharge neurologically intact or with mild defiits were they to experience cardiopulmonary arrest (CPA), so their physician can present the option of a DNR order. This information would also be useful anytime a patient raises the question of the likelihood of survival should they undergo CPA.The objective of this study was to determine key indicators for good outcome in patients with sudden cardiac arrest undergoing CPR and develop a prediction model to predict survival to hospital discharge in these patients.

Condition or disease Intervention/treatment
Cardiopulmonary Resuscitation Procedure: Cardiopulmonary resuscitation

Detailed Description:

A CPR coordinator prospectively collected data for the CPR registry according to the Utstein-style guidelines. Te registry included the following information:

demographic data, comorbidities, whether the arrest was witnessed, the incidence of suspected or confrmed trauma, presumed arrest time; presence of bystander CPR, frst documented arrest rhythm by the emergency medical service (EMS) provider, any return of spontaneous circulation (ROSC), presence of ECPR, the presence of return of spontaneous heart beating (ROSB) after CPR, presumed cause of arrest; the application of therapeutic hypothermia and the use of coronary angiography(CAG) or percutaneous coronary intervention (PCI),24-hour survival, the presence of ROSC more than 20 min, hospital length of stay (LOS), survival to hospital discharge,Glasgow-Pittsburgh cerebral performance category (CPC) score at discharge, and the fnal diagnosis at discharge. Te comorbidity score was calculated using the Charlson comorbidity index. Te duration of CPR was defned as the time interval from the frst chest compression provided by healthcare providers to the termination of resuscitation eforts due to ROSC (more than 20 min),ROSB after CPR, or a declaration of death. A favorable neurologic outcome was defned as a CPC score of 1 or 2 on the fve-category scale.

Study Design
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Study Type : Observational
Estimated Enrollment : 120 participants
Observational Model: Cohort
Time Perspective: Retrospective
Official Title: Prognostic Indicators of Survival Following Cardiopulmonary Resuscitation in Patients With Cardiac Arrest: a Single-institutional Study
Actual Study Start Date : January 1, 2017
Estimated Primary Completion Date : January 1, 2020
Estimated Study Completion Date : January 1, 2020

Resource links provided by the National Library of Medicine


Groups and Cohorts
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Intervention Details:
  • Procedure: Cardiopulmonary resuscitation
    Cardiopulmonary resuscitation (CPR) is an emergency treatment for patients with respiratory arrest and cardiac arrest in an attempt to restore the patient to spontaneous breathing and heartbeat through cardiopulmonary resuscitation

Outcome Measures
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Primary Outcome Measures :
  1. indicators of survival [ Time Frame: an average of 1 year ]
    The survival outcome was analyzed with logstic regression


Eligibility Criteria
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Ages Eligible for Study:   18 Years to 75 Years   (Adult, Older Adult)
Sexes Eligible for Study:   All
Sampling Method:   Probability Sample
Study Population
patients with cardiac arrest
Criteria

Inclusion Criteria:

  • age more than 18 years,
  • sudden arrest with potentially reversible causes,
  • a short no fow time (time interval from presumed arrest to CPR initiation)
  • even for unwitnessed arrests

Exclusion Criteria:

  • presence of a terminal illness or malignancy, severe irreversible neurologic defcit,
  • suspected or confrmed traumatic origin of arrest,
  • no informed consent from the family
Contacts and Locations
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Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT03597425


Contacts
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Contact: Genglong Liu, MD +8615626405844 lglong3@mail2.sysu.edu.cn

Locations
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China, Guangdong
Genglong Liu Recruiting
Shunde, Guangdong, China
Contact: Genglong Liu, MD    +8615626405844    lglong3@mail2.sysu.edu.cn   
Sponsors and Collaborators
First Affiliated Hospital, Sun Yat-Sen University
Investigators
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Study Chair: Genglong Liu Shunde Hospital of Southern Medical University
More Information
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Responsible Party: GengLong Liu, Principal Investigator, First Affiliated Hospital, Sun Yat-Sen University
ClinicalTrials.gov Identifier: NCT03597425    
Other Study ID Numbers: cardiopulmonary resuscitation
First Posted: July 24, 2018    Key Record Dates
Last Update Posted: July 24, 2018
Last Verified: July 2018
Individual Participant Data (IPD) Sharing Statement:
Plan to Share IPD: Undecided

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Studies a U.S. FDA-regulated Drug Product: No
Studies a U.S. FDA-regulated Device Product: No
Keywords provided by GengLong Liu, First Affiliated Hospital, Sun Yat-Sen University:
Cardiac arrest
Cardiopulmonary resuscitation
Survival
Prediction
Additional relevant MeSH terms:
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Heart Arrest
Heart Diseases
Cardiovascular Diseases