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Acute Strawberry Intake on Endothelial Function (SFMD)

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
 
ClinicalTrials.gov Identifier: NCT03596008
Recruitment Status : Completed
First Posted : July 23, 2018
Last Update Posted : July 27, 2021
Sponsor:
Information provided by (Responsible Party):
Clinical Nutrition Research Center, Illinois Institute of Technology

Study Description
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Brief Summary:
The primary objectives of the study are (1) to evaluate the effects of acute dietary strawberry intake on measures of vascular function in healthy adults following a meal challenge, (2) to evaluate the effects of acute dietary strawberry intake on metabolic status, and (3) to assess intervention-associated metabolite and inflammatory signatures and their relationship to vascular function.

Condition or disease Intervention/treatment Phase
Healthy Dietary Supplement: Active drink Dietary Supplement: Placebo drink Not Applicable

Detailed Description:

This study is a randomized, 2-arm, single-blinded, within subject cross-over trial focused on evaluating the effects of acute dietary strawberry intake on measures of vascular function, metabolic status, as well as metabolite and inflammatory signatures and their relationship to vascular function in healthy adults following a meal challenge.

A planned sample size of 15 will be enrolled into the study. This study will require one initial screening visit and 2 study visits. This study will take approximately 1 week per subject to complete.

The initial screening visit will provide subject with the informed consent document and determine subject eligibility through anthropometric measurements, vital signs, fasting blood glucose test (finger prick), and completion of a survey relate to general eating, health, and exercise habits.

If willing and eligible to participate, subjects will be invited to participate in the study for 2 study days. Subjects will be instructed to maintain their usual diet pattern and physical activity throughout study duration.

Subject will arrive at the center in a fasted state for at least 10 hours, well hydrated and rested. Each study visit will require blood draws and ultrasound measurement throughout the visit. After evaluation of subject's health status (via anthropometric, vital sign and blood glucose measurements and in-person interview), a Licensed Health Care Professional will place a catheter in subject's arm for the purpose of multiple blood sample collections and take the initial blood draw in the fasting state. A baseline FMD procedure will be completed immediately after baseline blood sample collection. Afterwards, subjects will be randomized to receive the strawberry powder treatment or placebo based on randomized treatment sequences for 2 study visits immediately after fasting blood draw. The sequences of receiving the supplement at each visit will be randomly assigned to one of 2 following sequences: A-B or B-A Each study visit will involve with blood samples collection at time points 0 (fasting), 1, 2, 4, 6, and 24 hour (h) for assessment of change in metabolites and inflammatory signatures. FMD procedure will be conducted after completing the baseline blood draw and later at 2h, 4h, 6h, and 24h. A standard breakfast will be provided immediately after the 0h blood collection.

Study Design
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Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 7 participants
Allocation: Randomized
Intervention Model: Crossover Assignment
Intervention Model Description: Randomized, single-blind, 2-arm, placebo-controlled, within subject cross-over trial, featuring a repeated postprandial sampling paradigm
Masking: Single (Participant)
Masking Description: Single blinded
Primary Purpose: Other
Official Title: A Pilot Study Investigating the Effect of Acute Strawberry Intake on Endothelial Function Measured by Flow Mediated Dilation
Actual Study Start Date : July 20, 2018
Actual Primary Completion Date : October 12, 2020
Actual Study Completion Date : October 12, 2020
Arms and Interventions
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Arm Intervention/treatment
Experimental: Active1
freeze-dried strawberry powder (25 g) in active drink
 Dietary Supplement: Active drink
The freeze-dried strawberry powder (25 g) in active drink
Other Name: 25g strawberry drink
Placebo Comparator: Placebo
Placebo drink
 Dietary Supplement: Placebo drink
Placebo drink


Outcome Measures
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Primary Outcome Measures :
  1. Changes in postprandial endothelial function using Flow Mediated Dilation (FMD) between 2 treatments [ Time Frame: Baseline to 6 hours ]
    postprandial endothelial function using Flow Mediated Dilation (FMD)


Secondary Outcome Measures :
  1. Change in plasma blood glucose concentration response between 2 treatments [ Time Frame: Baseline to 24 hours ]
    blood glucose concentration response

  2. Change in plasma blood insulin concentration response between 2 treatments [ Time Frame: Baseline to 24 hours ]
    blood insulin concentration response


Other Outcome Measures:
  1. Changes in plasma polyphenol metabolites between 2 treatments [ Time Frame: Baseline to 24 hours ]
    plasma polyphenol metabolites

  2. Changes in plasma inflammation (monocytes isolation) responses between 2 treatments [ Time Frame: Baseline to 24 hours ]
    Monocytes inflammation responses


Eligibility Criteria
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Ages Eligible for Study:   18 Years to 45 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • Body Mass Index (BMI) between 20 to 35 kg/m2
  • Aged 18-45 years old
  • Willing to maintain stable body weight and follow his/her habitual diet and physical activity patterns throughout the trail
  • Judged by the Investigator to be in general good health on the basis of medical history and screening laboratory tests
  • Able to provide informed consent and comply with study procedures

Exclusion Criteria:

  • Current smoker and/or marijuana user, past smokers may be allowed in the study if stopped >2 years
  • Have a history or presence of atherosclerotic cardiovascular disease, inflammatory disease, diabetes mellitus, or other systemic diseases, psychological or psychiatric disorders that may interfere with study outcomes
  • Men and women with known or suspected intolerance, allergies or hypersensitivity to study foods or treatments
  • Taking any medications and/or supplements that would interfere with outcomes of the study (i.e., lipid-lowering medications, anti-inflammatory drugs, etc),
  • Unstable use of any medication/supplement
  • Have a history of cancer, except for non-melanoma skin cancer within past 5 years
  • Addicted to drugs and/or alcohol (>4 drinks/day)
  • Have been exposed to any non-registered drug product within last 30 days.
  • Working overnight (e.g. 3rd shift of overnight workers)
  • Excessive exercisers or trained athletes
  • Have allergies/intolerances to strawberries
  • Extreme dietary habits (ie. vegetarian/vegan)
  • Excessive coffee/tea drinker (>4 cups/day)
  • Actively losing weight/ trying to lose weight (unstable body weight fluctuations of > 5 kg in 3 months)
  • Donated blood within last 3 months
  • Female who is pregnant, planning to be pregnant, breastfeeding
  • Current regular consumption of berries which exceeds > 2 servings per day
  • Any condition the Investigator believes would interfere with his or her ability to provide informed consent or comply with the study protocol, or which might confound the interpretation of the study results or put the person at undue risk.
  • Fasting glucose concentration >125 mg/dL
Contacts and Locations
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Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT03596008


Locations
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United States, Illinois
Clinical Nutrition Research Center
Chicago, Illinois, United States, 60616
Sponsors and Collaborators
Clinical Nutrition Research Center, Illinois Institute of Technology
Investigators
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Principal Investigator: Britt Burton-Freeman, Ph.D Illinois Institute of Technology
More Information
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Responsible Party: Clinical Nutrition Research Center, Illinois Institute of Technology
ClinicalTrials.gov Identifier: NCT03596008    
Other Study ID Numbers: IRB2018-065
First Posted: July 23, 2018    Key Record Dates
Last Update Posted: July 27, 2021
Last Verified: July 2021
Individual Participant Data (IPD) Sharing Statement:
Plan to Share IPD: No

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Studies a U.S. FDA-regulated Drug Product: No
Studies a U.S. FDA-regulated Device Product: No
Keywords provided by Clinical Nutrition Research Center, Illinois Institute of Technology:
strawberry
monocytes
endothelial function