Try the modernized ClinicalTrials.gov beta website. Learn more about the modernization effort.
Working…
ClinicalTrials.gov
ClinicalTrials.gov Menu

Urine Levels of Metanephrin and Normetanephrin in Patients With Frequent Ventricular Premature Complex

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
 
ClinicalTrials.gov Identifier: NCT03447002
Recruitment Status : Completed
First Posted : February 27, 2018
Last Update Posted : November 14, 2019
Sponsor:
Information provided by (Responsible Party):
Burak Cesur, TC Erciyes University

Study Description
Go to 
Top of Page Study Description Study Design Groups and Cohorts Outcome Measures Eligibility Criteria Contacts and Locations More Information
Brief Summary:
Enhanced automaticity process is the underlying mechanism for arrhythmias due to excess catecholamines. Catecholamines may increase in patients with PVC. Metabolites of catecholamines are metanephrine and normetanephrine. Our aim is to measure 24 hours urine levels of metanephrine and normetanephrine.

Condition or disease Intervention/treatment
Premature Ventricular Contraction Diagnostic Test: 24 hours urine levels metanephrine and normetanephrine

Detailed Description:
Premature ventricular complex is a very frequent arrhythmia. Suggested mechanisms for PVCs are reentry, triggered activity, and enhanced automaticity. Enhanced automaticity process is the underlying mechanism for arrhythmias due to excess catecholamines. Catecholamines may increase in patients with PVC. Half-lives of catecholamines are very short and rather changeable. Therefore, 24 hours urine levels of catecholamines are the more sensitive than plasma levels. Metabolites of catecholamines are metanephrine and normetanephrine. Our aim is to measure 24 hours urine levels of metanephrine and normetanephrine.
Study Design
Go to 
Top of Page Study Description Study Design Groups and Cohorts Outcome Measures Eligibility Criteria Contacts and Locations More Information

Layout table for study information
Study Type : Observational
Actual Enrollment : 100 participants
Observational Model: Case-Control
Time Perspective: Prospective
Official Title: Urine Levels of Metanephrin and Normetanephrin in Patients With Frequent Ventricular Premature Complex
Actual Study Start Date : February 15, 2018
Actual Primary Completion Date : September 30, 2019
Actual Study Completion Date : September 30, 2019

Resource links provided by the National Library of Medicine


Groups and Cohorts
Go to 
Top of Page Study Description Study Design Groups and Cohorts Outcome Measures Eligibility Criteria Contacts and Locations More Information

Intervention Details:
  • Diagnostic Test: 24 hours urine levels metanephrine and normetanephrine
    24 hours rhythm recording and 24 hours urine measurement
    Other Name: rhythm recording

Outcome Measures
Go to 
Top of Page Study Description Study Design Groups and Cohorts Outcome Measures Eligibility Criteria Contacts and Locations More Information

Primary Outcome Measures :
  1. metanephrine and normetanephrine levels [ Time Frame: about 10 months ]
    metanephrine and normetanephrine levels asociated premature ventricular complex frequents


Eligibility Criteria
Go to 
Top of Page Study Description Study Design Groups and Cohorts Outcome Measures Eligibility Criteria Contacts and Locations More Information

Information from the National Library of Medicine

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.


Layout table for eligibility information
Ages Eligible for Study:   18 Years to 90 Years   (Adult, Older Adult)
Sexes Eligible for Study:   All
Sampling Method:   Non-Probability Sample
Study Population
patients with % 5 or higher frequents premature ventricular complex in 24 hours rhythm recording will be taken our study.
Criteria

Inclusion Criteria:

  • PVC's rate is more than % 5 in 24 hours rhythm recording

Exclusion Criteria:

  • ischemic heart disease
  • hyperthyroidism
  • patients with low ejection fraction
Contacts and Locations
Go to 
Top of Page Study Description Study Design Groups and Cohorts Outcome Measures Eligibility Criteria Contacts and Locations More Information

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT03447002


Locations
Layout table for location information
Turkey
Erciyes university Yilmaz- mehmet öztaşkın heart hospital
Kayseri, Turkey
Sponsors and Collaborators
TC Erciyes University
More Information
Go to 
Top of Page Study Description Study Design Groups and Cohorts Outcome Measures Eligibility Criteria Contacts and Locations More Information
Publications:

Layout table for additonal information
Responsible Party: Burak Cesur, burak cesur, TC Erciyes University
ClinicalTrials.gov Identifier: NCT03447002    
Other Study ID Numbers: ErciyesU
First Posted: February 27, 2018    Key Record Dates
Last Update Posted: November 14, 2019
Last Verified: November 2019

Layout table for additional information
Studies a U.S. FDA-regulated Drug Product: No
Studies a U.S. FDA-regulated Device Product: No
Keywords provided by Burak Cesur, TC Erciyes University:
premature
pvc
Additional relevant MeSH terms:
Layout table for MeSH terms
Premature Birth
Ventricular Premature Complexes
Obstetric Labor, Premature
Obstetric Labor Complications
Pregnancy Complications
Cardiac Complexes, Premature
 Arrhythmias, Cardiac
Heart Diseases
Cardiovascular Diseases
Cardiac Conduction System Disease
Pathologic Processes