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Neural Mechanism Underlying Social Cognition in Depressive Patients

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ClinicalTrials.gov Identifier: NCT03413670
Recruitment Status : Unknown
Verified February 2018 by ma, yina, Beijing Normal University.
Recruitment status was:  Recruiting
First Posted : January 29, 2018
Last Update Posted : February 7, 2018
Sponsor:
Collaborator:
Huilongguan Hospital
Information provided by (Responsible Party):
ma, yina, Beijing Normal University

Study Description
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Brief Summary:
In the project, investigators plan to test difference of social cognition between depressive patients and healthy individuals and the brain activation underlying the difference to further understand the neural mechanism of depressive disorder.

Condition or disease
Depression

Study Design
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Study Type : Observational [Patient Registry]
Estimated Enrollment : 25 participants
Observational Model: Case-Control
Time Perspective: Cross-Sectional
Target Follow-Up Duration: 1 Month
Official Title: Neural Mechanism Underlying Social Cognition in Depressive Patients
Actual Study Start Date : January 1, 2017
Estimated Primary Completion Date : February 8, 2018
Estimated Study Completion Date : March 1, 2018

Resource links provided by the National Library of Medicine


Groups and Cohorts
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Outcome Measures
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Primary Outcome Measures :
  1. emotion recognition [ Time Frame: Baseline ]
    After viewing a video, participants will be asked to judge the person's attitude in the video. Through this paradigm, investigators could test emotional bias in social interaction in depressive patients.

  2. resting state [ Time Frame: Baseline ]
    In this part, investigators basically want to test the automatic neural activity for depressive patients while they are resting.

  3. self-reflection [ Time Frame: Baseline ]
    Participants will be asked to judge the discrepancy between actual self and ideal self.

  4. response to negative stimuli [ Time Frame: Baseline ]
    investigators used face-matching task to measure their response to negative stimuli. The participants will be asked to detect the identical face with same emotion.

  5. structure [ Time Frame: Baseline ]
    Investigators scanned structural images to detect the difference between clinical population and healthy population.

  6. white matter [ Time Frame: Baseline ]
    Investigators scanned DTI to detect the difference between clinical population and healthy population.


Eligibility Criteria
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Ages Eligible for Study:   18 Years to 60 Years   (Adult)
Sexes Eligible for Study:   All
Sampling Method:   Probability Sample
Study Population
Individuals diagnosed with depression and healthy control
Criteria

Inclusion Criteria:

  • Age range between 18 and 60
  • Education experience above high school
  • Score for Hamilton's Depression Scale >=17
  • Diagnosis of depression through Scid

Exclusion Criteria:

  • Undergoing electric shock treatment in 3 months
  • Excluding those who with bipolar disorder
  • Excluding those who with postpartum depression
  • Excluding those who with hysteria
Contacts and Locations
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Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT03413670


Contacts
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Contact: Yina Ma, Doctor +8613810258647 yma@bnu.edu.cn

Locations
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China
Huilongguan Hospital Recruiting
Beijing, China
Contact: Yina Ma, Doctor         
Principal Investigator: Yina Ma, Doctor         
Sponsors and Collaborators
Beijing Normal University
Huilongguan Hospital
More Information
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Additional Information:

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Responsible Party: ma, yina, Principal Investigator, Beijing Normal University
ClinicalTrials.gov Identifier: NCT03413670    
Other Study ID Numbers: HLGdepression-fMRI
First Posted: January 29, 2018    Key Record Dates
Last Update Posted: February 7, 2018
Last Verified: February 2018

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Studies a U.S. FDA-regulated Drug Product: No
Studies a U.S. FDA-regulated Device Product: No
Additional relevant MeSH terms:
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Depression
Behavioral Symptoms