Nosocomial Bacterial and Fungal Chest Infections in Cirrhotic Patients

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ClinicalTrials.gov Identifier: NCT03413293

Recruitment Status : Unknown

Verified February 2018 by NZBakhiet, Assiut University.
Recruitment status was: Not yet recruiting

First Posted : January 29, 2018

Last Update Posted : May 18, 2018

Sponsor:

Information provided by (Responsible Party):

NZBakhiet, Assiut University

Study Description

Brief Summary:

Hospital acquired chest Infections are common complications in hospitalized cirrhotic patients. Infectious complications are the most common cause of mortality in cirrhotic patients with bronchopneumonia early antibiotic treatment at the base of culture and sensitivity is an optimal therapeutic approach in cirrhotics with nosocomial pneumonia Intensive care unit acquired pneumonia is the leading infection in critically ill patients and a major cause of morbidity and mortality despite recent major advances in antimicrobial therapy, supportive care, and the use of a broad range of preventive measures

Condition or disease	Intervention/treatment
Nosocomial Infection	Diagnostic Test: Diagnosis of bacterial infections

Detailed Description:

Aim of the work

To estimate the frequency and risk factors of nosocomial chest infections in cirrhotic patients .
To determine the causative pathogens of nosocomial chest infections in patients with cirrhosis including fungal infections in order to establish our local empirical antimicrobial protocol.
To define the impact of nosocomial chest infections on survival of our patients.
To develop an effective and continuous surveillance program and infection control measures to reduce the burden of these infections as well as morbidity , mortality , hospital stay ,hospital cost and to achieve quality of care .
To motivate pharmaceutical companies to create a new umbrella coverage of antimicrobials through the ongoing knowledge of the changes in microbial resistance pattern inside hospitals

Study Design

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Study Type :	Observational
Estimated Enrollment :	20 participants
Observational Model:	Case-Only
Time Perspective:	Prospective
Official Title:	Nosocomial Bacterial and Fungal Chest Infections in Cirrhotic Patients
Estimated Study Start Date :	June 2018
Estimated Primary Completion Date :	May 2019
Estimated Study Completion Date :	August 2019

Resource links provided by the National Library of Medicine

Genetic and Rare Diseases Information Center resources: Oculocerebral Syndrome With Hypopigmentation

U.S. FDA Resources

Groups and Cohorts

Group/Cohort	Intervention/treatment
Nosocomial infected cirrhotic patients	Diagnostic Test: Diagnosis of bacterial infections Cultures

Outcome Measures

Primary Outcome Measures :

Frequency of nosocomial infection in patients with liver cirrhosis [ Time Frame: baseline ]
nosocomial infection is one of predictors of bad outcome in liver cirrhosis

Eligibility Criteria

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Ages Eligible for Study:	Child, Adult, Older Adult
Sexes Eligible for Study:	All
Accepts Healthy Volunteers:	No
Sampling Method:	Probability Sample

Study Population

patient were known to have liver cirrhois and admitted at hospital secondary to any cause

Criteria

Inclusion Criteria:

All cirrhotic patients , decompensated , child pug score B or C ,may have Hepatocellular carcinoma , other comorbidities may present as (Diabetius mellitus , Hypertension , Heart disease and renal impairment ) , both sex and with clinical suspicion of chest infections acquired after 48 hours of admission

Exclusion Criteria:

Patients have any chronic chest disease
Patients have severe immunosuppression (neutropenia after chemotherapy or hematopoietic transplant, drug-induced immunosuppression in solid-organ transplant or cytotoxic therapy, and HIV-related disorders.

Contacts and Locations

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT03413293

Contacts

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Contact: Nariman zaghluol bakhiet, postgraduate	01005546130	narimandoctor@yahoo.com

Sponsors and Collaborators

Assiut University

More Information

Publications:

Di Pasquale M, Esperatti M, Crisafulli E, Ferrer M, Bassi GL, Rinaudo M, Escorsell A, Fernandez J, Mas A, Blasi F, Torres A. Impact of chronic liver disease in intensive care unit acquired pneumonia: a prospective study. Intensive Care Med. 2013 Oct;39(10):1776-84. doi: 10.1007/s00134-013-3025-6. Epub 2013 Aug 2.

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Responsible Party:	NZBakhiet, resident doctor, Assiut University
ClinicalTrials.gov Identifier:	NCT03413293
Other Study ID Numbers:	NBFCIIHCP
First Posted:	January 29, 2018 Key Record Dates
Last Update Posted:	May 18, 2018
Last Verified:	February 2018

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Studies a U.S. FDA-regulated Drug Product:	No
Studies a U.S. FDA-regulated Device Product:	No

Additional relevant MeSH terms:

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Infections Communicable Diseases Cross Infection	Disease Attributes Pathologic Processes Iatrogenic Disease

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