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BIOMARKER TRIAL of APALUTAMIDE and RADIATION for RECURRENT PROSTATE CANCER (BALANCE)

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Know the risks and potential benefits of clinical studies and talk to your health care provider before participating. Read our disclaimer for details.
 
ClinicalTrials.gov Identifier: NCT03371719
Recruitment Status : Recruiting
First Posted : December 13, 2017
Last Update Posted : September 5, 2019
Sponsor:
Collaborator:
National Cancer Institute (NCI)
Information provided by (Responsible Party):
NRG Oncology

Brief Summary:
This phase II trial studies how well radiation therapy with or without apalutamide works in treating patients with stage III-IV prostate cancer. Radiation therapy uses high energy x-ray to kill tumor cells and shrink tumors. Androgen can cause the growth of prostate cancer cells. Drugs, such as apalutamide, may lessen the amount of androgen made by the body. Giving radiation therapy and apalutamide may work better at treating prostate cancer than radiation alone.

Condition or disease Intervention/treatment Phase
PSA Progression Stage III Prostate Adenocarcinoma Stage IV Prostate Adenocarcinoma Drug: Apalutamide Radiation: External Beam Radiation Therapy Other: Placebo Phase 2

Detailed Description:

PRIMARY OBJECTIVES:

I. To determine whether, in men with post-prostatectomy PSA recurrences, salvage radiation (SRT) with enhanced anti-androgen therapy with apalutamide will improve biochemical progression-free survival (bPFS) compared to SRT alone.

SECONDARY OBJECTIVES:

I. To assess whether molecular stratification by the PAM50 gene expression clustering will identify subsets of prostate cancer (luminal A or basal, luminal B) which derive the greatest benefit from anti-androgen therapy.

II. To assess overall survival. III. To assess cancer-specific mortality. IV. To assess metastasis-free survival. V. To assess distant metastasis. VI. To assess local-regional progression. VII. To assess PSA nadir during first year of treatment and prior to initiation of any hormonal salvage therapy.

VIII. To assess initiation of salvage hormonal therapy. IX. To assess PSA with a non-castrate testosterone at 1 and 3 years post randomization: PSA < 0.1 ng/ml and testosterone >= 50 ng/dl.

X. To assess acute and late physician-reported morbidity (per the Common Terminology Criteria for Adverse Events [CTCAE] version 5) after SRT +/- apalutamide.

XI. To assess acute and late patient-reported morbidity (per the patient reported outcomes [PRO]-CTCAE) after SRT +/- apalutamide.

XII. To assess testosterone levels at 3, 6, 9, 12, and 36 months post randomization.

OUTLINE: Patients are randomized to 1 of 2 arms.

ARM 1: Patients undergo external beam radiation therapy on Day 1 for 7.5 weeks. Beginning on Day 1 of radiation therapy, patients receive placebo orally (PO) once daily (QD) on days 1-30. Treatment repeats every 30 days for up to 6 courses (6 months) in the absence of disease progression or unacceptable toxicity.

ARM 2: Patients undergo external beam radiation therapy on Day 1 for 7.5 weeks. Beginning on Day 1 of radiation therapy, patients receive apalutamide PO QD on Days 1-30. Treatment repeats every 30 days for up to 6 courses (6 months) in the absence of disease progression or unacceptable toxicity.

After completion of study treatment, patients are followed up every 3 months for 2 years, then every 6 months for 3 years, and then yearly thereafter.


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Study Type : Interventional  (Clinical Trial)
Estimated Enrollment : 324 participants
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double (Participant, Investigator)
Primary Purpose: Treatment
Official Title: A Phase II, Double-Blinded, Placebo Controlled Randomized Trial of Salvage Radiotherapy With or Without Enhanced Anti-androgen Therapy With Apalutamide in Recurrent Prostate Cancer
Actual Study Start Date : April 27, 2018
Estimated Primary Completion Date : February 16, 2024
Estimated Study Completion Date : October 31, 2028

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Prostate Cancer
Drug Information available for: Apalutamide

Arm Intervention/treatment
Placebo Comparator: Arm 1 (Radiation Therapy + Placebo)
Patients undergo external beam radiation therapy on Day 1 for 7.5 weeks. Beginning on Day 1 of radiation therapy, patients receive placebo PO QD on Days 1-30. Treatment repeats every 30 days for up to 6 courses (6 months) in the absence of disease progression or unacceptable toxicity.
Radiation: External Beam Radiation Therapy
Undergo external beam radiation therapy
Other Names:
  • Definitive Radiation Therapy
  • EBRT
  • External Beam Radiotherapy
  • External Beam RT
  • external radiation
  • External Radiation Therapy
  • external-beam radiation

Other: Placebo
Given PO
Other Names:
  • placebo therapy
  • PLCB
  • sham therapy

Experimental: Arm 2 (Radiation Therapy + Apalutamide)
Patients undergo external beam radiation therapy on Day 1 for 7.5 weeks. Beginning on Day 1 of radiation therapy, patients receive apalutamide PO QD on Days 1-30. Treatment repeats every 30 days for up to 6 courses (6 months)in the absence of disease progression or unacceptable toxicity.
Drug: Apalutamide
Given PO
Other Names:
  • ARN 509
  • ARN-509
  • ARN509
  • JNJ 56021927
  • JNJ-56021927

Radiation: External Beam Radiation Therapy
Undergo external beam radiation therapy
Other Names:
  • Definitive Radiation Therapy
  • EBRT
  • External Beam Radiotherapy
  • External Beam RT
  • external radiation
  • External Radiation Therapy
  • external-beam radiation




Primary Outcome Measures :
  1. Biochemical Progression-free survival (bPFS) [ Time Frame: From randomization to the first occurrence of a rise in PSA, clinical or radiographic local, regional, or distant metastases, or death from any cause, assessed up to 6 years ]
    bPFS curves will be estimated by the Kaplan-Meier (1958) method and compared between the two treatment arms using a one-sided logrank test at the alpha = 0.12 significance level. Analysis will include evaluation of a potential predictive biomarker (molecular subtype) to inform the design of a subsequent, phase III clinical trial. In addition, a multivariable Cox (1972) regression model will be fit incorporating the three stratification factors used in the randomization (surgical margins, pre-salvage radiation (SRT) PSA, and molecular subtype) as covariates to estimate the adjusted hazard ratio (HR) between the two treatment groups. Additional regression models will be fit including other pretreatment characteristics as covariates.


Secondary Outcome Measures :
  1. Acute Patient-Reported Morbidity (per the patient reported outcomes [PRO]- Common Terminology Criteria for Adverse Events [CTCAE]) [ Time Frame: Up to 30 days after radiation therapy ]
    Adverse events will also be assessed using PRO-CTCAE items. Assessments will be collected before and at the end of radiotherapy treatment and in follow-up. For each symptom and each domain (i.e., frequency, severity, and interference), counts and frequencies will be provided for the worst score experienced by the patient by treatment arm. The proportion of patients with scores >= 1 and >= 3 will be compared between groups using a chi-square test, or Fisher's exact test if cell frequencies are < 5.

  2. Acute Physician-Reported Morbidity (per the Common Terminology Criteria for Adverse Events [CTCAE] version 5) [ Time Frame: Up to 30 days after radiation therapy ]
    Adverse events will be scored according to the National Cancer Institute (NCI)'s CTCAE version 5.0. For each type of adverse event, frequencies will be provided for the worst grade experienced by the patient by treatment arm. The proportion of patients with grades >= 1 and >= 3 will be compared between groups using a chi-square test, or Fisher's exact test.

  3. Late Patient-Reported Morbidity (per the patient reported outcomes [PRO]- Common Terminology Criteria for Adverse Events [CTCAE]) [ Time Frame: From the end of radiation therapy + 30 days up to 6 years ]
    Adverse events will also be assessed using PRO-CTCAE items. Assessments will be collected before and at the end of radiotherapy treatment and in follow-up. For each symptom and each domain (i.e., frequency, severity, and interference), counts and frequencies will be provided for the worst score experienced by the patient by treatment arm. The proportion of patients with scores >= 1 and >= 3 will be compared between groups using a chi-square test, or Fisher's exact test if cell frequencies are < 5.

  4. Late Physician-Reported Morbidity (per the Common Terminology Criteria for Adverse Events [CTCAE] version 4) defined as grade 3+ adverse events occurring more than 30 days after the completion of radiation therapy [ Time Frame: From the end of radiation therapy + 30 days to the time of the first recorded late grade 3+ adverse event, assessed up to 6 years ]
    Adverse events will be scored according to the NCI's CTCAE version 5.0. For each type of adverse event, counts and frequencies will be provided for the worst grade experienced by the patient by treatment arm. The proportion of patients with grades >= 1 and >= 3 will be compared between groups using a chi-square test, or Fisher's exact test.

  5. Cancer-Specific Mortality (CSM) [ Time Frame: From the date of randomization to the date of death due to prostate cancer, assessed up to 6 years ]
    CSM will be estimated by the Kaplan-Meier method and compared between treatment arms via the logrank test. Patients dying from other causes will be censored as of the date of death. Cox regression will be used to obtain HRs for this outcome, both unadjusted and adjusted for covariates. A competing risks analysis will also be performed treating death from prostate cancer and death from all other causes as competing risks. Cumulative incidence curves will be generated (Gooley et al., 1999; Dignam et al., 2004) along with 95% confidence intervals and compared between the two treatment arms using Gray's method (Gray, 1988).

  6. Distant Metastasis [ Time Frame: Up to 6 years ]
    Will also be analyzed under a competing risks framework, treating death without experiencing the event in question as a competing risk.

  7. Initiation of Salvage Hormonal Therapy [ Time Frame: Up to 6 years ]
    Will also be analyzed under a competing risks framework, treating death without experiencing the event in question as a competing risk.

  8. Local-Regional Progression [ Time Frame: From randomization to local or regional recurrence, assessed up to 6 years ]
    Will also be analyzed under a competing risks framework, treating death without experiencing the event in question as a competing risk.

  9. Metastasis-Free Survival (MFS) [ Time Frame: From randomization until distant metastasis (clinical and/or radiographic appearance of disseminated disease) or death from any cause, assessed up to 6 years ]
    MFS will be estimated by the Kaplan-Meier method and compared between treatment arms via the logrank test. Cox regression will be used to obtain HRs for this outcome, both unadjusted and adjusted for covariates.

  10. Overall survival (OS) [ Time Frame: From randomization until death from any cause, assessed up to 6 years ]
    OS will be estimated by the Kaplan-Meier method and compared between treatment arms via the logrank test. Cox regression will be used to obtain HRs for this outcome, both unadjusted and adjusted for covariates.

  11. PSA Nadir During First Year of Treatment and Prior to Initiation of any Hormonal Salvage Therapy [ Time Frame: During first year of treatment ]
    Will be compared between the two groups using a two-sample t-test.

  12. Testosterone Levels [ Time Frame: Every 3 months until 36 months post randomization ]
    Testosterone levels over time will be assessed using mixed effects regression modeling.

  13. Undetectable PSA with a Non-Castrate Testosterone (PSA < 0.1 ng/ml and testosterone >= 50 ng/dl) [ Time Frame: 1 year ]
    The proportion of patients with undetectable PSA and non-castrate testosterone level will be compared between the two treatment arms using chi square tests.

  14. Undetectable PSA with a Non-Castrate testosterone (PSA < 0.1 ng/ml and testosterone >= 50 ng/dl)) [ Time Frame: 3 years ]
    The proportion of patients with undetectable PSA and non-castrate testosterone level will be compared between the two treatment arms using chi square tests.



Information from the National Library of Medicine

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.


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Ages Eligible for Study:   18 Years and older   (Adult, Older Adult)
Sexes Eligible for Study:   Male
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • Pathologically (histologically) proven diagnosis of prostate adenocarcinoma; prostatectomy must have been performed within 10 years prior to Step 1 registration and any type of radical prostatectomy is permitted, including retropubic, perineal, laparoscopic or robotically assisted
  • Post-prostatectomy patients with a detectable serum PSA (≥ 0.1, but ≤ 1.0 ng/mL) at study entry (within 90 days of Step 1 registration) and at least one of the following:

    • Gleason score 7-10 (International Society of Urological Pathology [ISUP] grade group 2 to 5)
    • ISUP grade group:

      • Grade Group 1: Gleason score ≤ 6,
      • Grade Group 2: Gleason score 3 + 4 = 7,
      • Grade Group 3: Gleason score 4 + 3 = 7,
      • Grade Group 4: Gleason score 8,
      • Grade Group 5: Gleason scores 9 and 10
    • >= T3a disease
    • Persistent elevation of PSA after prostatectomy measured within 90 days after surgery (PSA never became undetectable) of > 0.04 but < 0.2 ng/mL (PSA nadir)
  • pN0 or pNx
  • History/physical examination within 90 days prior to Step 1 registration
  • Karnofsky performance status of 70-100 within 90 days prior to Step 1 registration
  • Surgical formalin-fixed paraffin-embedded (FFPE) specimen must be available for submission to GenomeDx for genomic analysis on Decipher GRID platform; Note: if Decipher results have already been obtained, in lieu of tissue, results must be submitted to GenomeDx for validation
  • Prior androgen deprivation therapy (luteinizing hormone-releasing hormone [LHRH] agonist and/or non-steroidal anti-androgen) is allowed if discontinued at least 90 days prior to Step 1 registration and given for ≤ 90 days duration

    • For example: patients on prior LHRH analogs (post-prostatectomy), the discontinuation date should be calculated based on the expected duration of the sustained release injection, not simply the injection date of the drug; for instance, if a 22.5 mg sustained release dose of leuprolide acetate is given (3 month duration), then the expected duration of such a dose would be 90 days after the injection date; for a 7.5 mg leuprolide (1 month duration), the discontinuation date would be 30 days after the injection date
    • Please note: finasteride or dutasteride must be stopped before treatment starts but prior usage will not affect eligibility
  • Hemoglobin ≥ 9.0 g/dL, independent of transfusion and/or growth factors within 90 days prior to Step 1 registration
  • Platelet count ≥ 100,000 x 10^9/uL independent of transfusion and/or growth factors within 90 days prior to step 1 registration
  • Serum albumin ≥ 3.0 g/dL within 90 days prior to Step 1 registration
  • Glomerular filtration rate (GFR) ≥ 35 mL/min estimated by Cockcroft-Gault or measured directly by 24 hour urine creatinine within 90 days prior to Step 1 registration
  • Serum total bilirubin ≤ 1.5 x upper limit of normal (ULN) (Note: in subjects with Gilbert's syndrome, if total bilirubin is > 1.5 x ULN, measure direct and indirect bilirubin and if direct bilirubin is ≤ 1.5 x ULN, subject is eligible) within 90 days prior to Step 1 registration
  • Aspartate aminotransferase (AST) or alanine aminotransferase (ALT) < 2.5 x ULN within 90 days prior to Step 1 registration
  • Testosterone > 50 ng/dL within 90 days prior to Step 1 registration
  • Concomitant medications known to lower the seizure threshold discontinued or substituted at least 4 weeks (30 days) prior to Step 1 registration.
  • The patient must agree to use a condom (even men with vasectomies) and another effective method of birth control if he is having sex with a woman of childbearing potential or agree to use a condom if he is having sex with a woman who is pregnant while on study drug and for 3 months following the last dose of study drug
  • The patient must agree not to donate sperm during the study treatment and for 3 months after receiving the last dose of study drug
  • The patient or a legally authorized representative must provide study-specific informed consent prior to study entry

Exclusion Criteria:

  • Definitive clinical, radiologic, or pathologic evidence of metastatic disease (M1) or lymph node involvement (N1)
  • Prior invasive malignancy (except non-melanomatous skin cancer, carcinoma in situ of the male breast, penis, oral cavity, or stage Ta of the bladder, or stage I completely resected melanoma) unless disease free for a minimum of 2 years
  • Prior systemic chemotherapy for the study cancer; note that prior chemotherapy for a different cancer is allowable
  • Prior radiotherapy to the region of the study cancer that would result in overlap of radiation therapy fields
  • History of any of the following:

    • Seizure or known condition that may pre-dispose to seizure (e.g. prior stroke within 1 year prior to Step 1 registration)
    • History of documented inflammatory bowel disease
    • Transmural myocardial infarction within the last 4 months prior to Step 1 registration.
    • Unstable angina and/or congestive heart failure requiring hospitalization within the last 6 months prior to Step 1 registration
    • History of any condition that in the opinion of the investigator, would preclude participation in this study
  • Current evidence of any of the following:

    • Known gastrointestinal disorder affecting absorption of oral medications
    • Active uncontrolled infection (eg, human immunodeficiency virus [HIV] or viral hepatitis)
    • Uncontrolled hypertension
    • Any current condition that in the opinion of the investigator, would preclude participation in this study
  • Prior whole gland ablative therapy (i.e. cryoablation or high intensity focused ultrasound [HIFU]) for prostate cancer is not allowed
  • HIV positive with CD4 count < 200 cells/microliter within 30 days prior to registration
  • HIV patients under treatment with highly active antiretroviral therapy (HAART) within 30 days prior to registration regardless of CD4 count. (Note: HIV testing is not required for eligibility for this protocol as it is self-reported.)
  • For patients who have not undergone prior Decipher analysis, submission of the specimen to GenomeDx should be as soon as possible after study registration (Step 1) as these results can take up 21 days after the specimen is received at GenomeDx; Step 2 registration must occur within 6 weeks (42 days) of Step 1 registration; if Decipher results have already been obtained, in lieu of tissue, results must be submitted to GenomeDx for validation

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT03371719


Contacts
Layout table for location contacts
Contact: Daniel Spratt, MD 734-232-5244 sprattda@med.umich.edu

  Hide Study Locations
Locations
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United States, Arizona
Arizona Breast Cancer Specialists-Gilbert Recruiting
Gilbert, Arizona, United States, 85297
Contact: Site Public Contact    480-922-4600      
Principal Investigator: Jason M. Samuelian         
Arizona Center for Cancer Care-Peoria Recruiting
Peoria, Arizona, United States, 85381
Contact: Site Public Contact    623-773-2873      
Principal Investigator: Jason M. Samuelian         
Arizona Breast Cancer Specialists-Scottsdale Recruiting
Scottsdale, Arizona, United States, 85258
Contact: Site Public Contact    480-922-4600      
Principal Investigator: Jason M. Samuelian         
Arizona Center for Cancer Care-Surprise Recruiting
Surprise, Arizona, United States, 85374
Contact: Site Public Contact    412-339-5294    Roster@nrgoncology.org   
Principal Investigator: Jason M. Samuelian         
United States, Arkansas
University of Arkansas for Medical Sciences Recruiting
Little Rock, Arkansas, United States, 72205
Contact: Site Public Contact    501-686-8274      
Principal Investigator: Sanjay Maraboyina         
United States, California
Alta Bates Summit Medical Center-Herrick Campus Recruiting
Berkeley, California, United States, 94704
Contact: Site Public Contact    415-209-2686    bernicl@sutterhealth.org   
Principal Investigator: Christopher U. Jones         
Marin General Hospital Recruiting
Greenbrae, California, United States, 94904
Contact: Site Public Contact    415-925-7325      
Principal Investigator: Lloyd T. Miyawaki         
Los Angeles County-USC Medical Center Recruiting
Los Angeles, California, United States, 90033
Contact: Site Public Contact    323-865-0451      
Principal Investigator: Leslie Ballas         
USC / Norris Comprehensive Cancer Center Recruiting
Los Angeles, California, United States, 90033
Contact: Site Public Contact    323-865-0451      
Principal Investigator: Leslie Ballas         
Cedars Sinai Medical Center Recruiting
Los Angeles, California, United States, 90048
Contact: Site Public Contact    310-423-8965      
Principal Investigator: Zachary S. Zumsteg         
Sutter Medical Center Sacramento Recruiting
Sacramento, California, United States, 95816
Contact: Site Public Contact    415-209-2686    bernicl@sutterhealth.org   
Principal Investigator: Christopher U. Jones         
Gene Upshaw Memorial Tahoe Forest Cancer Center Recruiting
Truckee, California, United States, 96161
Contact: Site Public Contact    530-582-6450      
Principal Investigator: Richard K. Valicenti         
Sutter Solano Medical Center/Cancer Center Recruiting
Vallejo, California, United States, 94589
Contact: Site Public Contact    415-209-2686    bernicl@sutterhealth.org   
Principal Investigator: Christopher U. Jones         
United States, Colorado
Penrose-Saint Francis Healthcare Recruiting
Colorado Springs, Colorado, United States, 80907
Contact: Site Public Contact    308-398-6518    clinicaltrials@sfmc-gi.org   
Principal Investigator: Richard L. Deming         
UCHealth Memorial Hospital Central Recruiting
Colorado Springs, Colorado, United States, 80909
Contact: Site Public Contact    719-365-2406      
Principal Investigator: Thomas W. Flaig         
Memorial Hospital North Recruiting
Colorado Springs, Colorado, United States, 80920
Contact: Site Public Contact    719-364-6700      
Principal Investigator: Thomas W. Flaig         
Poudre Valley Hospital Recruiting
Fort Collins, Colorado, United States, 80524
Contact: Site Public Contact    970-297-6150      
Principal Investigator: Thomas W. Flaig         
Cancer Care and Hematology-Fort Collins Recruiting
Fort Collins, Colorado, United States, 80528
Contact: Site Public Contact    412-339-5294    Roster@nrgoncology.org   
Principal Investigator: Thomas W. Flaig         
Valley View Hospital Cancer Center Recruiting
Glenwood Springs, Colorado, United States, 81601
Contact: Site Public Contact    970-384-7570      
Principal Investigator: Peter J. Rossi         
UCHealth Greeley Hospital Recruiting
Greeley, Colorado, United States, 80631
Contact: Site Public Contact    412-339-5294    Roster@nrgoncology.org   
Principal Investigator: Thomas W. Flaig         
Medical Center of the Rockies Recruiting
Loveland, Colorado, United States, 80538
Contact: Site Public Contact    970-203-7083      
Principal Investigator: Thomas W. Flaig         
United States, Connecticut
Stamford Hospital/Bennett Cancer Center Recruiting
Stamford, Connecticut, United States, 06904
Contact: Site Public Contact    203-323-8944      
Principal Investigator: Anthony P. Gulati         
United States, Delaware
Helen F Graham Cancer Center Recruiting
Newark, Delaware, United States, 19713
Contact: Site Public Contact    302-623-4450    KDempsey@christianacare.org   
Principal Investigator: Gregory A. Masters         
Christiana Care Health System-Christiana Hospital Recruiting
Newark, Delaware, United States, 19718
Contact: Site Public Contact    302-623-4450    KDempsey@christianacare.org   
Principal Investigator: Gregory A. Masters         
Beebe Health Campus Recruiting
Rehoboth Beach, Delaware, United States, 19971
Contact: Site Public Contact    302-645-3100    Dmiskin@Beebehealthcare.org   
Principal Investigator: Gregory A. Masters         
United States, Florida
AdventHealth Orlando Recruiting
Orlando, Florida, United States, 32803
Contact: Site Public Contact    407-303-2090    FH.Cancer.Research@flhosp.org   
Principal Investigator: Carlos A. Alemany         
United States, Georgia
Grady Health System Recruiting
Atlanta, Georgia, United States, 30303
Contact: Site Public Contact    404-489-9164      
Principal Investigator: Ashesh B. Jani         
Emory University Hospital Midtown Recruiting
Atlanta, Georgia, United States, 30308
Contact: Site Public Contact    888-946-7447      
Principal Investigator: Ashesh B. Jani         
Emory University Hospital/Winship Cancer Institute Recruiting
Atlanta, Georgia, United States, 30322
Contact: Site Public Contact    404-778-1868      
Principal Investigator: Ashesh B. Jani         
Emory Saint Joseph's Hospital Recruiting
Atlanta, Georgia, United States, 30342
Contact: Site Public Contact    404-851-7115      
Principal Investigator: Ashesh B. Jani         
Northside Hospital Recruiting
Atlanta, Georgia, United States, 30342
Contact: Site Public Contact    404-303-3355    ClinicalTrials@northside.com   
Principal Investigator: Louis C. Garrot         
Augusta University Medical Center Recruiting
Augusta, Georgia, United States, 30912
Contact: Site Public Contact    706-721-2388    ga_cares@augusta.edu   
Principal Investigator: Sharad A. Ghamande         
Lewis Cancer and Research Pavilion at Saint Joseph's/Candler Recruiting
Savannah, Georgia, United States, 31405
Contact: Site Public Contact    912-819-5704    underberga@sjchs.org   
Principal Investigator: Howard A. Zaren         
United States, Illinois
Rush University Medical Center Recruiting
Chicago, Illinois, United States, 60612
Contact: Site Public Contact    312-942-5498    clinical_trials@rush.edu   
Principal Investigator: Dian Wang         
University of Illinois Recruiting
Chicago, Illinois, United States, 60612
Contact: Site Public Contact    312-355-3046      
Principal Investigator: David J. Peace         
Decatur Memorial Hospital Recruiting
Decatur, Illinois, United States, 62526
Contact: Site Public Contact    217-876-4740    rhamrick@dmhhs.org   
Principal Investigator: Bryan A. Faller         
Crossroads Cancer Center Recruiting
Effingham, Illinois, United States, 62401
Contact: Site Public Contact    217-876-4740    rhamrick@dmhhs.org   
Principal Investigator: Bryan A. Faller         
Edward Hines Jr VA Hospital Recruiting
Hines, Illinois, United States, 60141
Contact: Site Public Contact    708-202-8387      
Principal Investigator: Abhishek A. Solanki         
Loyola University Medical Center Recruiting
Maywood, Illinois, United States, 60153
Contact: Site Public Contact    708-226-4357      
Principal Investigator: Abhishek A. Solanki         
Illinois CancerCare-Peoria Recruiting
Peoria, Illinois, United States, 61615
Contact: Site Public Contact    309-243-3605    andersonj@illinoiscancercare.com   
Principal Investigator: Bryan A. Faller         
OSF Saint Francis Radiation Oncology at Peoria Cancer Center Recruiting
Peoria, Illinois, United States, 61615
Contact: Site Public Contact    309-243-3605    andersonj@illinoiscancercare.com   
Principal Investigator: Bryan A. Faller         
OSF Saint Francis Medical Center Recruiting
Peoria, Illinois, United States, 61637
Contact: Site Public Contact    309-243-3605    andersonj@illinoiscancercare.com   
Principal Investigator: Bryan A. Faller         
Southern Illinois University School of Medicine Recruiting
Springfield, Illinois, United States, 62702
Contact: Site Public Contact    217-545-7929      
Principal Investigator: Bryan A. Faller         
Springfield Clinic Recruiting
Springfield, Illinois, United States, 62702
Contact: Site Public Contact    800-444-7541      
Principal Investigator: Bryan A. Faller         
Memorial Medical Center Recruiting
Springfield, Illinois, United States, 62781
Contact: Site Public Contact    217-788-3528      
Principal Investigator: Bryan A. Faller         
Carle Cancer Center Recruiting
Urbana, Illinois, United States, 61801
Contact: Site Public Contact    800-446-5532    Research@carle.com   
Principal Investigator: Daniel H. Barnett         
United States, Indiana
Parkview Hospital Randallia Active, not recruiting
Fort Wayne, Indiana, United States, 46805
Parkview Regional Medical Center Recruiting
Fort Wayne, Indiana, United States, 46845
Contact: Site Public Contact    877-784-4673      
Principal Investigator: Brian K. Chang         
Goshen Center for Cancer Care Suspended
Goshen, Indiana, United States, 46526
Reid Health Recruiting
Richmond, Indiana, United States, 47374
Contact: Site Public Contact    937-775-1350    som_dcop@wright.edu   
Principal Investigator: Howard M. Gross         
United States, Iowa
Medical Oncology and Hematology Associates-West Des Moines Recruiting
Clive, Iowa, United States, 50325
Contact: Site Public Contact    308-398-6518    clinicaltrials@sfmc-gi.org   
Principal Investigator: Richard L. Deming         
Mercy Cancer Center-West Lakes Recruiting
Clive, Iowa, United States, 50325
Contact: Site Public Contact    308-398-6518    clinicaltrials@sfmc-gi.org   
Principal Investigator: Richard L. Deming         
Greater Regional Medical Center Suspended
Creston, Iowa, United States, 50801
Medical Oncology and Hematology Associates-Laurel Recruiting
Des Moines, Iowa, United States, 50314
Contact: Site Public Contact    308-398-6518    clinicaltrials@sfmc-gi.org   
Principal Investigator: Richard L. Deming         
Mercy Medical Center - Des Moines Recruiting
Des Moines, Iowa, United States, 50314
Contact: Site Public Contact    308-398-6518    clinicaltrials@sfmc-gi.org   
Principal Investigator: Richard L. Deming         
Mercy Medical Center-West Lakes Recruiting
West Des Moines, Iowa, United States, 50266
Contact: Site Public Contact    308-398-6518    clinicaltrials@sfmc-gi.org   
Principal Investigator: Richard L. Deming         
United States, Kansas
University of Kansas Cancer Center Recruiting
Kansas City, Kansas, United States, 66160
Contact: Site Public Contact    913-945-7552    ctnursenav@kumc.edu   
Principal Investigator: Xinglei Shen         
Olathe Medical Center Recruiting
Olathe, Kansas, United States, 66061
Contact: Site Public Contact    913-791-3500    Jeni.wakefield@olathehealth.org   
Principal Investigator: Xinglei Shen         
University of Kansas Cancer Center-Overland Park Recruiting
Overland Park, Kansas, United States, 66210
Contact: Site Public Contact    913-945-7552    ctnursenav@kumc.edu   
Principal Investigator: Xinglei Shen         
Salina Regional Health Center Recruiting
Salina, Kansas, United States, 67401
Contact: Site Public Contact    785-452-7038    kkavoura@srhc.com   
Principal Investigator: Xinglei Shen         
University of Kansas Hospital-Westwood Cancer Center Recruiting
Westwood, Kansas, United States, 66205
Contact: Site Public Contact    913-945-7552    ctnursenav@kumc.edu   
Principal Investigator: Xinglei Shen         
United States, Kentucky
University of Kentucky/Markey Cancer Center Recruiting
Lexington, Kentucky, United States, 40536
Contact: Site Public Contact    859-257-3379      
Principal Investigator: William H. St. Clair         
United States, Louisiana
Mary Bird Perkins Cancer Center Recruiting
Baton Rouge, Louisiana, United States, 70809
Contact: Site Public Contact    225-215-1353    clinicalresearch@marybird.com   
Principal Investigator: David S. Hanson         
East Jefferson General Hospital Recruiting
Metairie, Louisiana, United States, 70006
Contact: Site Public Contact    504-210-3539    emede1@lsuhsc.edu   
Principal Investigator: Scott E. Delacroix         
LSU Healthcare Network / Metairie Multi-Specialty Clinic Recruiting
Metairie, Louisiana, United States, 70006
Contact: Site Public Contact    504-210-3539    emede1@lsuhsc.edu   
Principal Investigator: Scott E. Delacroix         
United States, Maine
MaineHealth Coastal Cancer Treatment Center Recruiting
Bath, Maine, United States, 04530
Contact: Site Public Contact    412-339-5294    Roster@nrgoncology.org   
Principal Investigator: Matthew D. Cheney         
Waldo County General Hospital Recruiting
Belfast, Maine, United States, 04915
Contact: Site Public Contact    207-338-2500      
Principal Investigator: Matthew D. Cheney         
MaineHealth/SMHC Cancer Care and Blood Disorders-Biddeford Recruiting
Biddeford, Maine, United States, 04005
Contact: Site Public Contact       LLemire@mmc.org   
Principal Investigator: Matthew D. Cheney         
Lafayette Family Cancer Center-EMMC Recruiting
Brewer, Maine, United States, 04412
Contact: Site Public Contact    800-987-3005      
Principal Investigator: Sarah J. Sinclair         
Stephens Memorial Hospital Recruiting
Norway, Maine, United States, 04268
Contact: Site Public Contact    207-396-8670    OncClinicalResearch@mmc.org   
Principal Investigator: Matthew D. Cheney         
Maine Medical Center-Bramhall Campus Recruiting
Portland, Maine, United States, 04102
Contact: Site Public Contact    207-885-7565      
Principal Investigator: Matthew D. Cheney         
Penobscot Bay Medical Center Recruiting
Rockport, Maine, United States, 04856
Contact: Site Public Contact    207-396-8670    ClinicalResearch@mmc.org   
Principal Investigator: Matthew D. Cheney         
MaineHealth Cancer Care Center of York County Recruiting
Sanford, Maine, United States, 04073
Contact: Site Public Contact    207-459-1600      
Principal Investigator: Matthew D. Cheney         
MaineHealth/SMHC Cancer Care and Blood Disorders-Sanford Recruiting
Sanford, Maine, United States, 04073
Contact: Site Public Contact       LLemire@mmc.org   
Principal Investigator: Matthew D. Cheney         
Maine Medical Center- Scarborough Campus Recruiting
Scarborough, Maine, United States, 04074
Contact: Site Public Contact    207-396-8090    wrighd@mmc.org   
Principal Investigator: Matthew D. Cheney         
Maine Medical Partners - South Portland Recruiting
South Portland, Maine, United States, 04106
Contact: Site Public Contact    207-396-8670    ClinicalResearch@mmc.org   
Principal Investigator: Matthew D. Cheney         
United States, Maryland
Saint Agnes Hospital Recruiting
Baltimore, Maryland, United States, 21229
Contact: Site Public Contact    410-368-2910      
Principal Investigator: Richard S. Hudes         
United States, Massachusetts
Lahey Hospital and Medical Center Recruiting
Burlington, Massachusetts, United States, 01805
Contact: Site Public Contact    781-744-8027      
Principal Investigator: Brendan Connell         
Lowell General Hospital Recruiting
Lowell, Massachusetts, United States, 01854
Contact: Site Public Contact    978-788-7084    ghincks@lowellgeneral.org   
Principal Investigator: Murat A. Anamur         
United States, Michigan
Saint Joseph Mercy Hospital Recruiting
Ann Arbor, Michigan, United States, 48106
Contact: Site Public Contact    734-712-3671    stephanie.couch@stjoeshealth.org   
Principal Investigator: Samir Narayan         
University of Michigan Comprehensive Cancer Center Recruiting
Ann Arbor, Michigan, United States, 48109
Contact: Site Public Contact    800-865-1125      
Principal Investigator: Daniel E. Spratt         
Bronson Battle Creek Recruiting
Battle Creek, Michigan, United States, 49017
Contact: Site Public Contact    616-391-1230    crcwm-regulatory@crcwm.org   
Principal Investigator: Kathleen J. Yost         
Saint Joseph Mercy Brighton Recruiting
Brighton, Michigan, United States, 48114
Contact: Site Public Contact    734-712-3671    stephanie.couch@stjoeshealth.org   
Principal Investigator: Samir Narayan         
Saint Joseph Mercy Canton Recruiting
Canton, Michigan, United States, 48188
Contact: Site Public Contact    734-712-3671    stephanie.couch@stjoeshealth.org   
Principal Investigator: Samir Narayan         
Saint Joseph Mercy Chelsea Recruiting
Chelsea, Michigan, United States, 48118
Contact: Site Public Contact    734-712-3671    stephanie.couch@stjoeshealth.org   
Principal Investigator: Samir Narayan         
21st Century Oncology MHP - Clarkston Recruiting
Clarkston, Michigan, United States, 48346
Contact: Site Public Contact    248-338-0663      
Principal Investigator: Frank A. Vicini         
Beaumont Hospital ? Dearborn Recruiting
Dearborn, Michigan, United States, 48124
Contact: Site Public Contact    248-551-7695      
Principal Investigator: Zachary A. Seymour         
Michigan State University Clinical Center Recruiting
East Lansing, Michigan, United States, 48824-7016
Contact: Site Public Contact    517-975-9547      
Principal Investigator: Jatin Rana         
21st Century Oncology MHP - Farmington Recruiting
Farmington Hills, Michigan, United States, 48334
Contact: Site Public Contact    248-338-0663      
Principal Investigator: Frank A. Vicini         
Mercy Health Saint Mary's Recruiting
Grand Rapids, Michigan, United States, 49503
Contact: Site Public Contact    616-391-1230    crcwm-regulatory@crcwm.org   
Principal Investigator: Kathleen J. Yost         
Spectrum Health at Butterworth Campus Recruiting
Grand Rapids, Michigan, United States, 49503
Contact: Site Public Contact    616-391-1230    crcwm-regulatory@crcwm.org   
Principal Investigator: Kathleen J. Yost         
West Michigan Cancer Center Recruiting
Kalamazoo, Michigan, United States, 49007
Contact: Site Public Contact    616-391-1230    crcwm-regulatory@crcwm.org   
Principal Investigator: Kathleen J. Yost         
Sparrow Hospital Recruiting
Lansing, Michigan, United States, 48912
Contact: Site Public Contact    734-712-3671    stephanie.couch@stjoeshealth.org   
Principal Investigator: Samir Narayan         
Lakeland Hospital Niles Recruiting
Niles, Michigan, United States, 49120
Contact: Site Public Contact    616-391-1230      
Principal Investigator: Kathleen J. Yost         
Spectrum Health Reed City Hospital Recruiting
Reed City, Michigan, United States, 49677
Contact: Site Public Contact    616-391-1230    crcwm-regulatory@crcwm.org   
Principal Investigator: Kathleen J. Yost         
William Beaumont Hospital-Royal Oak Recruiting
Royal Oak, Michigan, United States, 48073
Contact: Site Public Contact    248-551-7695      
Principal Investigator: Zachary A. Seymour         
Lakeland Medical Center Saint Joseph Recruiting
Saint Joseph, Michigan, United States, 49085
Contact: Site Public Contact    616-391-1230    crcwm-regulatory@crcwm.org   
Principal Investigator: Kathleen J. Yost         
Marie Yeager Cancer Center Recruiting
Saint Joseph, Michigan, United States, 49085
Contact: Site Public Contact    616-391-1230    crcwm-regulatory@crcwm.org   
Principal Investigator: Kathleen J. Yost         
Munson Medical Center Recruiting
Traverse City, Michigan, United States, 49684
Contact: Site Public Contact    616-391-1230    crcwm-regulatory@crcwm.org   
Principal Investigator: Kathleen J. Yost         
21st Century Oncology MHP - Troy Recruiting
Troy, Michigan, United States, 48098
Contact: Site Public Contact    248-338-0663      
Principal Investigator: Frank A. Vicini         
Metro Health Hospital Recruiting
Wyoming, Michigan, United States, 49519
Contact: Site Public Contact    616-391-1230    crcwm-regulatory@crcwm.org   
Principal Investigator: Kathleen J. Yost         
United States, Minnesota
Mayo Clinic Health System in Albert Lea Recruiting
Albert Lea, Minnesota, United States, 56007
Contact: Site Public Contact    855-776-0015      
Principal Investigator: Bradley J. Stish         
Fairview Ridges Hospital Recruiting
Burnsville, Minnesota, United States, 55337
Contact: Site Public Contact    952-993-1517    mmcorc@healthpartners.com   
Principal Investigator: Paul W. Sperduto         
Mercy Hospital Recruiting
Coon Rapids, Minnesota, United States, 55433
Contact: Site Public Contact    952-993-1517    mmcorc@healthpartners.com   
Principal Investigator: Paul W. Sperduto         
Fairview-Southdale Hospital Recruiting
Edina, Minnesota, United States, 55435
Contact: Site Public Contact    952-993-1517    mmcorc@healthpartners.com   
Principal Investigator: Paul W. Sperduto         
Unity Hospital Recruiting
Fridley, Minnesota, United States, 55432
Contact: Site Public Contact    952-993-1517    mmcorc@healthpartners.com   
Principal Investigator: Paul W. Sperduto         
Mayo Clinic Health Systems-Mankato Recruiting
Mankato, Minnesota, United States, 56001
Contact: Site Public Contact    855-776-0015      
Principal Investigator: Bradley J. Stish         
Fairview Maple Grove Medical Center Recruiting
Maple Grove, Minnesota, United States, 55369
Contact: Site Public Contact    952-993-1517    mmcorc@healthpartners.com   
Principal Investigator: Paul W. Sperduto         
Minnesota Oncology Hematology PA-Maplewood Recruiting
Maplewood, Minnesota, United States, 55109
Contact: Site Public Contact    952-993-1517    mmcorc@healthpartners.com   
Principal Investigator: Paul W. Sperduto         
Saint John's Hospital - Healtheast Recruiting
Maplewood, Minnesota, United States, 55109
Contact: Site Public Contact    952-993-1517    mmcorc@healthpartners.com   
Principal Investigator: Paul W. Sperduto         
Abbott-Northwestern Hospital Recruiting
Minneapolis, Minnesota, United States, 55407
Contact: Site Public Contact    952-993-1517    mmcorc@healthpartners.com   
Principal Investigator: Paul W. Sperduto         
Hennepin County Medical Center Recruiting
Minneapolis, Minnesota, United States, 55415
Contact: Site Public Contact    952-993-1517    mmcorc@healthpartners.com   
Principal Investigator: Paul W. Sperduto         
Health Partners Inc Recruiting
Minneapolis, Minnesota, United States, 55454
Contact: Site Public Contact    952-993-1517    mmcorc@healthpartners.com   
Principal Investigator: Paul W. Sperduto         
Monticello Cancer Center Recruiting
Monticello, Minnesota, United States, 55362
Contact: Site Public Contact    952-993-1517    mmcorc@healthpartners.com   
Principal Investigator: Paul W. Sperduto         
North Memorial Medical Health Center Recruiting
Robbinsdale, Minnesota, United States, 55422
Contact: Site Public Contact    952-993-1517    mmcorc@healthpartners.com   
Principal Investigator: Paul W. Sperduto         
Mayo Clinic Recruiting
Rochester, Minnesota, United States, 55905
Contact: Site Public Contact    855-776-0015      
Principal Investigator: Bradley J. Stish         
Coborn Cancer Center at Saint Cloud Hospital Recruiting
Saint Cloud, Minnesota, United States, 56303
Contact: Site Public Contact    877-229-4907    coborncancercenter@centracare.com   
Principal Investigator: Donald J. Jurgens         
Park Nicollet Clinic - Saint Louis Park Recruiting
Saint Louis Park, Minnesota, United States, 55416
Contact: Site Public Contact    952-993-1517    mmcorc@healthpartners.com   
Principal Investigator: Paul W. Sperduto         
Regions Hospital Recruiting
Saint Paul, Minnesota, United States, 55101
Contact: Site Public Contact    952-993-1517    mmcorc@healthpartners.com   
Principal Investigator: Paul W. Sperduto         
United Hospital Recruiting
Saint Paul, Minnesota, United States, 55102
Contact: Site Public Contact    952-993-1517    mmcorc@healthpartners.com   
Principal Investigator: Paul W. Sperduto         
Saint Francis Regional Medical Center Recruiting
Shakopee, Minnesota, United States, 55379
Contact: Site Public Contact    952-993-1517    mmcorc@healthpartners.com   
Principal Investigator: Paul W. Sperduto         
Lakeview Hospital Recruiting
Stillwater, Minnesota, United States, 55082
Contact: Site Public Contact    952-993-1517    mmcorc@healthpartners.com   
Principal Investigator: Paul W. Sperduto         
Ridgeview Medical Center Recruiting
Waconia, Minnesota, United States, 55387
Contact: Site Public Contact    952-993-1517    mmcorc@healthpartners.com   
Principal Investigator: Paul W. Sperduto         
Rice Memorial Hospital Recruiting
Willmar, Minnesota, United States, 56201
Contact: Site Public Contact    952-993-1517    mmcorc@healthpartners.com   
Principal Investigator: Paul W. Sperduto         
Minnesota Oncology Hematology PA-Woodbury Recruiting
Woodbury, Minnesota, United States, 55125
Contact: Site Public Contact    952-993-1517    mmcorc@healthpartners.com   
Principal Investigator: Paul W. Sperduto         
Fairview Lakes Medical Center Recruiting
Wyoming, Minnesota, United States, 55092
Contact: Site Public Contact    952-993-1517    mmcorc@healthpartners.com   
Principal Investigator: Paul W. Sperduto         
United States, Mississippi
University of Mississippi Medical Center Recruiting
Jackson, Mississippi, United States, 39216
Contact: Site Public Contact    601-815-6700      
Principal Investigator: John C. Henegan         
United States, Missouri
Southeast Cancer Center Recruiting
Cape Girardeau, Missouri, United States, 63703
Contact: Site Public Contact    573-651-5550      
Principal Investigator: Bryan A. Faller         
Siteman Cancer Center at West County Hospital Recruiting
Creve Coeur, Missouri, United States, 63141
Contact: Site Public Contact    800-600-3606    info@siteman.wustl.edu   
Principal Investigator: Hiram A. Gay         
Capital Region Southwest Campus Recruiting
Jefferson City, Missouri, United States, 65109
Contact: Site Public Contact    573-632-4814    swooden@mail.crmc.org   
Principal Investigator: Bryan A. Faller         
Kansas City Veterans Affairs Medical Center Recruiting
Kansas City, Missouri, United States, 64128
Contact: Site Public Contact    800-525-1483      
Principal Investigator: Eashwer K. Reddy         
The University of Kansas Cancer Center-North Recruiting
Kansas City, Missouri, United States, 64154
Contact: Site Public Contact    913-945-7552    ctnursenav@kumc.edu   
Principal Investigator: Xinglei Shen         
The University of Kansas Cancer Center-Lee's Summit Recruiting
Lee's Summit, Missouri, United States, 64064
Contact: Site Public Contact    913-945-7552    ctnursenav@kumc.edu   
Principal Investigator: Xinglei Shen         
Delbert Day Cancer Institute at PCRMC Recruiting
Rolla, Missouri, United States, 65401
Contact: Site Public Contact    573-458-7504    jrichards@research.pcrmc.com   
Principal Investigator: Jay W. Carlson         
Washington University School of Medicine Recruiting
Saint Louis, Missouri, United States, 63110
Contact: Site Public Contact    800-600-3606    info@siteman.wustl.edu   
Principal Investigator: Hiram A. Gay         
Siteman Cancer Center-South County Recruiting
Saint Louis, Missouri, United States, 63129
Contact: Site Public Contact    800-600-3606    info@siteman.wustl.edu   
Principal Investigator: Hiram A. Gay         
Mercy Hospital Saint Louis Recruiting
Saint Louis, Missouri, United States, 63141
Contact: Site Public Contact    314-251-7066      
Principal Investigator: Jay W. Carlson         
Siteman Cancer Center at Saint Peters Hospital Recruiting
Saint Peters, Missouri, United States, 63376
Contact: Site Public Contact    800-600-3606    info@siteman.wustl.edu   
Principal Investigator: Hiram A. Gay         
United States, Montana
Billings Clinic Cancer Center Recruiting
Billings, Montana, United States, 59101
Contact: Site Public Contact    800-996-2663    research@billingsclinic.org   
Principal Investigator: John M. Schallenkamp         
Bozeman Deaconess Hospital Recruiting
Bozeman, Montana, United States, 59715
Contact: Site Public Contact    406-969-6060    mccinfo@mtcancer.org   
Principal Investigator: John M. Schallenkamp         
Benefis Healthcare- Sletten Cancer Institute Recruiting
Great Falls, Montana, United States, 59405
Contact: Site Public Contact    406-969-6060    mccinfo@mtcancer.org   
Principal Investigator: John M. Schallenkamp         
United States, Nebraska
Nebraska Methodist Hospital Recruiting
Omaha, Nebraska, United States, 68114
Contact: Site Public Contact    402-354-5144      
Principal Investigator: Ralph J. Hauke         
Alegent Health Bergan Mercy Medical Center Recruiting
Omaha, Nebraska, United States, 68124
Contact: Site Public Contact    308-398-6518    clinicaltrials@sfmc-gi.org   
Principal Investigator: Richard L. Deming         
University of Nebraska Medical Center Recruiting
Omaha, Nebraska, United States, 68198
Contact: Site Public Contact    402-559-6941    unmcrsa@unmc.edu   
Principal Investigator: Charles A. Enke         
United States, Nevada
Comprehensive Cancer Centers of Nevada - Henderson Recruiting
Henderson, Nevada, United States, 89052
Contact: Site Public Contact    702-384-0013    research@sncrf.org   
Principal Investigator: John A. Ellerton         
Comprehensive Cancer Centers of Nevada-Horizon Ridge Recruiting
Henderson, Nevada, United States, 89052
Contact: Site Public Contact    702-384-0013    research@sncrf.org   
Principal Investigator: John A. Ellerton         
Las Vegas Cancer Center-Henderson Recruiting
Henderson, Nevada, United States, 89052
Contact: Site Public Contact    702-384-0013    research@sncrf.org   
Principal Investigator: John A. Ellerton         
OptumCare Cancer Care at Seven Hills Recruiting
Henderson, Nevada, United States, 89052
Contact: Site Public Contact    702-384-0013    research@sncrf.org   
Principal Investigator: John A. Ellerton         
21st Century Oncology-Henderson Recruiting
Henderson, Nevada, United States, 89074
Contact: Site Public Contact    702-384-0013    research@sncrf.org   
Principal Investigator: John A. Ellerton         
Comprehensive Cancer Centers of Nevada-Southeast Henderson Recruiting
Henderson, Nevada, United States, 89074
Contact: Site Public Contact    702-384-0013    research@sncrf.org   
Principal Investigator: John A. Ellerton         
Desert West Surgery Recruiting
Las Vegas, Nevada, United States, 89102
Contact: Site Public Contact    702-384-0013    research@sncrf.org   
Principal Investigator: John A. Ellerton         
University Medical Center of Southern Nevada Recruiting
Las Vegas, Nevada, United States, 89102
Contact: Site Public Contact    702-384-0013    research@sncrf.org   
Principal Investigator: John A. Ellerton         
Hope Cancer Care of Nevada Recruiting
Las Vegas, Nevada, United States, 89103
Contact: Site Public Contact    702-384-0013    research@sncrf.org   
Principal Investigator: John A. Ellerton         
OptumCare Cancer Care at Oakey Recruiting
Las Vegas, Nevada, United States, 89106
Contact: Site Public Contact    702-384-0013    research@sncrf.org   
Principal Investigator: John A. Ellerton         
Radiation Oncology Centers of Nevada Central Recruiting
Las Vegas, Nevada, United States, 89106
Contact: Site Public Contact    702-384-0013    research@sncrf.org   
Principal Investigator: John A. Ellerton         
21st Century Oncology Recruiting
Las Vegas, Nevada, United States, 89109
Contact: Site Public Contact    702-384-0013    research@sncrf.org   
Principal Investigator: John A. Ellerton         
HealthCare Partners Medical Group Oncology/Hematology-Maryland Parkway Recruiting
Las Vegas, Nevada, United States, 89109
Contact: Site Public Contact    702-384-0013    research@sncrf.org   
Principal Investigator: John A. Ellerton         
HealthCare Partners Medical Group Oncology/Hematology-San Martin Recruiting
Las Vegas, Nevada, United States, 89113
Contact: Site Public Contact    702-384-0013    research@sncrf.org   
Principal Investigator: John A. Ellerton         
Radiation Oncology Centers of Nevada Southeast Recruiting
Las Vegas, Nevada, United States, 89119
Contact: Site Public Contact    702-384-0013    research@sncrf.org   
Principal Investigator: John A. Ellerton         
Cancer Therapy and Integrative Medicine Suspended
Las Vegas, Nevada, United States, 89121
21st Century Oncology-Vegas Tenaya Recruiting
Las Vegas, Nevada, United States, 89128
Contact: Site Public Contact    702-384-0013    research@sncrf.org   
Principal Investigator: John A. Ellerton         
Ann M Wierman MD LTD Recruiting
Las Vegas, Nevada, United States, 89128
Contact: Site Public Contact    702-384-0013    research@sncrf.org   
Principal Investigator: John A. Ellerton         
Comprehensive Cancer Centers of Nevada - Northwest Recruiting
Las Vegas, Nevada, United States, 89128
Contact: Site Public Contact    702-384-0013    research@sncrf.org   
Principal Investigator: John A. Ellerton         
HealthCare Partners Medical Group Oncology/Hematology-Tenaya Recruiting
Las Vegas, Nevada, United States, 89128
Contact: Site Public Contact    702-384-0013    research@sncrf.org   
Principal Investigator: John A. Ellerton         
OptumCare Cancer Care at MountainView Recruiting
Las Vegas, Nevada, United States, 89128
Contact: Site Public Contact    702-384-0013    research@sncrf.org   
Principal Investigator: John A. Ellerton         
Comprehensive Cancer Centers of Nevada-Summerlin Recruiting
Las Vegas, Nevada, United States, 89144
Contact: Site Public Contact    702-384-0013    research@sncrf.org   
Principal Investigator: John A. Ellerton         
Summerlin Hospital Medical Center Recruiting
Las Vegas, Nevada, United States, 89144
Contact: Site Public Contact    702-384-0013    research@sncrf.org   
Principal Investigator: John A. Ellerton         
Las Vegas Cancer Center-Medical Center Recruiting
Las Vegas, Nevada, United States, 89148-2405
Contact: Site Public Contact    702-384-0013    research@sncrf.org   
Principal Investigator: John A. Ellerton         
21st Century Oncology-Fort Apache Recruiting
Las Vegas, Nevada, United States, 89148
Contact: Site Public Contact    702-384-0013    research@sncrf.org   
Principal Investigator: John A. Ellerton         
Comprehensive Cancer Centers of Nevada Recruiting
Las Vegas, Nevada, United States, 89148
Contact: Site Public Contact    702-384-0013    research@sncrf.org   
Principal Investigator: John A. Ellerton         
OptumCare Cancer Care at Fort Apache Recruiting
Las Vegas, Nevada, United States, 89148
Contact: Site Public Contact    702-384-0013    research@sncrf.org   
Principal Investigator: John A. Ellerton         
HealthCare Partners Medical Group Oncology/Hematology-Centennial Hills Recruiting
Las Vegas, Nevada, United States, 89149
Contact: Site Public Contact    702-384-0013    research@sncrf.org   
Principal Investigator: John A. Ellerton         
Comprehensive Cancer Centers of Nevada - Central Valley Recruiting
Las Vegas, Nevada, United States, 89169
Contact: Site Public Contact    702-384-0013    research@sncrf.org   
Principal Investigator: John A. Ellerton         
University Cancer Center Recruiting
Las Vegas, Nevada, United States, 89169
Contact: Site Public Contact    702-384-0013    research@sncrf.org   
Principal Investigator: John A. Ellerton         
Hope Cancer Care of Nevada-Pahrump Recruiting
Pahrump, Nevada, United States, 89048
Contact: Site Public Contact    702-384-0013    research@sncrf.org   
Principal Investigator: John A. Ellerton         
Radiation Oncology Associates Recruiting
Reno, Nevada, United States, 89509
Contact: Site Public Contact    702-384-0013    research@sncrf.org   
Principal Investigator: John A. Ellerton         
United States, New Hampshire
New Hampshire Oncology Hematology PA-Concord Recruiting
Concord, New Hampshire, United States, 03301
Contact: Site Public Contact    603-224-2556      
Principal Investigator: Douglas J. Weckstein         
New Hampshire Oncology Hematology PA-Hooksett Recruiting
Hooksett, New Hampshire, United States, 03106
Contact: Site Public Contact    800-339-6484      
Principal Investigator: Douglas J. Weckstein         
Dartmouth Hitchcock Medical Center Recruiting
Lebanon, New Hampshire, United States, 03756
Contact: Site Public Contact    800-639-6918    cancer.research.nurse@dartmouth.edu   
Principal Investigator: Alan C. Hartford         
United States, New Jersey
Virtua Memorial Active, not recruiting
Mount Holly, New Jersey, United States, 08060
Rutgers Cancer Institute of New Jersey Recruiting
New Brunswick, New Jersey, United States, 08903
Contact: Site Public Contact    732-235-8675      
Principal Investigator: Rahul R. Parikh         
Kennedy Health Systems-Cancer Center Recruiting
Sewell, New Jersey, United States, 08080
Contact: Site Public Contact    856-218-5790    t.carducci@kennedyhealth.org   
Principal Investigator: Robert B. Den         
United States, New Mexico
University of New Mexico Cancer Center Recruiting
Albuquerque, New Mexico, United States, 87102
Contact: Site Public Contact    505-925-0366    LByatt@nmcca.org   
Principal Investigator: Neda Hashemi Sadraei         
United States, New York
James J Peters VA Medical Center Recruiting
Bronx, New York, United States, 10468
Contact: Site Public Contact    718-584-9000    kl2965@cumc.columbia.edu   
Principal Investigator: Alice V. Cheuk         
New York-Presbyterian/Brooklyn Methodist Hospital Recruiting
Brooklyn, New York, United States, 11215
Contact: Site Public Contact    718-780-3677    Adg9003@nyp.org   
Principal Investigator: Hani L. Ashamalla         
Sands Cancer Center Recruiting
Canandaigua, New York, United States, 14424
Contact: Site Public Contact    585-396-6161      
Principal Investigator: Yuhchyau Chen         
Mary Imogene Bassett Hospital Recruiting
Cooperstown, New York, United States, 13326
Contact: Site Public Contact    877-547-1750    CancerClinicalTrials@bassett.org   
Principal Investigator: Timothy P. Korytko         
Laura and Isaac Perlmutter Cancer Center at NYU Langone Recruiting
New York, New York, United States, 10016
Contact: Site Public Contact    212-263-4434    prmc.coordinator@nyumc.org   
Principal Investigator: Peter B. Schiff         
Highland Hospital Recruiting
Rochester, New York, United States, 14620
Contact: Site Public Contact    585-341-8113      
Principal Investigator: Yuhchyau Chen         
University Radiation Oncology Recruiting
Rochester, New York, United States, 14626
Contact: Site Public Contact    585-723-7740      
Principal Investigator: Yuhchyau Chen         
University of Rochester Recruiting
Rochester, New York, United States, 14642
Contact: Site Public Contact    585-275-5830      
Principal Investigator: Yuhchyau Chen         
Stony Brook University Medical Center Recruiting
Stony Brook, New York, United States, 11794
Contact: Site Public Contact    800-862-2215      
Principal Investigator: Samuel Ryu         
State University of New York Upstate Medical University Recruiting
Syracuse, New York, United States, 13210
Contact: Site Public Contact    315-464-5476      
Principal Investigator: Jeffrey A. Bogart         
United States, North Carolina
UNC Lineberger Comprehensive Cancer Center Recruiting
Chapel Hill, North Carolina, United States, 27599
Contact: Site Public Contact    877-668-0683    cancerclinicaltrials@med.unc.edu   
Principal Investigator: Ronald C. Chen         
NHRMC Radiation Oncology - Supply Recruiting
Supply, North Carolina, United States, 28462
Contact: Site Public Contact    910-754-4716      
Principal Investigator: Michael A. Papagikos         
New Hanover Regional Medical Center/Zimmer Cancer Center Recruiting
Wilmington, North Carolina, United States, 28401
Contact: Site Public Contact    910-342-3000      
Principal Investigator: Michael A. Papagikos         
NHRMC Radiation Oncology - 16th Street Recruiting
Wilmington, North Carolina, United States, 28401
Contact: Site Public Contact    910-251-1839      
Principal Investigator: Michael A. Papagikos         
United States, Ohio
Summa Akron City Hospital/Cooper Cancer Center Recruiting
Akron, Ohio, United States, 44304
Contact: Site Public Contact    330-375-6101      
Principal Investigator: Desiree E. Doncals         
Cleveland Clinic Akron General Recruiting
Akron, Ohio, United States, 44307
Contact: Site Public Contact    866-223-8100    CancerAnswer@ccf.org   
Principal Investigator: Mitchel L. Fromm         
UHHS-Chagrin Highlands Medical Center Recruiting
Beachwood, Ohio, United States, 44122
Contact: Site Public Contact    800-641-2422    CTUReferral@UHhospitals.org   
Principal Investigator: Mitchell Machtay         
Indu and Raj Soin Medical Center Recruiting
Beavercreek, Ohio, United States, 45431
Contact: Site Public Contact    937-775-1350    som_dcop@wright.edu   
Principal Investigator: Howard M. Gross         
Dayton Physicians LLC-Miami Valley South Recruiting
Centerville, Ohio, United States, 45459
Contact: Site Public Contact    937-775-1350    som_dcop@wright.edu   
Principal Investigator: Howard M. Gross         
Miami Valley Hospital South Recruiting
Centerville, Ohio, United States, 45459
Contact: Site Public Contact    937-775-1350    som_dcop@wright.edu   
Principal Investigator: Howard M. Gross         
Geauga Hospital Recruiting
Chardon, Ohio, United States, 44024
Contact: Site Public Contact    800-641-2422    CTUReferral@UHhospitals.org   
Principal Investigator: Mitchell Machtay         
University of Cincinnati/Barrett Cancer Center Recruiting
Cincinnati, Ohio, United States, 45219
Contact: Site Public Contact    513-558-4553    uchealthnews@uc.edu   
Principal Investigator: Jordan Kharofa         
Oncology Hematology Care Inc-Kenwood Recruiting
Cincinnati, Ohio, United States, 45236
Contact: Site Public Contact    937-775-1350    som_dcop@wright.edu   
Principal Investigator: Howard M. Gross         
Case Western Reserve University Recruiting
Cleveland, Ohio, United States, 44106
Contact: Site Public Contact    800-641-2422    CTUReferral@UHhospitals.org   
Principal Investigator: Mitchell Machtay         
Cleveland Clinic Cancer Center/Fairview Hospital Recruiting
Cleveland, Ohio, United States, 44111
Contact: Site Public Contact    866-223-8100    CancerAnswer@ccf.org   
Principal Investigator: Rahul D. Tendulkar         
Cleveland Clinic Foundation Recruiting
Cleveland, Ohio, United States, 44195
Contact: Site Public Contact    866-223-8100    CancerAnswer@ccf.org   
Principal Investigator: Rahul D. Tendulkar         
Ohio State University Comprehensive Cancer Center Recruiting
Columbus, Ohio, United States, 43210
Contact: Site Public Contact    800-293-5066    Jamesline@osumc.edu   
Principal Investigator: Dayssy A. Diaz Pardo         
Good Samaritan Hospital - Dayton Recruiting
Dayton, Ohio, United States, 45406
Contact: Site Public Contact    937-775-1350    som_dcop@wright.edu   
Principal Investigator: Howard M. Gross         
Miami Valley Hospital Recruiting
Dayton, Ohio, United States, 45409
Contact: Site Public Contact    937-775-1350    som_dcop@wright.edu   
Principal Investigator: Howard M. Gross         
Dayton Physician LLC-Miami Valley Hospital North Recruiting
Dayton, Ohio, United States, 45415
Contact: Site Public Contact    937-775-1350    som_dcop@wright.edu   
Principal Investigator: Howard M. Gross         
Miami Valley Hospital North Recruiting
Dayton, Ohio, United States, 45415
Contact: Site Public Contact    937-775-1350    som_dcop@wright.edu   
Principal Investigator: Howard M. Gross         
Armes Family Cancer Center Recruiting
Findlay, Ohio, United States, 45840
Contact: Site Public Contact    937-775-1350    som_dcop@wright.edu   
Principal Investigator: Howard M. Gross         
Blanchard Valley Hospital Recruiting
Findlay, Ohio, United States, 45840
Contact: Site Public Contact    937-775-1350    som_dcop@wright.edu   
Principal Investigator: Howard M. Gross         
Orion Cancer Care Recruiting
Findlay, Ohio, United States, 45840
Contact: Site Public Contact    937-775-1350    som_dcop@wright.edu   
Principal Investigator: Howard M. Gross         
Atrium Medical Center-Middletown Regional Hospital Recruiting
Franklin, Ohio, United States, 45005-1066
Contact: Site Public Contact    937-775-1350    som_dcop@wright.edu   
Principal Investigator: Howard M. Gross         
Dayton Physicians LLC-Atrium Recruiting
Franklin, Ohio, United States, 45005
Contact: Site Public Contact    937-775-1350    som_dcop@wright.edu   
Principal Investigator: Howard M. Gross         
Dayton Physicians LLC-Wayne Recruiting
Greenville, Ohio, United States, 45331
Contact: Site Public Contact    937-775-1350    som_dcop@wright.edu   
Principal Investigator: Howard M. Gross         
Wayne Hospital Recruiting
Greenville, Ohio, United States, 45331
Contact: Site Public Contact    937-775-1350    som_dcop@wright.edu   
Principal Investigator: Howard M. Gross         
Greater Dayton Cancer Center Recruiting
Kettering, Ohio, United States, 45409
Contact: Site Public Contact    937-775-1350    som_dcop@wright.edu   
Principal Investigator: Howard M. Gross         
First Dayton Cancer Care Recruiting
Kettering, Ohio, United States, 45420
Contact: Site Public Contact    937-775-1350    som_dcop@wright.edu   
Principal Investigator: Howard M. Gross         
Kettering Medical Center Recruiting
Kettering, Ohio, United States, 45429
Contact: Site Public Contact    937-775-1350    som_dcop@wright.edu   
Principal Investigator: Howard M. Gross         
Cleveland Clinic Cancer Center Mansfield Recruiting
Mansfield, Ohio, United States, 44906
Contact: Site Public Contact    866-223-8100    CancerAnswer@ccf.org   
Principal Investigator: Rahul D. Tendulkar         
Hillcrest Hospital Cancer Center Recruiting
Mayfield Heights, Ohio, United States, 44124
Contact: Site Public Contact    866-223-8100    CancerAnswer@ccf.org   
Principal Investigator: Rahul D. Tendulkar         
University Hospitals Parma Medical Center Recruiting
Parma, Ohio, United States, 44129
Contact: Site Public Contact    800-641-2422    CTUReferral@UHhospitals.org   
Principal Investigator: Mitchell Machtay         
North Coast Cancer Care Recruiting
Sandusky, Ohio, United States, 44870
Contact: Site Public Contact    866-223-8100    CancerAnswer@ccf.org   
Principal Investigator: Rahul D. Tendulkar         
Springfield Regional Cancer Center Recruiting
Springfield, Ohio, United States, 45504
Contact: Site Public Contact    937-775-1350    som_dcop@wright.edu   
Principal Investigator: Howard M. Gross         
Springfield Regional Medical Center Recruiting
Springfield, Ohio, United States, 45505
Contact: Site Public Contact    937-775-1350    som_dcop@wright.edu   
Principal Investigator: Howard M. Gross         
Cleveland Clinic Cancer Center Strongsville Recruiting
Strongsville, Ohio, United States, 44136
Contact: Site Public Contact    866-223-8100    CancerAnswer@ccf.org   
Principal Investigator: Rahul D. Tendulkar         
Dayton Physicians LLC-Upper Valley Recruiting
Troy, Ohio, United States, 45373
Contact: Site Public Contact    937-775-1350    som_dcop@wright.edu   
Principal Investigator: Howard M. Gross         
Upper Valley Medical Center Recruiting
Troy, Ohio, United States, 45373
Contact: Site Public Contact    937-775-1350    som_dcop@wright.edu   
Principal Investigator: Howard M. Gross         
University Pointe Recruiting
West Chester, Ohio, United States, 45069
Contact: Site Public Contact       clinicaltrials@ucphysicians.com   
Principal Investigator: Jordan Kharofa         
UHHS-Westlake Medical Center Recruiting
Westlake, Ohio, United States, 44145
Contact: Site Public Contact    800-641-2422    CTUReferral@UHhospitals.org   
Principal Investigator: Mitchell Machtay         
Cleveland Clinic Wooster Family Health and Surgery Center Recruiting
Wooster, Ohio, United States, 44691
Contact: Site Public Contact    866-223-8100    CancerAnswer@ccf.org   
Principal Investigator: Rahul D. Tendulkar         
United States, Oklahoma
University of Oklahoma Health Sciences Center Recruiting
Oklahoma City, Oklahoma, United States, 73104
Contact: Site Public Contact    405-271-8777    ou-clinical-trials@ouhsc.edu   
Principal Investigator: J. S. Thompson         
United States, Oregon
Legacy Mount Hood Medical Center Recruiting
Gresham, Oregon, United States, 97030
Contact: Site Public Contact    503-413-2150      
Principal Investigator: Andrew Y. Kee         
Legacy Good Samaritan Hospital and Medical Center Recruiting
Portland, Oregon, United States, 97210
Contact: Site Public Contact    800-220-4937    cancer@lhs.org   
Principal Investigator: Andrew Y. Kee         
United States, Pennsylvania
UPMC Altoona Recruiting
Altoona, Pennsylvania, United States, 16601
Contact: Site Public Contact    412-339-5294    Roster@nrgoncology.org   
Principal Investigator: Adam Olson         
UPMC-Heritage Valley Health System Beaver Recruiting
Beaver, Pennsylvania, United States, 15009
Contact: Site Public Contact    724-773-7616      
Principal Investigator: Adam Olson         
Saint Luke's University Hospital-Bethlehem Campus Recruiting
Bethlehem, Pennsylvania, United States, 18015
Contact: Site Public Contact    484-503-4151      
Principal Investigator: Nimisha Deb         
Christiana Care Health System-Concord Health Center Recruiting
Chadds Ford, Pennsylvania, United States, 19317
Contact: Site Public Contact    302-623-4450    KDempsey@christianacare.org   
Principal Investigator: Gregory A. Masters         
Northeast Radiation Oncology Center Recruiting
Dunmore, Pennsylvania, United States, 18512
Contact: Site Public Contact    888-808-6762      
Principal Investigator: Robert B. Den         
UPMC Cancer Center at UPMC Horizon Recruiting
Farrell, Pennsylvania, United States, 16121
Contact: Site Public Contact    412-339-5294    Roster@nrgoncology.org   
Principal Investigator: Adam Olson         
UPMC Cancer Centers - Arnold Palmer Pavilion Recruiting
Greensburg, Pennsylvania, United States, 15601
Contact: Site Public Contact    724-838-1900      
Principal Investigator: Adam Olson         
UPMC Pinnacle Cancer Center/Community Osteopathic Campus Recruiting
Harrisburg, Pennsylvania, United States, 17109
Contact: Site Public Contact    717-724-6765    klitchfield@PINNACLEHEALTH.org   
Principal Investigator: Adam Olson         
Penn State Milton S Hershey Medical Center Recruiting
Hershey, Pennsylvania, United States, 17033-0850
Contact: Site Public Contact    717-531-3779    CTO@hmc.psu.edu   
Principal Investigator: Nicholas G. Zaorsky         
UPMC-Johnstown/John P. Murtha Regional Cancer Center Recruiting
Johnstown, Pennsylvania, United States, 15901
Contact: Site Public Contact    814-534-4724      
Principal Investigator: Adam Olson         
UPMC Cancer Center at UPMC McKeesport Recruiting
McKeesport, Pennsylvania, United States, 15132
Contact: Site Public Contact    412-647-8073      
Principal Investigator: Adam Olson         
UPMC Cancer Center - Monroeville Recruiting
Monroeville, Pennsylvania, United States, 15146
Contact: Site Public Contact    412-339-5294    Roster@nrgoncology.org   
Principal Investigator: Adam Olson         
UPMC-Coraopolis/Heritage Valley Radiation Oncology Recruiting
Moon, Pennsylvania, United States, 15108
Contact: Site Public Contact    412-604-2020      
Principal Investigator: Adam Olson         
Thomas Jefferson University Hospital Recruiting
Philadelphia, Pennsylvania, United States, 19107
Contact: Site Public Contact    215-955-6084      
Principal Investigator: Robert B. Den         
Aria Health-Torresdale Campus Recruiting
Philadelphia, Pennsylvania, United States, 19114
Contact: Site Public Contact    215-612-5296      
Principal Investigator: Robert B. Den         
UPMC-Magee Womens Hospital Recruiting
Pittsburgh, Pennsylvania, United States, 15213
Contact: Site Public Contact    412-647-2811      
Principal Investigator: Adam Olson         
UPMC-Saint Margaret Recruiting
Pittsburgh, Pennsylvania, United States, 15215
Contact: Site Public Contact    412-784-4900      
Principal Investigator: Adam Olson         
UPMC-Shadyside Hospital Recruiting
Pittsburgh, Pennsylvania, United States, 15232
Contact: Site Public Contact    412-621-2334      
Principal Investigator: Adam Olson         
UPMC-Passavant Hospital Recruiting
Pittsburgh, Pennsylvania, United States, 15237
Contact: Site Public Contact    412-367-6454      
Principal Investigator: Adam Olson         
UPMC-Saint Clair Hospital Cancer Center Recruiting
Pittsburgh, Pennsylvania, United States, 15243
Contact: Site Public Contact    412-502-3920      
Principal Investigator: Adam Olson         
Guthrie Medical Group PC-Robert Packer Hospital Recruiting
Sayre, Pennsylvania, United States, 18840
Contact: Site Public Contact    800-836-0388      
Principal Investigator: Thomas J. Gergel         
UPMC Cancer Center at UPMC Northwest Recruiting
Seneca, Pennsylvania, United States, 16346
Contact: Site Public Contact    814-676-7900      
Principal Investigator: Adam Olson         
UPMC Uniontown Hospital Radiation Oncology Recruiting
Uniontown, Pennsylvania, United States, 15401
Contact: Site Public Contact    724-437-2503      
Principal Investigator: Adam Olson         
UPMC Washington Hospital Radiation Oncology Recruiting
Washington, Pennsylvania, United States, 15301
Contact: Site Public Contact    724-223-3788    cancer@washingtonhospital.org   
Principal Investigator: Adam Olson         
Reading Hospital Recruiting
West Reading, Pennsylvania, United States, 19611
Contact: Site Public Contact    610-988-9323      
Principal Investigator: Terrence P. Cescon         
Abington Memorial Hospital-Asplundh Cancer Pavilion Recruiting
Willow Grove, Pennsylvania, United States, 19090
Contact: Site Public Contact    215-481-2402      
Principal Investigator: Wayne H. Pinover         
United States, South Carolina
Greenville Health System Cancer Institute-Faris Recruiting
Greenville, South Carolina, United States, 29605
Contact: Site Public Contact    864-241-6251    kwilliams8@ghs.org   
Principal Investigator: Michael D. Zurenko         
Greenville Health System Cancer Institute-Eastside Recruiting
Greenville, South Carolina, United States, 29615
Contact: Site Public Contact    864-241-6251    kwilliams8@ghs.org   
Principal Investigator: Michael D. Zurenko         
Self Regional Healthcare Recruiting
Greenwood, South Carolina, United States, 29646
Contact: Site Public Contact    864-725-4771    nmcgaha@selfregional.org   
Principal Investigator: David T. Marshall         
Greenville Health System Cancer Institute-Greer Recruiting
Greer, South Carolina, United States, 29650
Contact: Site Public Contact    864-241-6251    kwilliams8@ghs.org   
Principal Investigator: Michael D. Zurenko         
The Radiation Oncology Center-Hilton Head/Bluffton Recruiting
Hilton Head Island, South Carolina, United States, 29926
Contact: Site Public Contact    912-819-5704    underberga@sjchs.org   
Principal Investigator: Howard A. Zaren         
Greenville Health System Cancer Institute-Seneca Recruiting
Seneca, South Carolina, United States, 29672
Contact: Site Public Contact    864-241-6251    kwilliams8@ghs.org   
Principal Investigator: Michael D. Zurenko         
Greenville Health System Cancer Institute-Spartanburg Recruiting
Spartanburg, South Carolina, United States, 29307
Contact: Site Public Contact    864-241-6251    kwilliams8@ghs.org   
Principal Investigator: Michael D. Zurenko         
United States, South Dakota
Rapid City Regional Hospital Recruiting
Rapid City, South Dakota, United States, 57701
Contact: Site Public Contact    605-716-3982    research@rcrh.org   
Principal Investigator: Michael J. Swartz         
United States, Tennessee
The West Clinic - Wolf River Recruiting
Germantown, Tennessee, United States, 38138
Contact: Site Public Contact    901-683-0055    afletcher@westclinic.com   
Principal Investigator: Daniel A. Vaena         
Vanderbilt University/Ingram Cancer Center Recruiting
Nashville, Tennessee, United States, 37232
Contact: Site Public Contact    800-811-8480      
Principal Investigator: Austin N. Kirschner         
United States, Texas
UT Southwestern/Simmons Cancer Center-Dallas Recruiting
Dallas, Texas, United States, 75390
Contact: Site Public Contact    214-648-7097    canceranswerline@UTSouthwestern.edu   
Principal Investigator: Neil B. Desai         
University of Texas Health Science Center at San Antonio Recruiting
San Antonio, Texas, United States, 78229
Contact: Site Public Contact    210-450-3800    phoresearchoffice@uthscsa.edu   
Principal Investigator: Chethan Ramamurthy         
United States, Utah
American Fork Hospital / Huntsman Intermountain Cancer Center Recruiting
American Fork, Utah, United States, 84003
Contact: Site Public Contact    801-855-4100    officeofresearch@imail.org   
Principal Investigator: Brandon M. Barney         
Sandra L Maxwell Cancer Center Recruiting
Cedar City, Utah, United States, 84720
Contact: Site Public Contact    435-868-5680    officeofresearch@imail.org   
Principal Investigator: Brandon M. Barney         
Farmington Health Center Recruiting
Farmington, Utah, United States, 84025
Contact: Site Public Contact    888-424-2100    cancerinfo@hci.utah.edu   
Principal Investigator: Shane Lloyd         
Logan Regional Hospital Recruiting
Logan, Utah, United States, 84321
Contact: Site Public Contact    435-716-6400    officeofresearch@imail.org   
Principal Investigator: Brandon M. Barney         
Intermountain Medical Center Recruiting
Murray, Utah, United States, 84107
Contact: Site Public Contact    801-507-3950    officeofresearch@imail.org   
Principal Investigator: Brandon M. Barney         
McKay-Dee Hospital Center Recruiting
Ogden, Utah, United States, 84403
Contact: Site Public Contact    801-387-7426    officeofresearch@imail.org   
Principal Investigator: Brandon M. Barney         
Utah Valley Regional Medical Center Recruiting
Provo, Utah, United States, 84604
Contact: Site Public Contact    801-357-7965    officeofresearch@imail.org   
Principal Investigator: Brandon M. Barney         
Riverton Hospital Recruiting
Riverton, Utah, United States, 84065
Contact: Site Public Contact    801-507-3950    officeofresearch@imail.org   
Principal Investigator: Brandon M. Barney         
Dixie Medical Center Regional Cancer Center Recruiting
Saint George, Utah, United States, 84770
Contact: Site Public Contact    435-688-4167    officeofresearch@imail.org   
Principal Investigator: Brandon M. Barney         
Utah Cancer Specialists-Salt Lake City Recruiting
Salt Lake City, Utah, United States, 84106
Contact: Site Public Contact    801-933-6070    officeofresearch@imail.org   
Principal Investigator: Brandon M. Barney         
Huntsman Cancer Institute/University of Utah Recruiting
Salt Lake City, Utah, United States, 84112
Contact: Site Public Contact    888-424-2100    cancerinfo@hci.utah.edu   
Principal Investigator: Shane Lloyd         
LDS Hospital Recruiting
Salt Lake City, Utah, United States, 84143
Contact: Site Public Contact    801-408-1347    officeofresearch@imail.org   
Principal Investigator: Brandon M. Barney         
United States, Vermont
Southwestern Vermont Medical Center Suspended
Bennington, Vermont, United States, 05201
Central Vermont Medical Center/National Life Cancer Treatment Recruiting
Berlin, Vermont, United States, 05602
Contact: Site Public Contact    802-225-5400      
Principal Investigator: Harold J. Wallace         
University of Vermont Medical Center Recruiting
Burlington, Vermont, United States, 05401
Contact: Site Public Contact    802-656-4101    rpo@uvm.edu   
Principal Investigator: Harold J. Wallace         
University of Vermont and State Agricultural College Recruiting
Burlington, Vermont, United States, 05405
Contact: Site Public Contact    802-656-8990    rpo@uvm.edu   
Principal Investigator: Harold J. Wallace         
Norris Cotton Cancer Center-North Recruiting
Saint Johnsbury, Vermont, United States, 05819
Contact: Site Public Contact    802-473-4100      
Principal Investigator: Alan C. Hartford         
United States, Virginia
Naval Medical Center - Portsmouth Recruiting
Portsmouth, Virginia, United States, 23708-2197
Contact: Site Public Contact    757-953-5939      
Principal Investigator: Andrew S. Camarata         
United States, Washington
PeaceHealth Saint Joseph Medical Center Recruiting
Bellingham, Washington, United States, 98225
Contact: Site Public Contact    360-715-4133    mjohnson9@peacehealth.org   
Principal Investigator: Dan S. Zuckerman         
Legacy Salmon Creek Hospital Recruiting
Vancouver, Washington, United States, 98686
Contact: Site Public Contact    503-413-2150      
Principal Investigator: Andrew Y. Kee         
Providence Saint Mary Regional Cancer Center Recruiting
Walla Walla, Washington, United States, 99362
Contact: Site Public Contact    509-897-5993    Cheryl.Dodd@providence.org   
Principal Investigator: Dan S. Zuckerman         
United States, West Virginia
West Virginia University Healthcare Recruiting
Morgantown, West Virginia, United States, 26506
Contact: Site Public Contact    304-293-7374    cancertrialsinfo@hsc.wvu.edu   
Principal Investigator: Malcolm D. Mattes         
Camden Clark Medical Center Recruiting
Parkersburg, West Virginia, United States, 26101
Contact: Site Public Contact    304-293-7374    cancertrialsinfo@hsc.wvu.edu   
Principal Investigator: Malcolm D. Mattes         
United States, Wisconsin
Marshfield Medical Center-EC Cancer Center Recruiting
Eau Claire, Wisconsin, United States, 54701
Contact: Site Public Contact    800-782-8581    oncology.clinical.trials@marshfieldresearch.org   
Principal Investigator: John Simmons         
Aurora Cancer Care-Grafton Recruiting
Grafton, Wisconsin, United States, 53024
Contact: Site Public Contact    414-302-2304    ncorp@aurora.org   
Principal Investigator: Ellen L. Ziaja         
Aurora BayCare Medical Center Recruiting
Green Bay, Wisconsin, United States, 54311
Contact: Site Public Contact    414-302-2304    ncorp@aurora.org   
Principal Investigator: Ellen L. Ziaja         
Aurora Cancer Care-Kenosha South Recruiting
Kenosha, Wisconsin, United States, 53142
Contact: Site Public Contact    414-302-2304    ncorp@aurora.org   
Principal Investigator: Ellen L. Ziaja         
Marshfield Medical Center-Marshfield Recruiting
Marshfield, Wisconsin, United States, 54449
Contact: Site Public Contact    800-782-8581    oncology.clinical.trials@marshfieldresearch.org   
Principal Investigator: John Simmons         
Community Memorial Hospital Recruiting
Menomonee Falls, Wisconsin, United States, 53051
Contact: Site Public Contact    262-257-5100      
Principal Investigator: Colleen A. Lawton         
Aurora Saint Luke's Medical Center Recruiting
Milwaukee, Wisconsin, United States, 53215
Contact: Site Public Contact    414-302-2304    ncorp@aurora.org   
Principal Investigator: Ellen L. Ziaja         
Medical College of Wisconsin Recruiting
Milwaukee, Wisconsin, United States, 53226
Contact: Site Public Contact    414-805-3666      
Principal Investigator: Colleen A. Lawton         
Zablocki Veterans Administration Medical Center Recruiting
Milwaukee, Wisconsin, United States, 53295
Contact: Site Public Contact    888-469-6614      
Principal Investigator: Elizabeth M. Gore         
Marshfield Clinic-Minocqua Center Recruiting
Minocqua, Wisconsin, United States, 54548
Contact: Site Public Contact    800-782-8581    oncology.clinical.trials@marshfieldresearch.org   
Principal Investigator: John Simmons         
Cancer Center of Western Wisconsin Recruiting
New Richmond, Wisconsin, United States, 54017
Contact: Site Public Contact    952-993-1517    mmcorc@healthpartners.com   
Principal Investigator: Paul W. Sperduto         
Vince Lombardi Cancer Clinic - Oshkosh Recruiting
Oshkosh, Wisconsin, United States, 54904
Contact: Site Public Contact    414-302-2304    ncorp@aurora.org   
Principal Investigator: Ellen L. Ziaja         
Marshfield Medical Center-Rice Lake Recruiting
Rice Lake, Wisconsin, United States, 54868
Contact: Site Public Contact    800-782-8581    oncology.clinical.trials@marshfieldresearch.org   
Principal Investigator: John Simmons         
Vince Lombardi Cancer Clinic-Sheboygan Recruiting
Sheboygan, Wisconsin, United States, 53081
Contact: Site Public Contact    414-302-2304    ncorp@aurora.org   
Principal Investigator: Ellen L. Ziaja         
Marshfield Clinic Stevens Point Center Recruiting
Stevens Point, Wisconsin, United States, 54482
Contact: Site Public Contact    800-782-8581    oncology.clinical.trials@marshfieldresearch.org   
Principal Investigator: John Simmons         
Aurora Medical Center in Summit Recruiting
Summit, Wisconsin, United States, 53066
Contact: Site Public Contact    414-302-2304    ncorp@aurora.org   
Principal Investigator: Ellen L. Ziaja         
Vince Lombardi Cancer Clinic-Two Rivers Recruiting
Two Rivers, Wisconsin, United States, 54241
Contact: Site Public Contact    414-302-2304    ncorp@aurora.org   
Principal Investigator: Ellen L. Ziaja         
Aurora West Allis Medical Center Recruiting
West Allis, Wisconsin, United States, 53227
Contact: Site Public Contact    414-302-2304    ncorp@aurora.org   
Principal Investigator: Ellen L. Ziaja         
The Alyce and Elmore Kraemer Cancer Care Center Recruiting
West Bend, Wisconsin, United States, 53095
Contact: Site Public Contact    866-680-0505      
Principal Investigator: Colleen A. Lawton         
Diagnostic and Treatment Center Recruiting
Weston, Wisconsin, United States, 54476
Contact: Site Public Contact    888-799-3989    oncology.clinical.trials@marshfieldresearch.org   
Principal Investigator: John Simmons         
Marshfield Clinic - Weston Center Recruiting
Weston, Wisconsin, United States, 54476
Contact: Site Public Contact    800-782-8581    oncology.clinical.trials@marshfieldresearch.org   
Principal Investigator: John Simmons         
Canada, Alberta
Tom Baker Cancer Centre Recruiting
Calgary, Alberta, Canada, T2N 4N2
Contact: Site Public Contact    403-521-3433      
Principal Investigator: Alexander G. Balogh         
Canada, Ontario
University Health Network-Princess Margaret Hospital Recruiting
Toronto, Ontario, Canada, M5G 2M9
Contact: Site Public Contact    416-946-4501    clinical.trials@uhn.on.ca   
Principal Investigator: Alejandro Berlin         
Canada, Quebec
The Research Institute of the McGill University Health Centre (MUHC) Recruiting
Montreal, Quebec, Canada, H3H 2R9
Contact: Site Public Contact    514-934-1934 ext 48354    evelyn.ortega@muhc.mcgill.ca   
Principal Investigator: Fabio L. Cury         
CHU de Quebec-L'Hotel-Dieu de Quebec (HDQ) Recruiting
Quebec City, Quebec, Canada, G1R 2J6
Contact: Site Public Contact       rechclinique@crchuq.ulaval.ca   
Principal Investigator: Eric Vigneault         
Centre Hospitalier Universitaire de Sherbrooke-Fleurimont Recruiting
Sherbrooke, Quebec, Canada, J1H 5N4
Contact: Site Public Contact    819-820-6480    crcinformation.chus@ssss.gouv.qc.ca   
Principal Investigator: Annie Ebacher         
Canada, Saskatchewan
Allan Blair Cancer Centre Recruiting
Regina, Saskatchewan, Canada, S4T 7T1
Contact: Site Public Contact    306-766-2213      
Principal Investigator: Evgeny Sadikov         
Saskatoon Cancer Centre Recruiting
Saskatoon, Saskatchewan, Canada, S7N 4H4
Contact: Site Public Contact    306-655-2914      
Principal Investigator: Ali A. El-Gayed         
Sponsors and Collaborators
NRG Oncology
National Cancer Institute (NCI)
Investigators
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Principal Investigator: Daniel Spratt, MD NRG Oncology
Principal Investigator: Felix Feng, MD NRG Oncology

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Responsible Party: NRG Oncology
ClinicalTrials.gov Identifier: NCT03371719     History of Changes
Other Study ID Numbers: NRG-GU006
NCI-2017-01268 ( Registry Identifier: CTRP (Clinical Trial Reporting Program) )
NRG-GU006 ( Other Identifier: NRG Oncology )
NRG-GU006 ( Other Identifier: CTEP )
U10CA180868 ( U.S. NIH Grant/Contract )
First Posted: December 13, 2017    Key Record Dates
Last Update Posted: September 5, 2019
Last Verified: September 2019

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Studies a U.S. FDA-regulated Drug Product: Yes
Studies a U.S. FDA-regulated Device Product: No
Additional relevant MeSH terms:
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Prostatic Neoplasms
Genital Neoplasms, Male
Urogenital Neoplasms
Neoplasms by Site
Neoplasms
Neoplasms, Glandular and Epithelial
Neoplasms by Histologic Type
Adenocarcinoma
Genital Diseases, Male
Prostatic Diseases
Carcinoma