Brown Adipose Tissue Activation: Effect of Exercise Training and Irisin (EXEBAT)
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|ClinicalTrials.gov Identifier: NCT03359824|
Recruitment Status : Completed
First Posted : December 2, 2017
Last Update Posted : December 13, 2017
This study investigates the brown adipose tissue (BAT) activation and metabolism using positron emission tomography (PET) imaging before and after exercise training intervention at fasting state under normal room temperature and during cold stimulation.The investigators hypothesize that BAT glucose uptake is increased after exercise and BAT becomes metabolically more active.
Understanding the mechanisms of BAT activation and the role of exercise in humans is crucial to combat epidemic of obesity and diabetes.
|Condition or disease||Intervention/treatment|
|Physical Activity||Other: Exercise|
Exercise training has been suggested to activate and recruit human BAT through the activation of sympathetic nervous system and contracting skeletal muscles by the release of myokines such as lactate and irisin that signal WAT to induce expression of beige adipocytes. It has been also suggested that exercise training could enhance the metabolism of already existed functional BAT by increasing uncoupling protein-1 (UCP-1) gene transcription, mitochondrial biogenesis and hyperplasia. This is of clinical relevance because brown fat activation has been found to improve metabolic factors linked to obesity and diabetes.
In this study the investigators use a PET radiotracer 2-[18F] flouro-2-deoxy-D-glucose (FDG) to quantify the glucose uptake in BAT, whie adipose tissue and the muscle.The participants are scanned thrice at fast in this study once at room temperature, second at cold exposure and third after six weeks of exercise at cold exposure. This study will provide an insight about the role of exercise in activation of BAT metabolism.
|Study Type :||Interventional (Clinical Trial)|
|Actual Enrollment :||11 participants|
|Intervention Model:||Single Group Assignment|
|Masking:||None (Open Label)|
|Primary Purpose:||Basic Science|
|Official Title:||Brown Adipose Tissue Activation: Effect of Exercise Training and Irisin|
|Actual Study Start Date :||September 17, 2013|
|Primary Completion Date :||May 27, 2015|
|Study Completion Date :||May 27, 2015|
Arm: Exercise: Combination of moderate intensity continuous training, high intensity interval training and endurance training 5 times per week for a total of 6 weeks. Out of 5 sessions three were supervised by trainer and two sessions were performed by subjects on their own.The duration of the exercise was increased progressively. The first two weeks was 30 minutes that increased to 45 minutes in the third and fourth week. It was 60 minutes for the last two weeks.
- Cold-induced glucose uptake in BAT after exercise [ Time Frame: Within one study day ]Glucose uptake of brown adipose tissue acquired with PET under cold exposure after exercise intervention. PET imaging is used to quantify glucose uptake in tissues
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT03359824
|Principal Investigator:||Pirjo Nuutila, MD, PhD||Turku UH|