Cardiovascular Disease Cohort in Guangdong Province
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| ClinicalTrials.gov Identifier: NCT03351907 |
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Recruitment Status :
Recruiting
First Posted : November 24, 2017
Last Update Posted : September 18, 2019
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Sponsor:
Min Xia
Information provided by (Responsible Party):
Min Xia, Sun Yat-sen University
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Brief Summary:
Patients with cardiovascular diseases from Guangdong province will be recruited and followed up for at least 4 years to evaluate the risk factors for cardiovascular-related mortality and disability. Physical examination, questionnaire survey and biological sample collection will be conducted at baseline and the incidence of all-cause and cardiovascular mortality will be investigated during follow-up.
| Condition or disease |
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| Cardiovascular Disease |
5,000 patients (30-85 years old) with primary hypertension, coronary heart disease, heart failure or peripheral vascular disease and who have been living in Guangdong province for more than 5 years will be recruited. All participants will be prospectively followed up for the incidence of all-cause and cardiovascular mortality. Information about socio-demographic, diet, lifestyle, psychological status, medical history and current medication will be collected by questionnaires. Physical examinations including height, weight, waist and hip circumferences, blood pressure, fat mass and vital capacity will be conducted.Besides, blood, urine and fecal samples will be collected for further analysis. The associations between diet and lifestyle and risks for cardiovascular disease will be evaluated.
| Study Type : | Observational |
| Estimated Enrollment : | 5000 participants |
| Observational Model: | Cohort |
| Time Perspective: | Prospective |
| Official Title: | Prospective Cohort Study of Cardiovascular Disease in Guangdong Province |
| Actual Study Start Date : | November 1, 2017 |
| Estimated Primary Completion Date : | December 31, 2020 |
| Estimated Study Completion Date : | December 31, 2030 |
Primary Outcome Measures :
- All-Cause Mortality [ Time Frame: 4 years ]All-cause mortality was confrmed through a combination of hospital medical records, telephone contacts with patients or family members, and death registration at the Guangdong Provincial Center for Disease Control and Prevention.
Secondary Outcome Measures :
- Cardiovascular Mortality [ Time Frame: 4 years ]Cardiovascular mortality was defned as death attributable to an ischemic cardiovascular cause (including fatal MI, stroke, and peripheral arterial disease) or sudden death due to an unknown but presumed cardiovascular cause in high-risk patients.
Biospecimen Retention: Samples With DNA
Serum, Plasma, Urine and fecal samples for biochemical tests, biomarker examination and DNA extraction
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| Ages Eligible for Study: | 30 Years to 85 Years (Adult, Older Adult) |
| Sexes Eligible for Study: | All |
| Accepts Healthy Volunteers: | No |
| Sampling Method: | Non-Probability Sample |
Study Population
Cardiovascular disease patients (30-85 years old) who have been living in Guangdong province for more than 5 years.
Criteria
Inclusion Criteria:
- Cardiovascular disease patients (30-85 years old) who have been living in Guangdong province for more than 5 years.
- Patients have been diagnosed with primary hypertension, coronary heart disease, heart failure or peripheral vascular disease, etc.
Exclusion Criteria:
- Patients with cardiogenic (acute pericarditis, rheumatic coronary arteritis, hypertrophic cardiomyopathy, etc.) Or non-cardiogenic chest pain.
- any subject who suffer from malignant tumors, infectious diseases, advanced liver disease, major disability and cannot participate in the study.
Information from the National Library of Medicine
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT03351907
Contacts
| Contact: Min Xia | +86-2087332433 | xiamin@mail.sysu.edu.cn | |
| Contact: Min Xia | +86-2087332433 | 1186510653@qq.com |
Locations
| China, Guangdong | |
| Sun Yat-Sen University | Recruiting |
| Guangzhou, Guangdong, China, 510080 | |
| Contact: Min Xia, PhD +86-2087332433 xiamin@mail.sysu.edu.cn | |
| Contact: Min Xia +86-2087332433 1186510653@qq.com | |
Sponsors and Collaborators
Min Xia
Investigators
| Principal Investigator: | Min Xia | School of Public Health,Nutrition and Food Hygiene,Sun Yat-sen University |
Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
| Responsible Party: | Min Xia, Professer, Sun Yat-sen University |
| ClinicalTrials.gov Identifier: | NCT03351907 |
| Other Study ID Numbers: |
2017XXG1120 |
| First Posted: | November 24, 2017 Key Record Dates |
| Last Update Posted: | September 18, 2019 |
| Last Verified: | September 2019 |
| Individual Participant Data (IPD) Sharing Statement: | |
| Plan to Share IPD: | No |
| Studies a U.S. FDA-regulated Drug Product: | No |
| Studies a U.S. FDA-regulated Device Product: | No |
Additional relevant MeSH terms:
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Cardiovascular Diseases |