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Familial Clustering of Vitamin D Deficiency Via Shared Environment: The Korean National Health And Nutrition Examination Survey 2008-2012

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ClinicalTrials.gov Identifier: NCT03349879
Recruitment Status : Completed
First Posted : November 22, 2017
Last Update Posted : November 24, 2017
Sponsor:
Information provided by (Responsible Party):
Yonsei University

Study Description
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Brief Summary:
Vitamin D deficiency is a modifiable risk factor for poor bone health. Familial correlation of serum 25-hydroxyvitamin D concentration (25(OH)D) was reported in twin- or family-based studies, mostly from Caucasian parent-offspring pairs. However, data on the familial association of 25(OH)D in extended family structure and the relative contribution of genetic and shared environmental factors on serum 25(OH)D level are limited in Asian populations. In this study, the investigators aimed to assess the relative contribution of additive genetic and environmental components on serum 25(OH)D level by variance components method in a nationwide family-based cohort. Further, the investigators will evaluate the association of vitamin D status of index individual with prevalent vitamin D deficiency of each family member including spouse, offspring, sibling, and grand-offspring. Additive influences of paternal and maternal vitamin D status on offspring will be also investigated.

Condition or disease
Vitamin D Deficiency

Detailed Description:
From the Korean National Health and Nutritional Examination Survey (KNHANES) conducted between 2008 and 2012, familial correlations for 25(OH)D will be estimated in different types of family relation pairs in 28551 subjects from 10882 families. The relative contribution of additive genetic and shared or individual environmental factors for variance of 25(OH)D level will be calculated using variance component method. Interactions between paternal and maternal vitamin D status for 25(OH)D level of offspring will be evaluated.
Study Design
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Study Type : Observational
Actual Enrollment : 28551 participants
Observational Model: Family-Based
Time Perspective: Retrospective
Official Title: Familial Clustering of Vitamin D Deficiency Via Shared Environment: The Korean National Health And Nutrition Examination Survey 2008-2012
Actual Study Start Date : January 1, 2008
Actual Primary Completion Date : December 31, 2012
Actual Study Completion Date : December 31, 2012

Resource links provided by the National Library of Medicine

Drug Information available for: Vitamin D

Groups and Cohorts
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Group/Cohort
Vitamin D deficiency
serum 25(OH)D < 30 nmol/L
Vitamin D insufficiency
serum 25(OH)D between 30 and 49 nmol/L
Vitamin D sufficiency
serum 25(OH)D ≥ 50 nmol/L


Outcome Measures
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Primary Outcome Measures :
  1. Vitamin D deficiency [ Time Frame: 1 minute after the survey (cross-sectional analysis) ]
    Vitamin D deficiency (serum 25(OH)D < 30 nmol/L)


Eligibility Criteria
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Ages Eligible for Study:   10 Years to 95 Years   (Child, Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Probability Sample
Study Population
This study was based on data from the Korean National Health and Nutrition Examination Survey (KNHANES) (IV-2, 3 and V), conducted from 2008 to 2012. The KNHANES is a nationwide cross-sectional survey performed by the Division of Chronic Disease Surveillance, Korea Centers for Disease Control and Prevention (CDC), which assessed the health, nutritional status, and socioeconomic status of the non-institutionalized civilian population of South Korea. Subjects were selected using a stratified multistage clustered probability sampling design. Families, including at least two family members with serum 25(OH)D measurements and whose family relationships could be accurately identified were selected for the study. After the selection process, a total of 28,551 subjects from 10,882 families were included in our study.
Criteria

Inclusion Criteria:

  • KNHANES(Korean National Health and Nutrition Examination Survey) 2008-2012 participants

Exclusion Criteria:

  • missing value on 25-hydroxyvitamin D levels
  • data on another household member was unavailable
  • the precise family relationship between the subjects was unclear
Contacts and Locations
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Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT03349879


Locations
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Korea, Republic of
Division of Endocrinology, Department of internal Medicine, Yonsei University College of Medicine, Severance Hospital
Seoul, Korea, Republic of, 03722
Sponsors and Collaborators
Yonsei University
More Information
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Responsible Party: Yonsei University
ClinicalTrials.gov Identifier: NCT03349879    
Other Study ID Numbers: 2012-01EXP-01-2C
First Posted: November 22, 2017    Key Record Dates
Last Update Posted: November 24, 2017
Last Verified: November 2017
Individual Participant Data (IPD) Sharing Statement:
Plan to Share IPD: No

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Studies a U.S. FDA-regulated Drug Product: No
Studies a U.S. FDA-regulated Device Product: No
Additional relevant MeSH terms:
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Vitamin D Deficiency
Avitaminosis
Deficiency Diseases
Malnutrition
Nutrition Disorders