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Role of Complete Blood Picture in Predicting the Etiology of Extrahepatic Cholestasis

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT03237247
Recruitment Status : Completed
First Posted : August 2, 2017
Last Update Posted : August 8, 2017
Information provided by (Responsible Party):
Wael M Sayed, Assiut University

Brief Summary:
Cases with extrahepatic cholestasis are common and faced during day to day clinical practice, however reaching the final etiology is sometimes challenging and needs investigations which are usually expensive, may carry hazards to the patients, or inaccessible so we are in need for a method which is easily available, affordable and safe for aiding in the differential diagnosis of extrahepatic cholestasis. our study aiming to evaluate the role of complete blood count in predicting the etiology of extrahepatic cholestasis.

Condition or disease
Extrahepatic Cholestasis

Detailed Description:
Extrahepatic cholestasis has various etiologies including benign causes (benign stricture, chronic pancreatitis, choledochal cyst, mirizzi syndrome, etc...), choledocholithiasis, malignant causes (cancer pancreas, gallbladder cancer, cholangiocarcinoma, etc....), parasitic infestations (fasciola hepatica, ascaris lumbricoides, etc......) and other causes. it is essential to detect the exact cause of extrahepatic cholestasis in order to determine treatment options. diagnosing such conditions depends on clinical examination, laboratory investigations, imaging studies, endoscopic procedures, biopsy and even surgical intervention. some of these investigations are expensive, not available, or carry risk to the patients. moreover non of them is accurate 100%. Complete blood count is already available, easy to obtain, not invasive investigation. In these study we are trying to evaluate the role of complete blood count parameters namely RDW, MPV, PDW, PCT, NLR, PLR in the differential diagnosis of extrahepatic cholestasis.

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Study Type : Observational
Actual Enrollment : 38 participants
Observational Model: Case-Only
Time Perspective: Cross-Sectional
Official Title: Role of Complete Blood Picture in Predicting the Etiology of Extrahepatic Cholestasis
Actual Study Start Date : March 1, 2016
Actual Primary Completion Date : February 28, 2017
Actual Study Completion Date : February 28, 2017

cases with benign biliary stricture
Calcular OJ
cases with calcular extrahepatic cholestasis
Malignant Distal
cases with malignant distal extrahepatic cholestasis
Malignant Proximal
cases with malignant proximal extrahepatic cholestasis
cases with intrahepatic cholestasis

Primary Outcome Measures :
  1. differential diagnosis of extrahepatic cholestasis [ Time Frame: 10 days ]
    complete blood count parameters

Information from the National Library of Medicine

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Ages Eligible for Study:   14 Years and older   (Child, Adult, Older Adult)
Sexes Eligible for Study:   All
Sampling Method:   Probability Sample
Study Population
patients with extrahepatic cholestasis

Inclusion Criteria:

  • patients with extrahepatic cholestasis

Exclusion Criteria:

  • age under 14 years
  • previous bilio-pancreatic interventions
  • hemoglobinopathy
  • splenomegaly
  • myeloproliferative disorders
  • diabetes mellitus
  • recent blood transfusion in less than one month
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Responsible Party: Wael M Sayed, principle investigator, Assiut University Identifier: NCT03237247    
Other Study ID Numbers: 17100256
First Posted: August 2, 2017    Key Record Dates
Last Update Posted: August 8, 2017
Last Verified: August 2017
Keywords provided by Wael M Sayed, Assiut University:
extrahepatic cholestasis, CBC
Additional relevant MeSH terms:
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Cholestasis, Extrahepatic
Bile Duct Diseases
Biliary Tract Diseases
Digestive System Diseases