Early-onset Alzheimer's Disease Phenotypes: Neuropsychology and Neural Networks (EOAD-Subtype)
![]() |
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. |
ClinicalTrials.gov Identifier: NCT03153371 |
Recruitment Status : Unknown
Verified April 2020 by Mario F. Mendez, University of California, Los Angeles.
Recruitment status was: Recruiting
First Posted : May 15, 2017
Last Update Posted : April 28, 2020
|
- Study Details
- Tabular View
- No Results Posted
- Disclaimer
- How to Read a Study Record
Condition or disease |
---|
Alzheimer Disease, Early Onset Alzheimer Disease Alzheimer Disease, Late Onset Dementia, Alzheimer Type Logopenic Progressive Aphasia Primary Progressive Aphasia Visuospatial/Perceptual Abilities Posterior Cortical Atrophy Executive Dysfunction Corticobasal Degeneration Ideomotor Apraxia |
Unlike the usual late-onset Alzheimer's disease (LOAD), early-onset AD (EOAD), with onset before age 65, includes a high percentage of phenotypic variants. These non-familial, variants (vEOAD) present, not with progressive memory loss, but with language, visuospatial, or other cognitive difficulties. AD is now understood as a disorder that manifests with disturbed cognition reflecting disturbed neural networks. A multivariate analysis of neuropsychological tests, the "gold standard" for objectively defining neurocognitive impairments, coupled with structural and functional neuroimaging analysis of connectomes, can identify the neurocognitive-neural network profiles of vEOAD patients, compared to those with typical AD. This knowledge can increase our understanding of the heterogeneity of AD and how it causes disease.
This study hopes to show that vEOAD constitutes a "Type 2 AD", by (1) defining the neuropsychological components of Type 2 AD, and (2) understanding the anatomy and atrophy of the brains of vEOAD patients. Together, these components can outline the neurocognitive-neural network profile of Type 2 AD.
In addition to information that can help in the diagnosis and management of EOAD, this study can stimulate novel research into the reasons for this neurobiological heterogeneity in AD and could potentially lead to interventions based on alternate neurocognitive-neural network profiles.
Study Type : | Observational |
Estimated Enrollment : | 180 participants |
Observational Model: | Case-Control |
Time Perspective: | Prospective |
Official Title: | Early-onset Alzheimer's Disease Phenotypes: Neuropsychology and Neural Networks |
Actual Study Start Date : | April 4, 2016 |
Estimated Primary Completion Date : | March 31, 2021 |
Estimated Study Completion Date : | March 31, 2022 |

Group/Cohort |
---|
Early-onset Alzheimer's disease
This group will include 90 patients who have been diagnosed with clinically probable early-onset Alzheimer's disease by the UCLA Neurology Clinic (60 variant phenotypes; 30 typical amnestic).
|
Alzheimer's disease
This group will include 30 patients who have been diagnosed with clinically probable Alzheimer's disease (typical late-onset AD)
|
Controls
Healthy age-matched individuals without clinically significant cognitive impairments will be enrolled into this study.
|
- Alzheimer's disease Subtype [ Time Frame: Performed at baseline ]Neuropsychological testing results for use in a two-stage multivariate diagnostic method that combines the (weighted) test results in order to best discriminate Type 2 AD and typical AD.
- Change in overall Neurological profile [ Time Frame: Performed at baseline and 1-year follow-up visit ]Change in performance on neurological tasks between baseline visit and follow-up visit.
- Brain atrophy in MRI - Magnetic Resonance Imaging of the brain [ Time Frame: Performed at baseline visit ]Images from initial MRI scan taken at baseline visit will be analyzed for atrophy and white matter tract integrity
- Change in overall Neuropsychological profile [ Time Frame: Performed at baseline and 1-year follow-up visit ]Change in neuropsychological performance over time.

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.
Ages Eligible for Study: | 40 Years to 85 Years (Adult, Older Adult) |
Sexes Eligible for Study: | All |
Accepts Healthy Volunteers: | Yes |
Sampling Method: | Non-Probability Sample |
-
Inclusion criteria for patients with Alzheimer's disease (AD):
- Meet criteria for AD.
- Meet clinical criteria for either typical amnestic AD or variant phenotypes of early-onset (EOAD, or "Type 2 AD").
- Mild-moderate dementia severity
- Sufficient English fluency to complete neuropsychological testing in English.
- Ability to provide consent for participation, or willingness to provide assent and a legally-authorized representative willing to provide surrogate consent.
- Availability of a caregiver informant for participation
-
Exclusion criteria for patients with Alzheimer's disease (AD):
- Complicating medical illnesses.
- Significant primary visual impairments.
- Major psychiatric illness not due to the dementia.
- Confounding medications.
-
Inclusion criteria for control participants:
- Score 28/30 or higher on the Folstein Mini-Mental Status Exam.
- Age 40-85 years old
- Able to provide consent for participation and express willingness to participate in one-year follow-up visits.
- Have sufficient English fluency to complete neuropsychological testing in English.
-
Exclusion criteria for control participants:
- Complicating medical illnesses.
- Significant primary visual impairments.
- Major psychiatric illness not due to the dementia.
- Confounding medications.

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT03153371
Contact: Youssef I Khattab, BA | (310)-478-3711 ext 48176 | YKhattab@mednet.ucla.edu | |
Contact: Elivra E Jimenez, PhD | (310)-478-3711 ext 40584 or 43389 | eljimenez@mednet.ucla.edu |
United States, California | |
UCLA Department of Neurology | Recruiting |
Los Angeles, California, United States, 90095 | |
Contact: Youssef I Khattab, BA 310-478-3711 ext 48176 YKhattab@mednet.ucla.edu | |
Contact: Elvira E Jimenez, PhD (310)-478-3711 ext 40584 or 43389 eljimenez@mednet.ucla.edu | |
Principal Investigator: Mario F Mendez, MD, PhD |
Principal Investigator: | Mario F Mendez, MD, PhD | University of California, Los Angeles |
Documents provided by Mario F. Mendez, University of California, Los Angeles:
Responsible Party: | Mario F. Mendez, Professor of Neurology and Psychiatry, University of California, Los Angeles |
ClinicalTrials.gov Identifier: | NCT03153371 |
Other Study ID Numbers: |
1RF1AG050967 ( U.S. NIH Grant/Contract ) UCLA IRB#16-000496 ( Other Identifier: UCLA Institutional Research Board ) 1RF1AG050967-01A1 ( U.S. NIH Grant/Contract ) |
First Posted: | May 15, 2017 Key Record Dates |
Last Update Posted: | April 28, 2020 |
Last Verified: | April 2020 |
Individual Participant Data (IPD) Sharing Statement: | |
Plan to Share IPD: | No |
Studies a U.S. FDA-regulated Drug Product: | No |
Studies a U.S. FDA-regulated Device Product: | No |
Alzheimer's disease Young-onset variant visuospatial language apraxia control |
dementia memory MRI neurology neuropsychology brain |
Alzheimer Disease Dementia Aphasia Apraxias Aphasia, Primary Progressive Pick Disease of the Brain Frontotemporal Dementia Apraxia, Ideomotor Late Onset Disorders Brain Diseases Central Nervous System Diseases Nervous System Diseases Tauopathies Neurodegenerative Diseases |
Neurocognitive Disorders Mental Disorders Speech Disorders Language Disorders Communication Disorders Neurobehavioral Manifestations Neurologic Manifestations Psychomotor Disorders Frontotemporal Lobar Degeneration TDP-43 Proteinopathies Proteostasis Deficiencies Metabolic Diseases Disease Attributes Pathologic Processes |