Carbon Monoxide Migraine-inducing Effects in Patients With Migraine Without Aura.
|The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.|
|ClinicalTrials.gov Identifier: NCT03075020|
Recruitment Status : Completed
First Posted : March 9, 2017
Last Update Posted : December 21, 2017
|Condition or disease||Intervention/treatment||Phase|
|Headache, Migraine||Other: Carbon monoxide Other: AIR||Not Applicable|
To investigate headache score and accompanying symptoms during and after inhalation of carbon monoxide.
With transcranial Doppler imaging, c-scan and laser speckle the investigators will investigate changes in blood flow velocity of the middle cerebral artery (MCA), diameter of the superficial temporal artery (STA), the radial artery and facial skin perfusion.
|Study Type :||Interventional (Clinical Trial)|
|Actual Enrollment :||12 participants|
|Intervention Model:||Crossover Assignment|
|Masking:||Double (Participant, Investigator)|
|Primary Purpose:||Basic Science|
|Official Title:||Basic Research on Carbon Monoxide's Headache Inducing Characteristics in a Humane Experimental Headache Model|
|Actual Study Start Date :||October 2016|
|Actual Primary Completion Date :||August 31, 2017|
|Actual Study Completion Date :||December 20, 2017|
Active Comparator: Active carbon monoxide
Inhalation of carbon monoxide up to a carboxyhemoglobin concentration 22%
Other: Carbon monoxide
carbon monoxide, 4.7, Purity 99.997, inhalation of carbon monoxide in a volume corresponding to carboxyhemoglobin 10 and 20%, calculated from baseline Hg and body mass
|Placebo Comparator: Air||
Room air will be administered as placebo
- Headache scores, 12 hours [ Time Frame: 12 hours ]Comparison between carbon monoxide and placebo (atmospheric air)
- Facial blood flow [ Time Frame: [ Time Frame: 0-180 min ] ]Carbon monoxide induced changes in facial blood flow before and after inhalation.
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT03075020
|Danish Headache Center|
|Glostrup, Denmark, 2600|