Cytological Diagnosis of Hepatic Angiosarcoma and Its Histopathologic Correlation

• ClinicalTrials.gov Identifier: NCT03025438
• Recruitment Status: Completed
• First Posted: January 19, 2017
• Last Update Posted: December 18, 2017
• Sponsor: National Taiwan University Hospital
• Information provided by (Responsible Party): National Taiwan University Hospital

Study Description

Brief Summary:

Cytological diagnosis of hepatic angiosarcoma by fine-needle aspiration (FNA) or imprint cytology is difficult due not only to its various cytomorphologic features but also clinical rarity. Vasoformative features, such as pseudo-acini, branching pseudo-capillary structure, and intracytoplasmic lumina, are clues to achieve the diagnosis. But these features are not always present. In order to find clues for cytological diagnosis of angiosarcoma, we collected cases of hepatic angiosarcoma to study their cytological features. And then compared these features with those in their histopathological biopsy or resection.

Condition or disease
Hepatic Angiosarcoma

Detailed Description:

Hepatic angiosarcoma is a rare hepatic malignant tumor. Although diagnosis of hepatic angiosarcoma by FNA cytology has been reported since 1982, followed by several studies, its cytomorphologic features were still not well recognized by cytopathologists because of its clinical rarity and various morphologic features.

We reviewed literatures about cytomorphology of hepatic angiosarcoma by FNA. There are only 11 cases retrieved in 10 articles searched from Medline. The sex M/F ratio was 6/4 (one unknown); age range was 56 to 79 years old. In initial cytological evaluation, four cases got angiosarcoma or consistent/suspicious angiosarcoma diagnosis. Positive for malignancy, sarcoma, and poorly differentiated spindle cell lesion were in one case respectively. One was diagnosed as atypical cells. Remaining three were unavailable by their reports.

In cytological morphologic features, all but one met least 2 of 3 cytological cellular criteria of angiosarcoma cells: spindle cells, epithelioid cells, and pleomorphic cells. In cytological architectural features, 7 of 11 cases showed vasoformative structures; 5 of 11 cases showed intracytoplasmic lumen or erythrophagocytosis. Ten of 11 cases had histologic/pathologic confirmation as angiosarcoma. One case reported interrelation of tumor structures and their own accompanied liver tissue in cell blocks.

Study Design

• Study Type: Observational
• Actual Enrollment: 13 participants
• Observational Model: Case-Only
• Time Perspective: Retrospective
• Official Title: Cytological Diagnosis of Hepatic Angiosarcoma and Its Histopathologic Correlation
• Actual Study Start Date: January 17, 2017
• Actual Primary Completion Date: February 4, 2017
• Actual Study Completion Date: April 3, 2017

Groups and Cohorts

Outcome Measures

Primary Outcome Measures :

1. all cause mortality [ Time Frame: about 10 years from the date of diagnosis to the last follow-up date by medical record ]

Eligibility Criteria

• Ages Eligible for Study: 20 Years to 100 Years (Adult, Older Adult)
• Sexes Eligible for Study: All
• Accepts Healthy Volunteers: No
• Sampling Method: Probability Sample

Study Population

patients of a medical center in Taiwan; National Taiwan University Hospital (NTUH)

Criteria

Inclusion criteria:

Consecutive patients of hepatic angiosarcoma performed FNA and/or imprint cytological examinations in our hospital.

Exclusion criteria:

1. Patients without pathological confirmation.
2. Patients who are not angiosarcoma by pathological reviews.

Contacts and Locations

Locations

Taiwan

National Taiwan University Hospital, Department of laboratory medicine

Taipei, Taiwan, 10008

Sponsors and Collaborators

National Taiwan University Hospital

Investigators

• Principal Investigator: Wern-Cherng Cheng, MD; National Taiwan University Hospital

More Information

• Responsible Party: National Taiwan University Hospital
• ClinicalTrials.gov Identifier: NCT03025438
• Other Study ID Numbers: 201603013RINA
• First Posted: January 19, 2017
• Last Update Posted: December 18, 2017
• Last Verified: January 2017

Individual Participant Data (IPD) Sharing Statement:

• Plan to Share IPD: Undecided

Keywords provided by National Taiwan University Hospital:

angiosarcoma; Cytology; liver; cancer

Additional relevant MeSH terms:

Hemangiosarcoma; Sarcoma; Neoplasms, Connective and Soft Tissue; Neoplasms by Histologic Type; Neoplasms; Neoplasms, Vascular Tissue