Is wGRS Associated With DD Recurrence?
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|ClinicalTrials.gov Identifier: NCT02983162|
Recruitment Status : Active, not recruiting
First Posted : December 6, 2016
Last Update Posted : February 22, 2019
Rationale: Retrospectively reviewing the participants of the GODDAF database, revealed a significant association between the weighted genetic risk score and Dupuytren disease recurrence. However, a significant dose-response relation was not found. This might be caused by underestimating the recurrence rate, due to the retrospective nature of determining recurrence. Therefore, we want to do a follow-up measurement of the GODDAF participants, to see whether they suffered from recurrent disease.
Objective: We aim to determine whether the wGRS is associated with recurrent DD.
Study design: An observational study, in which the participants of the GODDAF study are followed up.
Study population: Patients affected by Dupuytren disease, aged 18-96 years, who were previously included in another study on the genetic basis of Dupuytren disease.
Intervention (if applicable): NA Main study parameters/endpoints: The main study parameter is the presence of recurrent Dupuytren disease.
|Condition or disease|
|Study Type :||Observational|
|Estimated Enrollment :||677 participants|
|Official Title:||Is the Weighted Genetic Risk Score Associated With Dupuytren Disease Recurrence?|
|Actual Study Start Date :||March 10, 2017|
|Actual Primary Completion Date :||August 1, 2018|
|Estimated Study Completion Date :||May 2020|
- Presence of recurrent Dupuytren disease [ Time Frame: 1 day ]there is only one measurement in this study
- Severity of Dupuytren recurrence [ Time Frame: 1 day ]there is only one measurement in this study
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02983162
|University Medical Center Groningen, dept Plastic Surgery|
|Groningen, Netherlands, 9700 RB|
|Principal Investigator:||P. M.N. Werker, MD, PhD||University Medical Center Groningen|