Mechanisms of Skeletal Muscle Insulin Resistance in Older Adults
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|ClinicalTrials.gov Identifier: NCT02971098|
Recruitment Status : Recruiting
First Posted : November 22, 2016
Last Update Posted : April 17, 2019
The over-65 population is not only increasing at an alarming rate, but because six out of 10 will be managing more than one chronic condition by 2030, they will make up a much greater proportion of hospitalizations than ever before. Hospitalizations for disease, injury, and/or surgery in this group are likely to impair physical mobility and, therefore, the older adults capacity to be physically active both during hospitalization and beyond. The resulting sedentary lifestyle is likely to be accepted as the "new normal", ultimately increasing the risk of skeletal muscle and metabolic dysfunction (e.g. impaired glucose disposal, insulin resistance). These devastating outcomes are neither inevitable nor necessary if prevented with an appropriate mechanism-based intervention.
A novel mechanism that may contribute to physical inactivity-induced insulin resistance is accumulation of inflammation and ceramide within skeletal muscle. Of interest, increased skeletal muscle inflammation and ceramide has been tied to various metabolic disturbances such as diabetes and insulin resistance. However, it is currently unknown if skeletal muscle inflammation and ceramide are a key mechanism associated with insulin resistance due to physical inactivity in older adults.
|Condition or disease||Intervention/treatment||Phase|
|Reduced Physical Activity||Procedure: Reduced activity||Phase 1|
Show Detailed Description
|Study Type :||Interventional (Clinical Trial)|
|Estimated Enrollment :||15 participants|
|Intervention Model:||Single Group Assignment|
|Intervention Model Description:||2 weeks of physical inactivity|
|Masking:||None (Open Label)|
|Official Title:||Novel Molecular Mechanisms of Skeletal Muscle Insulin, Resistance if Physically Inactive Older Adults|
|Study Start Date :||September 2016|
|Estimated Primary Completion Date :||April 2020|
|Estimated Study Completion Date :||April 2021|
Experimental: Reduced activity
participants will undergo a reduced physical activity period (75% step reduction) for two weeks.
Procedure: Reduced activity
Participants will reduced their physical activity level to approximately 2000 steps or 75% of their normal activity levels.
- Steady state glucose infusion rate [ Time Frame: percent change from baseline at 14 days ]Glucose infusion rate will be determined by a hyperinsulinemic-euglycemic clamp
- lean mass [ Time Frame: percent change from baseline at 14 days ]lean mass will be determined by DXA scan
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02971098
|Contact: Amy Rogersfirstname.lastname@example.org|
|Contact: Micah Drummondemail@example.com|
|United States, Utah|
|University of Utah||Recruiting|
|Salt Lake City, Utah, United States, 84108|
|Contact: Amy Rogers 801-581-5961 firstname.lastname@example.org|
|Principal Investigator:||Micah J Drummond, PhD||University of Utah|