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Memory and Emotion in Acute and Chronic Phases of Cerebrovascular Accident (MEMOIRE ET EMO)

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ClinicalTrials.gov Identifier: NCT02887105
Recruitment Status : Completed
First Posted : September 1, 2016
Last Update Posted : September 8, 2016
Sponsor:
Information provided by (Responsible Party):
Central Hospital, Nancy, France

Study Description
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Brief Summary:

The purpose is to determine the relationship between anxiety and cognitive performances in patients with acute and chronic phases of cerebrovascular accident (CVA). Data from neuropsychological assessment concerning cognitive processes (working and episodic memory) sensitive to different dimensions of anxiety will be analyzed.

The secondary purpose is to evaluate how some neurological (hemispherical lateralization of lesions), psychological (depression) and demographic (quality of life) variables can increase the effects of different dimensions of anxiety on cognitive processes, during the acute and/or chronic phase of CVA.


Condition or disease Intervention/treatment
Cerebrovascular Accident Other: Standard neuropsychological assessment Other: Brain MRI

Detailed Description:
Data will be collected during usual neuropsychological evaluation and cerebral imagery examination (NIHSS, Rankin scale) of patients in acute (0-1 month) and chronic (6 months) phases of CVA.
Study Design
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Study Type : Observational
Actual Enrollment : 76 participants
Observational Model: Cohort
Time Perspective: Prospective
Official Title: Memory and Emotion in Acute and Chronic Phases of Cerebrovascular Accident
Study Start Date : December 2012
Actual Primary Completion Date : April 2014
Actual Study Completion Date : April 2014

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Memory

Groups and Cohorts
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Group/Cohort Intervention/treatment
Patients with cerebrovascular accident Other: Standard neuropsychological assessment
Other: Brain MRI


Outcome Measures
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Primary Outcome Measures :
  1. State of anxiety evaluated with STAI-YA scale [ Time Frame: up to 1 month (from CVA) ]
  2. State of anxiety evaluated with STAI-YA scale [ Time Frame: 6 months (from CVA) ]
  3. Anxiety proneness evaluated with STAI-YB scale [ Time Frame: up to 1 month (from CVA) ]
  4. Anxiety proneness evaluated with STAI-YB scale [ Time Frame: 6 months (from CVA) ]
  5. Apprehension anxiety evaluated with Penn State Worry Questionnaire [ Time Frame: up to 1 month (from CVA) ]
  6. Apprehension anxiety evaluated with Penn State Worry Questionnaire [ Time Frame: 6 months (from CVA) ]
  7. Evaluation of working memory updating with N-back verbal and visuospatial task [ Time Frame: up to 1 month (from CVA) ]
  8. Evaluation of working memory updating with N-back verbal and visuospatial task [ Time Frame: 6 months (from CVA) ]
  9. Evaluation of working memory inhibition with Stimulus-response compatibility task [ Time Frame: up to 1 month (from CVA) ]
  10. Evaluation of working memory inhibition with Stimulus-response compatibility task [ Time Frame: 6 months (from CVA) ]
  11. Evaluation of working memory flexibility with Switching task [ Time Frame: up to 1 month (from CVA) ]
  12. Evaluation of working memory flexibility with Switching task [ Time Frame: 6 months (from CVA) ]
  13. Evaluation of verbal working memory with Wechsler memory scale [ Time Frame: up to 1 month (from CVA) ]
  14. Evaluation of verbal working memory with Wechsler memory scale [ Time Frame: 6 months (from CVA) ]
  15. Evaluation of visuospatial working memory with Wechsler memory scale [ Time Frame: up to 1 month (from CVA) ]
  16. Evaluation of visuospatial working memory with Wechsler memory scale [ Time Frame: 6 months (from CVA) ]
  17. Evaluation of visual episodic memory with Rey and Taylor figure test [ Time Frame: 6 months (from CVA) ]
  18. Evaluation of verbal episodic memory with RL/RI 16 item test [ Time Frame: 6 months (from CVA) ]

Secondary Outcome Measures :
  1. Hemispheric lateralization of lesions detected with MRI [ Time Frame: up to 1 month from CVA ]
  2. Depression state evaluated with Back depression inventory [ Time Frame: up to 1 month (from CVA) ]
  3. Depression state evaluated with Back depression inventory [ Time Frame: 6 months (from CVA) ]
  4. Quality of life evaluated with SF-36 test [ Time Frame: after 6 months from CVA ]

Eligibility Criteria
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Ages Eligible for Study:   18 Years to 80 Years   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
Patients hospitalized for a cerebrovascular accident
Criteria

Inclusion Criteria:

  • Acute phase of carotid, vertebrobasilar or lacunar cerebrovascular accident with ischemic or hemorrhagic origin
  • Right-handed
  • Possible cooperation: understanding of French instructions
  • Normal or corrected vision
  • Normal or corrected hearing
  • Mini-mental state examination score higher than pathologic threshold according to age and sociocultural level of patient
  • Possible follow up of patient

Exclusion Criteria:

  • Hearing problems
  • Vision problems
  • Right hemiplegia or acute monoparesis of right upper limb
  • Hemispatial neglect
  • Apraxia
  • Psychiatric or neurological history possibly interfering with neuropsychological evaluation
  • Important defect of working memory or executive functions
Contacts and Locations
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Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02887105


Locations
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France
Service de Neurologie - Hôpital Bon Secours - CHR de Metz-Thionville
Metz, France
Service de Neurologie - Hôpital Central - CHU de Nancy
Nancy, France
Sponsors and Collaborators
Central Hospital, Nancy, France
Investigators
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Principal Investigator: Xavier DUCROCQ, Pr Service de Neurologie - Unité Neurovasculaire - Hôpital Central Nancy
More Information
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Responsible Party: Central Hospital, Nancy, France
ClinicalTrials.gov Identifier: NCT02887105    
Other Study ID Numbers: PSS2012/MEMOIRE-DUCROCQ/MS
First Posted: September 1, 2016    Key Record Dates
Last Update Posted: September 8, 2016
Last Verified: August 2016
Additional relevant MeSH terms:
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Stroke
Cerebrovascular Disorders
Brain Diseases
Central Nervous System Diseases
 Nervous System Diseases
Vascular Diseases
Cardiovascular Diseases