Nivolumab and Ipilimumab in Treating Patients With Rare Tumors

• ClinicalTrials.gov Identifier: NCT02834013
• Recruitment Status: Active, not recruiting
• First Posted: July 15, 2016
• Last Update Posted: May 16, 2023
• Sponsor: National Cancer Institute (NCI)
• Information provided by (Responsible Party): National Cancer Institute (NCI)

Study Description

Brief Summary:

This phase II trial studies nivolumab and ipilimumab in treating patients with rare tumors. Immunotherapy with monoclonal antibodies, such as nivolumab and ipilimumab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread.

This trial enrolls participants for the following cohorts based on condition:

1. Epithelial tumors of nasal cavity, sinuses, nasopharynx: A) Squamous cell carcinoma with variants of nasal cavity, sinuses, and nasopharynx and trachea (excluding laryngeal, nasopharyngeal cancer [NPC], and squamous cell carcinoma of the head and neck [SCCHN]) B) Adenocarcinoma and variants of nasal cavity, sinuses, and nasopharynx (closed to accrual 07/27/2018)
2. Epithelial tumors of major salivary glands (closed to accrual 03/20/2018)
3. Salivary gland type tumors of head and neck, lip, esophagus, stomach, trachea and lung, breast and other location (closed to accrual)
4. Undifferentiated carcinoma of gastrointestinal (GI) tract
5. Adenocarcinoma with variants of small intestine (closed to accrual 05/10/2018)
6. Squamous cell carcinoma with variants of GI tract (stomach small intestine, colon, rectum, pancreas) (closed to accrual 10/17/2018)
7. Fibromixoma and low grade mucinous adenocarcinoma (pseudomixoma peritonei) of the appendix and ovary (closed to accrual 03/20/2018)
8. Rare pancreatic tumors including acinar cell carcinoma, mucinous cystadenocarcinoma or serous cystadenocarcinoma. Pancreatic adenocarcinoma is not eligible (closed to accrual)
9. Intrahepatic cholangiocarcinoma (closed to accrual 03/20/2018)
10. Extrahepatic cholangiocarcinoma and bile duct tumors (closed to accrual 03/20/2018)
11. Sarcomatoid carcinoma of lung
12. Bronchoalveolar carcinoma lung. This condition is now also referred to as adenocarcinoma in situ, minimally invasive adenocarcinoma, lepidic predominant adenocarcinoma, or invasive mucinous adenocarcinoma
13. Non-epithelial tumors of the ovary: A) Germ cell tumor of ovary B) Mullerian mixed tumor and adenosarcoma (closed to accrual 03/30/2018)
14. Trophoblastic tumor: A) Choriocarcinoma (closed to accrual)
15. Transitional cell carcinoma other than that of the renal, pelvis, ureter, or bladder (closed to accrual)
16. Cell tumor of the testes and extragonadal germ tumors: A) Seminoma and testicular sex cord cancer B) Non seminomatous tumor C) Teratoma with malignant transformation (closed to accrual)
17. Epithelial tumors of penis - squamous adenocarcinoma cell carcinoma with variants of penis (closed to accrual)
18. Squamous cell carcinoma variants of the genitourinary (GU) system
19. Spindle cell carcinoma of kidney, pelvis, ureter
20. Adenocarcinoma with variants of GU system (excluding prostate cancer) (closed to accrual 07/27/2018)
21. Odontogenic malignant tumors
22. Pancreatic neuroendocrine tumor (PNET) (formerly named: Endocrine carcinoma of pancreas and digestive tract.) (closed to accrual)
23. Neuroendocrine carcinoma including carcinoid of the lung (closed to accrual 12/19/2017)
24. Pheochromocytoma, malignant (closed to accrual)
25. Paraganglioma (closed to accrual 11/29/2018)
26. Carcinomas of pituitary gland, thyroid gland parathyroid gland and adrenal cortex (closed to accrual)
27. Desmoid tumors
28. Peripheral nerve sheath tumors and NF1-related tumors (closed to accrual 09/19/2018)
29. Malignant giant cell tumors
30. Chordoma (closed to accrual 11/29/2018)
31. Adrenal cortical tumors (closed to accrual 06/27/2018)
32. Tumor of unknown primary (Cancer of Unknown Primary; CuP) (closed to accrual 12/22/2017)
33. Not Otherwise Categorized (NOC) Rare Tumors [To obtain permission to enroll in the NOC cohort, contact: S1609SC@swog.org] (closed to accrual 03/15/2019)
34. Adenoid cystic carcinoma (closed to accrual 02/06/2018)
35. Vulvar cancer (closed to accrual)
36. MetaPLASTIC carcinoma (of the breast) (closed to accrual)
37. Gastrointestinal stromal tumor (GIST) (closed to accrual 09/26/2018)
38. Perivascular epithelioid cell tumor (PEComa)
39. Apocrine tumors/extramammary Paget's disease (closed to accrual)
40. Peritoneal mesothelioma
41. Basal cell carcinoma (temporarily closed to accrual 04/29/2020)
42. Clear cell cervical cancer
43. Esthenioneuroblastoma (closed to accrual)
44. Endometrial carcinosarcoma (malignant mixed Mullerian tumors) (closed to accrual)
45. Clear cell endometrial cancer
46. Clear cell ovarian cancer (closed to accrual)
47. Gestational trophoblastic disease (GTD)
48. Gallbladder cancer
49. Small cell carcinoma of the ovary, hypercalcemic type
50. PD-L1 amplified tumors
51. Angiosarcoma
52. High-grade neuroendocrine carcinoma (pancreatic neuroendocrine tumor [PNET] should be enrolled in Cohort 22; prostatic neuroendocrine carcinomas should be enrolled into Cohort 53). Small cell lung cancer is not eligible (closed to accrual)
53. Treatment-emergent small-cell neuroendocrine prostate cancer (t-SCNC)

Condition or disease	Intervention/treatment	Phase
Acinar Cell Carcinoma; Adenoid Cystic Carcinoma; Adrenal Cortical Carcinoma; Adrenal Gland Pheochromocytoma; Anal Canal Neuroendocrine Carcinoma; Anal Canal Undifferentiated Carcinoma; Angiosarcoma; Apocrine Neoplasm; Appendix Mucinous Adenocarcinoma; Bartholin Gland Transitional Cell Carcinoma; Basal Cell Carcinoma; Bladder Adenocarcinoma; Breast Metaplastic Carcinoma; Cervical Adenocarcinoma; Cholangiocarcinoma; Chordoma; Colorectal Squamous Cell Carcinoma; Desmoid Fibromatosis; Endometrial Transitional Cell Carcinoma; Endometrioid Adenocarcinoma; Esophageal Neuroendocrine Carcinoma; Esophageal Undifferentiated Carcinoma; Extrahepatic Bile Duct Carcinoma; Extramammary Paget Disease; Fallopian Tube Adenocarcinoma; Fallopian Tube Transitional Cell Carcinoma; Fibromyxoid Tumor; Gallbladder Carcinoma; Gastric Neuroendocrine Carcinoma; Gastric Squamous Cell Carcinoma; Gastric Undifferentiated Carcinoma; Gastrointestinal Stromal Tumor; Gestational Trophoblastic Tumor; Giant Cell Carcinoma; Human Papillomavirus-Independent Cervical Adenocarcinoma, Clear Cell-Type; Intestinal Neuroendocrine Carcinoma; Intrahepatic Cholangiocarcinoma; Lung Carcinoid Tumor; Lung Sarcomatoid Carcinoma; Major Salivary Gland Carcinoma; Malignant Odontogenic Neoplasm; Malignant Peripheral Nerve Sheath Tumor; Malignant Solid Neoplasm; Malignant Testicular Sex Cord-Stromal Tumor; Metastatic Malignant Neoplasm of Unknown Primary; Metastatic Pituitary Neuroendocrine Tumor; Minimally Invasive Lung Adenocarcinoma; Mixed Mesodermal (Mullerian) Tumor; Mucinous Adenocarcinoma; Mucinous Cystadenocarcinoma; Nasal Cavity Adenocarcinoma; Nasal Cavity Carcinoma; Nasopharyngeal Carcinoma; Nasopharyngeal Papillary Adenocarcinoma; Nasopharyngeal Undifferentiated Carcinoma; Oral Cavity Carcinoma; Oropharyngeal Undifferentiated Carcinoma; Ovarian Adenocarcinoma; Ovarian Germ Cell Tumor; Ovarian Mucinous Adenocarcinoma; Ovarian Squamous Cell Carcinoma; Ovarian Transitional Cell Carcinoma; Pancreatic Acinar Cell Carcinoma; Pancreatic Neuroendocrine Carcinoma; Paraganglioma; Paranasal Sinus Adenocarcinoma; Paranasal Sinus Carcinoma; Parathyroid Gland Carcinoma; PEComa; Penile Squamous Cell Carcinoma; Peritoneal Mesothelial Neoplasm; Placental Choriocarcinoma; Primary Peritoneal High Grade Serous Adenocarcinoma; Pseudomyxoma Peritonei; Rare Disorder; Scrotal Squamous Cell Carcinoma; Seminal Vesicle Adenocarcinoma; Seminoma; Serous Cystadenocarcinoma; Small Intestinal Adenocarcinoma; Small Intestinal Squamous Cell Carcinoma; Spindle Cell Neoplasm; Teratoma With Somatic-Type Malignancy; Testicular Non-Seminomatous Germ Cell Tumor; Thyroid Gland Carcinoma; Tracheal Carcinoma; Transitional Cell Carcinoma; Ureter Adenocarcinoma; Ureter Squamous Cell Carcinoma; Urethral Adenocarcinoma; Urethral Squamous Cell Carcinoma; Vaginal Adenocarcinoma; Vaginal Squamous Cell Carcinoma, Not Otherwise Specified; Vulvar Carcinoma	Procedure: Biospecimen Collection; Biological: Ipilimumab; Biological: Nivolumab	Phase 2

Detailed Description:

PRIMARY OBJECTIVES:

I. To evaluate the Response Evaluation Criteria in Solid Tumors (RECIST) version (v)1.1 overall response rate (ORR) in subsets of patients with advanced rare cancers treated with ipilimumab plus nivolumab combination immunotherapy.

II. To evaluate the overall response rate (ORR) in patients with gestational trophoblastic tumors treated with ipilimumab plus nivolumab combination immunotherapy.

III. To evaluate the RECIST v1.1 overall response rate (ORR) in patients PD-L1 amplified cancers treated with nivolumab immunotherapy.

SECONDARY OBJECTIVES:

I. To evaluate toxicities in each cohort. II. To estimate overall survival (OS), progression-free survival (PFS), clinical benefit rate; and to estimate immune related (i)RECIST ORR (iORR), and iRECIST PFS (iPFS) across cohorts and within each cohort.

OUTLINE: Patients are assigned to 1 of 2 arms.

ARM I (ALL COHORTS EXCEPT THE PD-L1 AMPLIFIED COHORT): Patients receive nivolumab intravenously (IV) over 30 minutes on days 1, 15, and 29 and ipilimumab IV over 60 minutes on day 1. Treatment repeats every 42 days for up to 17 cycles (2 years) in the absence of disease progression or unacceptable toxicity. Patients who complete 17 cycles (2 years) of therapy, may continue receiving the same treatment with nivolumab and ipilimumab, or receive nivolumab once every 14 or 28 days (2 weeks or 4 weeks) per physician discretion in the absence of disease progression or unacceptable toxicity. Patients who stop treatment prior to the completion of 17 cycles of therapy may receive nivolumab once every 14 or 28 days (2 weeks or 4 weeks) in the absence of disease progression or unacceptable toxicity.

ARM II (PD-L1 AMPLIFIED COHORT): Patients receive nivolumab IV over 30 minutes on days 1, 15 and 29. Treatment repeats every 42 days for up to 17 cycles (2 years) in the absence of disease progression or unacceptable toxicity. After 17 cycles (2 years) of therapy, patients may receive nivolumab once every 14 or 28 days (2 weeks or 4 weeks) in the absence of disease progression or unacceptable toxicity.

After completion of study treatment, patients are followed up for 10 years from registration.

Study Design

• Study Type: Interventional (Clinical Trial)
• Estimated Enrollment: 818 participants
• Allocation: Non-Randomized
• Intervention Model: Parallel Assignment
• Masking: None (Open Label)
• Primary Purpose: Treatment
• Official Title: DART: Dual Anti-CTLA-4 and Anti-PD-1 Blockade in Rare Tumors
• Actual Study Start Date: January 13, 2017
• Estimated Primary Completion Date: October 31, 2023
• Estimated Study Completion Date: October 31, 2023

Arms and Interventions

Arm	Intervention/treatment
Experimental: Arm I (nivolumab, ipilimumab); Patients receive nivolumab IV over 30 minutes on days 1, 15, and 29 and ipilimumab IV over 60 minutes on day 1. Treatment repeats every 42 days for up to 17 cycles (2 years) in the absence of disease progression or unacceptable toxicity. Patients who complete 17 cycles (2 years) of therapy, may continue receiving the same treatment with nivolumab and ipilimumab, or receive nivolumab once every 14 or 28 days (2 weeks or 4 weeks) per physician discretion in the absence of disease progression or unacceptable toxicity. Patients who stop treatment prior to the completion of 17 cycles of therapy may receive nivolumab once every 14 or 28 days (2 weeks or 4 weeks) in the absence of disease progression or unacceptable toxicity.	Procedure: Biospecimen Collection; Undergo optional collection of biopsy tissue and blood; Other Names: Biological Sample Collection; Biospecimen Collected; Specimen Collection; Biological: Ipilimumab; Given IV; Other Names: Anti-Cytotoxic T-Lymphocyte-Associated Antigen-4 Monoclonal Antibody; BMS-734016; Ipilimumab Biosimilar CS1002; MDX-010; MDX-CTLA4; Yervoy; Biological: Nivolumab; Given IV; Other Names: BMS-936558; CMAB819; MDX-1106; NIVO; Nivolumab Biosimilar CMAB819; ONO-4538; Opdivo
Experimental: Arm II (nivolumab); Patients receive nivolumab IV over 30 minutes on days 1, 15 and 29. Treatment repeats every 42 days for up to 17 cycles (2 years) in the absence of disease progression or unacceptable toxicity. After 17 cycles (2 years) of therapy, patients may receive nivolumab once every 14 or 28 days (2 weeks or 4 weeks) in the absence of disease progression or unacceptable toxicity.	Procedure: Biospecimen Collection; Undergo optional collection of biopsy tissue and blood; Other Names: Biological Sample Collection; Biospecimen Collected; Specimen Collection; Biological: Nivolumab; Given IV; Other Names: BMS-936558; CMAB819; MDX-1106; NIVO; Nivolumab Biosimilar CMAB819; ONO-4538; Opdivo

Outcome Measures

Primary Outcome Measures :

1. Overall response rate (ORR) [ Time Frame: Up to 10 years ]
   Defined as confirmed and unconfirmed complete and partial response. Assessed by Response Evaluation Criteria in Solid Tumors (RECIST) 1.1.

Secondary Outcome Measures :

1. Incidence of adverse events [ Time Frame: Up to 10 years ]
   Graded by National Cancer Institute (NCI) Common Terminology Criteria for Adverse Events (CTCAE) version 4.0. Assuming 16 eligible patients per stratum, this will be sufficient to estimate each binary version of this endpoint within +/- 25% (95% confidence interval).
2. Best response [ Time Frame: Up to 10 years ]
   Calculated from the sequence of RECIST 1.1 and immune-related (i)RECIST objectives. Assuming 16 eligible patients per stratum, this will be sufficient to estimate each binary version of this endpoint within +/- 25% (95% confidence interval).
3. Clinical benefit rate [ Time Frame: 6 months ]
   Defined as complete response, partial response, or stable disease, estimated using both RECIST and iRECIST. Assuming 16 eligible patients per stratum, this will be sufficient to estimate each binary version of this endpoint within +/- 25% (95% confidence interval).
4. Overall survival (OS) [ Time Frame: From date of registration to date of death due to any cause, assessed up to 10 years ]
   Estimated using both RECIST and immune-related (ir) RESIST criteria (RC). Assuming 16 eligible patients per stratum, this will be sufficient to estimate each binary version of this endpoint within +/- 25% (95% confidence interval).
5. Progression free survival (PFS) [ Time Frame: From date of registration to date of first documentation of progression or symptomatic deterioration or death, assessed up to 10 years ]
   Estimated using both RECIST and irRC. Assuming 16 eligible patients per stratum, this will be sufficient to estimate each binary version of this endpoint within +/- 25% (95% confidence interval).

Eligibility Criteria

• Ages Eligible for Study: 18 Years and older (Adult, Older Adult)
• Sexes Eligible for Study: All
• Accepts Healthy Volunteers: No

Criteria

Inclusion Criteria:

• Patients are eligible under ONE of the following criteria:

  • For all cohorts except the gestational trophoblastic disease (GTD) (Cohort #47), patients must have histologically and/or biochemically confirmed rare cancer and must be able to submit specimens; to be eligible for the GTD cohort: patients must have disease confirmed by quantitative serum beta-human chorionic gonadotropin (hCG) within 28 days prior to registration and must be able to submit blood specimens (tissue submission is not required for patients who will be registered to the GTD cohort [Cohort #47]); NOTE: Subsequent to site's Institutional Review Board (IRB) approval of revision 3, patients are NOT required to participate in EAY131 "National Cancer Institute (NCI)-Molecular Analysis for Therapy Choice (MATCH)" to register to S1609 OR
  • FOR PATIENTS WITH PD-L1 AMPLIFICATION (COHORT #50) ONLY: All solid tumors (excluding lymphoma) are allowed for the PD-L1 amplified cohort if they have PD-L1 amplification; patients may be considered for registration to the PD-L1 amplified cohort (Cohort #50) with the confirmation of at least one of the study chairs; PD-L1 amplification is defined as having deoxyribonucleic acid (DNA) copy number of equal to or greater than six by any of the following Clinical Laboratory Improvement Act (CLIA)-approved lab; (Immunohisochemistry [IHC] and fluorescence in situ hybridization [FISH] are not allowed); the assay must be done at or after the diagnosis of advanced disease, but PRIOR TO REGISTRATION; NOTE: patients with PD-L1 overexpression by IHC or PD-L1 amplification by FISH do not quality for this cohort; OR
  • FOR PATIENTS ENROLLED IN EAY131 "NCI-MATCH" PRIOR TO EAY131 ADDENDUM 10 ONLY: Patients must have histologically confirmed rare cancer that did not have a match to a molecularly-guided therapy on EAY131 "NCI-MATCH" protocol or who are off protocol treatment on EAY131, "NCI-MATCH" and have no further molecularly-matched treatment recommendations per EAY131, "NCI-MATCH" or who are otherwise unable to receive EAY131, "NCI-MATCH" therapy

• Patients who do not qualify for one of the histologic cohorts and are not on the ineligible histology list may be considered for registration in the "Not Otherwise Categorized" Rare Tumors cohort with confirmation of at least one of the study chairs via email

  • NOTE: The "Not Otherwise Categorized" Rare Tumors cohort was permanently closed to accrual on 3/15/2019

• Patients who are determined to have a rare cancer with unknown primary site are eligible under cohort #32 (tumor of unknown primary [cancer of unknown primary; CuP]), provided that there is histologic documentation of metastatic malignancy with no discernible primary site identified from histopathologic review, physical exam and associated cross-sectional imaging of the chest, abdomen, and pelvis

  • NOTE: The "Tumor of unknown primary (Cancer of Unknown Primary; CuP" cohort was permanently closed to accrual on 12/22/2017

• Patients must also meet one of the following:

  • Patients must have progressed following at least one line of standard systemic therapy and there must not be other approved/standard therapy available that has been shown to prolong overall survival (i.e. in a randomized trial against another standard treatment or by comparison to historical controls); patients who cannot receive other standard therapy that has been shown to prolonged survival due to medical issues will be eligible, if other eligibility criteria are met; OR
  • Patients for whose disease no standard treatment exists that has been shown to prolong overall survival
• For all cohorts except the GTD cohort (Cohort #47): Patients must have a diagnostic quality computed tomography (CT) scan or magnetic resonance imaging (MRI), performed within 28 days prior to registration, which demonstrates measurable disease, as defined in RECIST v. 1.1; scans must include imaging of the chest, abdomen and pelvis, with the exception of patients with head/neck cancer, who must have imaging of the chest, abdomen, pelvis and neck; if there is clinical suspicion for bone metastases at the time of enrollment (in the judgement of the treating investigator) bone scan should be performed; bone scans done within 42 days prior to registration may be used to establish baseline condition at registration

• No other prior malignancy is allowed except for the following:

  • Adequately managed stage I or II cancer from which the patient is currently in complete remission
  • Any other cancer from which the patient has been disease free for one year
  • Adequately managed stage I or II follicular thyroid or prostate cancer is also eligible, wherein patient is not required to be in complete remission
  • Note: Second primary tumors are not allowed concurrent with any of the eligible rare cancers
• For all cohorts except the PD-L1 amplified tumors cohort (Cohort # 50): Patients may have received either prior anti-CTLA4 or other prior anti-PD-1/anti-PD-L1 therapy, but not both, provided that it is completed >= 4 weeks prior to registration. To be eligible for the PD-L1 amplified tumors cohort (Cohort #50): Patients must not have received anti-PD-1/anti-PD-L1 therapy; prior anti-CTLA-4 is allowed provided that it is completed >= 4 weeks prior to registration
• Patients with clinically controlled thyroiditis or pituitary disorders on stable replacement therapy are eligible
• Patients with autoimmune disease who are otherwise eligible must not have received steroid and immunosuppressive therapy within 28 days prior to registration
• Patients with brain metastases or primary brain tumors must have completed treatment, surgery or radiation therapy >= 28 days prior to registration and have stable disease at time of registration; these patients must also have a CT or MRI of the brain to evaluate for CNS disease within 42 days prior to registration to S1609; metastatic brain parenchymal disease must have been treated and patient must be off steroids for 7 days prior to registration
• Hormonal or endocrine blockade is permitted as long as patient has demonstrated progression on prior therapy (e.g. gonadotrophin releasing hormone [GnRH], somatostatin); long-acting somatostatin analogs (including octreotide) and androgen deprivation treatment (including long-acting leuprolide) are permitted while on protocol therapy
• Patients must be >= 18 years of age
• Patients must have a Zubrod performance status of 0-2
• Absolute neutrophil count (ANC) >= 1,000/mcL (within 28 days prior to registration)
• Platelets >= 75,000/mcL (within 28 days prior to registration)
• Hemoglobin >= 8 g/dL (within 28 days prior to registration)
• Total bilirubin =< 2.0 x institutional upper limit of normal (IULN) or for documented/suspected Gilbert's disease, total bilirubin =< 3.0 x IULN (within 28 days prior to registration)
• Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) both =< 3 x IULN (within 28 days prior to registration)
• Serum creatinine =< 2.0 x IULN (within 28 days prior to registration)
• Creatinine clearance (CrCl) >= 50 mL/min., as estimated by the Cockcroft and Gault formula; estimated creatinine clearance is based on actual body weight (within 28 days prior to registration)
• Patients must have adequate thyroid function, as evidenced by either thyroid-stimulating hormone (TSH) or, free thyroxine (T4) serum tests demonstrating values within the normal range, within 28 days prior to registration; at pre-registration, if TSH is not within normal limits, then free T4 must be performed and must be within normal range for patient to be eligible; Note: TSH, with reflex T4 (if TSH is abnormal) is allowable if per institutional standard, provided that free T4 is within normal range; patients who have undergone thyroidectomy or who are on thyroid suppression for their cancer are not required to have normal TSH and free T4
• Patients must have adequate adrenal axis function, as evidenced by cortisol levels within institutional normal ranges (ante meridiem [AM] cortisol preferred), OR adrenocorticotropic hormone (ACTH) values within the institutional normal ranges within 28 days prior to registration; if cortisol levels are not within normal limits prior to registration, then ACTH must be performed and must be within normal ranges for patient to be eligible; Note: Neither cortisol nor ACTH levels are required for patients with primary adrenal tumors (e.g. adrenocortical carcinoma)
• For women of childbearing potential, the local investigator must rule out pregnancy; Except for Cohorts 13 and 47, where tumor types may express beta-hCG, women of childbearing potential must have a serum or urine pregnancy test within 7 days prior to registration; for Cohorts 13 and 47, where tumor types may produce hCG (e.g. germ cell tumors or trophoblastic disease), other pregnancy exclusion methods should be used to rule out pregnancy, such as ultrasound examination, documented history of effective contraception, or documented infertility; all females of childbearing potential must have been demonstrated not to be pregnant within 7 days prior to registration and agree to use birth control throughout study and for 23 weeks after completion of protocol therapy; patients must not be pregnant or nursing due to risk of fetal or nursing infant harm; women of childbearing potential must have agreed to use an effective contraceptive method; a woman is considered to be of "childbearing potential" if she has had menses at any time in the preceding 12 consecutive months; in addition to routine contraceptive methods, "effective contraception" also includes heterosexual celibacy and surgery intended to prevent pregnancy (or with a side-effect of pregnancy prevention) defined as a hysterectomy, bilateral oophorectomy or bilateral tubal ligation; however, if at any point a previously celibate patient chooses to become heterosexually active during the time period for use of contraceptive measures outlined in the protocol, she is responsible for beginning contraceptive measures
• Men of reproductive potential must have agreed to use birth control throughout the study and for 31 weeks after completion of protocol therapy; in addition to routine contraceptive methods, "effective contraception" also includes heterosexual celibacy and surgery intended to prevent pregnancy (vasectomy); however, if at any point a previously celibate patient chooses to become heterosexually active during the time period for use of contraceptive measures outlined in the protocol, he is responsible for beginning contraceptive measures

• Patients who are known to be human immunodeficiency virus (HIV)-positive at registration are eligible at the time of registration:

  • CD4+ cell count greater or equal to 250 cells/mm^3
  • No history of non-malignancy acquired immunodeficiency syndrome (AIDS)-defining conditions other than historical low CD4+ cell counts
• Patients must have amylase or lipase within =< 1.5 x IULN without symptoms of pancreatitis at registration, within 28 days prior to registration
• Patients must have fully recovered from any adverse effects of major surgery (to =< grade 1) at least 14 days prior to registration

Exclusion Criteria:

• Patients who had prior grade 3 or higher immune-related adverse event (e.g. pneumonitis, hepatitis, colitis, endocrinopathy) with prior immunotherapy (e.g. cancer vaccine, cytokine, etc.) are not eligible
• Patients are not eligible if they have had or are planned for solid organ transplant
• Patients must not currently be receiving any other investigational agents or any other systemic anti-cancer therapy (including radiation, excluding RANKL inhibitors and bisphosphonates); in event patient recently received any other systemic anti-cancer therapy, patient must be off therapy at least 7 days prior to registration and any therapy-induced toxicity must have recovered to =< grade 1, except alopecia and =< grade 2 neuropathy which are allowed; any planned radiation therapy must be completed before registration to S1609
• Patients must not have prior history of allergy or known hypersensitivity to nivolumab or ipilimumab
• Patients must not have known active hepatitis B virus (HBV) or hepatitis virus (HCV) infection at time of registration; patients with HBV or HCV that have an undetectable viral load and no residual hepatic impairment are eligible
• Patients must not have active autoimmune disease that has required systemic treatment in past 2 years (i.e., with use of disease modifying agents, immunosuppressive drugs, or corticosteroids with prednisone dose >= 10 mg); replacement therapy (e.g., thyroxine, insulin, or physiologic corticosteroid replacement therapy for adrenal or pituitary insufficiency, etc.) is not considered a form of systemic treatment; autoimmune diseases include but are not limited to autoimmune hepatitis, inflammatory bowel disease (including ulcerative colitis and Crohn's disease), as well as symptomatic disease (e.g.: rheumatoid arthritis, systemic progressive sclerosis [scleroderma], systemic lupus erythematosus, autoimmune vasculitis [e.g., Wegener's granulomatosis]); central nervous system (CNS) or motor neuropathy considered of autoimmune origin (e.g., Guillain-Barre syndrome and Myasthenia gravis, multiple sclerosis or glomerulonephritis); vitiligo, alopecia, hypothyroidism on stable doses of thyroid replacement therapy, psoriasis not requiring systemic therapy within the past 2 years is permitted; short-term steroid premedication for contrast allergy is permitted

• Patients must not have any uncontrolled intercurrent illness including (not limited to): symptomatic congestive heart failure (CHF) (New York Heart Association [NYHA] III/IV), unstable angina pectoris or coronary angioplasty, or stenting within 24 weeks prior to registration, unstable cardiac arrhythmia (ongoing cardiac dysrhythmias of NCI Common Terminology Criteria for Adverse Events [CTCAE] version [v] 4 grade >= 2), known psychiatric illness that would limit study compliance, intra-cardiac defibrillators, known cardiac metastases, or abnormal cardiac valve morphology (>= grade 3)

  • Note: Patients with history of CHF or patients who are deemed at risk because of underlying cardiovascular disease or exposure to cardiotoxic drugs should have an electrocardiogram (EKG) and echocardiogram (ECHO), as clinically indicated, at baseline and at the start of each cycle; patients who have evidence at baseline (or subsequently) of CHF, myocardial infarction (MI), cardiomyopathy, or myositis cardiac evaluation (NYHA I/II) should have additional consult by a cardiologist, including review of EKG, creatine phosphokinase (CPK), troponin, echocardiogram, as clinically indicated
• Patients must not have symptomatic interstitial lung disease or pneumonitis

Contacts and Locations

Locations

United States, Alabama

University of Alabama at Birmingham Cancer Center

Birmingham, Alabama, United States, 35233

University of South Alabama Mitchell Cancer Institute

Mobile, Alabama, United States, 36688

United States, Alaska

Anchorage Associates in Radiation Medicine

Anchorage, Alaska, United States, 98508

Anchorage Radiation Therapy Center

Anchorage, Alaska, United States, 99504

Alaska Breast Care and Surgery LLC

Anchorage, Alaska, United States, 99508

Alaska Oncology and Hematology LLC

Anchorage, Alaska, United States, 99508

Alaska Women's Cancer Care

Anchorage, Alaska, United States, 99508

Anchorage Oncology Centre

Anchorage, Alaska, United States, 99508

Katmai Oncology Group

Anchorage, Alaska, United States, 99508

Providence Alaska Medical Center

Anchorage, Alaska, United States, 99508

Fairbanks Memorial Hospital

Fairbanks, Alaska, United States, 99701

United States, Arizona

CTCA at Western Regional Medical Center

Goodyear, Arizona, United States, 85338

Kingman Regional Medical Center

Kingman, Arizona, United States, 86401

Cancer Center at Saint Joseph's

Phoenix, Arizona, United States, 85004

United States, Arkansas

Highlands Oncology Group - Fayetteville

Fayetteville, Arkansas, United States, 72703

Mercy Hospital Fort Smith

Fort Smith, Arkansas, United States, 72903

CHI Saint Vincent Cancer Center Hot Springs

Hot Springs, Arkansas, United States, 71913

NEA Baptist Memorial Hospital and Fowler Family Cancer Center - Jonesboro

Jonesboro, Arkansas, United States, 72401

University of Arkansas for Medical Sciences

Little Rock, Arkansas, United States, 72205

Highlands Oncology Group - Rogers

Rogers, Arkansas, United States, 72758

Highlands Oncology Group

Springdale, Arkansas, United States, 72762

United States, California

Kaiser Permanente-Anaheim

Anaheim, California, United States, 92806

Kaiser Permanente-Deer Valley Medical Center

Antioch, California, United States, 94531

Mission Hope Medical Oncology - Arroyo Grande

Arroyo Grande, California, United States, 93420

PCR Oncology

Arroyo Grande, California, United States, 93420

Sutter Auburn Faith Hospital

Auburn, California, United States, 95602

Sutter Cancer Centers Radiation Oncology Services-Auburn

Auburn, California, United States, 95603

AIS Cancer Center at San Joaquin Community Hospital

Bakersfield, California, United States, 93301

Kaiser Permanente-Baldwin Park

Baldwin Park, California, United States, 91706

Kaiser Permanente-Bellflower

Bellflower, California, United States, 90706

Alta Bates Summit Medical Center-Herrick Campus

Berkeley, California, United States, 94704

Keck Medicine of USC Buena Park

Buena Park, California, United States, 90621

Providence Saint Joseph Medical Center/Disney Family Cancer Center

Burbank, California, United States, 91505

Mills-Peninsula Medical Center

Burlingame, California, United States, 94010

Sutter Cancer Centers Radiation Oncology Services-Cameron Park

Cameron Park, California, United States, 95682

Mercy Cancer Center �� Carmichael

Carmichael, California, United States, 95608

Mercy San Juan Medical Center

Carmichael, California, United States, 95608

Eden Hospital Medical Center

Castro Valley, California, United States, 94546

UC Irvine Health Cancer Center-Newport

Costa Mesa, California, United States, 92627

Sutter Davis Hospital

Davis, California, United States, 95616

City of Hope Comprehensive Cancer Center

Duarte, California, United States, 91010

Epic Care-Dublin

Dublin, California, United States, 94568

Kaiser Permanente Dublin

Dublin, California, United States, 94568

Mercy Cancer Center - Elk Grove

Elk Grove, California, United States, 95758

Bay Area Breast Surgeons Inc

Emeryville, California, United States, 94608

Epic Care Partners in Cancer Care

Emeryville, California, United States, 94608

Kaiser Permanente-Fontana

Fontana, California, United States, 92335

Kaiser Permanente-Fremont

Fremont, California, United States, 94538

Palo Alto Medical Foundation-Fremont

Fremont, California, United States, 94538

Kaiser Permanente-Fresno

Fresno, California, United States, 93720

Kaiser Permanente - Harbor City

Harbor City, California, United States, 90710

Keck Medicine of USC Huntington Beach

Huntington Beach, California, United States, 92648

Kaiser Permanente-Irvine

Irvine, California, United States, 92618

UC San Diego Moores Cancer Center

La Jolla, California, United States, 92093

Loma Linda University Medical Center

Loma Linda, California, United States, 92354

Keck Medicine of USC Koreatown

Los Angeles, California, United States, 90020

Kaiser Permanente Los Angeles Medical Center

Los Angeles, California, United States, 90027

Los Angeles County-USC Medical Center

Los Angeles, California, United States, 90033

USC / Norris Comprehensive Cancer Center

Los Angeles, California, United States, 90033

Kaiser Permanente West Los Angeles

Los Angeles, California, United States, 90034

Cedars Sinai Medical Center

Los Angeles, California, United States, 90048

Contra Costa Regional Medical Center

Martinez, California, United States, 94553-3156

Fremont - Rideout Cancer Center

Marysville, California, United States, 95901

Mercy UC Davis Cancer Center

Merced, California, United States, 95340

Memorial Medical Center

Modesto, California, United States, 95355

Kaiser Permanente-Modesto

Modesto, California, United States, 95356

Palo Alto Medical Foundation-Camino Division

Mountain View, California, United States, 94040

Palo Alto Medical Foundation-Gynecologic Oncology

Mountain View, California, United States, 94040

Providence Queen of The Valley

Napa, California, United States, 94558

USC Norris Oncology/Hematology-Newport Beach

Newport Beach, California, United States, 92663

Sutter Cancer Research Consortium

Novato, California, United States, 94945

Alta Bates Summit Medical Center - Summit Campus

Oakland, California, United States, 94609

Bay Area Tumor Institute

Oakland, California, United States, 94609

Kaiser Permanente-Oakland

Oakland, California, United States, 94611

Kaiser Permanente-Ontario

Ontario, California, United States, 91761

Saint Joseph Hospital - Orange

Orange, California, United States, 92868

UC Irvine Health/Chao Family Comprehensive Cancer Center

Orange, California, United States, 92868

Desert Regional Medical Center

Palm Springs, California, United States, 92262

Palo Alto Medical Foundation Health Care

Palo Alto, California, United States, 94301

Kaiser Permanente - Panorama City

Panorama City, California, United States, 91402

Keck Medical Center of USC Pasadena

Pasadena, California, United States, 91105

Eisenhower Medical Center

Rancho Mirage, California, United States, 92270

Kaiser Permanente- Marshall Medical Offices

Redwood City, California, United States, 94063

Kaiser Permanente-Redwood City

Redwood City, California, United States, 94063

Kaiser Permanente-Richmond

Richmond, California, United States, 94801

Kaiser Permanente-Riverside

Riverside, California, United States, 92505

Mercy Cancer Center - Rocklin

Rocklin, California, United States, 95765

Kaiser Permanente-Roseville

Roseville, California, United States, 95661

Sutter Cancer Centers Radiation Oncology Services-Roseville

Roseville, California, United States, 95661

Sutter Roseville Medical Center

Roseville, California, United States, 95661

Kaiser Permanente Downtown Commons

Sacramento, California, United States, 95814

Mercy Cancer Center - Sacramento

Sacramento, California, United States, 95816

Sutter Medical Center Sacramento

Sacramento, California, United States, 95816

University of California Davis Comprehensive Cancer Center

Sacramento, California, United States, 95817

Kaiser Permanente-South Sacramento

Sacramento, California, United States, 95823

Kaiser Permanente - Sacramento

Sacramento, California, United States, 95825

UC San Diego Medical Center - Hillcrest

San Diego, California, United States, 92103

Kaiser Permanente-San Diego Mission

San Diego, California, United States, 92108

Kaiser Permanente-San Diego Zion

San Diego, California, United States, 92120

Sharp Memorial Hospital

San Diego, California, United States, 92123

California Pacific Medical Center-Pacific Campus

San Francisco, California, United States, 94115

Kaiser Permanente-San Francisco

San Francisco, California, United States, 94115

Kaiser Permanente-Santa Teresa-San Jose

San Jose, California, United States, 95119

Kaiser Permanente San Leandro

San Leandro, California, United States, 94577

Pacific Central Coast Health Center-San Luis Obispo

San Luis Obispo, California, United States, 93401

Kaiser Permanente-San Marcos

San Marcos, California, United States, 92078

Mills Health Center

San Mateo, California, United States, 94401

Kaiser Permanente-San Rafael

San Rafael, California, United States, 94903

Kaiser San Rafael-Gallinas

San Rafael, California, United States, 94903

Kaiser Permanente Medical Center - Santa Clara

Santa Clara, California, United States, 95051

Palo Alto Medical Foundation-Santa Cruz

Santa Cruz, California, United States, 95065

Mission Hope Medical Oncology - Santa Maria

Santa Maria, California, United States, 93444

Kaiser Permanente-Santa Rosa

Santa Rosa, California, United States, 95403

Providence Medical Foundation - Santa Rosa

Santa Rosa, California, United States, 95403

Sutter Pacific Medical Foundation

Santa Rosa, California, United States, 95403

Providence Santa Rosa Memorial Hospital

Santa Rosa, California, United States, 95405

Kaiser Permanente-South San Francisco

South San Francisco, California, United States, 94080

Kaiser Permanente-Stockton

Stockton, California, United States, 95210

Palo Alto Medical Foundation-Sunnyvale

Sunnyvale, California, United States, 94086

Gene Upshaw Memorial Tahoe Forest Cancer Center

Truckee, California, United States, 96161

Sutter Cancer Centers Radiation Oncology Services-Vacaville

Vacaville, California, United States, 95687

Kaiser Permanente Medical Center-Vacaville

Vacaville, California, United States, 95688

Kaiser Permanente-Vallejo

Vallejo, California, United States, 94589

Sutter Solano Medical Center/Cancer Center

Vallejo, California, United States, 94589

Kaiser Permanente-Walnut Creek

Walnut Creek, California, United States, 94596

Epic Care Cyberknife Center

Walnut Creek, California, United States, 94597

Kaiser Permanente-Woodland Hills

Woodland Hills, California, United States, 91367

Woodland Memorial Hospital

Woodland, California, United States, 95695

United States, Colorado

Rocky Mountain Cancer Centers-Aurora

Aurora, Colorado, United States, 80012

The Medical Center of Aurora

Aurora, Colorado, United States, 80012

University of Colorado Hospital

Aurora, Colorado, United States, 80045

Boulder Community Hospital

Boulder, Colorado, United States, 80301

Boulder Community Foothills Hospital

Boulder, Colorado, United States, 80303

Rocky Mountain Cancer Centers-Boulder

Boulder, Colorado, United States, 80304

Rocky Mountain Cancer Centers - Centennial

Centennial, Colorado, United States, 80112

Penrose-Saint Francis Healthcare

Colorado Springs, Colorado, United States, 80907

Rocky Mountain Cancer Centers-Penrose

Colorado Springs, Colorado, United States, 80907

UCHealth Memorial Hospital Central

Colorado Springs, Colorado, United States, 80909

Memorial Hospital North

Colorado Springs, Colorado, United States, 80920

Saint Francis Cancer Center

Colorado Springs, Colorado, United States, 80923

Cancer Center of Colorado at Sloan's Lake

Denver, Colorado, United States, 80204

Denver Health Medical Center

Denver, Colorado, United States, 80204

Kaiser Permanente-Franklin

Denver, Colorado, United States, 80205

National Jewish Health-Main Campus

Denver, Colorado, United States, 80206

The Women's Imaging Center

Denver, Colorado, United States, 80209

Porter Adventist Hospital

Denver, Colorado, United States, 80210

Colorado Blood Cancer Institute

Denver, Colorado, United States, 80218

Presbyterian - Saint Lukes Medical Center - Health One

Denver, Colorado, United States, 80218

Rocky Mountain Cancer Centers-Midtown

Denver, Colorado, United States, 80218

SCL Health Saint Joseph Hospital

Denver, Colorado, United States, 80218

Rocky Mountain Cancer Centers-Rose

Denver, Colorado, United States, 80220

Rose Medical Center

Denver, Colorado, United States, 80220

Mercy Medical Center

Durango, Colorado, United States, 81301

Southwest Oncology PC

Durango, Colorado, United States, 81301

Mountain Blue Cancer Care Center - Swedish

Englewood, Colorado, United States, 80113

Rocky Mountain Cancer Centers - Swedish

Englewood, Colorado, United States, 80113

Swedish Medical Center

Englewood, Colorado, United States, 80113

The Melanoma and Skin Cancer Institute

Englewood, Colorado, United States, 80113

Poudre Valley Hospital

Fort Collins, Colorado, United States, 80524

Valley View Hospital Cancer Center

Glenwood Springs, Colorado, United States, 81601

Mountain Blue Cancer Care Center

Golden, Colorado, United States, 80401

National Jewish Health-Western Hematology Oncology

Golden, Colorado, United States, 80401

Saint Mary's Hospital and Regional Medical Center

Grand Junction, Colorado, United States, 81501

Grand Valley Oncology

Grand Junction, Colorado, United States, 81505

North Colorado Medical Center

Greeley, Colorado, United States, 80631

Rocky Mountain Cancer Centers-Greenwood Village

Greenwood Village, Colorado, United States, 80111

Good Samaritan Medical Center

Lafayette, Colorado, United States, 80026

Kaiser Permanente-Rock Creek

Lafayette, Colorado, United States, 80026

Rocky Mountain Cancer Centers-Lakewood

Lakewood, Colorado, United States, 80228

Saint Anthony Hospital

Lakewood, Colorado, United States, 80228

Rocky Mountain Cancer Centers-Littleton

Littleton, Colorado, United States, 80120

Littleton Adventist Hospital

Littleton, Colorado, United States, 80122

Kaiser Permanente-Lone Tree

Lone Tree, Colorado, United States, 80124

Rocky Mountain Cancer Centers-Sky Ridge

Lone Tree, Colorado, United States, 80124

Sky Ridge Medical Center

Lone Tree, Colorado, United States, 80124

Longmont United Hospital

Longmont, Colorado, United States, 80501

Rocky Mountain Cancer Centers-Longmont

Longmont, Colorado, United States, 80501

McKee Medical Center

Loveland, Colorado, United States, 80539

Parker Adventist Hospital

Parker, Colorado, United States, 80138

Rocky Mountain Cancer Centers-Parker

Parker, Colorado, United States, 80138

Saint Mary Corwin Medical Center

Pueblo, Colorado, United States, 81004

Rocky Mountain Cancer Centers - Pueblo

Pueblo, Colorado, United States, 81008

National Jewish Health-Northern Hematology Oncology

Thornton, Colorado, United States, 80260

Rocky Mountain Cancer Centers-Thornton

Thornton, Colorado, United States, 80260

SCL Health Lutheran Medical Center

Wheat Ridge, Colorado, United States, 80033

United States, Connecticut

Smilow Cancer Hospital-Derby Care Center

Derby, Connecticut, United States, 06418

Smilow Cancer Hospital Care Center-Fairfield

Fairfield, Connecticut, United States, 06824

Smilow Cancer Hospital Care Center - Guilford

Guilford, Connecticut, United States, 06437

Smilow Cancer Hospital Care Center at Saint Francis

Hartford, Connecticut, United States, 06105

Smilow Cancer Center/Yale-New Haven Hospital

New Haven, Connecticut, United States, 06510

Yale University

New Haven, Connecticut, United States, 06520

Yale-New Haven Hospital North Haven Medical Center

North Haven, Connecticut, United States, 06473

Stamford Hospital/Bennett Cancer Center

Stamford, Connecticut, United States, 06904

Smilow Cancer Hospital Care Center-Trumbull

Trumbull, Connecticut, United States, 06611

Smilow Cancer Hospital-Waterbury Care Center

Waterbury, Connecticut, United States, 06708

Veterans Affairs Connecticut Healthcare System-West Haven Campus

West Haven, Connecticut, United States, 06516

United States, Delaware

Beebe South Coastal Health Campus

Frankford, Delaware, United States, 19945

Beebe Medical Center

Lewes, Delaware, United States, 19958

Delaware Clinical and Laboratory Physicians PA

Newark, Delaware, United States, 19713

Helen F Graham Cancer Center

Newark, Delaware, United States, 19713

Medical Oncology Hematology Consultants PA

Newark, Delaware, United States, 19713

Christiana Care Health System-Christiana Hospital

Newark, Delaware, United States, 19718

Beebe Health Campus

Rehoboth Beach, Delaware, United States, 19971

TidalHealth Nanticoke / Allen Cancer Center

Seaford, Delaware, United States, 19973

Christiana Care Health System-Wilmington Hospital

Wilmington, Delaware, United States, 19801

United States, District of Columbia

MedStar Georgetown University Hospital

Washington, District of Columbia, United States, 20007

Sibley Memorial Hospital

Washington, District of Columbia, United States, 20016

United States, Florida

AdventHealth Altamonte

Altamonte Springs, Florida, United States, 32701

Mount Sinai Comprehensive Cancer Center at Aventura

Aventura, Florida, United States, 33180

Holy Cross Hospital

Fort Lauderdale, Florida, United States, 33308

University of Florida Health Science Center - Gainesville

Gainesville, Florida, United States, 32610

Memorial Regional Hospital/Joe DiMaggio Children's Hospital

Hollywood, Florida, United States, 33021

AdventHealth Kissimmee

Kissimmee, Florida, United States, 34744

Mount Sinai Medical Center

Miami Beach, Florida, United States, 33140

AdventHealth Medical Group Urology at Orlando

Orlando, Florida, United States, 32803

AdventHealth Orlando

Orlando, Florida, United States, 32803

Orlando Health Cancer Institute

Orlando, Florida, United States, 32806

AdventHealth East Orlando

Orlando, Florida, United States, 32822

Memorial Hospital West

Pembroke Pines, Florida, United States, 33028

Moffitt Cancer Center-International Plaza

Tampa, Florida, United States, 33607

Moffitt Cancer Center - McKinley Campus

Tampa, Florida, United States, 33612

Moffitt Cancer Center

Tampa, Florida, United States, 33612

AdventHealth Winter Park

Winter Park, Florida, United States, 32792

United States, Georgia

Emory University Hospital Midtown

Atlanta, Georgia, United States, 30308

Piedmont Hospital

Atlanta, Georgia, United States, 30309

Emory University Hospital/Winship Cancer Institute

Atlanta, Georgia, United States, 30322

Emory Saint Joseph's Hospital

Atlanta, Georgia, United States, 30342

John B Amos Cancer Center

Columbus, Georgia, United States, 31904

Atlanta VA Medical Center

Decatur, Georgia, United States, 30033

Piedmont Fayette Hospital

Fayetteville, Georgia, United States, 30214

Harbin Clinic Medical Oncology and Clinical Research

Rome, Georgia, United States, 30165

Low Country Cancer Care

Savannah, Georgia, United States, 31404

Lewis Cancer and Research Pavilion at Saint Joseph's/Candler

Savannah, Georgia, United States, 31405

Summit Cancer Care-Candler

Savannah, Georgia, United States, 31405

South Georgia Medical Center/Pearlman Cancer Center

Valdosta, Georgia, United States, 31602

United States, Hawaii

Hawaii Cancer Care - Westridge

'Aiea, Hawaii, United States, 96701

Pali Momi Medical Center

'Aiea, Hawaii, United States, 96701

Queen's Cancer Center - Pearlridge

'Aiea, Hawaii, United States, 96701

Straub Pearlridge Clinic

'Aiea, Hawaii, United States, 96701

The Cancer Center of Hawaii-Pali Momi

'Aiea, Hawaii, United States, 96701

The Queen's Medical Center - West Oahu

'Ewa Beach, Hawaii, United States, 96706

Hawaii Cancer Care Inc - Waterfront Plaza

Honolulu, Hawaii, United States, 96813

Island Urology

Honolulu, Hawaii, United States, 96813

Queen's Cancer Cenrer - POB I

Honolulu, Hawaii, United States, 96813

Queen's Medical Center

Honolulu, Hawaii, United States, 96813

Straub Clinic and Hospital

Honolulu, Hawaii, United States, 96813

University of Hawaii Cancer Center

Honolulu, Hawaii, United States, 96813

Hawaii Cancer Care Inc-Liliha

Honolulu, Hawaii, United States, 96817

Hawaii Diagnostic Radiology Services LLC

Honolulu, Hawaii, United States, 96817

Kuakini Medical Center

Honolulu, Hawaii, United States, 96817

Queen's Cancer Center - Kuakini

Honolulu, Hawaii, United States, 96817

The Cancer Center of Hawaii-Liliha

Honolulu, Hawaii, United States, 96817

Kaiser Permanente Moanalua Medical Center

Honolulu, Hawaii, United States, 96819

Kapiolani Medical Center for Women and Children

Honolulu, Hawaii, United States, 96826

Straub Medical Center - Kahului Clinic

Kahului, Hawaii, United States, 96732

Castle Medical Center

Kailua, Hawaii, United States, 96734

Wilcox Memorial Hospital and Kauai Medical Clinic

Lihue, Hawaii, United States, 96766

United States, Idaho

Saint Alphonsus Cancer Care Center-Boise

Boise, Idaho, United States, 83706

Saint Luke's Cancer Institute - Boise

Boise, Idaho, United States, 83712

Saint Alphonsus Cancer Care Center-Caldwell

Caldwell, Idaho, United States, 83605

Kootenai Health - Coeur d'Alene

Coeur d'Alene, Idaho, United States, 83814

Walter Knox Memorial Hospital

Emmett, Idaho, United States, 83617

Saint Luke's Cancer Institute - Fruitland

Fruitland, Idaho, United States, 83619

Idaho Urologic Institute-Meridian

Meridian, Idaho, United States, 83642

Saint Luke's Cancer Institute - Meridian

Meridian, Idaho, United States, 83642

Saint Luke's Cancer Institute - Nampa

Nampa, Idaho, United States, 83686

Saint Alphonsus Cancer Care Center-Nampa

Nampa, Idaho, United States, 83687

Kootenai Clinic Cancer Services - Post Falls

Post Falls, Idaho, United States, 83854

Kootenai Cancer Clinic

Sandpoint, Idaho, United States, 83864

Saint Luke's Cancer Institute - Twin Falls

Twin Falls, Idaho, United States, 83301

United States, Illinois

Saint Anthony's Health

Alton, Illinois, United States, 62002

Rush - Copley Medical Center

Aurora, Illinois, United States, 60504

Saint Joseph Medical Center

Bloomington, Illinois, United States, 61701

Illinois CancerCare-Bloomington

Bloomington, Illinois, United States, 61704

Loyola Center for Health at Burr Ridge

Burr Ridge, Illinois, United States, 60527

Illinois CancerCare-Canton

Canton, Illinois, United States, 61520

Memorial Hospital of Carbondale

Carbondale, Illinois, United States, 62902

SIH Cancer Institute

Carterville, Illinois, United States, 62918

Illinois CancerCare-Carthage

Carthage, Illinois, United States, 62321

Centralia Oncology Clinic

Centralia, Illinois, United States, 62801

Mount Sinai Hospital Medical Center

Chicago, Illinois, United States, 60608

Northwestern University

Chicago, Illinois, United States, 60611

John H Stroger Jr Hospital of Cook County

Chicago, Illinois, United States, 60612

Rush University Medical Center

Chicago, Illinois, United States, 60612

University of Chicago Comprehensive Cancer Center

Chicago, Illinois, United States, 60637

Advocate Illinois Masonic Medical Center

Chicago, Illinois, United States, 60657

Carle at The Riverfront

Danville, Illinois, United States, 61832

Cancer Care Specialists of Illinois - Decatur

Decatur, Illinois, United States, 62526

Decatur Memorial Hospital

Decatur, Illinois, United States, 62526

Northwestern Medicine Cancer Center Kishwaukee

DeKalb, Illinois, United States, 60115

Illinois CancerCare-Dixon

Dixon, Illinois, United States, 61021

Carle Physician Group-Effingham

Effingham, Illinois, United States, 62401

Crossroads Cancer Center

Effingham, Illinois, United States, 62401

Illinois CancerCare-Eureka

Eureka, Illinois, United States, 61530

Illinois CancerCare-Galesburg

Galesburg, Illinois, United States, 61401

Western Illinois Cancer Treatment Center

Galesburg, Illinois, United States, 61401

Northwestern Medicine Cancer Center Delnor

Geneva, Illinois, United States, 60134

Ingalls Memorial Hospital

Harvey, Illinois, United States, 60426

Loyola Medicine Homer Glen

Homer Glen, Illinois, United States, 60491

Presence Saint Mary's Hospital

Kankakee, Illinois, United States, 60901

Illinois CancerCare-Kewanee Clinic

Kewanee, Illinois, United States, 61443

Northwestern Medicine Lake Forest Hospital

Lake Forest, Illinois, United States, 60045

Illinois CancerCare-Macomb

Macomb, Illinois, United States, 61455

Carle Physician Group-Mattoon/Charleston

Mattoon, Illinois, United States, 61938

Loyola University Medical Center

Maywood, Illinois, United States, 60153

Marjorie Weinberg Cancer Center at Loyola-Gottlieb

Melrose Park, Illinois, United States, 60160

Good Samaritan Regional Health Center

Mount Vernon, Illinois, United States, 62864

UC Comprehensive Cancer Center at Silver Cross

New Lenox, Illinois, United States, 60451

Cancer Care Center of O'Fallon

O'Fallon, Illinois, United States, 62269

University of Chicago Medicine-Orland Park

Orland Park, Illinois, United States, 60462

Illinois CancerCare-Ottawa Clinic

Ottawa, Illinois, United States, 61350

Illinois CancerCare-Pekin

Pekin, Illinois, United States, 61554

OSF Saint Francis Radiation Oncology at Pekin Cancer Treatment Center

Pekin, Illinois, United States, 61554

Illinois CancerCare-Peoria

Peoria, Illinois, United States, 61615

OSF Saint Francis Radiation Oncology at Peoria Cancer Center

Peoria, Illinois, United States, 61615

Methodist Medical Center of Illinois

Peoria, Illinois, United States, 61636

OSF Saint Francis Medical Center

Peoria, Illinois, United States, 61637

Illinois CancerCare-Peru

Peru, Illinois, United States, 61354

Valley Radiation Oncology

Peru, Illinois, United States, 61354

Illinois CancerCare-Princeton

Princeton, Illinois, United States, 61356

Southern Illinois University School of Medicine

Springfield, Illinois, United States, 62702

Springfield Clinic

Springfield, Illinois, United States, 62702

Memorial Medical Center

Springfield, Illinois, United States, 62781

Southwest Illinois Health Services LLP

Swansea, Illinois, United States, 62226

Carle Cancer Center

Urbana, Illinois, United States, 61801

The Carle Foundation Hospital

Urbana, Illinois, United States, 61801

Northwestern Medicine Cancer Center Warrenville

Warrenville, Illinois, United States, 60555

Illinois CancerCare - Washington

Washington, Illinois, United States, 61571

Rush-Copley Healthcare Center

Yorkville, Illinois, United States, 60560

Midwestern Regional Medical Center

Zion, Illinois, United States, 60099

United States, Indiana

IU Health West Hospital

Avon, Indiana, United States, 46123

IU Health North Hospital

Carmel, Indiana, United States, 46032

Deaconess Clinic Downtown

Evansville, Indiana, United States, 47713

Parkview Regional Medical Center

Fort Wayne, Indiana, United States, 46845

Indiana University/Melvin and Bren Simon Cancer Center

Indianapolis, Indiana, United States, 46202

Sidney and Lois Eskenazi Hospital

Indianapolis, Indiana, United States, 46202

Springmill Medical Center

Indianapolis, Indiana, United States, 46290

Memorial Regional Cancer Center Day Road

Mishawaka, Indiana, United States, 46545

Chancellor Center for Oncology

Newburgh, Indiana, United States, 47630

Reid Health

Richmond, Indiana, United States, 47374

Memorial Hospital of South Bend

South Bend, Indiana, United States, 46601

United States, Iowa

Mary Greeley Medical Center

Ames, Iowa, United States, 50010

McFarland Clinic PC - Ames

Ames, Iowa, United States, 50010

McFarland Clinic PC-Boone

Boone, Iowa, United States, 50036

Saint Anthony Regional Hospital

Carroll, Iowa, United States, 51401

Mercy Hospital

Cedar Rapids, Iowa, United States, 52403

Oncology Associates at Mercy Medical Center

Cedar Rapids, Iowa, United States, 52403

Medical Oncology and Hematology Associates-West Des Moines

Clive, Iowa, United States, 50325

Mercy Cancer Center-West Lakes

Clive, Iowa, United States, 50325

Alegent Health Mercy Hospital

Council Bluffs, Iowa, United States, 51503

Greater Regional Medical Center

Creston, Iowa, United States, 50801

Iowa Methodist Medical Center

Des Moines, Iowa, United States, 50309

Medical Oncology and Hematology Associates-Des Moines

Des Moines, Iowa, United States, 50309

Broadlawns Medical Center

Des Moines, Iowa, United States, 50314

Mercy Medical Center - Des Moines

Des Moines, Iowa, United States, 50314

Mission Cancer and Blood - Laurel

Des Moines, Iowa, United States, 50314

Iowa Lutheran Hospital

Des Moines, Iowa, United States, 50316

McFarland Clinic PC-Trinity Cancer Center

Fort Dodge, Iowa, United States, 50501

Trinity Regional Medical Center

Fort Dodge, Iowa, United States, 50501

McFarland Clinic PC-Jefferson

Jefferson, Iowa, United States, 50129

McFarland Clinic PC-Marshalltown

Marshalltown, Iowa, United States, 50158

Methodist West Hospital

West Des Moines, Iowa, United States, 50266-7700

Mercy Medical Center-West Lakes

West Des Moines, Iowa, United States, 50266

United States, Kansas

Cancer Center of Kansas - Chanute

Chanute, Kansas, United States, 66720

Coffeyville Regional Medical Center

Coffeyville, Kansas, United States, 67337

Cancer Center of Kansas - Dodge City

Dodge City, Kansas, United States, 67801

Cancer Center of Kansas - El Dorado

El Dorado, Kansas, United States, 67042

University of Kansas Clinical Research Center

Fairway, Kansas, United States, 66205

Cancer Center of Kansas - Fort Scott

Fort Scott, Kansas, United States, 66701

Central Care Cancer Center - Garden City

Garden City, Kansas, United States, 67846

Saint Catherine Hospital

Garden City, Kansas, United States, 67846

Central Care Cancer Center - Great Bend

Great Bend, Kansas, United States, 67530

HaysMed University of Kansas Health System

Hays, Kansas, United States, 67601

Cancer Center of Kansas-Independence

Independence, Kansas, United States, 67301

University of Kansas Cancer Center-West

Kansas City, Kansas, United States, 66112

University of Kansas Cancer Center

Kansas City, Kansas, United States, 66160

Cancer Center of Kansas-Kingman

Kingman, Kansas, United States, 67068

Lawrence Memorial Hospital

Lawrence, Kansas, United States, 66044

Cancer Center of Kansas-Liberal

Liberal, Kansas, United States, 67905

Cancer Center of Kansas-Manhattan

Manhattan, Kansas, United States, 66502

Cancer Center of Kansas - McPherson

McPherson, Kansas, United States, 67460

Cancer Center of Kansas - Newton

Newton, Kansas, United States, 67114

Olathe Health Cancer Center

Olathe, Kansas, United States, 66061

University of Kansas Cancer Center-Overland Park

Overland Park, Kansas, United States, 66210

University of Kansas Hospital-Indian Creek Campus

Overland Park, Kansas, United States, 66211

Cancer Center of Kansas - Parsons

Parsons, Kansas, United States, 67357

Ascension Via Christi - Pittsburg

Pittsburg, Kansas, United States, 66762

Freeman Physician Group of Pittsburg

Pittsburg, Kansas, United States, 66762

Cancer Center of Kansas - Pratt

Pratt, Kansas, United States, 67124

Cancer Center of Kansas - Salina

Salina, Kansas, United States, 67401

Salina Regional Health Center

Salina, Kansas, United States, 67401

University of Kansas Health System Saint Francis Campus

Topeka, Kansas, United States, 66606

Cancer Center of Kansas - Wellington

Wellington, Kansas, United States, 67152

University of Kansas Hospital-Westwood Cancer Center

Westwood, Kansas, United States, 66205

Associates In Womens Health

Wichita, Kansas, United States, 67208

Cancer Center of Kansas-Wichita Medical Arts Tower

Wichita, Kansas, United States, 67208

Ascension Via Christi Hospitals Wichita

Wichita, Kansas, United States, 67214

Cancer Center of Kansas - Wichita

Wichita, Kansas, United States, 67214

Wesley Medical Center

Wichita, Kansas, United States, 67214

Cancer Center of Kansas - Winfield

Winfield, Kansas, United States, 67156

United States, Kentucky

Flaget Memorial Hospital

Bardstown, Kentucky, United States, 40004

Commonwealth Cancer Center-Corbin

Corbin, Kentucky, United States, 40701

Saint Joseph Hospital

Lexington, Kentucky, United States, 40504

Saint Joseph Radiation Oncology Resource Center

Lexington, Kentucky, United States, 40504

Saint Joseph Hospital East

Lexington, Kentucky, United States, 40509

Saint Joseph London

London, Kentucky, United States, 40741

Jewish Hospital

Louisville, Kentucky, United States, 40202

Saints Mary and Elizabeth Hospital

Louisville, Kentucky, United States, 40215

UofL Health Medical Center Northeast

Louisville, Kentucky, United States, 40245

Saint Joseph Mount Sterling

Mount Sterling, Kentucky, United States, 40353

Jewish Hospital Medical Center South

Shepherdsville, Kentucky, United States, 40165

United States, Louisiana

Baton Rouge General Medical Center

Baton Rouge, Louisiana, United States, 70806

Hematology/Oncology Clinic PLLC

Baton Rouge, Louisiana, United States, 70809

Ochsner Health Center-Summa

Baton Rouge, Louisiana, United States, 70809

Medical Center of Baton Rouge

Baton Rouge, Louisiana, United States, 70816

Ochsner High Grove

Baton Rouge, Louisiana, United States, 70836

Ochsner Medical Center Kenner

Kenner, Louisiana, United States, 70065

East Jefferson General Hospital

Metairie, Louisiana, United States, 70006

LSU Healthcare Network / Metairie Multi-Specialty Clinic

Metairie, Louisiana, United States, 70006

Louisiana State University Health Science Center

New Orleans, Louisiana, United States, 70112

Tulane University Health Sciences Center

New Orleans, Louisiana, United States, 70112

University Medical Center New Orleans

New Orleans, Louisiana, United States, 70112

Ochsner Medical Center Jefferson

New Orleans, Louisiana, United States, 70121

United States, Maine

Eastern Maine Medical Center

Bangor, Maine, United States, 04401

Lafayette Family Cancer Center-EMMC

Brewer, Maine, United States, 04412

United States, Maryland

Greater Baltimore Medical Center

Baltimore, Maryland, United States, 21204

Johns Hopkins University/Sidney Kimmel Cancer Center

Baltimore, Maryland, United States, 21287

National Institutes of Health Clinical Center

Bethesda, Maryland, United States, 20892

UPMC Western Maryland

Cumberland, Maryland, United States, 21502

Frederick Memorial Hospital

Frederick, Maryland, United States, 21701

FMH James M Stockman Cancer Institute

Frederick, Maryland, United States, 21702

United States, Massachusetts

Lahey Hospital and Medical Center

Burlington, Massachusetts, United States, 01805

Lahey Medical Center-Peabody

Peabody, Massachusetts, United States, 01960

Mercy Medical Center

Springfield, Massachusetts, United States, 01104

Baystate Medical Center

Springfield, Massachusetts, United States, 01199

United States, Michigan

Hickman Cancer Center

Adrian, Michigan, United States, 49221

Saint Joseph Mercy Hospital

Ann Arbor, Michigan, United States, 48106

University of Michigan Comprehensive Cancer Center

Ann Arbor, Michigan, United States, 48109

Bronson Battle Creek

Battle Creek, Michigan, United States, 49017

Saint Joseph Mercy Brighton

Brighton, Michigan, United States, 48114

Trinity Health IHA Medical Group Hematology Oncology - Brighton

Brighton, Michigan, United States, 48114

University of Michigan - Brighton Center for Specialty Care

Brighton, Michigan, United States, 48116

Henry Ford Cancer Institute-Downriver

Brownstown, Michigan, United States, 48183

Saint Joseph Mercy Canton

Canton, Michigan, United States, 48188

Trinity Health IHA Medical Group Hematology Oncology - Canton

Canton, Michigan, United States, 48188

Caro Cancer Center

Caro, Michigan, United States, 48723

Saint Joseph Mercy Chelsea

Chelsea, Michigan, United States, 48118

Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital

Chelsea, Michigan, United States, 48118

Hematology Oncology Consultants-Clarkston

Clarkston, Michigan, United States, 48346

Newland Medical Associates-Clarkston

Clarkston, Michigan, United States, 48346

Henry Ford Hematology Oncology - Hayes

Clinton Township, Michigan, United States, 48038

Henry Ford Macomb Hospital-Clinton Township

Clinton Township, Michigan, United States, 48038

Beaumont Hospital - Dearborn

Dearborn, Michigan, United States, 48124

Henry Ford Medical Center-Fairlane

Dearborn, Michigan, United States, 48126

Henry Ford Hospital

Detroit, Michigan, United States, 48202

Ascension Saint John Hospital

Detroit, Michigan, United States, 48236

Great Lakes Cancer Management Specialists-Doctors Park

East China Township, Michigan, United States, 48054

Green Bay Oncology - Escanaba

Escanaba, Michigan, United States, 49829

Genesee Cancer and Blood Disease Treatment Center

Flint, Michigan, United States, 48503

Genesee Hematology Oncology PC

Flint, Michigan, United States, 48503

Genesys Hurley Cancer Institute

Flint, Michigan, United States, 48503

Hurley Medical Center

Flint, Michigan, United States, 48503

Helen DeVos Children's Hospital at Spectrum Health

Grand Rapids, Michigan, United States, 49503

Spectrum Health at Butterworth Campus

Grand Rapids, Michigan, United States, 49503

Trinity Health Grand Rapids Hospital

Grand Rapids, Michigan, United States, 49503

Academic Hematology Oncology Specialists

Grosse Pointe Woods, Michigan, United States, 48236

Great Lakes Cancer Management Specialists-Van Elslander Cancer Center

Grosse Pointe Woods, Michigan, United States, 48236

Michigan Breast Specialists-Grosse Pointe Woods

Grosse Pointe Woods, Michigan, United States, 48236

Allegiance Health

Jackson, Michigan, United States, 49201

Bronson Methodist Hospital

Kalamazoo, Michigan, United States, 49007

West Michigan Cancer Center

Kalamazoo, Michigan, United States, 49007

Ascension Borgess Cancer Center

Kalamazoo, Michigan, United States, 49009

Borgess Medical Center

Kalamazoo, Michigan, United States, 49048

Sparrow Hospital

Lansing, Michigan, United States, 48912

Hope Cancer Clinic

Livonia, Michigan, United States, 48154

Trinity Health Saint Mary Mercy Livonia Hospital

Livonia, Michigan, United States, 48154

Great Lakes Cancer Management Specialists-Macomb Medical Campus

Macomb, Michigan, United States, 48044

Michigan Breast Specialists-Macomb Township

Macomb, Michigan, United States, 48044

Green Bay Oncology-Manistique

Manistique, Michigan, United States, 49854

Saint Mary's Oncology/Hematology Associates of Marlette

Marlette, Michigan, United States, 48453

Monroe Cancer Center

Monroe, Michigan, United States, 48162

Toledo Clinic Cancer Centers-Monroe

Monroe, Michigan, United States, 48162

Trinity Health Muskegon Hospital

Muskegon, Michigan, United States, 49444

Lakeland Hospital Niles

Niles, Michigan, United States, 49120

Cancer and Hematology Centers of Western Michigan - Norton Shores

Norton Shores, Michigan, United States, 49444

Ascension Providence Hospitals - Novi

Novi, Michigan, United States, 48374

Henry Ford Medical Center-Columbus

Novi, Michigan, United States, 48377

21st Century Oncology-Pontiac

Pontiac, Michigan, United States, 48341

Hope Cancer Center

Pontiac, Michigan, United States, 48341

Newland Medical Associates-Pontiac

Pontiac, Michigan, United States, 48341

Saint Joseph Mercy Oakland

Pontiac, Michigan, United States, 48341

Huron Medical Center PC

Port Huron, Michigan, United States, 48060

Lake Huron Medical Center

Port Huron, Michigan, United States, 48060

Spectrum Health Reed City Hospital

Reed City, Michigan, United States, 49677

Great Lakes Cancer Management Specialists-Rochester Hills

Rochester Hills, Michigan, United States, 48309

Ascension Saint Mary's Hospital

Saginaw, Michigan, United States, 48601

Oncology Hematology Associates of Saginaw Valley PC

Saginaw, Michigan, United States, 48604

Lakeland Medical Center Saint Joseph

Saint Joseph, Michigan, United States, 49085

Marie Yeager Cancer Center

Saint Joseph, Michigan, United States, 49085

Henry Ford Macomb Health Center - Shelby Township

Shelby, Michigan, United States, 48315

Ascension Providence Hospitals - Southfield

Southfield, Michigan, United States, 48075

Bhadresh Nayak MD PC-Sterling Heights

Sterling Heights, Michigan, United States, 48312

Ascension Saint Joseph Hospital

Tawas City, Michigan, United States, 48764

Munson Medical Center

Traverse City, Michigan, United States, 49684

Advanced Breast Care Center PLLC

Warren, Michigan, United States, 48088

Great Lakes Cancer Management Specialists-Macomb Professional Building

Warren, Michigan, United States, 48093

Macomb Hematology Oncology PC

Warren, Michigan, United States, 48093

Michigan Breast Specialists-Warren

Warren, Michigan, United States, 48093

Saint John Macomb-Oakland Hospital

Warren, Michigan, United States, 48093

Henry Ford West Bloomfield Hospital

West Bloomfield, Michigan, United States, 48322

Saint Mary's Oncology/Hematology Associates of West Branch

West Branch, Michigan, United States, 48661

Henry Ford Wyandotte Hospital

Wyandotte, Michigan, United States, 48192

Metro Health Hospital

Wyoming, Michigan, United States, 49519

Huron Gastroenterology PC

Ypsilanti, Michigan, United States, 48106

Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus

Ypsilanti, Michigan, United States, 48197

United States, Minnesota

Riverwood Healthcare Center

Aitkin, Minnesota, United States, 56431

Essentia Health - Baxter Clinic

Baxter, Minnesota, United States, 56425

Sanford Joe Lueken Cancer Center

Bemidji, Minnesota, United States, 56601

Essentia Health Saint Joseph's Medical Center

Brainerd, Minnesota, United States, 56401

Fairview Ridges Hospital

Burnsville, Minnesota, United States, 55337

Minnesota Oncology - Burnsville

Burnsville, Minnesota, United States, 55337

Cambridge Medical Center

Cambridge, Minnesota, United States, 55008

Mercy Hospital

Coon Rapids, Minnesota, United States, 55433

Essentia Health - Deer River Clinic

Deer River, Minnesota, United States, 56636

Essentia Health Saint Mary's - Detroit Lakes Clinic

Detroit Lakes, Minnesota, United States, 56501

Essentia Health Cancer Center

Duluth, Minnesota, United States, 55805

Essentia Health Saint Mary's Medical Center

Duluth, Minnesota, United States, 55805

Miller-Dwan Hospital

Duluth, Minnesota, United States, 55805

Fairview Southdale Hospital

Edina, Minnesota, United States, 55435

Essentia Health - Ely Clinic

Ely, Minnesota, United States, 55731

Lake Region Healthcare Corporation-Cancer Care

Fergus Falls, Minnesota, United States, 56537

Essentia Health - Fosston

Fosston, Minnesota, United States, 56542

Unity Hospital

Fridley, Minnesota, United States, 55432

Essentia Health Hibbing Clinic

Hibbing, Minnesota, United States, 55746

Essentia Health - International Falls Clinic

International Falls, Minnesota, United States, 56649

Fairview Clinics and Surgery Center Maple Grove

Maple Grove, Minnesota, United States, 55369

Minnesota Oncology Hematology PA-Maplewood

Maplewood, Minnesota, United States, 55109

Saint John's Hospital - Healtheast

Maplewood, Minnesota, United States, 55109

Abbott-Northwestern Hospital

Minneapolis, Minnesota, United States, 55407

Hennepin County Medical Center

Minneapolis, Minnesota, United States, 55415

Health Partners Inc

Minneapolis, Minnesota, United States, 55454

Monticello Cancer Center

Monticello, Minnesota, United States, 55362

Essentia Health - Moose Lake Clinic

Moose Lake, Minnesota, United States, 55767

New Ulm Medical Center

New Ulm, Minnesota, United States, 56073

Essentia Health - Park Rapids

Park Rapids, Minnesota, United States, 56470

Fairview Northland Medical Center

Princeton, Minnesota, United States, 55371

North Memorial Medical Health Center

Robbinsdale, Minnesota, United States, 55422

Park Nicollet Clinic - Saint Louis Park

Saint Louis Park, Minnesota, United States, 55416

Regions Hospital

Saint Paul, Minnesota, United States, 55101

United Hospital

Saint Paul, Minnesota, United States, 55102

Essentia Health Sandstone

Sandstone, Minnesota, United States, 55072

Saint Francis Regional Medical Center

Shakopee, Minnesota, United States, 55379

Lakeview Hospital

Stillwater, Minnesota, United States, 55082

Sanford Thief River Falls Medical Center

Thief River Falls, Minnesota, United States, 56701

Essentia Health Virginia Clinic

Virginia, Minnesota, United States, 55792

Ridgeview Medical Center

Waconia, Minnesota, United States, 55387

Rice Memorial Hospital

Willmar, Minnesota, United States, 56201

Minnesota Oncology Hematology PA-Woodbury

Woodbury, Minnesota, United States, 55125

Sanford Cancer Center Worthington

Worthington, Minnesota, United States, 56187

Fairview Lakes Medical Center

Wyoming, Minnesota, United States, 55092

United States, Mississippi

Baptist Memorial Hospital and Cancer Center-Golden Triangle

Columbus, Mississippi, United States, 39705

Baptist Cancer Center-Grenada

Grenada, Mississippi, United States, 38901

Gulfport Memorial Hospital

Gulfport, Mississippi, United States, 39502

Hattiesburg Clinic - Hematology/Oncology Clinic

Hattiesburg, Mississippi, United States, 39401

Forrest General Hospital / Cancer Center

Hattiesburg, Mississippi, United States, 39404

University of Mississippi Medical Center

Jackson, Mississippi, United States, 39216

Baptist Memorial Hospital and Cancer Center-Union County

New Albany, Mississippi, United States, 38652

Baptist Memorial Hospital and Cancer Center-Oxford

Oxford, Mississippi, United States, 38655

Baptist Memorial Hospital and Cancer Center-Desoto

Southhaven, Mississippi, United States, 38671

United States, Missouri

Saint Louis Cancer and Breast Institute-Ballwin

Ballwin, Missouri, United States, 63011

Central Care Cancer Center - Bolivar

Bolivar, Missouri, United States, 65613

Parkland Health Center-Bonne Terre

Bonne Terre, Missouri, United States, 63628

Cox Cancer Center Branson

Branson, Missouri, United States, 65616

Saint Francis Medical Center

Cape Girardeau, Missouri, United States, 63703

Southeast Cancer Center

Cape Girardeau, Missouri, United States, 63703

Saint Luke's Hospital

Chesterfield, Missouri, United States, 63017

Siteman Cancer Center at West County Hospital

Creve Coeur, Missouri, United States, 63141

Parkland Health Center - Farmington

Farmington, Missouri, United States, 63640

Capital Region Southwest Campus

Jefferson City, Missouri, United States, 65109

Freeman Health System

Joplin, Missouri, United States, 64804

Mercy Hospital Joplin

Joplin, Missouri, United States, 64804

Truman Medical Centers

Kansas City, Missouri, United States, 64108

Kansas City Veterans Affairs Medical Center

Kansas City, Missouri, United States, 64128

The University of Kansas Cancer Center-South

Kansas City, Missouri, United States, 64131

University of Kansas Cancer Center - North

Kansas City, Missouri, United States, 64154

University of Kansas Cancer Center - Lee's Summit

Lee's Summit, Missouri, United States, 64064

Delbert Day Cancer Institute at PCRMC

Rolla, Missouri, United States, 65401

Mercy Clinic-Rolla-Cancer and Hematology

Rolla, Missouri, United States, 65401

Heartland Regional Medical Center

Saint Joseph, Missouri, United States, 64506

Saint Louis Cancer and Breast Institute-South City

Saint Louis, Missouri, United States, 63109

Washington University School of Medicine

Saint Louis, Missouri, United States, 63110

Mercy Hospital South

Saint Louis, Missouri, United States, 63128

Siteman Cancer Center-South County

Saint Louis, Missouri, United States, 63129

Missouri Baptist Medical Center

Saint Louis, Missouri, United States, 63131

Siteman Cancer Center at Christian Hospital

Saint Louis, Missouri, United States, 63136

Mercy Hospital Saint Louis

Saint Louis, Missouri, United States, 63141

Siteman Cancer Center at Saint Peters Hospital

Saint Peters, Missouri, United States, 63376

Sainte Genevieve County Memorial Hospital

Sainte Genevieve, Missouri, United States, 63670

Mercy Hospital Springfield

Springfield, Missouri, United States, 65804

CoxHealth South Hospital

Springfield, Missouri, United States, 65807

Missouri Baptist Sullivan Hospital

Sullivan, Missouri, United States, 63080

Missouri Baptist Outpatient Center-Sunset Hills

Sunset Hills, Missouri, United States, 63127

Mercy Hospital Washington

Washington, Missouri, United States, 63090

United States, Montana

Community Hospital of Anaconda

Anaconda, Montana, United States, 59711

Billings Clinic Cancer Center

Billings, Montana, United States, 59101

Saint Vincent Healthcare

Billings, Montana, United States, 59101

Saint Vincent Frontier Cancer Center

Billings, Montana, United States, 59102

Bozeman Deaconess Hospital

Bozeman, Montana, United States, 59715

Saint James Community Hospital and Cancer Treatment Center

Butte, Montana, United States, 59701

Benefis Healthcare- Sletten Cancer Institute

Great Falls, Montana, United States, 59405

Great Falls Clinic

Great Falls, Montana, United States, 59405

Saint Peter's Community Hospital

Helena, Montana, United States, 59601

Kalispell Regional Medical Center

Kalispell, Montana, United States, 59901

Community Medical Hospital

Missoula, Montana, United States, 59804

United States, Nebraska

CHI Health Saint Francis

Grand Island, Nebraska, United States, 68803

Heartland Hematology and Oncology

Kearney, Nebraska, United States, 68845

CHI Health Good Samaritan

Kearney, Nebraska, United States, 68847

Saint Elizabeth Regional Medical Center

Lincoln, Nebraska, United States, 68510

Nebraska Cancer Specialists/Oncology Hematology West PC - MECC

Omaha, Nebraska, United States, 68114

Nebraska Methodist Hospital

Omaha, Nebraska, United States, 68114

Oncology Associates PC

Omaha, Nebraska, United States, 68114

Alegent Health Immanuel Medical Center

Omaha, Nebraska, United States, 68122

Hematology and Oncology Consultants PC

Omaha, Nebraska, United States, 68122

Alegent Health Bergan Mercy Medical Center

Omaha, Nebraska, United States, 68124

Alegent Health Lakeside Hospital

Omaha, Nebraska, United States, 68130

Creighton University Medical Center

Omaha, Nebraska, United States, 68131

Midlands Community Hospital

Papillion, Nebraska, United States, 68046

United States, Nevada

Carson Tahoe Regional Medical Center

Carson City, Nevada, United States, 89703

Cancer and Blood Specialists-Henderson

Henderson, Nevada, United States, 89052

Comprehensive Cancer Centers of Nevada - Henderson

Henderson, Nevada, United States, 89052

Comprehensive Cancer Centers of Nevada-Horizon Ridge

Henderson, Nevada, United States, 89052

Las Vegas Cancer Center-Henderson

Henderson, Nevada, United States, 89052

OptumCare Cancer Care at Seven Hills

Henderson, Nevada, United States, 89052

Comprehensive Cancer Centers of Nevada-Southeast Henderson

Henderson, Nevada, United States, 89074

GenesisCare USA - Henderson

Henderson, Nevada, United States, 89074

Las Vegas Urology - Green Valley

Henderson, Nevada, United States, 89074

Las Vegas Urology - Pebble

Henderson, Nevada, United States, 89074

Urology Specialists of Nevada - Green Valley

Henderson, Nevada, United States, 89074

Las Vegas Urology - Pecos

Las Vegas, Nevada, United States, 89074

Desert West Surgery

Las Vegas, Nevada, United States, 89102

OptumCare Cancer Care at Charleston

Las Vegas, Nevada, United States, 89102

University Medical Center of Southern Nevada

Las Vegas, Nevada, United States, 89102

Hope Cancer Care of Nevada

Las Vegas, Nevada, United States, 89103

Cancer and Blood Specialists-Shadow

Las Vegas, Nevada, United States, 89106

Radiation Oncology Centers of Nevada Central

Las Vegas, Nevada, United States, 89106

Urology Specialists of Nevada - Central

Las Vegas, Nevada, United States, 89106

GenesisCare USA - Las Vegas

Las Vegas, Nevada, United States, 89109

HealthCare Partners Medical Group Oncology/Hematology-Maryland Parkway

Las Vegas, Nevada, United States, 89109

Sunrise Hospital and Medical Center

Las Vegas, Nevada, United States, 89109

HealthCare Partners Medical Group Oncology/Hematology-San Martin

Las Vegas, Nevada, United States, 89113

Las Vegas Prostate Cancer Center

Las Vegas, Nevada, United States, 89113

Las Vegas Urology - Sunset

Las Vegas, Nevada, United States, 89113

Urology Specialists of Nevada - Southwest

Las Vegas, Nevada, United States, 89113

Radiation Oncology Centers of Nevada Southeast

Las Vegas, Nevada, United States, 89119

Cancer Therapy and Integrative Medicine

Las Vegas, Nevada, United States, 89121

Ann M Wierman MD LTD

Las Vegas, Nevada, United States, 89128

Cancer and Blood Specialists-Tenaya

Las Vegas, Nevada, United States, 89128

Comprehensive Cancer Centers of Nevada - Northwest

Las Vegas, Nevada, United States, 89128

GenesisCare USA - Vegas Tenaya

Las Vegas, Nevada, United States, 89128

HealthCare Partners Medical Group Oncology/Hematology-Tenaya

Las Vegas, Nevada, United States, 89128

Las Vegas Urology - Cathedral Rock

Las Vegas, Nevada, United States, 89128

Las Vegas Urology - Smoke Ranch

Las Vegas, Nevada, United States, 89128

OptumCare Cancer Care at MountainView

Las Vegas, Nevada, United States, 89128

Urology Specialists of Nevada - Northwest

Las Vegas, Nevada, United States, 89128

Alliance for Childhood Diseases/Cure 4 the Kids Foundation

Las Vegas, Nevada, United States, 89135

Comprehensive Cancer Centers of Nevada - Town Center

Las Vegas, Nevada, United States, 89144

Comprehensive Cancer Centers of Nevada-Summerlin

Las Vegas, Nevada, United States, 89144

Summerlin Hospital Medical Center

Las Vegas, Nevada, United States, 89144

Las Vegas Cancer Center-Medical Center

Las Vegas, Nevada, United States, 89148-2405

Comprehensive Cancer Centers of Nevada

Las Vegas, Nevada, United States, 89148

GenesisCare USA - Fort Apache

Las Vegas, Nevada, United States, 89148

OptumCare Cancer Care at Fort Apache

Las Vegas, Nevada, United States, 89148

HealthCare Partners Medical Group Oncology/Hematology-Centennial Hills

Las Vegas, Nevada, United States, 89149

Comprehensive Cancer Centers of Nevada - Central Valley

Las Vegas, Nevada, United States, 89169

University Cancer Center

Las Vegas, Nevada, United States, 89169

Hope Cancer Care of Nevada-Pahrump

Pahrump, Nevada, United States, 89048

Renown Regional Medical Center

Reno, Nevada, United States, 89502

Saint Mary's Regional Medical Center

Reno, Nevada, United States, 89503

Radiation Oncology Associates

Reno, Nevada, United States, 89509

United States, New Hampshire

Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center

Lebanon, New Hampshire, United States, 03756

Norris Cotton Cancer Center-Manchester

Manchester, New Hampshire, United States, 03102

Dartmouth Cancer Center - Nashua

Nashua, New Hampshire, United States, 03063

United States, New Jersey

Morristown Medical Center

Morristown, New Jersey, United States, 07960

Chilton Medical Center

Pompton, New Jersey, United States, 07444

Overlook Hospital

Summit, New Jersey, United States, 07902

Inspira Medical Center Vineland

Vineland, New Jersey, United States, 08360

United States, New Mexico

Lovelace Medical Center-Saint Joseph Square

Albuquerque, New Mexico, United States, 87102

University of New Mexico Cancer Center

Albuquerque, New Mexico, United States, 87102

Southwest Gynecologic Oncology Associates Inc

Albuquerque, New Mexico, United States, 87106

New Mexico Oncology Hematology Consultants

Albuquerque, New Mexico, United States, 87109

Presbyterian Kaseman Hospital

Albuquerque, New Mexico, United States, 87110

Memorial Medical Center - Las Cruces

Las Cruces, New Mexico, United States, 88011

Presbyterian Rust Medical Center/Jorgensen Cancer Center

Rio Rancho, New Mexico, United States, 87124

Christus Saint Vincent Regional Cancer Center

Santa Fe, New Mexico, United States, 87505

United States, New York

Montefiore Medical Center-Einstein Campus

Bronx, New York, United States, 10461

Montefiore Medical Center-Weiler Hospital

Bronx, New York, United States, 10461

Montefiore Medical Center - Moses Campus

Bronx, New York, United States, 10467

Roswell Park Cancer Institute

Buffalo, New York, United States, 14263

Arnot Ogden Medical Center/Falck Cancer Center

Elmira, New York, United States, 14905

Glens Falls Hospital

Glens Falls, New York, United States, 12801

Laura and Isaac Perlmutter Cancer Center at NYU Langone

New York, New York, United States, 10016

University of Rochester

Rochester, New York, United States, 14642

Stony Brook University Medical Center

Stony Brook, New York, United States, 11794

United States, North Carolina

AdventHealth Infusion Center Asheville

Asheville, North Carolina, United States, 28803

Southeastern Medical Oncology Center-Clinton

Clinton, North Carolina, United States, 28328

AdventHealth Infusion Center Haywood

Clyde, North Carolina, United States, 28721

Southeastern Medical Oncology Center-Goldsboro

Goldsboro, North Carolina, United States, 27534

Wayne Memorial Hospital

Goldsboro, North Carolina, United States, 27534

Margaret R Pardee Memorial Hospital

Hendersonville, North Carolina, United States, 28791

AdventHealth Hendersonville

Hendersonville, North Carolina, United States, 28792

Onslow Memorial Hospital

Jacksonville, North Carolina, United States, 28546

Southeastern Medical Oncology Center-Jacksonville

Jacksonville, North Carolina, United States, 28546

Vidant Oncology-Kenansville

Kenansville, North Carolina, United States, 28349

Vidant Oncology-Kinston

Kinston, North Carolina, United States, 28501

Vidant Oncology-Richlands

Richlands, North Carolina, United States, 28574

AdventHealth Infusion Center Weaverville

Weaverville, North Carolina, United States, 28787

United States, North Dakota

Sanford Bismarck Medical Center

Bismarck, North Dakota, United States, 58501

Essentia Health Cancer Center-South University Clinic

Fargo, North Dakota, United States, 58103

Sanford South University Medical Center

Fargo, North Dakota, United States, 58103

Sanford Broadway Medical Center

Fargo, North Dakota, United States, 58122

Sanford Roger Maris Cancer Center

Fargo, North Dakota, United States, 58122

Essentia Health - Jamestown Clinic

Jamestown, North Dakota, United States, 58401

United States, Ohio

Indu and Raj Soin Medical Center

Beavercreek, Ohio, United States, 45431

Strecker Cancer Center-Belpre

Belpre, Ohio, United States, 45714

Saint Elizabeth Boardman Hospital

Boardman, Ohio, United States, 44512

Cleveland Clinic Mercy Hospital

Canton, Ohio, United States, 44708

Mercy Hematology and Oncology Associates Inc

Canton, Ohio, United States, 44708

Dayton Physicians LLC-Miami Valley South

Centerville, Ohio, United States, 45459

Miami Valley Hospital South

Centerville, Ohio, United States, 45459

Adena Regional Medical Center

Chillicothe, Ohio, United States, 45601

Good Samaritan Hospital - Cincinnati

Cincinnati, Ohio, United States, 45220

Oncology Hematology Care Inc-Kenwood

Cincinnati, Ohio, United States, 45236

Bethesda North Hospital

Cincinnati, Ohio, United States, 45242

TriHealth Cancer Institute-Westside

Cincinnati, Ohio, United States, 45247

TriHealth Cancer Institute-Anderson

Cincinnati, Ohio, United States, 45255

MetroHealth Medical Center

Cleveland, Ohio, United States, 44109

Cleveland Clinic Foundation

Cleveland, Ohio, United States, 44195

Ohio State University Comprehensive Cancer Center

Columbus, Ohio, United States, 43210

Mount Carmel East Hospital

Columbus, Ohio, United States, 43213

Columbus Oncology and Hematology Associates Inc

Columbus, Ohio, United States, 43214

Riverside Methodist Hospital

Columbus, Ohio, United States, 43214

Grant Medical Center

Columbus, Ohio, United States, 43215

The Mark H Zangmeister Center

Columbus, Ohio, United States, 43219

Mount Carmel Health Center West

Columbus, Ohio, United States, 43222

Doctors Hospital

Columbus, Ohio, United States, 43228

Good Samaritan Hospital - Dayton

Dayton, Ohio, United States, 45406

Miami Valley Hospital

Dayton, Ohio, United States, 45409

Dayton Physician LLC-Miami Valley Hospital North

Dayton, Ohio, United States, 45415

Miami Valley Hospital North

Dayton, Ohio, United States, 45415

Delaware Health Center-Grady Cancer Center

Delaware, Ohio, United States, 43015

Delaware Radiation Oncology

Delaware, Ohio, United States, 43015

Grady Memorial Hospital

Delaware, Ohio, United States, 43015

Columbus Oncology and Hematology Associates

Dublin, Ohio, United States, 43016

Dublin Methodist Hospital

Dublin, Ohio, United States, 43016

Armes Family Cancer Center

Findlay, Ohio, United States, 45840

Blanchard Valley Hospital

Findlay, Ohio, United States, 45840

Orion Cancer Care

Findlay, Ohio, United States, 45840

Atrium Medical Center-Middletown Regional Hospital

Franklin, Ohio, United States, 45005-1066

Dayton Physicians LLC-Atrium

Franklin, Ohio, United States, 45005

Dayton Physicians LLC-Wayne

Greenville, Ohio, United States, 45331

Wayne Hospital

Greenville, Ohio, United States, 45331

Mount Carmel Grove City Hospital

Grove City, Ohio, United States, 43123

Zangmeister Center Grove City

Grove City, Ohio, United States, 43123

Greater Dayton Cancer Center

Kettering, Ohio, United States, 45409

First Dayton Cancer Care

Kettering, Ohio, United States, 45420

Kettering Medical Center

Kettering, Ohio, United States, 45429

Fairfield Medical Center

Lancaster, Ohio, United States, 43130

Saint Rita's Medical Center

Lima, Ohio, United States, 45801

OhioHealth Mansfield Hospital

Mansfield, Ohio, United States, 44903

Marietta Memorial Hospital

Marietta, Ohio, United States, 45750

OhioHealth Marion General Hospital

Marion, Ohio, United States, 43302

Toledo Clinic Cancer Centers-Maumee

Maumee, Ohio, United States, 43537

Toledo Radiation Oncology at Northwest Ohio Onocolgy Center

Maumee, Ohio, United States, 43537

Dayton Physicians LLC-Signal Point

Middletown, Ohio, United States, 45042

Knox Community Hospital

Mount Vernon, Ohio, United States, 43050

Mount Carmel New Albany Surgical Hospital

New Albany, Ohio, United States, 43054

Licking Memorial Hospital

Newark, Ohio, United States, 43055

Newark Radiation Oncology

Newark, Ohio, United States, 43055

Mercy Health Perrysburg Cancer Center

Perrysburg, Ohio, United States, 43551

Southern Ohio Medical Center

Portsmouth, Ohio, United States, 45662

North Coast Cancer Care

Sandusky, Ohio, United States, 44870

Dayton Physicians LLC-Wilson

Sidney, Ohio, United States, 45365

Springfield Regional Cancer Center

Springfield, Ohio, United States, 45504

Springfield Regional Medical Center

Springfield, Ohio, United States, 45505

ProMedica Flower Hospital

Sylvania, Ohio, United States, 43560

ProMedica Toledo Hospital/Russell J Ebeid Children's Hospital

Toledo, Ohio, United States, 43606

Saint Vincent Mercy Medical Center

Toledo, Ohio, United States, 43608

Mercy Health - Saint Anne Hospital

Toledo, Ohio, United States, 43623

Toledo Clinic Cancer Centers-Toledo

Toledo, Ohio, United States, 43623

Dayton Physicians LLC - Troy

Troy, Ohio, United States, 45373

Upper Valley Medical Center

Troy, Ohio, United States, 45373

South Pointe Hospital

Warrensville Heights, Ohio, United States, 44122

Saint Joseph Warren Hospital

Warren, Ohio, United States, 44484

Saint Ann's Hospital

Westerville, Ohio, United States, 43081

Saint Elizabeth Youngstown Hospital

Youngstown, Ohio, United States, 44501

Genesis Healthcare System Cancer Care Center

Zanesville, Ohio, United States, 43701

United States, Oklahoma

Cancer Centers of Southwest Oklahoma Research

Lawton, Oklahoma, United States, 73505

University of Oklahoma Health Sciences Center

Oklahoma City, Oklahoma, United States, 73104

Mercy Hospital Oklahoma City

Oklahoma City, Oklahoma, United States, 73120

Cancer Treatment Centers of America

Tulsa, Oklahoma, United States, 74133

Oklahoma Cancer Specialists and Research Institute-Tulsa

Tulsa, Oklahoma, United States, 74146

United States, Oregon

Saint Alphonsus Medical Center-Baker City

Baker City, Oregon, United States, 97814

Saint Charles Health System

Bend, Oregon, United States, 97701

Clackamas Radiation Oncology Center

Clackamas, Oregon, United States, 97015

Kaiser Sunnyside Medical Center

Clackamas, Oregon, United States, 97015

Providence Cancer Institute Clackamas Clinic

Clackamas, Oregon, United States, 97015

Bay Area Hospital

Coos Bay, Oregon, United States, 97420

Legacy Mount Hood Medical Center

Gresham, Oregon, United States, 97030

Providence Newberg Medical Center

Newberg, Oregon, United States, 97132

Saint Alphonsus Medical Center-Ontario

Ontario, Oregon, United States, 97914

Providence Willamette Falls Medical Center

Oregon City, Oregon, United States, 97045

Legacy Good Samaritan Hospital and Medical Center

Portland, Oregon, United States, 97210

Providence Portland Medical Center

Portland, Oregon, United States, 97213

Providence Saint Vincent Medical Center

Portland, Oregon, United States, 97225

Kaiser Permanente Northwest

Portland, Oregon, United States, 97227

Oregon Health and Science University

Portland, Oregon, United States, 97239

Saint Charles Health System-Redmond

Redmond, Oregon, United States, 97756

Legacy Meridian Park Hospital

Tualatin, Oregon, United States, 97062

United States, Pennsylvania

Lehigh Valley Hospital-Cedar Crest

Allentown, Pennsylvania, United States, 18103

UPMC-Heritage Valley Health System Beaver

Beaver, Pennsylvania, United States, 15009

Lehigh Valley Hospital - Muhlenberg

Bethlehem, Pennsylvania, United States, 18017

Christiana Care Health System-Concord Health Center

Chadds Ford, Pennsylvania, United States, 19317

UPMC Hillman Cancer Center - Passavant - Cranberry

Cranberry Township, Pennsylvania, United States, 16066

Doylestown Hospital

Doylestown, Pennsylvania, United States, 18901

Pocono Medical Center

East Stroudsburg, Pennsylvania, United States, 18301

Saint Vincent Hospital

Erie, Pennsylvania, United States, 16544

UPMC Cancer Centers - Arnold Palmer Pavilion

Greensburg, Pennsylvania, United States, 15601

Lehigh Valley Hospital-Hazleton

Hazleton, Pennsylvania, United States, 18201

IRMC Cancer Center

Indiana, Pennsylvania, United States, 15701

Jefferson Hospital

Jefferson Hills, Pennsylvania, United States, 15025

UPMC-Johnstown/John P. Murtha Regional Cancer Center

Johnstown, Pennsylvania, United States, 15901

UPMC Cancer Center at UPMC McKeesport

McKeesport, Pennsylvania, United States, 15132

Forbes Hospital

Monroeville, Pennsylvania, United States, 15146

UPMC Hillman Cancer Center - Monroeville

Monroeville, Pennsylvania, United States, 15146

UPMC Hillman Cancer Center in Coraopolis

Moon, Pennsylvania, United States, 15108

UPMC Hillman Cancer Center - Part of Frick Hospital

Mount Pleasant, Pennsylvania, United States, 15666

Arnold Palmer Cancer Center Medical Oncology Norwin

N. Huntingdon, Pennsylvania, United States, 15642

Thomas Jefferson University Hospital

Philadelphia, Pennsylvania, United States, 19107

Eastern Regional Medical Center

Philadelphia, Pennsylvania, United States, 19124

Temple University Hospital

Philadelphia, Pennsylvania, United States, 19140

Allegheny General Hospital

Pittsburgh, Pennsylvania, United States, 15212

UPMC-Magee Womens Hospital

Pittsburgh, Pennsylvania, United States, 15213

UPMC-Presbyterian Hospital

Pittsburgh, Pennsylvania, United States, 15213

UPMC-Saint Margaret

Pittsburgh, Pennsylvania, United States, 15215

West Penn Hospital

Pittsburgh, Pennsylvania, United States, 15224

University of Pittsburgh Cancer Institute (UPCI)

Pittsburgh, Pennsylvania, United States, 15232

UPMC-Shadyside Hospital

Pittsburgh, Pennsylvania, United States, 15232

UPMC-Passavant Hospital

Pittsburgh, Pennsylvania, United States, 15237

UPMC-Saint Clair Hospital Cancer Center

Pittsburgh, Pennsylvania, United States, 15243

Pottstown Hospital

Pottstown, Pennsylvania, United States, 19464

UPMC Cancer Center at UPMC Northwest

Seneca, Pennsylvania, United States, 16346

UPMC Uniontown Hospital Radiation Oncology

Uniontown, Pennsylvania, United States, 15401

UPMC Cancer Center-Washington

Washington, Pennsylvania, United States, 15301

UPMC Washington Hospital Radiation Oncology

Washington, Pennsylvania, United States, 15301

UPMC West Mifflin-Cancer Center Jefferson

West Mifflin, Pennsylvania, United States, 15122

Wexford Health and Wellness Pavilion

Wexford, Pennsylvania, United States, 15090

United States, South Carolina

Prisma Health Cancer Institute - Spartanburg

Boiling Springs, South Carolina, United States, 29316

Medical University of South Carolina

Charleston, South Carolina, United States, 29425

Prisma Health Cancer Institute - Laurens

Clinton, South Carolina, United States, 29325

Prisma Health Cancer Institute - Easley

Easley, South Carolina, United States, 29640

Gibbs Cancer Center-Gaffney

Gaffney, South Carolina, United States, 29341

Tidelands Georgetown Memorial Hospital

Georgetown, South Carolina, United States, 29440

Saint Francis Hospital

Greenville, South Carolina, United States, 29601

Prisma Health Cancer Institute - Butternut

Greenville, South Carolina, United States, 29605

Prisma Health Cancer Institute - Faris

Greenville, South Carolina, United States, 29605

Prisma Health Greenville Memorial Hospital

Greenville, South Carolina, United States, 29605

Saint Francis Cancer Center

Greenville, South Carolina, United States, 29607

Prisma Health Cancer Institute - Eastside

Greenville, South Carolina, United States, 29615

Prisma Health Cancer Institute - Greer

Greer, South Carolina, United States, 29650

Gibbs Cancer Center-Pelham

Greer, South Carolina, United States, 29651

Prisma Health Cancer Institute - Seneca

Seneca, South Carolina, United States, 29672

North Grove Medical Park

Spartanburg, South Carolina, United States, 29303

Spartanburg Medical Center

Spartanburg, South Carolina, United States, 29303

Spartanburg Medical Center - Mary Black Campus

Spartanburg, South Carolina, United States, 29307

MGC Hematology Oncology-Union

Union, South Carolina, United States, 29379

United States, South Dakota

Sanford Cancer Center Oncology Clinic

Sioux Falls, South Dakota, United States, 57104

Sanford USD Medical Center - Sioux Falls

Sioux Falls, South Dakota, United States, 57117-5134

United States, Tennessee

Memorial Hospital

Chattanooga, Tennessee, United States, 37404

Baptist Memorial Hospital and Cancer Center-Collierville

Collierville, Tennessee, United States, 38017

Vanderbilt-Ingram Cancer Center Cool Springs

Franklin, Tennessee, United States, 37067

Pulmonary Medicine Center of Chattanooga-Hixson

Hixson, Tennessee, United States, 37343

Baptist Memorial Hospital and Cancer Center-Memphis

Memphis, Tennessee, United States, 38120

Vanderbilt Breast Center at One Hundred Oaks

Nashville, Tennessee, United States, 37204

Meharry Medical College

Nashville, Tennessee, United States, 37208

Vanderbilt University/Ingram Cancer Center

Nashville, Tennessee, United States, 37232

Memorial GYN Plus

Ooltewah, Tennessee, United States, 37363

United States, Texas

Saint Joseph Regional Cancer Center

Bryan, Texas, United States, 77802

Parkland Memorial Hospital

Dallas, Texas, United States, 75235

Baylor University Medical Center

Dallas, Texas, United States, 75246

UT Southwestern/Simmons Cancer Center-Dallas

Dallas, Texas, United States, 75390

UT Southwestern/Simmons Cancer Center-Fort Worth

Fort Worth, Texas, United States, 76104

Lyndon Baines Johnson General Hospital

Houston, Texas, United States, 77026-1967

M D Anderson Cancer Center

Houston, Texas, United States, 77030

UT Southwestern Clinical Center at Richardson/Plano

Richardson, Texas, United States, 75080

University Hospital

San Antonio, Texas, United States, 78229

University of Texas Health Science Center at San Antonio

San Antonio, Texas, United States, 78229

United States, Utah

American Fork Hospital / Huntsman Intermountain Cancer Center

American Fork, Utah, United States, 84003

Sandra L Maxwell Cancer Center

Cedar City, Utah, United States, 84720

Farmington Health Center

Farmington, Utah, United States, 84025

Logan Regional Hospital

Logan, Utah, United States, 84321

Intermountain Medical Center

Murray, Utah, United States, 84107

McKay-Dee Hospital Center

Ogden, Utah, United States, 84403

Utah Valley Regional Medical Center

Provo, Utah, United States, 84604

Riverton Hospital

Riverton, Utah, United States, 84065

Saint George Regional Medical Center

Saint George, Utah, United States, 84770

Utah Cancer Specialists-Salt Lake City

Salt Lake City, Utah, United States, 84106

Huntsman Cancer Institute/University of Utah

Salt Lake City, Utah, United States, 84112

LDS Hospital

Salt Lake City, Utah, United States, 84143

South Jordan Health Center

South Jordan, Utah, United States, 84009

United States, Vermont

Central Vermont Medical Center/National Life Cancer Treatment

Berlin, Vermont, United States, 05602

University of Vermont Medical Center

Burlington, Vermont, United States, 05401

University of Vermont and State Agricultural College

Burlington, Vermont, United States, 05405

Norris Cotton Cancer Center-North

Saint Johnsbury, Vermont, United States, 05819

United States, Virginia

Virginia Commonwealth University/Massey Cancer Center

Richmond, Virginia, United States, 23298

United States, Washington

Providence Regional Cancer System-Aberdeen

Aberdeen, Washington, United States, 98520

Cancer Care Center at Island Hospital

Anacortes, Washington, United States, 98221

MultiCare Auburn Medical Center

Auburn, Washington, United States, 98001

Virginia Mason Bainbridge Island Medical Center

Bainbridge Island, Washington, United States, 98110

Overlake Medical Center

Bellevue, Washington, United States, 98004

PeaceHealth Saint Joseph Medical Center

Bellingham, Washington, United States, 98225

Harrison HealthPartners Hematology and Oncology-Bremerton

Bremerton, Washington, United States, 98310

Harrison Medical Center

Bremerton, Washington, United States, 98310

Highline Medical Center-Main Campus

Burien, Washington, United States, 98166

Providence Regional Cancer System-Centralia

Centralia, Washington, United States, 98531

Swedish Cancer Institute-Edmonds

Edmonds, Washington, United States, 98026

Saint Elizabeth Hospital

Enumclaw, Washington, United States, 98022

Providence Regional Cancer Partnership

Everett, Washington, United States, 98201

Virginia Mason Federal Way Medical Center

Federal Way, Washington, United States, 98002

Saint Francis Hospital

Federal Way, Washington, United States, 98003

Tacoma/Valley Radiation Oncology Centers-Gig Harbor

Gig Harbor, Washington, United States, 98332

MultiCare Gig Harbor Medical Park

Gig Harbor, Washington, United States, 98335

Swedish Cancer Institute-Issaquah

Issaquah, Washington, United States, 98029

Kadlec Clinic Hematology and Oncology

Kennewick, Washington, United States, 99336

Northwest Cancer Clinic

Kennewick, Washington, United States, 99336

Providence Regional Cancer System-Lacey

Lacey, Washington, United States, 98503

Saint Clare Hospital

Lakewood, Washington, United States, 98499

PeaceHealth Saint John Medical Center

Longview, Washington, United States, 98632

Virginia Mason Lynnwood Medical Center

Lynnwood, Washington, United States, 98036

Skagit Regional Health Cancer Care Center

Mount Vernon, Washington, United States, 98274

Skagit Valley Hospital

Mount Vernon, Washington, United States, 98274

Jefferson Healthcare

Port Townsend, Washington, United States, 98368

Harrison HealthPartners Hematology and Oncology-Poulsbo

Poulsbo, Washington, United States, 98370

Peninsula Cancer Center

Poulsbo, Washington, United States, 98370

MultiCare Good Samaritan Hospital

Puyallup, Washington, United States, 98372

Tacoma/Valley Radiation Oncology Centers-Puyallup

Puyallup, Washington, United States, 98372

Valley Medical Center

Renton, Washington, United States, 98055

Virginia Mason Medical Center

Seattle, Washington, United States, 98101

Pacific Gynecology Specialists

Seattle, Washington, United States, 98104

Swedish Medical Center-Ballard Campus

Seattle, Washington, United States, 98107

FHCC South Lake Union

Seattle, Washington, United States, 98109

Fred Hutchinson Cancer Research Center

Seattle, Washington, United States, 98109

Kaiser Permanente Washington

Seattle, Washington, United States, 98112

Swedish Medical Center-First Hill

Seattle, Washington, United States, 98122

University of Washington Medical Center - Montlake

Seattle, Washington, United States, 98195

PeaceHealth United General Medical Center

Sedro-Woolley, Washington, United States, 98284

Providence Regional Cancer System-Shelton

Shelton, Washington, United States, 98584

MultiCare Deaconess Cancer and Blood Specialty Center - Valley

Spokane Valley, Washington, United States, 99216

MultiCare Deaconess Cancer and Blood Specialty Center - Downtown

Spokane, Washington, United States, 99204

Spokane Valley Cancer Center-Mayfair

Spokane, Washington, United States, 99208

Spokane Valley Cancer Center-Mission

Spokane, Washington, United States, 99216

MultiCare Deaconess Cancer and Blood Specialty Center - North

Spokane, Washington, United States, 99218

Tacoma/Valley Radiation Oncology Centers-Jackson Hall

Tacoma, Washington, United States, 97405

Franciscan Research Center-Northwest Medical Plaza

Tacoma, Washington, United States, 98405

Mary Bridge Children's Hospital and Health Center

Tacoma, Washington, United States, 98405

MultiCare Tacoma General Hospital

Tacoma, Washington, United States, 98405

Northwest Medical Specialties PLLC

Tacoma, Washington, United States, 98405

Tacoma/Valley Radiation Oncology Centers-Saint Joe's

Tacoma, Washington, United States, 98405

PeaceHealth Southwest Medical Center

Vancouver, Washington, United States, 98664

Legacy Cancer Institute Medical Oncology and Day Treatment

Vancouver, Washington, United States, 98684

Legacy Salmon Creek Hospital

Vancouver, Washington, United States, 98686

Providence Saint Mary Regional Cancer Center

Walla Walla, Washington, United States, 99362

Wenatchee Valley Hospital and Clinics

Wenatchee, Washington, United States, 98801

North Star Lodge Cancer Center at Yakima Valley Memorial Hospital

Yakima, Washington, United States, 98902

Providence Regional Cancer System-Yelm

Yelm, Washington, United States, 98597

United States, West Virginia

Edwards Comprehensive Cancer Center

Huntington, West Virginia, United States, 25701

United States, Wisconsin

Ascension Saint Elizabeth Hospital

Appleton, Wisconsin, United States, 54915

Duluth Clinic Ashland

Ashland, Wisconsin, United States, 54806

Northwest Wisconsin Cancer Center

Ashland, Wisconsin, United States, 54806

Ascension Southeast Wisconsin Hospital - Elmbrook Campus

Brookfield, Wisconsin, United States, 53045

Ascension Calumet Hospital

Chilton, Wisconsin, United States, 53014

Marshfield Clinic-Chippewa Center

Chippewa Falls, Wisconsin, United States, 54729

Marshfield Clinic Cancer Center at Sacred Heart

Eau Claire, Wisconsin, United States, 54701

Marshfield Medical Center-EC Cancer Center

Eau Claire, Wisconsin, United States, 54701

Ascension Saint Francis - Reiman Cancer Center

Franklin, Wisconsin, United States, 53132

Ascension Southeast Wisconsin Hospital - Franklin

Franklin, Wisconsin, United States, 53132

Saint Vincent Hospital Cancer Center Green Bay

Green Bay, Wisconsin, United States, 54301

Saint Vincent Hospital Cancer Center at Saint Mary's

Green Bay, Wisconsin, United States, 54303

Gundersen Lutheran Medical Center

La Crosse, Wisconsin, United States, 54601

Marshfield Clinic - Ladysmith Center

Ladysmith, Wisconsin, United States, 54848

Holy Family Memorial Hospital

Manitowoc, Wisconsin, United States, 54221

Saint Vincent Hospital Cancer Center at Marinette

Marinette, Wisconsin, United States, 54143

Marshfield Medical Center-Marshfield

Marshfield, Wisconsin, United States, 54449

Ascension Columbia Saint Mary's Hospital Ozaukee

Mequon, Wisconsin, United States, 53097

Ascension Southeast Wisconsin Hospital - Saint Joseph Campus

Milwaukee, Wisconsin, United States, 53210

Ascension Columbia Saint Mary's Hospital - Milwaukee

Milwaukee, Wisconsin, United States, 53211

Ascension Saint Francis Hospital

Milwaukee, Wisconsin, United States, 53215

Marshfield Clinic-Minocqua Center

Minocqua, Wisconsin, United States, 54548

Cancer Center of Western Wisconsin

New Richmond, Wisconsin, United States, 54017

Saint Vincent Hospital Cancer Center at Oconto Falls

Oconto Falls, Wisconsin, United States, 54154

Ascension Mercy Hospital

Oshkosh, Wisconsin, United States, 54904

Ascension All Saints Hospital

Racine, Wisconsin, United States, 53405

Ascension Saint Mary's Hospital

Rhinelander, Wisconsin, United States, 54501

Marshfield Medical Center-Rice Lake

Rice Lake, Wisconsin, United States, 54868

HSHS Saint Nicholas Hospital

Sheboygan, Wisconsin, United States, 53081

Ascension Saint Michael's Hospital

Stevens Point, Wisconsin, United States, 54481

Marshfield Medical Center-River Region at Stevens Point

Stevens Point, Wisconsin, United States, 54482

Saint Vincent Hospital Cancer Center at Sturgeon Bay

Sturgeon Bay, Wisconsin, United States, 54235-1495

Marshfield Clinic-Wausau Center

Wausau, Wisconsin, United States, 54401

Ascension Medical Group Southeast Wisconsin - Mayfair Road

Wauwatosa, Wisconsin, United States, 53226

Marshfield Medical Center - Weston

Weston, Wisconsin, United States, 54476

Marshfield Clinic - Wisconsin Rapids Center

Wisconsin Rapids, Wisconsin, United States, 54494

United States, Wyoming

Cheyenne Regional Medical Center-West

Cheyenne, Wyoming, United States, 82001

Billings Clinic-Cody

Cody, Wyoming, United States, 82414

Welch Cancer Center

Sheridan, Wyoming, United States, 82801

Guam

FHP Health Center-Guam

Tamuning, Guam, 96913

Sponsors and Collaborators

National Cancer Institute (NCI)

Investigators

• Principal Investigator: Sandip P Patel; SWOG Cancer Research Network

More Information

Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):

Adams S, Othus M, Patel SP, Miller KD, Chugh R, Schuetze SM, Chamberlin MD, Haley BJ, Storniolo AMV, Reddy MP, Anderson SA, Zimmerman CT, O'Dea AP, Mirshahidi HR, Ahnert JR, Brescia FJ, Hahn O, Raymond JM, Biggs DD, Connolly RM, Sharon E, Korde LA, Gray RJ, Mayerson E, Plets M, Blanke CD, Chae YK, Kurzrock R. A Multicenter Phase II Trial of Ipilimumab and Nivolumab in Unresectable or Metastatic Metaplastic Breast Cancer: Cohort 36 of Dual Anti-CTLA-4 and Anti-PD-1 Blockade in Rare Tumors (DART, SWOG S1609). Clin Cancer Res. 2022 Jan 15;28(2):271-278. doi: 10.1158/1078-0432.CCR-21-2182. Epub 2021 Oct 29.

Wagner MJ, Othus M, Patel SP, Ryan C, Sangal A, Powers B, Budd GT, Victor AI, Hsueh CT, Chugh R, Nair S, Leu KM, Agulnik M, Sharon E, Mayerson E, Plets M, Blanke C, Streicher H, Chae YK, Kurzrock R. Multicenter phase II trial (SWOG S1609, cohort 51) of ipilimumab and nivolumab in metastatic or unresectable angiosarcoma: a substudy of dual anti-CTLA-4 and anti-PD-1 blockade in rare tumors (DART). J Immunother Cancer. 2021 Aug;9(8):e002990. doi: 10.1136/jitc-2021-002990.

Patel SP, Mayerson E, Chae YK, Strosberg J, Wang J, Konda B, Hayward J, McLeod CM, Chen HX, Sharon E, Othus M, Ryan CW, Plets M, Blanke CD, Kurzrock R. A phase II basket trial of Dual Anti-CTLA-4 and Anti-PD-1 Blockade in Rare Tumors (DART) SWOG S1609: High-grade neuroendocrine neoplasm cohort. Cancer. 2021 Sep 1;127(17):3194-3201. doi: 10.1002/cncr.33591. Epub 2021 Apr 21.

Dai C, Liang S, Sun B, Kang J. The Progress of Immunotherapy in Refractory Pituitary Adenomas and Pituitary Carcinomas. Front Endocrinol (Lausanne). 2020 Dec 11;11:608422. doi: 10.3389/fendo.2020.608422. eCollection 2020.

Patel SP, Othus M, Chae YK, Giles FJ, Hansel DE, Singh PP, Fontaine A, Shah MH, Kasi A, Baghdadi TA, Matrana M, Gatalica Z, Korn WM, Hayward J, McLeod C, Chen HX, Sharon E, Mayerson E, Ryan CW, Plets M, Blanke CD, Kurzrock R. A Phase II Basket Trial of Dual Anti-CTLA-4 and Anti-PD-1 Blockade in Rare Tumors (DART SWOG 1609) in Patients with Nonpancreatic Neuroendocrine Tumors. Clin Cancer Res. 2020 May 15;26(10):2290-2296. doi: 10.1158/1078-0432.CCR-19-3356. Epub 2020 Jan 22.

• Responsible Party: National Cancer Institute (NCI)
• ClinicalTrials.gov Identifier: NCT02834013
• Other Study ID Numbers: NCI-2016-01041; NCI-2016-01041 ( Registry Identifier: CTRP (Clinical Trial Reporting Program) ); S1609; S1609 ( Other Identifier: SWOG ); S1609 ( Other Identifier: CTEP ); U10CA180888 ( U.S. NIH Grant/Contract )
• First Posted: July 15, 2016
• Last Update Posted: May 16, 2023
• Last Verified: March 2023

• Studies a U.S. FDA-regulated Drug Product: Yes
• Studies a U.S. FDA-regulated Device Product: No

Additional relevant MeSH terms:

Carcinoma; Neoplasms; Carcinoma, Squamous Cell; Adenocarcinoma; Nasopharyngeal Carcinoma; Neoplasms, Germ Cell and Embryonal; Cholangiocarcinoma; Neuroendocrine Tumors; Carcinoma, Basal Cell; Gastrointestinal Stromal Tumors; Carcinoid Tumor; Adenocarcinoma of Lung; Carcinoma, Transitional Cell; Carcinoma, Adenoid Cystic; Carcinoma, Neuroendocrine; Teratoma; Pheochromocytoma; Cystadenocarcinoma, Serous; Seminoma; Choriocarcinoma; Carcinoma, Endometrioid; Paraganglioma; Cystadenocarcinoma; Chordoma; Hemangiosarcoma; Fibromatosis, Aggressive; Adenocarcinoma, Mucinous; Nerve Sheath Neoplasms; Trophoblastic Neoplasms; Neurofibrosarcoma