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Aortic Elongation and Dissection

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ClinicalTrials.gov Identifier: NCT02722889
Recruitment Status : Completed
First Posted : March 30, 2016
Last Update Posted : March 22, 2017
Sponsor:
Information provided by (Responsible Party):
Maastricht University Medical Center

Study Description
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Brief Summary:
Aim of this study is to measure length of the ascending aorta in adults and to investigate the clinical implication of 'elongation' of the aorta.

Condition or disease
Thoracic Aorta

Detailed Description:
Regarding to aortic geometry, attention is often drawn to aortic diameters since an increase in these diameters (e.g. aneurysm) can lead to life-threatening complications such as dissection and/or rupture. In daily practice however (e.g. imaging reports), the investigators often encounter patients with elongation of the ascending aorta. Little is known about the length of the proximal aorta. Furthermore, the clinical implications of an elongated aorta are unknown.
Study Design
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Study Type : Observational
Actual Enrollment : 298 participants
Observational Model: Cohort
Time Perspective: Retrospective
Official Title: Ascending Aortic Length in Relation to Age and the Occurrence of Type A Aortic Dissection
Actual Study Start Date : March 2016
Actual Primary Completion Date : December 2016
Actual Study Completion Date : January 2017
Groups and Cohorts
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Group/Cohort
Healthy controls
Healthy control patients
Type A dissection
Patients with proven type A dissection,


Outcome Measures
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Primary Outcome Measures :
  1. Length of the ascending aorta [ Time Frame: Up to 72 months ]
    Ascending aortic length as measured on computed tomography.


Eligibility Criteria
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Ages Eligible for Study:   18 Years and older   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
Reference group to assess 'normal' aortic length.
Criteria

Inclusion Criteria:

  • Underwent recent (<6 years) contrast-enhanced CT scan which allows for segmentation and assessment of aortic geometry.

Exclusion Criteria:

  • Age <18 years old.
  • Prior thoracic, cardiac or aortic surgery.
  • Genetic disease with cardiac and/or aortic involvement (e.g. Marfan's disease).
  • Infectious disease of the aorta.
  • Malignant disease with involvement of heart and/or aorta.
Contacts and Locations
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Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02722889


Locations
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Netherlands
Maastricht University Medical Center
Maastricht, Limburg, Netherlands, 6202AZ
Sponsors and Collaborators
Maastricht University Medical Center
Investigators
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Principal Investigator: Joachim Wildberger, MD, PhD Head of department of Radiology
More Information
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Responsible Party: Maastricht University Medical Center
ClinicalTrials.gov Identifier: NCT02722889    
Other Study ID Numbers: 16-4-027
First Posted: March 30, 2016    Key Record Dates
Last Update Posted: March 22, 2017
Last Verified: March 2016
Individual Participant Data (IPD) Sharing Statement:
Plan to Share IPD: No
Keywords provided by Maastricht University Medical Center:
Ascending aorta
Elongation of the aorta
Type A dissection
Aortic rupture
Aortic length