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An Investigational Immuno-therapy Study of Nivolumab, Compared to Placebo, in Patients With Bladder or Upper Urinary Tract Cancer, Following Surgery to Remove the Cancer (CheckMate 274)

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Know the risks and potential benefits of clinical studies and talk to your health care provider before participating. Read our disclaimer for details. Identifier: NCT02632409
Recruitment Status : Recruiting
First Posted : December 16, 2015
Last Update Posted : July 30, 2019
Ono Pharmaceutical Co. Ltd
Information provided by (Responsible Party):
Bristol-Myers Squibb

Brief Summary:
The purpose of this study is to determine the effectiveness and safety of Nivolumab compared to placebo in participants who have undergone radical surgery for invasive urothelial cancer.

Condition or disease Intervention/treatment Phase
Various Advanced Cancer Biological: Nivolumab Other: Placebo Phase 3

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Study Type : Interventional  (Clinical Trial)
Estimated Enrollment : 700 participants
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Triple (Participant, Care Provider, Investigator)
Primary Purpose: Treatment
Official Title: A Phase 3 Randomized, Double-blind, Multi-center Study of Adjuvant Nivolumab Versus Placebo in Subjects With High Risk Invasive Urothelial Carcinoma (CheckMate 274: CHECKpoint Pathway and nivoluMAb Clinical Trial Evaluation 274)
Actual Study Start Date : February 11, 2016
Estimated Primary Completion Date : November 30, 2020
Estimated Study Completion Date : November 27, 2026

Resource links provided by the National Library of Medicine

Drug Information available for: Nivolumab

Arm Intervention/treatment
Experimental: Nivolumab
Nivolumab dose as specified
Biological: Nivolumab
Placebo Comparator: Placebo
Placebo dose as specified
Other: Placebo

Primary Outcome Measures :
  1. Disease free survival (DFS) [ Time Frame: Approximately 5 years after the first subject is randomized ]
    DFS defined as the time between the date of randomization and the date of first recurrence or death (of any cause) whichever occurs first.

Secondary Outcome Measures :
  1. Overall survival (OS) [ Time Frame: Approximately 5 years after the first subject is randomized ]
    OS is defined as the time between the date of randomization and the date of death (of any cause).

  2. Non-Urothelial track recurrence free survival (NUTRFS) [ Time Frame: Approximately 5 years after the first subject is randomized ]
    NUTRFS is defined as the time between the date of randomization and the date of first local non urothelial tract or distant recurrence or death (of any cause), whichever occurs first.

  3. Disease specific survival (DSS) [ Time Frame: Approximately 5 years after the first subject is randomized ]
    DSS is defined as the time between the date of randomization and the date of death due to disease (urothelial cancer).

Information from the National Library of Medicine

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.

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Ages Eligible for Study:   18 Years and older   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

For more information regarding BMS clinical trial participation, please visit

Inclusion Criteria:

  • Must have had invasive urothelial cancer at high risk of recurrence originating in the bladder, ureter, or renal pelvis
  • Must have had radical surgical resection (e.g. radical cystectomy), performed within the last 120 days
  • Must have disease free status as determined by imaging within 4 weeks of dosing
  • Tumor tissue must be provided for biomarker analysis
  • Patients who have not received prior neoadjuvant cisplatin chemotherapy must be ineligible for or refuse cisplatin-based adjuvant chemotherapy

Exclusion Criteria:

  • Partial bladder or partial kidney removal (eg, partial cystectomy or partial nephrectomy)
  • Secondary Treatment (eg, adjuvant systemic chemotherapy for bladder cancer) following surgical removal of bladder cancer
  • Subjects with active, known or suspected autoimmune disease
  • Prior malignancy active within the previous 3 years except for locally curable cancers that have been apparently cured
  • Condition requiring systemic treatment with either corticosteroids or other immunosuppressive medications within 14 day of study drug administration
  • Positive test for hepatitis B virus surface antigen (HBV s Ag) or hepatitis C virus ribonucleic acid (HCV antibody) indicating acute or chronic infection

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT02632409

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Contact: Recruiting sites have contact information. Please contact the sites directly. If there is no contact information, please email:
Contact: First line of the email MUST contain NCT# and Site #.

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United States, Alaska
Alaska Urological Institute dba Alaska Clinical Research Center Recruiting
Anchorage, Alaska, United States, 99503
Contact: William Clark, Site 0015    907-276-1455      
United States, Arizona
Arizona Oncology Associates Recruiting
Tucson, Arizona, United States, 85711
Contact: Christopher Di Simone, Site 0179    520-269-3821      
United States, California
University Of California San Francisco-Fresno Recruiting
Clovis, California, United States, 93611
Contact: Uzair Chaudhary, Site 0061    559-499-6636      
University Of California - Davis Recruiting
Sacramento, California, United States, 95817
Contact: Chong-Xian Pan, Site 0172    916-734-3691      
California Pacific Medical Center Terminated
San Francisco, California, United States, 94115
United States, Colorado
Rocky Mountain Cancer Centers Recruiting
Lakewood, Colorado, United States, 80228
Contact: Nauman Moazzam, Site 0178    303-285-5081      
United States, Florida
University Of Florida Active, not recruiting
Gainesville, Florida, United States, 32610
Mount Sinai Comprehensive Cancer Center Completed
Miami Beach, Florida, United States, 33140
H. Lee Moffitt Cancer Center Active, not recruiting
Tampa, Florida, United States, 33612
United States, Illinois
Loyola University Medical Center Recruiting
Maywood, Illinois, United States, 60153
Contact: Elizabeth Henry, Site 0168    708-327-2237      
United States, Indiana
Ft. Wayne Med Onco-Hema Inc Recruiting
Fort Wayne, Indiana, United States, 46804
Contact: Sunil Babu, Site 0094    260-484-8830      
United States, Louisiana
Tulane University Recruiting
New Orleans, Louisiana, United States, 70112
Contact: Brian Lewis, Site 0171    504-988-6542      
United States, Michigan
Cancer & Hematology Centers Of Western Michigan Completed
Grand Rapids, Michigan, United States, 49503
United States, Minnesota
Fairview Health Services Recruiting
Burnsville, Minnesota, United States, 55337
Contact: Gautam Jha, Site 0051    952-836-3608      
Mayo Clinic Active, not recruiting
Rochester, Minnesota, United States, 55905
United States, Nebraska
GU Research Network, LLC Recruiting
Omaha, Nebraska, United States, 68130
Contact: Luke Nordquist, Site 0003    402-991-8468      
United States, Nevada
Comprehensive Cancer Centers of Nevada Terminated
Las Vegas, Nevada, United States, 89148
United States, New York
New York Oncology Hematology, P.C. Recruiting
Albany, New York, United States, 12208
Contact: David Shaffer, Site 0176    518-262-6696      
Roswell Park Cancer Institute Active, not recruiting
Buffalo, New York, United States, 14263
Winthrop University Hospital Recruiting
Mineola, New York, United States, 11501
Contact: Mary O'Keeffe, Site 0007    516-663-3115      
Mount Sinai Medical Center Recruiting
New York, New York, United States, 10029
Contact: Matthew Galsky, Site 0006    212-824-7372      
Memorial Sloan Kettering Cancer Center Recruiting
New York, New York, United States, 10065
Contact: Dean Bajorin, Site 0001    646-422-4333      
United States, North Carolina
University Of North Carolina Recruiting
Chapel Hill, North Carolina, United States, 27599-7305
Contact: Matthew Milowsky, Site 0166    919-962-8489      
Local Institution Not yet recruiting
Durham, North Carolina, United States, 27708
Contact: Site 0235         
United States, Oregon
Providence Portland Medical Center Recruiting
Portland, Oregon, United States, 97213
Contact: Brendan Curti, Site 0044    503-215-3943      
Oregon Health & Science University Recruiting
Portland, Oregon, United States, 97239
Contact: Jeremy Cetnar, Site 0010    503-494-3618      
Northwest Cancer Specialists, Pc Recruiting
Tigard, Oregon, United States, 97223
Contact: Ian Schnadig, Site 0180    503-528-5002      
United States, Pennsylvania
Lehigh Valley Health Network Recruiting
Allentown, Pennsylvania, United States, 18103
Contact: Suresh Nair, Site 0074    610-402-1642      
Allegheny General Hospital Recruiting
Pittsburgh, Pennsylvania, United States, 15212
Contact: Shifeng Mao, Site 0011    412-359-6452      
University of Pittsburgh Cancer Institute Cancer Services Recruiting
Pittsburgh, Pennsylvania, United States, 15232
Contact: Leonard Appleman, Site 0040    412-623-8962      
United States, South Carolina
Carolina Urologic Research Center Terminated
Myrtle Beach, South Carolina, United States, 29572
United States, Tennessee
Erlanger Oncology & Hematology - Univ. of TN Recruiting
Chattanooga, Tennessee, United States, 37403
Contact: Robert Graham, Site 0009    423-778-2982      
United States, Virginia
Virginia Oncology Associates Recruiting
Virginia Beach, Virginia, United States, 23456
Contact: Mark Fleming, Site 0234    757-262-4633      
COIBA Recruiting
Berazategui, Buenos Aires, Argentina, 1880
Contact: Mirta Varela, Site 0021    +541143509606      
Instituto Medico Especializado Alexander Fleming Recruiting
Capital Federal, Buenos Aires, Argentina, 1426
Contact: Juan Sade, Site 0090    +541132218900      
Hospital Italiano De Buenos Aires Recruiting
Ciudad Autonoma De Buenos Aire, Buenos Aires, Argentina, 1181
Contact: Federico Cayol, Site 0089    +541149590200      
Hospital Britanico De Buenos Aires Recruiting
Ciudad Autonoma de BuenosAires, Buenos Aires, Argentina, C1280AEB
Contact: Ernesto Korbenfeld, Site 0022    541163819972      
Clinica Viedma S.A. Recruiting
Viedma, RIO Negro, Argentina, 8500
Contact: Ruben Kowalyszyn, Site 0102    +542920424417      
Centro Para La Atencion Integral Del Paciente Oncologico Recruiting
San Miguel De Tucuman, Tucuman, Argentina, 4000
Contact: Felipe Palazzo, Site 0020    +543814215825      
Australia, New South Wales
Liverpool Hospital Recruiting
Liverpool, New South Wales, Australia, 2170
Contact: Bavanthi Balakrishnar, Site 0048    +61287385234      
Royal North Shore Hospital Completed
St. Leonards, New South Wales, Australia, 2065
Calvary Mater Newcastle Recruiting
Waratah, New South Wales, Australia, 2298
Contact: Craig Gedye, Site 0046    +61240143282      
Australia, Victoria
Frankston Hospital Recruiting
Frankston, Victoria, Australia, 3199
Contact: Emma Beardsley, Site 0184    +61397848562      
Australia, Western Australia
St John of God Murdoch Hospital Recruiting
Perth, Western Australia, Australia, 6150
Contact: Kynan Feeney, Site 0175    +61894288556      
Lyell McEwin Hospital Recruiting
Elizabeth Vale, Australia, 5112
Contact: Christopher Hocking, Site 0050    +61882820833      
Krankenhaus der Elisabethinen Linz GmbH Recruiting
Linz, Austria, 4010
Contact: Wolfgang Loidl, Site 0133         
Salzburger Landeskliniken Lkh Recruiting
Salzburg, Austria, 5020
Contact: Daniela Colleselli, Site 0136         
Akh Wien Recruiting
Vienna, Austria, 1090
Contact: Gottfried Locker, Site 0132         
AKH Allgemeines Krankenhaus Wien Recruiting
Wien, Austria, 1090
Contact: Shahrokh Shariat, Site 0183         
Local Institution Recruiting
Hasselt, Belgium, 3500
Contact: Site 0029         
Chu De Liege Recruiting
Liege, Belgium, 4000
Contact: Christine Gennigens, Site 0027    +3243667664      
Local Institution Withdrawn
Roeselare, Belgium, 8800
Associacao Hospital de Caridade Ijui Recruiting
Ijui, RIO Grande DO SUL, Brazil, 98700-000
Contact: Fabio Franke, Site 0071    +555533319393      
Hospital Sao Lucas Da Pucrs Recruiting
Porto Alegre, RIO Grande DO SUL, Brazil, 90610-000
Contact: Andre Fay, Site 0072    5133203236      
Fundacao Pio Xii Hosp Cancer De Barretos Recruiting
Barretos, SAO Paulo, Brazil, 14780-070
Contact: Joao Neif Junior, Site 0070    +551733216638      
Local Institution Recruiting
Cerqueira Cesar, SAO Paulo, Brazil, 01246-000
Contact: Site 0073         
Ibcc - Inst. Bras. De Controle De Cancer Recruiting
S?o Paulo, SAO Paulo, Brazil, 03102-006
Contact: Felipe Cruz, Site 0100    1134744222      
Inca - Instituto Nacional Do Cancer Recruiting
Rio De Janeiro, Brazil, 20231-050
Contact: Alexander Dias, Site 0231    +552132076585      
Canada, Alberta
Local Institution Recruiting
Edmonton, Alberta, Canada, T6G 1Z2
Contact: Site 0139         
Canada, Quebec
Mcgill University Health Center - Royal Victoria Hospital Recruiting
Montreal, Quebec, Canada, H4A 3J1
Contact: Wassim Kassouf, Site 0109    514934193436686      
Centre integre universitaire de sante et de service sociaux de l'estrie - CHUS Recruiting
Sherbrooke, Quebec, Canada, J1H 5N4
Contact: Michel Pavic, Site 0112    819346111012811      
Centre Hospitalier De L'Universite De Montreal Recruiting
Montreal, Canada, H2X 0A9
Contact: Fred Saad, Site 0101    514890800026161      
Fundacion Arturo Lopez Perez Recruiting
Santiago, Metropolitana, Chile
Contact: Pamela Salman, Site 0099    +5624457254      
Instituto Oncologico Clinica Renaca Recruiting
Vina Del Mar, Valparaiso, Chile, 2540364
Contact: Pablo Gonzalez Mella, Site 0038    +56322891219      
Clinica Alemana de Temuco S.A. Recruiting
Temuco, Chile, 4810297
Contact: Felipe Rey, Site 0137    56452201611      
China, Beijing
Local Institution Recruiting
Beijing, Beijing, China, 100001
Contact: Site 0191         
Local Institution Recruiting
Beijing, Beijing, China, 100034
Contact: Site 0206         
Local Institution Recruiting
Beijing, Beijing, China, 100050
Contact: Site 0192         
China, Chongqing
Local Institution Recruiting
Chongqing, Chongqing, China, 400030
Contact: Site 0210         
China, Fujian
Local Institution Recruiting
Fuzhou, Fujian, China, 350001
Contact: Site 0198         
China, Guangdong
Local Institution Recruiting
Guangzhou, Guangdong, China, 510120
Contact: Site 0222         
Local Institution Recruiting
Guangzhou, Guangdong, China, 510288
Contact: Site 0203         
China, Guangxi
Local Institution Recruiting
Nanning, Guangxi, China, 530021
Contact: Site 0227         
China, Hubei
Local Institution Recruiting
Wuhan, Hubei, China, 430030
Contact: Site 0196         
China, Jiangsu
Local Institution Recruiting
Nanjing, Jiangsu, China, 210008
Contact: Site 0220         
Local Institution Recruiting
Nanjing, Jiangsu, China, 210029
Contact: Site 0204         
China, Jiangxi
Local Institution Recruiting
Nanchang, Jiangxi, China, 330006
Contact: Site 0223         
China, Shan3xi
Local Institution Not yet recruiting
Xi'an, Shan3xi, China, 710061
Contact: Site 0190         
China, Shandong
Local Institution Recruiting
Yantai, Shandong, China, 264000
Contact: Site 0212         
China, Shanghai
Local Institution Recruiting
Shanghai, Shanghai, China, 200032
Contact: Site 0193         
Local Institution Recruiting
Shanghai, Shanghai, China, 200040
Contact: Site 0199         
Local Institution Recruiting
Shanghai, Shanghai, China, 200040
Contact: Site 0217         
China, Sichuan
Local Institution Recruiting
Chengdu, Sichuan, China, 610041
Contact: Site 0229         
Local Institution Recruiting
Chengdu, Sichuan, China, 610072
Contact: Site 0219         
China, Zhejiang
Local Institution Recruiting
Hangzhou, Zhejiang, China, 310009
Contact: Site 0221         
Local Institution Recruiting
Hangzhou, Zhejiang, China, 310014
Contact: Site 0195         
Local Institution Recruiting
Wenzhou, Zhejiang, China, 325003
Contact: Site 0230         
Local Institution Recruiting
Shanghai, China, 200032
Contact: Site 0202         
Administradora Del Country S.A. - Clinica Del Country Recruiting
Bogota, Colombia
Contact: Andres Felipe Cardona Zorrilla, Site 0092    57153004702907      
Fundacion Oftalmologica De Santander - Foscal Recruiting
Floridablanca, Colombia
Contact: Milton Salazar, Site 0093    57767979796161      
Hospital Pablo Tobon Uribe Recruiting
Medellin, Colombia, MEDELLIN
Contact: Jose Correa, Site 0091    5744459753      
Local Institution Recruiting
Aalborg, Denmark, 9100
Contact: Site 0108         
Local Institution Recruiting
Aarhus N, Denmark, 8200
Contact: Site 0106         
Local Institution Recruiting
Copenhagen, Denmark, 2100
Contact: Site 0107         
Local Institution Recruiting
Clermont-ferrand, France, 63000
Contact: Site 0233         
Local Institution Recruiting
La Roche sur Yon, France, 85320
Contact: Site 0115         
Local Institution Recruiting
Marseille Cedex 9, France, 13273
Contact: Site 0080         
Local Institution Recruiting
Paris, France, 75475
Contact: Site 0081         
Local Institution Recruiting
Strasbourg, France, 67091
Contact: Site 0113         
Local Institution Recruiting
Suresnes, France, 92151
Contact: Site 0097         
Local Institution Terminated
Villejuif, France, 94800
Zeisigwaldkliniken Bethanien Recruiting
Chemnitz, Germany, 09130
Contact: Hanjo Belz, Site 0131    +493714301730      
Klinik Essen-Mitte Recruiting
Essen, Germany, 45136
Contact: Susanne Krege, Site 0125    +4920117424523      
Univ Klinikum Der Ernst-Moritz-Arndt-Univ Greifswald Recruiting
Greifswald, Germany, 17475
Contact: Uwe Zimmermann, Site 0127    +493834865961      
Uni Hamburg-Eppendorf Recruiting
Hamburg, Germany, 20246
Contact: Gunhild von Amsberg, Site 0126    +4940741053994      
Local Institution Recruiting
Heidelberg, Germany, 69120
Contact: Site 0124         
Universitaetsklinikum Jena Recruiting
Jena, Germany, 07747
Contact: Marc-Oliver Grimm, Site 0123    +4936419329956      
Universitatsklinikum Giessen Und Marburg Recruiting
Marburg, Germany, 35043
Contact: Axel Hegele, Site 0188    +4964215863695      
Universitaetsklinikum Muenster Recruiting
Muenster, Germany, 48149
Contact: Martin Boegemann, Site 0128    +492518349161      
Klinikum rechts der Isar der Technischen Universitat Munchen Recruiting
Munich, Germany, 81675
Contact: Juergen Gschwend, Site 0122    +498941409858      
Local Institution Recruiting
Nuernberg, Germany, 90419
Contact: Site 0185         
Klinikum Der Universitaet Regensburg Completed
Regensburg, Germany, 93053
Klinikum Stuttgart Recruiting
Stuttgart, Germany, 70174
Contact: Jan Schleicher, Site 0129    +4971127830411      
Alexandra General Hospital Recruiting
Athens, Greece, 11528
Contact: Aristotelis Bamias, Site 0110    +302103381543      
Theagenio Hospital Recruiting
Thessaloniki, Greece, 54007
Contact: Charalambos Andreadis, Site 0111    +302310898721      
Local Institution Recruiting
Wilton, Cork, Ireland
Contact: Site 0054         
Adelaide And Meath Hospital Recruiting
Dublin, Ireland
Contact: Ray Mcdermott, Site 0052    +35314142012      
Local Institution Recruiting
Haifa, Israel, 3109601
Contact: Site 0118         
Local Institution Recruiting
Jerusalem, Israel, 91120
Contact: Site 0121         
Local Institution Recruiting
Ramat Gan, Israel, 5262100
Contact: Site 0120         
Local Institution Recruiting
Zerifin, Israel, 70300
Contact: Site 0119         
Ospedale S. Donato - Usl 8 Recruiting
Arezzo, Italy, 52100
Contact: Alketa Hamzaj, Site 0088    +3905752551 0000 0000      
ASST Papa Giovanni XXIII Recruiting
Bergamo, Italy, 24127
Contact: Caterina Messina, Site 0197    +39035267111 000.000 000      
IRCCS Istituto Nazionale Tumori Milano Recruiting
Milano, Italy, 20133
Contact: Andrea Necchi, Site 0082    +390223901 00 00000      
Local Institution Withdrawn
Pavia, Italy, 27100
Azienda Ospedaliera Universitaria Pisana Recruiting
Pisa, Italy, 56126
Contact: Luca Galli, Site 0084    +39050992111 000.000000      
Arcispedale S. Maria Nuova - A.O. Reggio Emilia Recruiting
Reggio Emilia, Italy, 42100
Contact: Cristina Masini, Site 0189    +390522335111 0000.000000      
Istituto Regina Elena Recruiting
Roma, Italy, 00144
Contact: Francesco Cognetti, Site 0085    +390652661 00 00000      
Azienda Ospedaliera S. Camillo Forlanini Terminated
Roma, Italy, 00152
AOUS - Policlinico S.Maria Alle Scotte Recruiting
Siena, Italy, 53100
Contact: Michele Maio, Site 0083    +390577585111 0000 000000      
Local Institution Recruiting
Akita-shi, Akita, Japan, 0108543
Contact: Site 0142         
Local Institution Recruiting
Hirosaki-shi, Aomori, Japan, 036-8563
Contact: Site 0144         
Local Institution Recruiting
Chiba-shi, Chiba, Japan, 260-8717
Contact: Site 0143         
Local Institution Recruiting
Fukuoka-shi, Fukuoka, Japan, 8128582
Contact: Site 0162         
Local Institution Recruiting
Sapporo-shi, Hokai-do, Japan, 060-8543
Contact: Site 0160         
Local Institution Recruiting
Sapporo-shi, Hokkaido, Japan, 0608648
Contact: Site 0161         
Local Institution Recruiting
Tsukuba-shi, Ibaraki, Japan, 3058576
Contact: Site 0148         
Local Institution Recruiting
Nagasaki-shi, Nagasaki, Japan, 8528501
Contact: Site 0163         
Local Institution Recruiting
Niigata-shi, Niigata, Japan, 9518520
Contact: Site 0150         
Local Institution Recruiting
Okayama-shi, Okayama, Japan, 7000914
Contact: Site 0141         
Local Institution Recruiting
Higashinari-ku, Osaka, Japan, 5378511
Contact: Site 0164         
Local Institution Recruiting
Osaka-Sayama-Shi, Osaka, Japan, 5898511
Contact: Site 0149         
Local Institution Recruiting
Hamamatsu-shi, Shizuoka, Japan, 4313192
Contact: Site 0151         
Local Institution Recruiting
Bunkyo-ku, Tokyo, Japan, 113-8603
Contact: Site 0146         
Local Institution Recruiting
Shinjuku-Ku, Tokyo, Japan, 1608582
Contact: Site 0145         
Local Institution Recruiting
Shinjuku-ku, Tokyo, Japan, 1628666
Contact: Site 0147         
Korea, Republic of
Local Institution Recruiting
Seongnam-si, Gyeonggi-do, Korea, Republic of, 13620
Contact: Site 0155         
Local Institution Recruiting
Seoul, Korea, Republic of, 03722
Contact: Site 0154         
Local Institution Recruiting
Seoul, Korea, Republic of, 05505
Contact: Site 0152         
Local Institution Recruiting
Seoul, Korea, Republic of, 06351
Contact: Site 0156         
Local Institution Recruiting
Df, Distrito Federal, Mexico, 06720
Contact: Site 0138         
Instituto Nacional De Cancerologia Active, not recruiting
Mexico City, Distrito Federal, Mexico, 14080
Arke Estudios Clinicos Sa De Cv Recruiting
Mexico, Distrito Federal, Mexico, 06700
Contact: Manuel Magallanes, Site 0116    5554137773      
Local Institution Recruiting
Mexico, Distrito Federal, Mexico, 14080
Contact: Site 0039         
Local Institution Recruiting
Guadalajara, Jalisco, Mexico, 44270
Contact: Site 0035         
Hospital Universitario Dr. Jose Eleuterio Gonzalez Recruiting
Monterrey, Nuevo LEON, Mexico, 64460
Contact: Yamil-Alonso Lopez Chuken, Site 0032    8115443345      
Local Institution Recruiting
Amsterdam, Netherlands, 1105 AZ
Contact: Site 0069         
Local Institution Recruiting
Maastrict, Netherlands, 6229 HX
Contact: Site 0068         
Local Institution Recruiting
Nijmegen, Netherlands, 6525 GA
Contact: Site 0041         
Local Institution Withdrawn
Arequipa, Peru
Clinica Internacional sede San Borja Recruiting
Lima, Peru, Lima 41
Contact: Renzo Salas, Site 0043         
Klinika Onkologii i Radioterapii Recruiting
Gdansk, Poland, 80-952
Contact: Elzbieta Senkus-Konefka, Site 0055    +48583492214      
Regionalny Osrodek Onkologiczny Terminated
Lodz, Poland, 93-513
Local Institution Not yet recruiting
Warsaw, Poland, 02-797
Contact: Site 0187         
Local Institution Not yet recruiting
Wroclaw, Poland, 50-556
Contact: Site 0058         
Oddzial Onkologii Klinicznej Recruiting
Wroclaw, Poland, 53-413
Contact: Krzysztof Tupikowski, Site 0186    +48713689677      
Local Institution Recruiting
Bucuresti, Romania, 021389
Contact: Site 0182         
Local Institution Recruiting
Craiova, Romania, 200347
Contact: Site 0096         
Local Institution Recruiting
Floresti, Romania, 407280
Contact: Site 0078         
Local Institution Recruiting
Timisoara, Timis, Romania, 300239
Contact: Site 0181         
Russian Federation
Local Institution Not yet recruiting
Moscow, Russian Federation, 115478
Contact: Site 0018         
Local Institution Recruiting
Moscow, Russian Federation, 125284
Contact: Site 0140         
Local Institution Recruiting
Saint-Petersburg, Russian Federation, 197758
Contact: Site 0031         
Hospital Universitari Germans Trias I Pujol Recruiting
Badalona-barcelona, Spain, 08916
Contact: Olatz Etxaniz, Site 0067    +34934978729      
Hospital General Universitari Vall D'Hebron Recruiting
Barcelona, Spain, 08035
Contact: Rafael Morales, Site 0066    +34932746000      
Hospital General Universitario Gregorio Maranon Recruiting
Madrid, Spain, 28007
Contact: Jose Angel Arranz, Site 0064    +34915868115      
Hospital Ramon Y Cajal Recruiting
Madrid, Spain, 28034
Contact: Pablo Gajate, Site 0062    +34913368263      
Hosp Univer 12 De Octubre Recruiting
Madrid, Spain, 28041
Contact: Daniel Castellano, Site 0063    +34913908339      
H. U. Marques de Valdecilla Recruiting
Santander, Spain, 39008
Contact: Ignacio Duran, Site 0232    +34942315004      
Hosp. Univ. Virgen Del Rocio Recruiting
Sevilla, Spain, 41013
Contact: Begona Perez Valderrama, Site 0065    +34955011368      
Local Institution Recruiting
Lund, Sweden, 221 85
Contact: Site 0105         
Kantonsspital Basel Recruiting
Basel, Switzerland, 4031
Contact: Frank Stenner, Site 0134    +41613287538      
OnkoZentrum Zurich Recruiting
Zuerich, Switzerland, 8038
Contact: Ulf Petrausch, Site 0135         
Local Institution Recruiting
Kaohsiung, Taiwan, 80765
Contact: Site 0158         
Local Institution Recruiting
Taichung, Taiwan, 404
Contact: Site 0159         
Local Institution Recruiting
Taipei, Taiwan, 100
Contact: Site 0153         
United Kingdom
Local Institution Withdrawn
Cardiff, Cardiganshire, United Kingdom, CF142TL
Local Institution Withdrawn
London, Greater London, United Kingdom, NW3 2QG
Local Institution Recruiting
London, Greater London, United Kingdom, SE1 9RT
Contact: Site 0036         
Local Institution Recruiting
Manchester, Greater Manchester, United Kingdom, M20 4BX
Contact: Site 0025         
Local Institution Recruiting
Edinburgh, Midlothian, United Kingdom, EH4 2XU
Contact: Site 0076         
Local Institution Recruiting
Sutton, Surrey, United Kingdom, SM2 5PT
Contact: Site 0024         
Cancer Research Centre Recruiting
Sheffield, Yorkshire, United Kingdom, S10 2SJ
Contact: Linda Evans, Site 0059    +441142265000      
Local Institution Recruiting
London, United Kingdom, SW3 6JJ
Contact: Site 0114         
Sponsors and Collaborators
Bristol-Myers Squibb
Ono Pharmaceutical Co. Ltd
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Study Director: Bristol-Myers Squibb Bristol-Myers Squibb

Additional Information:
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Responsible Party: Bristol-Myers Squibb Identifier: NCT02632409     History of Changes
Other Study ID Numbers: CA209-274
2014-003626-40 ( EudraCT Number )
First Posted: December 16, 2015    Key Record Dates
Last Update Posted: July 30, 2019
Last Verified: July 2019

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Studies a U.S. FDA-regulated Drug Product: Yes
Studies a U.S. FDA-regulated Device Product: No
Additional relevant MeSH terms:
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Antineoplastic Agents, Immunological
Antineoplastic Agents